Výsledky vyhľadávania - "Brown, J William L"

Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study Autor Jacobs, Benjamin M., Daruwalla, Cyrus, McKeon, Mollie O., Al-Najjar, Raghda, Simcock-Davies, Andrea, Tuite-Dalton, Katherine, Brown, J. William L., Dobson, Ruth, Rodgers, Jeff, Middleton, Rod

“…Understanding the associations and potential drivers of long-term disability in Multiple Sclerosis (MS) is of clinical and prognostic value. Previous data have…”
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A real-world clinical validation for AI-based MRI monitoring in multiple sclerosis Autor Barnett, Michael, Wang, Dongang, Beadnall, Heidi, Bischof, Antje, Brunacci, David, Butzkueven, Helmut, Brown, J. William L., Cabezas, Mariano, Das, Tilak, Dugal, Tej, Guilfoyle, Daniel, Klistorner, Alexander, Krieger, Stephen, Kyle, Kain, Ly, Linda, Masters, Lynette, Shieh, Andy, Tang, Zihao, van der Walt, Anneke, Ward, Kayla, Wiendl, Heinz, Zhan, Geng, Zivadinov, Robert, Barnett, Yael, Wang, Chenyu

“…Modern management of MS targets No Evidence of Disease Activity (NEDA): no clinical relapses, no magnetic resonance imaging (MRI) disease activity and no…”
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Remyelination in humans due to a retinoid‐X receptor agonist is age‐dependent Autor McMurran, Christopher E., Mukherjee, Trisha, Brown, J William L., Michell, Andrew W., Chard, Declan T., Franklin, Robin J. M., Coles, Alasdair J., Cunniffe, Nick G.

“…Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that…”
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An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis Autor De Meo, Ermelinda, Prados Carrasco, Ferran, Brown, J. William L., Coles, Alasdair J., Cunniffe, Nick G., Jolly, Amy E., Kanber, Baris, Samson, Rebecca, Barkhof, Frederik, Chard, Declan

“…Objective To assess the pathological mechanisms contributing to white matter (WM) lesion expansion or contraction and remyelination in multiple sclerosis (MS)…”
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Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis Autor Brown, J William L, Coles, Alasdair, Horakova, Dana, Havrdova, Eva, Izquierdo, Guillermo, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Trojano, Maria, Lugaresi, Alessandra, Bergamaschi, Roberto, Grammond, Pierre, Alroughani, Raed, Hupperts, Raymond, McCombe, Pamela, Van Pesch, Vincent, Sola, Patrizia, Ferraro, Diana, Grand'Maison, Francois, Terzi, Murat, Lechner-Scott, Jeannette, Flechter, Schlomo, Slee, Mark, Shaygannejad, Vahid, Pucci, Eugenio, Granella, Franco, Jokubaitis, Vilija, Willis, Mark, Rice, Claire, Scolding, Neil, Wilkins, Alastair, Pearson, Owen R, Ziemssen, Tjalf, Hutchinson, Michael, Harding, Katharine, Jones, Joanne, McGuigan, Christopher, Butzkueven, Helmut, Kalincik, Tomas, Robertson, Neil

“…Within 2 decades of onset, 80% of untreated patients with relapsing-remitting multiple sclerosis (MS) convert to a phase of irreversible disability accrual…”
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Association of obstructive sleep apnea with risk of serious cardiovascular events: a systematic review and meta-analysis Autor Loke, Yoon K, Brown, J William L, Kwok, Chun Shing, Niruban, Alagaratnam, Myint, Phyo K

“…The relationship between obstructive sleep apnea (OSA) and cardiovascular events remains unclear. We conducted a systematic review to determine the incident…”
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Bexarotene leads to durable improvements in visual evoked potential latency: A follow-up study of the Cambridge Centre for Myelin Repair One trial Autor McMurran, Christopher E, Mukherjee, Trisha, Brown, J William L, Coles, Alasdair J, Cunniffe, Nick G

“…The Cambridge Centre for Myelin Repair One (CCMR-One) trial showed that 6 months of bexarotene reduces visual evoked potential (VEP) latency in people with…”
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Treatment effectiveness of alemtuzumab compared with natalizumab, fingolimod, and interferon beta in relapsing-remitting multiple sclerosis: a cohort study Autor Kalincik, Tomas, Brown, J William L, Robertson, Neil, Willis, Mark, Scolding, Neil, Rice, Claire M, Wilkins, Alastair, Pearson, Owen, Ziemssen, Tjalf, Hutchinson, Michael, McGuigan, Christopher, Jokubaitis, Vilija, Spelman, Tim, Horakova, Dana, Havrdova, Eva, Trojano, Maria, Izquierdo, Guillermo, Lugaresi, Alessandra, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Grammond, Pierre, Alroughani, Raed, Pucci, Eugenio, Sola, Patrizia, Hupperts, Raymond, Lechner-Scott, Jeannette, Terzi, Murat, Van Pesch, Vincent, Rozsa, Csilla, Grand'Maison, François, Boz, Cavit, Granella, Franco, Slee, Mark, Spitaleri, Daniele, Olascoaga, Javier, Bergamaschi, Roberto, Verheul, Freek, Vucic, Steve, McCombe, Pamela, Hodgkinson, Suzanne, Sanchez-Menoyo, Jose Luis, Ampapa, Radek, Simo, Magdolna, Csepany, Tunde, Ramo, Cristina, Cristiano, Edgardo, Barnett, Michael, Butzkueven, Helmut, Coles, Alasdair

