Suchergebnisse - "Boeree, Martin J."

A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses von Svensson, Robin J., Aarnoutse, Rob E., Diacon, Andreas H., Dawson, Rodney, Gillespie, Stephen H., Boeree, Martin J., Simonsson, Ulrika S.H.

“… Accumulating evidence suggests that increasing doses of rifampicin may shorten tuberculosis treatment. The PanACEA HIGHRIF1 trial assessed safety, …”
Volltext

Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria von van Ingen, Jakko, Boeree, Martin J., van Soolingen, Dick, Mouton, Johan W.

“… Nontuberculous mycobacteria (NTM) are increasingly recognized as causative agents of opportunistic infections in humans. For most NTM infections the therapy of …”
Volltext

Characterization of Mycobacterium orygis as M. tuberculosis Complex Subspecies von van Ingen, Jakko, Rahim, Zeaur, Mulder, Arnout, Boeree, Martin J., Simeone, Roxane, Brosch, Roland, van Soolingen, Dick

“… The oryx bacilli are Mycobacterium tuberculosis complex organisms for which phylogenetic position and host range are unsettled. We characterized 22 isolates by …”
Volltext

Nontuberculous Mycobacteria in Respiratory Tract Infections, Eastern Asia von Simons, Sami, van Ingen, Jakko, Hsueh, Po-Ren, Van Hung, Nguyen, Dekhuijzen, P.N. Richard, Boeree, Martin J., van Soolingen, Dick

Volltext

In vitro synergy between clofazimine and amikacin in treatment of nontuberculous mycobacterial disease von van Ingen, Jakko, Totten, Sarah E, Helstrom, Niels K, Heifets, Leonid B, Boeree, Martin J, Daley, Charles L

“… Disease caused by nontuberculous mycobacteria (NTM) is increasing in frequency. The outcome of treatment for NTM lung disease is poor, particularly lung …”
Weitere Angaben

Nontuberculous mycobacteria in respiratory tract infections, eastern Asia von Simons, Sami, van Ingen, Jakko, Hsueh, Po-Ren, Van Hung, Nguyen, Dekhuijzen, P N Richard, Boeree, Martin J, van Soolingen, Dick

“… To characterize the distribution of nontuberculous mycobacteria (NTM) species isolated from pulmonary samples from persons in Asia and their association with …”
Volltext

Treatment and outcome of non-tuberculous mycobacterial pulmonary disease in a predominantly fibro-cavitary disease cohort von Zweijpfenning, Sanne, Kops, Stephan, Magis-Escurra, Cecile, Boeree, Martin J., van Ingen, Jakko, Hoefsloot, Wouter

“… The incidence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) has increased in the Netherlands. The fibro-cavitary disease manifestation …”
Volltext

The Pharmacokinetics and Pharmacodynamics of Pulmonary Mycobacterium avium Complex Disease Treatment von van Ingen, Jakko, Egelund, Eric F., Levin, Adrah, Totten, Sarah E., Boeree, Martin J., Mouton, Johan W., Aarnoutse, Rob E., Heifets, Leonid B., Peloquin, Charles A., Daley, Charles L.

“… Currently recommended multidrug treatment regimens for Mycobacterium avium complex (MAC) lung disease yield limited cure rates. This results, in part, from …”
Volltext

Tuberculosis transmission by patients with smear-negative pulmonary tuberculosis in a large cohort in the Netherlands von Tostmann, Alma, Kik, Sandra V, Kalisvaart, Nico A, Sebek, Maruschka M, Verver, Suzanne, Boeree, Martin J, van Soolingen, Dick

“… Sputum smear microscopy is commonly used for diagnosing tuberculosis (TB). Although patients with sputum smear-negative TB are less infectious than patients …”
Weitere Angaben

New drugs against tuberculosis: problems, progress, and evaluation of agents in clinical development von van den Boogaard, Jossy, Kibiki, Gibson S, Kisanga, Elton R, Boeree, Martin J, Aarnoutse, Rob E

Weitere Angaben

High rifampicin peak plasma concentrations accelerate the slow phase of bacterial decline in tuberculosis patients: Evidence for heteroresistance von Martinecz, Antal, Boeree, Martin J., Diacon, Andreas H., Dawson, Rodney, Hemez, Colin, Aarnoutse, Rob E., Abel zur Wiesch, Pia

“… Antibiotic treatments are often associated with a late slowdown in bacterial killing. This separates the killing of bacteria into at least two distinct phases: …”
Volltext

Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development von Ayoun Alsoud, Rami, Svensson, Robin J., Svensson, Elin M., Gillespie, Stephen H., Boeree, Martin J., Diacon, Andreas H., Dawson, Rodney, Aarnoutse, Rob E., Simonsson, Ulrika S. H.

