Suchergebnisse - "Bis, Joshua C"

Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease von Schmidt, Amand F., Hunt, Nicholas B., Gordillo-Marañón, Maria, Charoen, Pimphen, Drenos, Fotios, Kivimaki, Mika, Lawlor, Deborah A., Giambartolomei, Claudia, Papacosta, Olia, Chaturvedi, Nishi, Bis, Joshua C., O’Donnell, Christopher J., Wannamethee, Goya, Wong, Andrew, Price, Jackie F., Hughes, Alun D., Gaunt, Tom R., Franceschini, Nora, Mook-Kanamori, Dennis O., Zwierzyna, Magdalena, Sofat, Reecha, Hingorani, Aroon D., Finan, Chris

“… Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary heart disease (CHD) has yet to deliver licensed medicines. To distinguish …”
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The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE) von Wolters, Frank J., Yang, Qiong, Biggs, Mary L., Jakobsdottir, Johanna, Li, Shuo, Evans, Daniel S., Bis, Joshua C., Harris, Tamara B., Vasan, Ramachandran S., Zilhao, Nuno R., Ghanbari, Mohsen, Ikram, M. Arfan, Launer, Lenore, Psaty, Bruce M., Tranah, Gregory J., Kulminski, Alexander M., Gudnason, Vilmundur, Seshadri, Sudha

“… Apolipoprotein E is a glycoprotein best known as a mediator and regulator of lipid transport and uptake. The APOE-ε4 allele has long been associated with …”
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Genomewide Association Study of Statin‐Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink von Carr, Daniel F., Francis, Ben, Jorgensen, Andrea L., Zhang, Eunice, Chinoy, Hector, Heckbert, Susan R., Bis, Joshua C., Brody, Jennifer A., Floyd, James S., Psaty, Bruce M., Molokhia, Mariam, Lapeyre‐Mestre, Maryse, Conforti, Anita, Alfirevic, Ana, Staa, Tjeerd, Pirmohamed, Munir

“… Statins can be associated with myopathy. We have undertaken a genomewide association study (GWAS) to discover and validate genetic risk factors for …”
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Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes von Yaghootkar, Hanieh, Scott, Robert A, White, Charles C, Zhang, Weihua, Speliotes, Elizabeth, Munroe, Patricia B, Ehret, Georg B, Bis, Joshua C, Fox, Caroline S, Walker, Mark, Borecki, Ingrid B, Knowles, Joshua W, Yerges-Armstrong, Laura, Ohlsson, Claes, Perry, John R B, Chambers, John C, Kooner, Jaspal S, Franceschini, Nora, Langenberg, Claudia, Hivert, Marie-France, Dastani, Zari, Richards, J Brent, Semple, Robert K, Frayling, Timothy M

“… The mechanisms that predispose to hypertension, coronary artery disease (CAD), and type 2 diabetes (T2D) in individuals of normal weight are poorly understood …”
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Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium von Ganesh, Santhi K, Zakai, Neil A, van Rooij, Frank J A, Soranzo, Nicole, Smith, Albert V, Nalls, Michael A, Chen, Ming-Huei, Kottgen, Anna, Glazer, Nicole L, Dehghan, Abbas, Kuhnel, Brigitte, Aspelund, Thor, Yang, Qiong, Tanaka, Toshiko, Jaffe, Andrew, Bis, Joshua C M, Verwoert, Germaine C, Teumer, Alexander, Fox, Caroline S, Guralnik, Jack M, Ehret, Georg B, Rice, Kenneth, Felix, Janine F, Rendon, Augusto, Eiriksdottir, Gudny, Levy, Daniel, Patel, Kushang V, Boerwinkle, Eric, Rotter, Jerome I, Hofman, Albert, Sambrook, Jennifer G, Hernandez, Dena G, Zheng, Gang, Bandinelli, Stefania, Singleton, Andrew B, Coresh, Josef, Lumley, Thomas, Uitterlinden, André G, vanGils, Janine M, Launer, Lenore J, Cupples, L Adrienne, Oostra, Ben A, Zwaginga, Jaap-Jan, Ouwehand, Willem H, Thein, Swee-Lay, Meisinger, Christa, Deloukas, Panos, Nauck, Matthias, Spector, Tim D, Gieger, Christian, Gudnason, Vilmundur, van Duijn, Cornelia M, Psaty, Bruce M, Ferrucci, Luigi, Chakravarti, Aravinda, Greinacher, Andreas, O'Donnell, Christopher J, Witteman, Jacqueline C M, Furth, Susan, Cushman, Mary, Harris, Tamara B, Lin, Jing-Ping

