Výsledky vyhľadávania - "Blasi, Francesco"

The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling Autor Blasi, Francesco, Sidenius, Nicolai

“…Plasma membrane urokinase-type plasminogen activator (uPA)-receptor (uPAR) is a GPI-anchored protein that binds with high-affinity and activates the serine…”
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Management of bronchiectasis in adults Autor Chalmers, James D, Aliberti, Stefano, Blasi, Francesco

“…Formerly regarded as a rare disease, bronchiectasis is now increasingly recognised and a renewed interest in the condition is stimulating drug development and…”
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Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis Autor Chalmers, James D, Haworth, Charles S, Metersky, Mark L, Loebinger, Michael R, Blasi, Francesco, Sibila, Oriol, O’Donnell, Anne E, Sullivan, Eugene J, Mange, Kevin C, Fernandez, Carlos, Zou, Jun, Daley, Charles L

“…The causal role of neutrophil serine proteases in the pathogenesis of bronchiectasis was studied with brensocatib, an inhibitor of protease activation…”
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Characterization of Eosinophilic Bronchiectasis: A European Multicohort Study Autor Shoemark, Amelia, Shteinberg, Michal, De Soyza, Anthony, Haworth, Charles S, Richardson, Hollian, Gao, Yonghua, Perea, Lidia, Dicker, Alison J, Goeminne, Pieter C, Cant, Erin, Polverino, Eva, Altenburg, Josje, Keir, Holly R, Loebinger, Michael R, Blasi, Francesco, Welte, Tobias, Sibila, Oriol, Aliberti, Stefano, Chalmers, James D

“…Bronchiectasis is classically considered a neutrophilic disorder, but eosinophilic subtypes have recently been described. To use multiple datasets available…”
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European Respiratory Society guidelines for the management of adult bronchiectasis Autor Polverino, Eva, Goeminne, Pieter C, McDonnell, Melissa J, Aliberti, Stefano, Marshall, Sara E, Loebinger, Michael R, Murris, Marlene, Cantón, Rafael, Torres, Antoni, Dimakou, Katerina, De Soyza, Anthony, Hill, Adam T, Haworth, Charles S, Vendrell, Montserrat, Ringshausen, Felix C, Subotic, Dragan, Wilson, Robert, Vilaró, Jordi, Stallberg, Bjorn, Welte, Tobias, Rohde, Gernot, Blasi, Francesco, Elborn, Stuart, Almagro, Marta, Timothy, Alan, Ruddy, Thomas, Tonia, Thomy, Rigau, David, Chalmers, James D

“…Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent exacerbations in many patients. There have been no previous…”
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Treatment strategies for asthma: reshaping the concept of asthma management Autor Papi, Alberto, Blasi, Francesco, Canonica, Giorgio Walter, Morandi, Luca, Richeldi, Luca, Rossi, Andrea

“…Asthma is a common chronic disease characterized by episodic or persistent respiratory symptoms and airflow limitation. Asthma treatment is based on a stepwise…”
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The effect of N-acetylcysteine on biofilms: Implications for the treatment of respiratory tract infections Autor Blasi, Francesco, Page, Clive, Rossolini, Gian Maria, Pallecchi, Lucia, Matera, Maria Gabriella, Rogliani, Paola, Cazzola, Mario

“…In airway infections, biofilm formation has been demonstrated to be responsible for both acute and chronic events, and constitutes a genuine challenge in…”
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A tale of TALE, PREP1, PBX1, and MEIS1: Interconnections and competition in cancer Autor Blasi, Francesco, Bruckmann, Chiara, Penkov, Dmitry, Dardaei, Leila

“…We report the latest structural information on PREP1 tumor suppressor, the specific “oncogene” and “tumor suppressive” signatures of MEIS1 and PREP1, the…”
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Severe community-acquired pneumonia: Characteristics and prognostic factors in ventilated and non-ventilated patients Autor Ferrer, Miquel, Travierso, Chiara, Cilloniz, Catia, Gabarrus, Albert, Ranzani, Otavio T., Polverino, Eva, Liapikou, Adamantia, Blasi, Francesco, Torres, Antoni

“…Patients with severe community-acquired pneumonia (SCAP) and life-threatening acute respiratory failure may require invasive mechanical ventilation (IMV)…”
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Impact of age and comorbidity on cause and outcome in community-acquired pneumonia Autor Cillóniz, Catia, Polverino, Eva, Ewig, Santiago, Aliberti, Stefano, Gabarrús, Albert, Menéndez, Rosario, Mensa, Josep, Blasi, Francesco, Torres, Antoni

