Suchergebnisse - "Brambilla, Christian"

Exposure to Phthalates and Phenols during Pregnancy and Offspring Size at Birth von Philippat, Claire, Mortamais, Marion, Chevrier, Cécile, Petit, Claire, Calafat, Antonia M., Ye, Xiaoyun, Silva, Manori J., Brambilla, Christian, Pin, Isabelle, Charles, Marie-Aline, Cordier, Sylvaine, Slama, Rémy

“… Background: Data concerning the effects of prenatal exposures to phthalates and phenols on fetal growth are limited in humans. Previous findings suggest …”
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Circulating free DNA concentration is an independent prognostic biomarker in lung cancer von Tissot, Claire, Toffart, Anne-Claire, Villar, Stéphanie, Souquet, Pierre-Jean, Merle, Patrick, Moro-Sibilot, Denis, Pérol, Maurice, Zavadil, Jiri, Brambilla, Christian, Olivier, Magali, Couraud, Sébastien

“… Plasma circulating cell-free (cf)DNA is of interest in oncology because it has been shown to contain tumour DNA and may thus be used as liquid biopsy. In …”
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Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers von Rousseaux, Sophie, Debernardi, Alexandra, Jacquiau, Baptiste, Vitte, Anne-Laure, Vesin, Aurélien, Nagy-Mignotte, Hélène, Moro-Sibilot, Denis, Brichon, Pierre-Yves, Lantuejoul, Sylvie, Hainaut, Pierre, Laffaire, Julien, de Reyniès, Aurélien, Beer, David G, Timsit, Jean-François, Brambilla, Christian, Brambilla, Elisabeth, Khochbin, Saadi

“… Activation of normally silent tissue-specific genes and the resulting cell "identity crisis" are the unexplored consequences of malignant epigenetic …”
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CD74-NRG1 fusions in lung adenocarcinoma von Fernandez-Cuesta, Lynnette, Plenker, Dennis, Osada, Hirotaka, Sun, Ruping, Menon, Roopika, Leenders, Frauke, Ortiz-Cuaran, Sandra, Peifer, Martin, Bos, Marc, Daßler, Juliane, Malchers, Florian, Schöttle, Jakob, Vogel, Wenzel, Dahmen, Ilona, Koker, Mirjam, Ullrich, Roland T, Wright, Gavin M, Russell, Prudence A, Wainer, Zoe, Solomon, Benjamin, Brambilla, Elisabeth, Nagy-Mignotte, Hélène, Moro-Sibilot, Denis, Brambilla, Christian G, Lantuejoul, Sylvie, Altmüller, Janine, Becker, Christian, Nürnberg, Peter, Heuckmann, Johannes M, Stoelben, Erich, Petersen, Iver, Clement, Joachim H, Sänger, Jörg, Muscarella, Lucia A, la Torre, Annamaria, Fazio, Vito M, Lahortiga, Idoya, Perera, Timothy, Ogata, Souichi, Parade, Marc, Brehmer, Dirk, Vingron, Martin, Heukamp, Lukas C, Buettner, Reinhard, Zander, Thomas, Wolf, Jürgen, Perner, Sven, Ansén, Sascha, Haas, Stefan A, Yatabe, Yasushi, Thomas, Roman K

“… We discovered a novel somatic gene fusion, CD74-NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung …”
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Next-generation sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer von Vignot, Stéphane, Frampton, Garrett M, Soria, Jean-Charles, Yelensky, Roman, Commo, Frédéric, Brambilla, Christian, Palmer, Gary, Moro-Sibilot, Denis, Ross, Jeffrey S, Cronin, Maureen T, André, Fabrice, Stephens, Philip J, Lazar, Vladimir, Miller, Vincent A, Brambilla, Elisabeth