“… Santhi Ganesh and colleagues report meta-analyses of genome-wide association studies of six erythrocyte traits within the CHARGE consortium, with replication …”
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Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology von Levy, Daniel, Neuhausen, Susan L, Hunt, Steven C, Kimura, Masayuki, Hwang, Shih-Jen, Chen, Wei, Bis, Joshua C, Fitzpatrick, Annette L, Smith, Erin, Johnson, Andrew D, Gardner, Jeffrey P, Srinivasan, Sathanur R, Schork, Nicholas, Rotter, Jerome I, Herbig, Utz, Psaty, Bruce M, Sastrasinh, Malinee, Murray, Sarah S, Vasan, Ramachandran S, Province, Michael A, Glazer, Nicole L, Lu, Xiaobin, Cao, Xiaojian, Kronmal, Richard, Mangino, Massimo, Soranzo, Nicole, Spector, Tim D, Berenson, Gerald S, Aviv, Abraham

“… Telomeres are engaged in a host of cellular functions, and their length is regulated by multiple genes. Telomere shortening, in the course of somatic cell …”
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Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci von Paré, Guillaume, Ridker, Paul M., Rose, Lynda, Barbalic, Maja, Dupuis, Josée, Dehghan, Abbas, Bis, Joshua C., Benjamin, Emelia J., Shiffman, Dov, Parker, Alexander N., Chasman, Daniel I.

“… Soluble ICAM-1 (sICAM-1) is an endothelium-derived inflammatory marker that has been associated with diverse conditions such as myocardial infarction, …”
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Associations of Immune Cell Subsets With Coronary Artery Calcium Incidence and Progression in the Multi‐Ethnic Study of Atherosclerosis von Patel, Riddhi D., Buzkova, Petra, Huber, Sally, Landay, Alan, Budoff, Matthew, Bis, Joshua C., Olson, Nels, Rich, Stephen, Heckbert, Susan R., Manichaikul, Ani, Floyd, James, Tracy, Russell P., Psaty, Bruce M., Doyle, Margaret F., Sitlani, Colleen M, Delaney, Joseph A.C., Fohner, Alison E., Feinstein, Matthew J.

“… Limited data exist on associations of immune cell subsets with longitudinal changes in subclinical coronary artery disease. In the MESA (Multi-Ethnic Study of …”
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Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study von Sweet, Robert A, Seltman, Howard, Emanuel, James E, Lopez, Oscar L, Becker, James T, Bis, Joshua C, Weamer, Elise A, DeMichele-Sweet, Mary Ann A, Kuller, Lewis H

“… The trajectory of cognitive decline in patients with late-onset Alzheimer's disease varies widely. Genetic variations in CLU, PICALM, and CR1 are associated …”
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Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes von Schmidt, Amand F., Joshi, Roshni, Gordillo-Marañón, Maria, Drenos, Fotios, Charoen, Pimphen, Giambartolomei, Claudia, Bis, Joshua C., Gaunt, Tom R., Hughes, Alun D., Lawlor, Deborah A., Wong, Andrew, Price, Jackie F., Chaturvedi, Nishi, Wannamethee, Goya, Franceschini, Nora, Kivimaki, Mika, Hingorani, Aroon D., Finan, Chris

