Výsledky vyhľadávania - "Blucher, Aurora"

Precision oncology for breast cancer through clinical trials Autor Blucher, Aurora S., Mills, Gordon B., Tsang, Yiu Huen

“…Precision treatment for breast cancers has made several notable advances in recent decades, but challenges of tumor heterogeneity, drug resistance, and…”
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Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer Autor Park, Soon Young, Jeong, Kang Jin, Poire, Alfonso, Zhang, Dong, Tsang, Yiu Huen, Blucher, Aurora S., Mills, Gordon B.

“…Ferroptosis, a form of programed cell death, can be promoted by inhibitors of the xCT transporter (erastin) or GPX4 (RSL3). We found that GPX4, but not the xCT…”
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Evidence-Based Precision Oncology with the Cancer Targetome Autor Blucher, Aurora S., Choonoo, Gabrielle, Kulesz-Martin, Molly, Wu, Guanming, McWeeney, Shannon K.

“…A core tenet of precision oncology is the rational choice of drugs to interact with patient-specific biological targets of interest, but it is currently…”
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Natural Product Target Network Reveals Potential for Cancer Combination Therapies Autor Chamberlin, Steven R., Blucher, Aurora, Wu, Guanming, Shinto, Lynne, Choonoo, Gabrielle, Kulesz-Martin, Molly, McWeeney, Shannon

“…A body of research demonstrates examples of and synergy between natural products and anti-neoplastic drugs for some cancers. However, the underlying biological…”
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Assessing individual head and neck squamous cell carcinoma patient response to therapy through integration of functional and genomic data Autor Bottomly, Daniel, Mathieson, Chase, Vigoda, Myles, Jeng, Sophia, Evans, Nathaniel, Anderson, Ashley, Blucher, Aurora, Lesch, Aletha, Zheng, Christina, Laderas, Ted, Jacobs, James, Kulesz-Martin, Molly, McWeeney, Shannon

“…Even though head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide, there are only two PD-1 targeted immunotherapies…”
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Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma Autor Choonoo, Gabrielle, Blucher, Aurora S., Higgins, Samuel, Boardman, Mitzi, Jeng, Sophia, Zheng, Christina, Jacobs, James, Anderson, Ashley, Chamberlin, Steven, Evans, Nathaniel, Vigoda, Myles, Cordier, Benjamin, Tyner, Jeffrey W., Kulesz-Martin, Molly, McWeeney, Shannon K., Laderas, Ted

“…Head and neck squamous cell carcinoma (HNSCC) remains a morbid disease with poor prognosis and treatment that typically leaves patients with permanent damage…”
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Which path to follow? Utilizing proteomics to improve therapy choices for breast cancer patients Autor Blucher, Aurora S., Mills, Gordon B., Tsang, Yiu Huen

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Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz [version 1; peer review: 3 approved] Autor Blucher, Aurora S, McWeeney, Shannon K, Stein, Lincoln, Wu, Guanming

“…The precision medicine paradigm is centered on therapies targeted to particular molecular entities that will elicit an anticipated and controlled therapeutic…”
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Challenges in Secondary Analysis of High Throughput Screening Data Autor Blucher, Aurora, Mcweeney, Shannon

“…Repurposing an existing drug for an alternative use is not only a cost effective method of development, but also a faster process due to the drug's previous…”
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Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies Autor Labrie, Marilyne, Li, Allen, Creason, Allison, Betts, Courtney, Keck, Jamie, Johnson, Brett, Sivagnanam, Shamilene, Boniface, Christopher, Ma, Hongli, Blucher, Aurora, Chang, Young Hwan, Chin, Koei, Vuky, Jacqueline, Guimaraes, Alexander R., Downey, Molly, Lim, Jeong Youn, Gao, Lina, Siex, Kiara, Parmar, Swapnil, Kolodzie, Annette, Spellman, Paul T., Goecks, Jeremy, Coussens, Lisa M., Corless, Christopher L., Bergan, Raymond, Gray, Joe W., Mills, Gordon B., Mitri, Zahi I.

