Suchergebnisse - "British journal of cancer"

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy von Raskov, Hans, Orhan, Adile, Christensen, Jan Pravsgaard, Gögenur, Ismail

“… The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface …”
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Cancer health disparities in racial/ethnic minorities in the United States von Zavala, Valentina A., Bracci, Paige M., Carethers, John M., Carvajal-Carmona, Luis, Coggins, Nicole B., Cruz-Correa, Marcia R., Davis, Melissa, de Smith, Adam J., Dutil, Julie, Figueiredo, Jane C., Fox, Rena, Graves, Kristi D., Gomez, Scarlett Lin, Llera, Andrea, Neuhausen, Susan L., Newman, Lisa, Nguyen, Tung, Palmer, Julie R., Palmer, Nynikka R., Pérez-Stable, Eliseo J., Piawah, Sorbarikor, Rodriquez, Erik J., Sanabria-Salas, María Carolina, Schmit, Stephanie L., Serrano-Gomez, Silvia J., Stern, Mariana C., Weitzel, Jeffrey, Yang, Jun J., Zabaleta, Jovanny, Ziv, Elad, Fejerman, Laura

“… There are well-established disparities in cancer incidence and outcomes by race/ethnicity that result from the interplay between structural, socioeconomic, …”
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Reprogramming of fatty acid metabolism in cancer von Koundouros, Nikos, Poulogiannis, George

“… A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, …”
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Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer von Leonetti, Alessandro, Sharma, Sugandhi, Minari, Roberta, Perego, Paola, Giovannetti, Elisa, Tiseo, Marcello

“… Osimertinib is an irreversible, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that is highly selective for EGFR- …”
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Deep learning in cancer pathology: a new generation of clinical biomarkers von Echle, Amelie, Rindtorff, Niklas Timon, Brinker, Titus Josef, Luedde, Tom, Pearson, Alexander Thomas, Kather, Jakob Nikolas

“… Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers. However, the growing number of these complex biomarkers tends to …”
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Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours von Hong, David S., Kang, Yoon-Koo, Borad, Mitesh, Sachdev, Jasgit, Ejadi, Samuel, Lim, Ho Yeong, Brenner, Andrew J., Park, Keunchil, Lee, Jae-Lyun, Kim, Tae-You, Shin, Sangjoon, Becerra, Carlos R., Falchook, Gerald, Stoudemire, Jay, Martin, Desiree, Kelnar, Kevin, Peltier, Heidi, Bonato, Vinicius, Bader, Andreas G., Smith, Susan, Kim, Sinil, O’Neill, Vincent, Beg, Muhammad S.

“… Background In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of …”
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The lingering mysteries of metastatic recurrence in breast cancer von Riggio, Alessandra I., Varley, Katherine E., Welm, Alana L.

“… Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic …”
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Cytokines in clinical cancer immunotherapy von Berraondo, Pedro, Sanmamed, Miguel F., Ochoa, María C, Etxeberria, Iñaki, Aznar, Maria A., Pérez-Gracia, José Luis, Rodríguez-Ruiz, María E., Ponz-Sarvise, Mariano, Castañón, Eduardo, Melero, Ignacio

“… Cytokines are soluble proteins that mediate cell-to-cell communication. Based on the discovery of the potent anti-tumour activities of several pro-inflammatory …”
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IDH mutation in glioma: molecular mechanisms and potential therapeutic targets von Han, Sue, Liu, Yang, Cai, Sabrina J., Qian, Mingyu, Ding, Jianyi, Larion, Mioara, Gilbert, Mark R., Yang, Chunzhang

“… Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular …”
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Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression von Lüönd, Fabiana, Tiede, Stefanie, Christofori, Gerhard

“… Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response …”
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Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression von Groth, Christopher, Hu, Xiaoying, Weber, Rebekka, Fleming, Viktor, Altevogt, Peter, Utikal, Jochen, Umansky, Viktor

“… Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC) differentiate into granulocytes, macrophages and dendritic cells (DCs). This …”
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Mechanisms of resistance to immune checkpoint inhibitors von Jenkins, Russell W, Barbie, David A, Flaherty, Keith T

“… Immune checkpoint inhibitors (ICI) targeting CTLA-4 and the PD-1/PD-L1 axis have shown unprecedented clinical activity in several types of cancer and are …”
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The clinical role of the TME in solid cancer von Giraldo, Nicolas A., Sanchez-Salas, Rafael, Peske, J. David, Vano, Yann, Becht, Etienne, Petitprez, Florent, Validire, Pierre, Ingels, Alexandre, Cathelineau, Xavier, Fridman, Wolf Herman, Sautès-Fridman, Catherine

“… The highly complex and heterogenous ecosystem of a tumour not only contains malignant cells, but also interacting cells from the host such as endothelial …”
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Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond von Keller, Laura, Belloum, Yassine, Wikman, Harriet, Pantel, Klaus

“… Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The majority of currently available studies on the use of this …”
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Achieving clinical success with BET inhibitors as anti-cancer agents von Shorstova, Tatiana, Foulkes, William D., Witcher, Michael

“… The transcriptional upregulation of oncogenes is a driving force behind the progression of many tumours. However, until a decade ago, the concept of ‘switching …”
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New aspects of amino acid metabolism in cancer von Vettore, Lisa, Westbrook, Rebecca L., Tennant, Daniel A.

“… An abundant supply of amino acids is important for cancers to sustain their proliferative drive. Alongside their direct role as substrates for protein …”
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Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance von Krook, Melanie A., Reeser, Julie W., Ernst, Gabrielle, Barker, Hannah, Wilberding, Max, Li, Gary, Chen, Hui-Zi, Roychowdhury, Sameek

“… Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-nucleotide variants, gene fusions and copy number amplifications in 5–10% of …”
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Tumour treating fields therapy for glioblastoma: current advances and future directions von Rominiyi, Ola, Vanderlinden, Aurelie, Clenton, Susan Jane, Bridgewater, Caroline, Al-Tamimi, Yahia, Collis, Spencer James

“… Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and continues to portend poor survival, despite multimodal treatment using …”
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Insights into the role of sialylation in cancer progression and metastasis von Dobie, Christopher, Skropeta, Danielle

“… Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to growing glycoconjugate chains—and the resultant hypersialylation …”
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Tumour-infiltrating lymphocytes: from prognosis to treatment selection von Brummel, Koen, Eerkens, Anneke L, de Bruyn, Marco, Nijman, Hans W

“… Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive …”
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