“…Prolonged life expectancy has currently increased the proportion of the very elderly among patients with community-acquired pneumonia (CAP). The aim of this…”
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Complement activation and endothelial perturbation parallel COVID-19 severity and activity Autor Cugno, Massimo, Meroni, Pier Luigi, Gualtierotti, Roberta, Griffini, Samantha, Grovetti, Elena, Torri, Adriana, Lonati, Paola, Grossi, Claudia, Borghi, Maria Orietta, Novembrino, Cristina, Boscolo, Massimo, Uceda Renteria, Sara Colonia, Valenti, Luca, Lamorte, Giuseppe, Manunta, Maria, Prati, Daniele, Pesenti, Antonio, Blasi, Francesco, Costantino, Giorgio, Gori, Andrea, Bandera, Alessandra, Tedesco, Francesco, Peyvandi, Flora

“…Animal models and few clinical reports suggest the involvement of the complement system in the onset of severe manifestations of coronavirus disease-2019…”
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The biology of pulmonary exacerbations in bronchiectasis Autor Amati, Francesco, Simonetta, Edoardo, Gramegna, Andrea, Tarsia, Paolo, Contarini, Martina, Blasi, Francesco, Aliberti, Stefano

“…Bronchiectasis is a heterogeneous chronic disease. Heterogeneity characterises bronchiectasis not only in the stable state but also during exacerbations,…”
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Neutrophil elastase in bronchiectasis Autor Gramegna, Andrea, Amati, Francesco, Terranova, Leonardo, Sotgiu, Giovanni, Tarsia, Paolo, Miglietta, Daniela, Calderazzo, Maria Adelaide, Aliberti, Stefano, Blasi, Francesco

“…The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about…”
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Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study Autor Keir, Holly R, Shoemark, Amelia, Dicker, Alison J, Perea, Lidia, Pollock, Jennifer, Giam, Yan Hui, Suarez-Cuartin, Guillermo, Crichton, Megan L, Lonergan, Mike, Oriano, Martina, Cant, Erin, Einarsson, Gisli G, Furrie, Elizabeth, Elborn, J Stuart, Fong, Christopher J, Finch, Simon, Rogers, Geraint B, Blasi, Francesco, Sibila, Oriol, Aliberti, Stefano, Simpson, Jodie L, Huang, Jeffrey T J, Chalmers, James D

“…Bronchiectasis is predominantly a neutrophilic inflammatory disease. There are no established therapies that directly target neutrophilic inflammation because…”
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Future trends in cystic fibrosis demography in 34 European countries Autor Burgel, Pierre-Régis, Bellis, Gil, Olesen, Hanne V, Viviani, Laura, Zolin, Anna, Blasi, Francesco, Elborn, J Stuart

“…Median survival has increased in people with cystic fibrosis (CF) during the past six decades, which has led to an increased number of adults with CF. The…”
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Fabry Disease Beyond Storage: The Role of Inflammation in Disease Progression Autor Biddeci, Giuseppa, Spinelli, Gaetano, Colomba, Paolo, Duro, Giovanni, Giacalone, Irene, Di Blasi, Francesco

“…Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the GLA gene, resulting in a deficient activity of the enzyme…”
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A review of national guidelines for management of COPD in Europe Autor Miravitlles, Marc, Vogelmeier, Claus, Roche, Nicolas, Halpin, David, Cardoso, João, Chuchalin, Alexander G, Kankaanranta, Hannu, Sandström, Thomas, Śliwiński, Paweł, Zatloukal, Jaromir, Blasi, Francesco

“…The quality of care can be improved by the development and implementation of evidence-based treatment guidelines. Different national guidelines for chronic…”
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Procalcitonin-guided antibiotic therapy: an expert consensus Autor Bartoletti, Michele, Antonelli, Massimo, Bruno Blasi, Francesco Arturo, Casagranda, Ivo, Chieregato, Arturo, Fumagalli, Roberto, Girardis, Massimo, Pieralli, Filippo, Plebani, Mario, Rossolini, Gian Maria, Sartelli, Massimo, Viaggi, Bruno, Viale, Pierluigi, Viscoli, Claudio, Pea, Federico

“…Procalcitonin (PCT) is a useful biomarker of bacterial infection and its use is associated to reduced duration of antibiotic therapy in the setting of…”
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Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis Autor Dardaei, Leila, Longobardi, Elena, Blasi, Francesco

“…Pbx-regulating protein-1 (Prep1) is a tumor suppressor, whereas myeloid ecotropic viral integration site-1 (Meis1) is an oncogene. We show that, to perform…”
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Safety of steroids in severe community-acquired pneumonia Autor Piedepalumbo, Federica Viola, Motos, Ana, Blasi, Francesco, Torres, Antoni

“…The systemic use of corticosteroids for patients with severe community-acquired pneumonia (sCAP) remains controversial in clinical practice, particularly in…”
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