“…In a pilot study, we evaluated the feasibility of real-time deep analysis of serial tumor samples from triple negative breast cancer patients to identify…”
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Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma Autor Anderson, Ashley N, McClanahan, Danielle, Jacobs, James, Jeng, Sophia, Vigoda, Myles, Blucher, Aurora S, Zheng, Christina, Yoo, Yeon Jung, Hale, Carolyn, Ouyang, Xiaoming, Clayburgh, Daniel, Andersen, Peter, Tyner, Jeffrey W, Bar, Anna, Lucero, Olivia M, Leitenberger, Justin J, McWeeney, Shannon K, Kulesz-Martin, Molly

“…Although cutaneous squamous cell carcinoma (cSCC) is treatable in the majority of cases, deadly invasive and metastatic cases do occur. To date there are…”
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Integrative analysis of drug response and clinical outcome in acute myeloid leukemia Autor Bottomly, Daniel, Long, Nicola, Schultz, Anna Reister, Kurtz, Stephen E, Tognon, Cristina E, Johnson, Kara, Abel, Melissa, Agarwal, Anupriya, Avaylon, Sammantha, Benton, Erik, Blucher, Aurora, Borate, Uma, Braun, Theodore P, Brown, Jordana, Bryant, Jade, Burke, Russell, Carlos, Amy, Chang, Bill H, Cho, Hyun Jun, Christy, Stephen, Coblentz, Cody, Cohen, Aaron M, d'Almeida, Amanda, Cook, Rachel, Danilov, Alexey, Dao, Kim-Hien T, Degnin, Michie, Dibb, James, Eide, Christopher A, English, Isabel, Hagler, Stuart, Harrelson, Heath, Henson, Rachel, Ho, Hibery, Joshi, Sunil K, Junio, Brian, Kaempf, Andy, Kosaka, Yoko, Laderas, Ted, Lawhead, Matt, Lee, Hyunjung, Leonard, Jessica T, Lin, Chenwei, Lind, Evan F, Liu, Selina Qiuying, Lo, Pierrette, Loriaux, Marc M, Luty, Samuel, Maxson, Julia E, Macey, Tara, Martinez, Jacqueline, Minnier, Jessica, Monteblanco, Andrea, Mori, Motomi, Morrow, Quinlan, Nelson, Dylan, Ramsdill, Justin, Rofelty, Angela, Rogers, Alexandra, Romine, Kyle A, Ryabinin, Peter, Saultz, Jennifer N, Sampson, David A, Savage, Samantha L, Schuff, Robert, Searles, Robert, Smith, Rebecca L, Spurgeon, Stephen E, Sweeney, Tyler, Swords, Ronan T, Thapa, Aashis, Thiel-Klare, Karina, Traer, Elie, Wagner, Jake, Wilmot, Beth, Wolf, Joelle, Wu, Guanming, Yates, Amy, Zhang, Haijiao, Cogle, Christopher R, Collins, Robert H, Deininger, Michael W, Hourigan, Christopher S, Jordan, Craig T, Lin, Tara L, Martinez, Micaela E, Pallapati, Rachel R, Pollyea, Daniel A, Pomicter, Anthony D, Watts, Justin M, Weir, Scott J, Druker, Brian J, McWeeney, Shannon K, Tyner, Jeffrey W

“…Acute myeloid leukemia (AML) is a cancer of myeloid-lineage cells with limited therapeutic options. We previously combined ex vivo drug sensitivity with…”
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Phase Ib Dose Expansion and Translational Analyses of Olaparib in Combination with Capivasertib in Recurrent Endometrial, Triple-Negative Breast, and Ovarian Cancer Autor Westin, Shannon N, Labrie, Marilyne, Litton, Jennifer K, Blucher, Aurora, Fang, Yong, Vellano, Christopher P, Marszalek, Joseph R, Feng, Ningping, Ma, XiaoYan, Creason, Allison, Fellman, Bryan, Yuan, Ying, Lee, Sanghoon, Kim, Tae-Beom, Liu, Jinsong, Chelariu-Raicu, Anca, Chen, Tsun Hsuan, Kabil, Nashwa, Soliman, Pamela T, Frumovitz, Michael, Schmeler, Katheleen M, Jazaeri, Amir, Lu, Karen H, Murthy, Rashmi, Meyer, Larissa A, Sun, Charlotte C, Sood, Anil K, Coleman, Robert L, Mills, Gordon B

