Suchergebnisse - "Bonetto, Andrea"

STAT3 in the systemic inflammation of cancer cachexia von Zimmers, Teresa A., Fishel, Melissa L., Bonetto, Andrea

“… Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to morbidity and mortality in cancer. Most research has probed mechanisms …”
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Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition von Pin, Fabrizio, Couch, Marion E, Bonetto, Andrea

“… Cancer patients undergoing chemotherapy often experience very debilitating side effects, including unintentional weight loss, nausea, and vomiting. Changes in …”
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Role of myokines and osteokines in cancer cachexia von Pin, Fabrizio, Bonewald, Lynda F, Bonetto, Andrea

“… Cancer-induced muscle wasting, i.e. cachexia, is associated with different types of cancer such as pancreatic, colorectal, lung, liver, gastric and esophageal …”
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Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia von Rupert, Joseph E, Narasimhan, Ashok, Jengelley, Daenique H A, Jiang, Yanlin, Liu, Jianguo, Au, Ernie, Silverman, Libbie M, Sandusky, George, Bonetto, Andrea, Cao, Sha, Lu, Xiaoyu, O'Connell, Thomas M, Liu, Yunlong, Koniaris, Leonidas G, Zimmers, Teresa A

“… Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To model heterogeneity, we used patient-derived orthotopic xenografts. These …”
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Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism von Pin, Fabrizio, Barreto, Rafael, Couch, Marion E., Bonetto, Andrea, O'Connell, Thomas M.

“… Background Cancer cachexia is a metabolic disorder involving perturbed energy balance and altered mitochondrial function. Chemotherapy is a primary treatment …”
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Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways von Barreto, Rafael, Mandili, Giorgia, Witzmann, Frank A., Novelli, Francesco, Zimmers, Teresa A., Bonetto, Andrea

“… Cachexia represents one of the primary complications of colorectal cancer due to its effects on depletion of muscle and fat. Evidence suggests that …”
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JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia von Bonetto, Andrea, Aydogdu, Tufan, Jin, Xiaoling, Zhang, Zongxiu, Zhan, Rui, Puzis, Leopold, Koniaris, Leonidas G, Zimmers, Teresa A

“… Cachexia, the metabolic dysregulation leading to sustained loss of muscle and adipose tissue, is a devastating complication of cancer and other chronic …”
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PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia von Pin, Fabrizio, Novinger, Leah J, Huot, Joshua R, Harris, Robert A, Couch, Marion E, O'Connell, Thomas M, Bonetto, Andrea

“… Cachexia is frequently accompanied by severe metabolic derangements, although the mechanisms responsible for this debilitating condition remain unclear …”
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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia von Bonetto, Andrea, Rupert, Joseph E., Barreto, Rafael, Zimmers, Teresa A.

“… Cancer cachexia is the progressive loss of skeletal muscle mass and adipose tissue, negative nitrogen balance, anorexia, fatigue, inflammation, and activation …”
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STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia von Bonetto, Andrea, Aydogdu, Tufan, Kunzevitzky, Noelia, Guttridge, Denis C., Khuri, Sawsan, Koniaris, Leonidas G., Zimmers, Teresa A.

“… Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients. In cancer patients, …”
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The Mitochondria-Targeting Agent MitoQ Improves Muscle Atrophy, Weakness and Oxidative Metabolism in C26 Tumor-Bearing Mice von Pin, Fabrizio, Huot, Joshua R., Bonetto, Andrea

“… Cancer cachexia is a debilitating syndrome characterized by skeletal muscle wasting, weakness and fatigue. Several pathogenetic mechanisms can contribute to …”
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HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia von Huot, Joshua R., Novinger, Leah J., Pin, Fabrizio, Bonetto, Andrea

“… Colorectal cancer (CRC) is often accompanied by formation of liver metastases (LM) and skeletal muscle wasting, i.e. cachexia. Despite affecting the majority …”
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Reduced rDNA transcription diminishes skeletal muscle ribosomal capacity and protein synthesis in cancer cachexia von Kim, Hyo-Gun, Huot, Joshua R, Pin, Fabrizio, Guo, Bin, Bonetto, Andrea, Nader, Gustavo A

“… Muscle wasting in cancer is associated with deficits in protein synthesis, yet, the mechanisms underlying this anabolic impairment remain poorly understood …”
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PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia von Huot, Joshua R., Pin, Fabrizio, Chatterjee, Rohit, Bonetto, Andrea

“… Background Chemotherapy induces a cachectic‐like phenotype, accompanied by skeletal muscle wasting, weakness and mitochondrial dysfunction. Peroxisome …”
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Vincristine impairs musculoskeletal development in pediatric mice von Jamnick, Nicholas A., Livingston, Patrick D., Gammon, Caleb J., Weinzierl, Natalia M., Novinger, Leah J., Adams, Douglas J., Bonetto, Andrea

“… Background Over 85% of children diagnosed with cancer now survive their disease, yet cancer and chemotherapy frequently associate with long-term health …”
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Prevalence of ovarian cancer cachexia in patients undergoing debulking surgery at the University of Colorado between 2014–2024 von Ehimiaghe, Eseohi, Wang, Stephanie, Bonetto, Andrea, Novinger, Leah J

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Short-term pharmacologic RAGE inhibition differentially affects bone and skeletal muscle in middle-aged mice von Davis, Hannah M., Essex, Alyson L., Valdez, Sinai, Deosthale, Padmini J., Aref, Mohammad W., Allen, Matthew R., Bonetto, Andrea, Plotkin, Lilian I.

“… Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals …”
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Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia von Pin, Fabrizio, Barreto, Rafael, Kitase, Yukiko, Mitra, Sumegha, Erne, Carlie E., Novinger, Leah J., Zimmers, Teresa A., Couch, Marion E., Bonewald, Lynda F., Bonetto, Andrea

“… Background Cachexia frequently occurs in women with advanced ovarian cancer (OC), along with enhanced inflammation. Despite being responsible for one third of …”
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Skeletal Muscle Index's Impact on Discharge Disposition After Head and Neck Cancer Free Flap Reconstruction von Jones, Alexander Joseph, Campiti, Vincent Joseph, Alwani, Mohamedkazim, Novinger, Leah J, Bonetto, Andrea, Sim, Michael W, Yesensky, Jessica A, Moore, Michael G, Mantravadi, Avinash V

“… To determine the role of skeletal muscle index (SMI) in the assessment of frailty and determination of discharge to post-acute care facilities (PACF) after …”
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Impact of Sarcopenia on Outcomes of Autologous Head and Neck Free Tissue Reconstruction von Alwani, Mohamedkazim M, Jones, Alexander J, Novinger, Leah J, Pittelkow, Eric, Bonetto, Andrea, Sim, Michael W, Moore, Michael G, Mantravadi, Avinash V

“… Sarcopenia has been implicated as a positive predictor of postsurgical complications. Its role in head and neck (H&N) free flap reconstruction has yet to be …”
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