“…Alemtuzumab, an anti-CD52 antibody, is proven to be more efficacious than interferon beta-1a in the treatment of relapsing-remitting multiple sclerosis, but…”
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Periventricular magnetisation transfer ratio abnormalities in multiple sclerosis improve after alemtuzumab Autor Brown, J William L, Prados Carrasco, Ferran, Eshaghi, Arman, Sudre, Carole H, Button, Tom, Pardini, Matteo, Samson, Rebecca S, Ourselin, Sebastien, Wheeler-Kingshott, Claudia Am Gandini, Jones, Joanne L, Coles, Alasdair J, Chard, Declan T

“…In multiple sclerosis (MS), disease effects on magnetisation transfer ratio (MTR) increase towards the ventricles. This periventricular gradient is evident…”
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Remyelination varies between and within lesions in multiple sclerosis following bexarotene Autor Brown, J. William L., Prados, Ferran, Altmann, Daniel R., Kanber, Baris, Stutters, Jonathan, Cunniffe, Nick G., Jones, Joanne L., Georgieva, Zoya G., Needham, Edward J., Daruwalla, Cyrus, Wheeler‐Kingshott, Claudia Gandini, Connick, Peter, Chandran, Siddharthan, Franklin, Robin, MacManus, David, Samson, Rebecca, Coles, Alasdair, Chard, Declan

“…Objective In multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability…”
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Long-term remission with rituximab in refractory leucine-rich glioma inactivated 1 antibody encephalitis Autor Brown, J. William L., Martin, Peter J., Thorpe, John W., Michell, Andrew W., Coles, Alasdair J., Cox, Amanda L., Vincent, Angela, Zandi, Michael S.

“…Autoimmune encephalitis associated with antibodies to leucine-rich glioma inactivated 1 (LGI1) is recently described and there is a lack of detailed reports on…”
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The role of MRI in the evaluation of secondary progressive multiple sclerosis Autor Brown, J. William L., Chard, Declan T.

“…Magnetic resonance imaging already has an established role in the diagnosis of multiple sclerosis, but it also has the potential to provide prognostic…”
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Surface-in pathology in multiple sclerosis: a new view on pathogenesis? Autor Pardini, Matteo, Brown, J William L, Magliozzi, Roberta, Reynolds, Richard, Chard, Declan T

“…While multiple sclerosis can affect any part of the CNS, it does not do so evenly. In white matter it has long been recognized that lesions tend to occur…”
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Visual outcome measures in clinical trials of remyelinating drugs Autor Riboni-Verri, Gioia, Chen, Benson S, McMurran, Christopher E, Halliwell, Gregory J, Brown, J William L, Coles, Alasdair J, Cunniffe, Nick G

“…One of the most promising approaches to delay, prevent or reverse disability progression in multiple sclerosis (MS) is to enhance endogenous remyelination and…”
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Amphetamine‐associated seizures: Clinical features and prognosis Autor Brown, J. William L., Dunne, John W., Fatovic, Daniel M., Lee, Judy, Lawn, Nicholas D.

“…Summary Forty‐four patients presenting with first‐ever seizure within 24 h of illicit use of amphetamine or related analogs (amphetamine‐associated seizures,…”
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Keratinocyte growth factor impairs human thymic recovery from lymphopenia Autor Coles, Alasdair J., Azzopardi, Laura, Kousin-Ezewu, Onajite, Mullay, Harpreet Kaur, Thompson, Sara A.J., Jarvis, Lorna, Davies, Jessica, Howlett, Sarah, Rainbow, Daniel, Babar, Judith, Sadler, Timothy J., Brown, J. William L., Needham, Edward, May, Karen, Georgieva, Zoya G., Handel, Adam E., Maio, Stefano, Deadman, Mary, Rota, Ioanna, Holländer, Georg, Dawson, Sarah, Jayne, David, Seggewiss-Bernhardt, Ruth, Douek, Daniel C., Isaacs, John D., Jones, Joanne L.

“…The lymphocyte-depleting antibody alemtuzumab is a highly effective treatment of relapsing-remitting multiple sclerosis (RRMS); however 50% of patients develop…”
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Alemtuzumab: evidence for its potential in relapsing-remitting multiple sclerosis Autor Brown, William, Coles, Alasdair

“…Alemtuzumab (previously known as Campath(®)) is a humanized monoclonal antibody directed against the CD52 antigen on mature lymphocytes that results in…”
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Clinician and patient experience of neurology telephone consultations during the COVID-19 pandemic Autor Nakornchai, Tagore, Conci, Elena, Hensiek, Anke, Brown, J William L

“…BackgroundTelephone consultations are already employed in specific neurological settings. At Cambridge University Hospitals, the COVID-19 pandemic initially…”
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Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study Autor Brown, J William L, Cunniffe, Nick G, Prados, Ferran, Kanber, Baris, Jones, Joanne L, Needham, Edward, Georgieva, Zoya, Rog, David, Pearson, Owen R, Overell, James, MacManus, David, Samson, Rebecca S, Stutters, Jonathan, ffrench-Constant, Charles, Gandini Wheeler-Kingshott, Claudia A M, Moran, Carla, Flynn, Paul D, Michell, Andrew W, Franklin, Robin J M, Chandran, Siddharthan, Altmann, Daniel R, Chard, Declan T, Connick, Peter, Coles, Alasdair J

“…Progressive disability in multiple sclerosis occurs because CNS axons degenerate as a late consequence of demyelination. In animals, retinoic acid receptor…”
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An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis Autor Brown, J William L, Pardini, Matteo, Brownlee, Wallace J, Fernando, Kryshani, Samson, Rebecca S, Prados Carrasco, Ferran, Ourselin, Sebastien, Gandini Wheeler-Kingshott, Claudia A M, Miller, David H, Chard, Declan T

“…In established multiple sclerosis, tissue abnormality-as assessed using magnetization transfer ratio-increases close to the lateral ventricles. We aimed to…”
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