“… Characterization of the genomic changes that drive an individual patient's disease is critical in management of many cancers. In patients with non-small-cell …”
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Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer von Van Den Broeck, Arnaud, Brambilla, Elisabeth, Moro-Sibilot, Denis, Lantuejoul, Sylvie, Brambilla, Christian, Eymin, Beatrice, Khochbin, Saadi, Gazzeri, Sylvie

“… Epigenetic modifications of histone have crucial roles in the control of gene activity, nuclear architecture, and genomic stability. In this respect, they may …”
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Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin von Edmond, Valerie, Moysan, Elodie, Khochbin, Saadi, Matthias, Patrick, Brambilla, Christian, Brambilla, Elisabeth, Gazzeri, Sylvie, Eymin, Beatrice

“… SRSF2 is a serine/arginine‐rich protein belonging to the family of SR proteins that are crucial regulators of constitutive and alternative pre‐mRNA splicing …”
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Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer von Fernandez-Cuesta, Lynnette, Perdomo, Sandra, Avogbe, Patrice H., Leblay, Noemie, Delhomme, Tiffany M., Gaborieau, Valerie, Abedi-Ardekani, Behnoush, Chanudet, Estelle, Olivier, Magali, Zaridze, David, Mukeria, Anush, Vilensky, Marta, Holcatova, Ivana, Polesel, Jerry, Simonato, Lorenzo, Canova, Cristina, Lagiou, Pagona, Brambilla, Christian, Brambilla, Elisabeth, Byrnes, Graham, Scelo, Ghislaine, Le Calvez-Kelm, Florence, Foll, Matthieu, McKay, James D., Brennan, Paul

“… Circulating tumor DNA (ctDNA) is emerging as a key potential biomarker for post-diagnosis surveillance but it may also play a crucial role in the detection of …”
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Expression of tumor-derived vascular endothelial growth factor and its receptors is associated with outcome in early squamous cell carcinoma of the lung von Pajares, María J, Agorreta, Jackeline, Larrayoz, Marta, Vesin, Aurélien, Ezponda, Teresa, Zudaire, Isabel, Torre, Wenceslao, Lozano, María D, Brambilla, Elisabeth, Brambilla, Christian, Wistuba, Ignacio I, Behrens, Carmen, Timsit, Jean-Francois, Pio, Ruben, Field, John K, Montuenga, Luis M

“… Antiangiogenic therapies targeting the vascular endothelial growth factor (VEGF) pathway have yielded more modest clinical benefit to patients with …”
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Baseline results of the Depiscan study: A French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR) von Blanchon, Thierry, Bréchot, Jeanne-Marie, Grenier, Philippe A., Ferretti, Gilbert R., Lemarié, Etienne, Milleron, Bernard, Chagué, Dominique, Laurent, François, Martinet, Yves, Beigelman-Aubry, Catherine, Blanchon, François, Revel, Marie-Pierre, Friard, Sylvie, Rémy-Jardin, Martine, Vasile, Manuela, Santelmo, Nicola, Lecalier, Alain, Lefébure, Patricia, Moro-Sibilot, Denis, Breton, Jean-Luc, Carette, Marie-France, Brambilla, Christian, Fournel, François, Kieffer, Alexia, Frija, Guy, Flahault, Antoine

“… Lung cancer has the highest mortality-rate per cancer, with an overall 5-year survival <15%. Several non-randomized studies pointed out the high sensitivity of …”
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ING2 controls the G1 to S-phase transition by regulating p21 expression von Larrieu, Delphine, Ythier, Damien, Brambilla, Christian, Pedeux, Rémy

“… ING2 (Inhibitor of Growth 2) is a candidate tumor suppressive protein frequently lost in human tumors. Recently, we have reported that ING2 downregulation …”
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Telomere maintenance and DNA damage responses during lung carcinogenesis von Lantuejoul, Sylvie, Raynaud, Christophe, Salameire, Dimitri, Gazzeri, Sylvie, Moro-Sibilot, Denis, Soria, Jean-Charles, Brambilla, Christian, Brambilla, Elizabeth

