Suchergebnisse - "Broughton Pipkin, F."

The placental renin–angiotensin system and oxidative stress in pre-eclampsia von Mistry, H.D., Kurlak, L.O., Broughton Pipkin, F.

“… There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin …”
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Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy von Mistry, H.D., Kurlak, L.O., Williams, P.J., Ramsay, M.M., Symonds, M.E., Broughton Pipkin, F.

“… Preeclampsia is a pregnancy-specific condition affecting 2–7% of women and a leading cause of perinatal and maternal morbidity and mortality; it may also …”
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Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development von Bispham, J, Gopalakrishnan, G S, Dandrea, J, Wilson, V, Budge, H, Keisler, D H, Broughton Pipkin, F, Stephenson, T, Symonds, M E

“… Maternal nutrient restriction at specific stages of gestation has differential effects on fetal development such that the offspring are programmed to be at …”
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Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia von Smith-Jackson, K., Hentschke, M.R., Poli-de-Figueiredo, C.E., Pinheiro da Costa, B.E., Kurlak, L.O., Broughton Pipkin, F., Czajka, A., Mistry, H.D.

“… Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by …”
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Expression of AT1R, AT2R and AT4R and Their Roles in Extravillous Trophoblast Invasion in the Human von Williams, P.J., Mistry, H.D., Innes, B.A., Bulmer, J.N., Broughton Pipkin, F.

“… The placental renin-angiotensin system (RAS) is active from early pregnancy and may have a role in placentation. Angiotensin II (AngII) acts via binding to …”
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Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy von Kurlak, L.O., Mistry, H.D., Kaptein, E., Visser, T.J., Broughton Pipkin, F.

“… Pre-eclampsia is associated with lower serum selenium concentrations and glutathione peroxidase expression/activity; total thyroid hormones are also lower. We …”
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Regional variation in angiotensin converting enzyme activity in the human placenta von Brameld, J.M., Hold, R., Broughton Pipkin, F.

“… Sensitivity of chorionic plate arteries to angiotensin II (AngII) is greatest at the placental periphery. Angiotensin converting enzyme (ACE) is central to the …”
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Smoking in moderate/severe preeclampsia worsens pregnancy outcome, but smoking cessation limits the damage von Pipkin, F Broughton

“… We studied phenotypic and clinical outcome data in an observational, multicenter cohort study of 1001 Western European white women and their singleton babies, …”
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Expression of voltage-dependent potassium channels in first trimester human placentae von Mistry, H.D., Kurlak, L.O., Whitley, G.S., Cartwright, J.E., Broughton Pipkin, F., Tribe, R.M.

“… Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to …”
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Pomegranates (Punica granatum) and their effect on blood pressure: a randomised double-blind placebo-controlled trial von Carpenter, L. A., Conway, C. J., Broughton Pipkin, F.

“… ProQuest: ... denotes non-US-ASCII text omitted.) Increased levels of reactive oxygen and nitrogen species and decreased levels of antioxidants are …”
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The effect of pomegranate juice (PomWonderful™) on platelet function von Conway, C. J., Carpenter, L., Broughton Pipkin, F., Fox, S. C.

“… The blood samples were then analysed for platelet surface P-selectin expression, a marker of platelet activation, which was detected by flow cytometry using a …”
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A prospective, longitudinal study of the renin-angiotensin system, prostacyclin and thromboxane in the first trimester of normal human pregnancy: association with birthweight von Al Kadi, H, Nasrat, H, Broughton Pipkin, F

“… Very early human pregnancy is a state of cardiovascular underfilling. The renin-angiotensin system (RAS) is directly concerned with sodium and water …”
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Hypertension in pregnancy von Broughton Pipkin, F, Roberts, JM

“… Hypertension arising during pregnancy remains one of the two most frequently-cited causes of maternal death in the UK. In some cases, pregnancy is unmasking …”
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In vitro development of pig preantral follicles cultured in a serum-free medium and the effect of angiotensin II von Shuttleworth, G, Broughton Pipkin, F, Hunter, M G

“… A novel culture system is reported in which pig preantral follicles (< 300 microm in diameter) with an intact thecal cell layer were isolated and cultured in a …”
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What Is the Place of Genetics in the Pathogenesis of Pre-Eclampsia? von Broughton Pipkin, F.

“… It is most unlikely that there is a single ‘pre-eclampsia (PE) gene’. We are probably looking for a cluster of polymorphisms which, possibly in conjunction …”
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Placental expression of adenosine A(2A) receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system von Kurlak, L O, Williams, P J, Bulmer, J N, Broughton Pipkin, F, Mistry, H D

“… Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) promote angiogenesis and vascularisation. We investigated the temporal …”
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Immunolocalization and protein expression of the alpha subunit of the large-conductance calcium-activated potassium channel in human myometrium von Chanrachakul, B, Matharoo-Ball, B, Turner, A, Robinson, G, Broughton-Pipkin, F, Arulkumaran, S, Khan, R N

“… Large-conductance calcium-activated potassium (BKCa) channels play an important role in the control of myometrial excitability. The aim of the present study …”
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How common are ongoing problems after a hypertensive pregnancy? von Green, A, Loughna, P, Pipkin, F Broughton

“… Background New onset hypertension in pregnancy affects up to 6–8% of all pregnancies. For most women, hypertension and proteinuria settles following delivery …”
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Maternal and fetal angiotensinogen gene allele sharing in pre‐eclampsia von Morgan, L., Crawshaw, S., Baker, P. N., Pipkin, F. Broughton, Kalsheker, N.

“… Objective To compare the angiotensinogen genotypes in normotensive and pre‐eclamptic pregnancies in maternal and fetal samples. Design Prospective …”
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The effect of the menstrual cycle on human cerebral blood flow: studies using Doppler ultrasound von Brackley, K. J., Ramsay, M. M., Broughton Pipkin, F., Rubin, P. C.

“… Objective Previous studies have demonstrated hemodynamic changes at different phases in the menstrual cycle, but the cerebral circulation has not been …”
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