“… Biomarkers are quantifiable characteristics of biological processes. In Mycobacterium tuberculosis , common biomarkers used in clinical drug development are …”
Volltext

Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study von Bryant, Josephine M, Harris, Simon R, Parkhill, Julian, Dawson, Rodney, Diacon, Andreas H, van Helden, Paul, Pym, Alex, Mahayiddin, Aziah A, Chuchottaworn, Charoen, Sanne, Ian M, Louw, Cheryl, Boeree, Martin J, Hoelscher, Michael, McHugh, Timothy D, Bateson, Anna L C, Hunt, Robert D, Mwaigwisya, Solomon, Wright, Laura, Gillespie, Stephen H, Bentley, Stephen D

“… Recurrence of tuberculosis after treatment makes management difficult and is a key factor for determining treatment efficacy. Two processes can cause …”
Weitere Angaben

Phenotypic Changes on Mycobacterium Tuberculosis-Specific CD4 T Cells as Surrogate Markers for Tuberculosis Treatment Efficacy von Ahmed, Mohamed I. M., Ntinginya, Nyanda E., Kibiki, Gibson, Mtafya, Bariki A, Semvua, Hadija, Mpagama, Stellah, Mtabho, Charles, Saathoff, Elmar, Held, Kathrin, Loose, Rebecca, Kroidl, Inge, Chachage, Mkunde, Both, Ulrich von, Haule, Antelmo, Mekota, Anna-Maria, Boeree, Martin J., Gillespie, Stephen H., Hoelscher, Michael, Heinrich, Norbert, Geldmacher, Christof

“… The analysis of phenotypic characteristics on (MTB)-specific T cells is a promising approach for the diagnosis of active tuberculosis (aTB) and for monitoring …”
Volltext

Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment von Friedrich, Sven O, Rachow, Andrea, Saathoff, Elmar, Singh, Kasha, Mangu, Chacha D, Dawson, Rodney, Phillips, Patrick Pj, Venter, Amour, Bateson, Anna, Boehme, Catharina C, Heinrich, Norbert, Hunt, Robert D, Boeree, Martin J, Zumla, Alimuddin, McHugh, Timothy D, Gillespie, Stephen H, Diacon, Andreas H, Hoelscher, Michael

“… An accurate biomarker is urgently needed to monitor the response to treatment in patients with pulmonary tuberculosis. The Xpert MTB/RIF assay is a …”
Weitere Angaben

Drug treatment of pulmonary nontuberculous mycobacterial disease in HIV-negative patients: the evidence von van Ingen, Jakko, Ferro, Beatriz E, Hoefsloot, Wouter, Boeree, Martin J, van Soolingen, Dick

“… Pulmonary disease (PD) caused by nontuberculous mycobacteria is an emerging infection mainly in countries where the incidence of tuberculosis is in decline. It …”
Volltext

Pharmacokinetics of first-line tuberculosis drugs in Tanzanian patients von Tostmann, Alma, Mtabho, Charles M, Semvua, Hadija H, van den Boogaard, Jossy, Kibiki, Gibson S, Boeree, Martin J, Aarnoutse, Rob E

“… East Africa has a high tuberculosis (TB) incidence and mortality, yet there are very limited data on exposure to TB drugs in patients from this region. We …”
Weitere Angaben

Epidemiology of Mycobacterium bovis Disease in Humans, the Netherlands, 1993–2007 von Majoor, Christof J., Magis-Escurra, Cecile, van Ingen, Jakko, Boeree, Martin J., van Soolingen, Dick

“… In the Netherlands, 1.4% of tuberculosis (TB) cases are caused by Mycobacterium bovis. After we admitted 3 patients with M. bovis infections to our reference …”
Volltext

Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB von de Steenwinkel, Jurriaan E.M., ten Kate, Marian T., de Knegt, Gerjo J., Kremer, Kristin, Aarnoutse, Rob E., Boeree, Martin J., Verbrugh, Henri A., van Soolingen, Dick, Bakker-Woudenberg, Irma A.J.M.

“… To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of …”
Volltext

The Antipsychotic Thioridazine Shows Promising Therapeutic Activity in a Mouse Model of Multidrug-Resistant Tuberculosis von van Soolingen, Dick, Hernandez-Pando, Rogelio, Orozco, Hector, Aguilar, Diana, Magis-Escurra, Cecile, Amaral, Leonard, van Ingen, Jakko, Boeree, Martin J.

“… Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely …”
Volltext