“…On the basis of strong preclinical rationale, we sought to confirm recommended phase II dose (RP2D) for olaparib, a PARP inhibitor, combined with the AKT…”
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IMP1/IGF2BP1 in human colorectal cancer extracellular vesicles Autor Kuhn, Madeline, Zhang, Yang, Favate, John, Morita, Mayu, Blucher, Aurora, Das, Sukanya, Liang, Shun, Preet, Ranjan, Parham, Louis R, Williams, Kathy N, Molugu, Sudheer, Armstrong, Randall J, Zhang, Wei, Yang, Jiegang, Hamilton, Kathryn E, Dixon, Dan A, Mills, Gordon, Morgan, Terry K, Shah, Premal, Andres, Sarah F

“…Colorectal cancer (CRC) is a leading cause of cancer-related death. There is an urgent need for new methods of early CRC detection and monitoring to improve…”
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An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer Autor Johnson, Brett E., Creason, Allison L., Stommel, Jayne M., Keck, Jamie M., Parmar, Swapnil, Betts, Courtney B., Blucher, Aurora, Boniface, Christopher, Bucher, Elmar, Burlingame, Erik, Camp, Todd, Chin, Koei, Eng, Jennifer, Estabrook, Joseph, Feiler, Heidi S., Heskett, Michael B., Hu, Zhi, Kolodzie, Annette, Kong, Ben L., Labrie, Marilyne, Lee, Jinho, Leyshock, Patrick, Mitri, Souraya, Patterson, Janice, Riesterer, Jessica L., Sivagnanam, Shamilene, Somers, Julia, Sudar, Damir, Thibault, Guillaume, Weeder, Benjamin R., Zheng, Christina, Nan, Xiaolin, Thompson, Reid F., Heiser, Laura M., Spellman, Paul T., Thomas, George, Demir, Emek, Chang, Young Hwan, Coussens, Lisa M., Guimaraes, Alexander R., Corless, Christopher, Goecks, Jeremy, Bergan, Raymond, Mitri, Zahi, Mills, Gordon B., Gray, Joe W.

“…Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during…”
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An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer Autor Johnson, Brett E., Creason, Allison L., Stommel, Jayne M., Keck, Jamie M., Parmar, Swapnil, Betts, Courtney B., Blucher, Aurora, Boniface, Christopher, Bucher, Elmar, Burlingame, Erik, Camp, Todd, Chin, Koei, Eng, Jennifer, Estabrook, Joseph, Feiler, Heidi S., Hu, Zhi, Kolodzie, Annette, Kong, Ben L., Labrie, Marilyne, Lee, Jinho, Leyshock, Patrick, Mitri, Souraya, Patterson, Janice, Riesterer, Jessica L., Sivagnanam, Shamilene, Somers, Julia, Sudar, Damir, Thibault, Guillaume, Zheng, Christina, Nan, Xiaolin, Heiser, Laura M., Spellman, Paul T., Thomas, George, Demir, Emek, Chang, Young Hwan, Coussens, Lisa M., Guimaraes, Alexander R., Corless, Christopher, Goecks, Jeremy, Bergan, Raymond, Mitri, Zahi, Mills, Gordon B., Gray, Joe W.

“…Mechanisms of therapeutic resistance manifest in metastatic cancers as tumor cell intrinsic alterations and extrinsic microenvironmental influences that can…”
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An Integrated Clinical, Omic, and Image Atlas of an Evolving Metastatic Breast Cancer Autor Johnson, Brett E, Creason, Allison L, Stommel, Jayne M, Keck, Jamie, Parmar, Swapnil, Betts, Courtney B, Blucher, Aurora, Boniface, Christopher, Bucher, Elmar, Burlingame, Erik, Chin, Koei, Eng, Jennifer, Feiler, Heidi S, Kolodzie, Annette, Kong, Ben, Labrie, Marilyne, Leyshock, Patrick, Mitri, Souraya, Patterson, Janice, Riesterer, Jessica L, Sivagnanam, Shamilene, Sudar, Damir, Thibault, Guillaume, Zheng, Christina, Nan, Xiaolin, Heiser, Laura M, Spellman, Paul T, Thomas, George, Demir, Emek, Chang, Young Hwan, Coussens, Lisa M, Guimaraes, Alexander R, Corless, Christopher, Goecks, Jeremy, Bergan, Raymond, Mitri, Zahi, Mills, Gordon B, Gray, Joe W

“…Summary Metastatic cancers often respond to treatment initially but almost universally escape therapeutic control through molecular mechanisms intrinsic to…”
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