“… Telomere shortening is an early event in bronchial carcinogenesis, preceding P53/Rb pathway inactivation and telomerase reactivation, and leading to DNA damage …”
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Correcting for the influence of sampling conditions on biomarkers of exposure to phenols and phthalates: a 2-step standardization method based on regression residuals von Mortamais, Marion, Chevrier, Cécile, Philippat, Claire, Petit, Claire, Calafat, Antonia M, Ye, Xiaoyun, Silva, Manori J, Brambilla, Christian, Eijkemans, Marinus JC, Charles, Marie-Aline, Cordier, Sylvaine, Slama, Rémy

“… Background Environmental epidemiology and biomonitoring studies typically rely on biological samples to assay the concentration of non-persistent exposure …”
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Clinically Relevant Characterization of Lung Adenocarcinoma Subtypes Based on Cellular Pathways: An International Validation Study von Bryant, Christopher M., Albertus, Daniel L., Kim, Sinae, Chen, Guoan, Brambilla, Christian, Guedj, Mickael, Arima, Chinatsu, Travis, William D., Yatabe, Yasushi, Takahashi, Takashi, Brambilla, Elisabeth, Beer, David G.

“… Lung adenocarcinoma (AD) represents a predominant type of lung cancer demonstrating significant morphologic and molecular heterogeneity. We sought to …”
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SRSF2 is required for sodium butyrate-mediated p21WAF1 induction and premature senescence in human lung carcinoma cell lines von Edmond, Valerie, Brambilla, Christian, Brambilla, Elisabeth, Gazzeri, Sylvie, Eymin, Beatrice

“… Sodium butyrate (NaBu) is a histone deacetylase inhibitor that exhibits numerous antiproliferative activities in various cancer cell lines, notably through the …”
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Telomere shortening and telomerase reverse transcriptase expression in preinvasive bronchial lesions von Lantuejoul, Sylvie, Soria, Jean Charles, Morat, Luc, Lorimier, Philippe, Moro-Sibilot, Denis, Sabatier, Laure, Brambilla, Christian, Brambilla, Elisabeth

“… Telomerase, a ribonucleoprotein complex whose activity is related to the expression of its catalytic subunit human telomerase reverse transcriptase (hTERT), …”
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Human ARF binds E2F1 and inhibits its transcriptional activity von Eymin, Béatrice, Karayan, Lucie, Séité, Paule, Brambilla, Christian, Brambilla, Elisabeth, Larsen, Christian-Jacques, Gazzéri, Sylvie

“… The INK4a/ARF locus which is frequently inactivated in human tumours encodes two different tumour suppressive proteins, p16(INK4a) and ARF. p16(INK4a) is a …”
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Value of immunohistochemical markers in preinvasive bronchial lesions in risk assessment of lung cancer von Jeanmart, Michel, Lantuejoul, Sylvie, Fievet, Frédéric, Moro, Denis, Sturm, Nathalie, Brambilla, Christian, Brambilla, Elisabeth

“… Bronchial carcinogenesis is a multistep process characterized by accumulation of genetic and molecular abnormalities, which precedes and accompanies the …”
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Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34βE12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung von Sturm, Nathalie, Lantuéjoul, Sylvie, Laverrière, Marie-Hélène, Papotti, Mauro, Brichon, Pierre-Yves, Brambilla, Christian, Brambilla, Elisabeth

“… Basaloid carcinoma (BC) and large-cell neuroendocrine carcinoma (LCNEC) are 2 recently recognized variants of large-cell lung carcinomas that may overlap in …”
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Mechanisms of p16INK4A inactivation in non small-cell lung cancers von Gazzeri, Sylvie, Gouyer, Valerie, Vour'ch, Clair, Brambilla, Christian, Brambilla, Elisabeth

“… The cyclin-dependent kinase inhibitor p16 (p16INK4A/CDKN2/MTS1) is a potent inhibitor of the cyclin D-dependent phosphorylation of the retinoblastoma gene (Rb) …”
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