“… Background Higher concentrations of cholesterol-containing low-density lipoprotein (LDL-C) increase the risk of cardiovascular disease (CVD). The association …”
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Cerivastatin, genetic variants, and the risk of rhabdomyolysis von Marciante, Kristin D, Durda, Jon P, Heckbert, Susan R, Lumley, Thomas, Rice, Ken, McKnight, Barbara, Totah, Rheem A, Tamraz, Bani, Kroetz, Deanna L, Fukushima, Hisayo, Kaspera, Rüdiger, Bis, Joshua C, Glazer, Nicole L, Li, Guo, Austin, Thomas R, Taylor, Kent D, Rotter, Jerome I, Jaquish, Cashell E, Kwok, Pui-Yan, Tracy, Russell P, Psaty, Bruce M

“… The withdrawal of cerivastatin involved an uncommon but serious adverse reaction, rhabdomyolysis. The bimodal response, rhabdomyolysis in a small proportion of …”
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Genes from a translational analysis support a multifactorial nature of white matter hyperintensities von Lopez, Lorna M, Hill, W David, Harris, Sarah E, Valdes Hernandez, Maria, Munoz Maniega, Susana, Bastin, Mark E, Bailey, Emma, Smith, Colin, McBride, Martin, McClure, John, Graham, Delyth, Dominiczak, Anna, Yang, Qiong, Fornage, Myriam, Ikram, M Arfan, Debette, Stephanie, Launer, Lenore, Bis, Joshua C, Schmidt, Reinhold, Seshadri, Sudha, Porteous, David J, Starr, John, Deary, Ian J, Wardlaw, Joanna M

“… White matter hyperintensities (WMH) of presumed vascular origin increase the risk of stroke and dementia. Despite strong WMH heritability, few gene …”
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Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations von Horimoto, Andrea R.V.R., Boyken, Lisa A., Blue, Elizabeth E., Grinde, Kelsey E., Nafikov, Rafael A., Sohi, Harkirat K., Nato, Alejandro Q., Bis, Joshua C., Brusco, Luis I., Morelli, Laura, Ramirez, Alfredo, Dalmasso, Maria Carolina, Temple, Seth, Satizabal, Claudia, Browning, Sharon R., Seshadri, Sudha, Wijsman, Ellen M., Thornton, Timothy A.

“… Alzheimer disease (AD) is the most common form of senile dementia, with high incidence late in life in many populations including Caribbean Hispanic (CH) …”
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Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease von Manichaikul, Ani, Wang, Xin-Qun, Li, Li, Erdmann, Jeanette, Lettre, Guillaume, Bis, Joshua C., Waterworth, Dawn, Cushman, Mary, Jenny, Nancy S., Post, Wendy S., Palmas, Walter, Tsai, Michael Y., Wallentin, Lars, White, Harvey, Schunkert, Heribert, O’Donnell, Christopher J., Herrington, David M., Rich, Stephen S., O’Donoghue, Michelle L., Rodriguez, Annabelle

“… We previously reported association of SCARB1 SNP rs10846744 with common carotid IMT (cIMT) and cardiovascular disease (CVD) events. Since rs10846744 has been …”
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Sequence Analysis of Six Blood Pressure Candidate Regions in 4,178 Individuals: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study von Morrison, Alanna C., Bis, Joshua C., Hwang, Shih-Jen, Ehret, Georg B., Lumley, Thomas, Rice, Kenneth, Muzny, Donna, Gibbs, Richard A., Boerwinkle, Eric, Psaty, Bruce M., Chakravarti, Aravinda, Levy, Daniel

“… Genome-wide association studies (GWAS) identified multiple loci for blood pressure (BP) and hypertension. Six genes--ATP2B1, CACNB2, CYP17A1, JAG1, PLEKHA7, …”
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Large‐scale sequencing studies expand the known genetic architecture of Alzheimer's disease von Xue, Diane, Bush, William S., Renton, Alan E., Marcora, Edoardo A., Bis, Joshua C., Kunkle, Brian W., Boerwinkle, Eric, DeStefano, Anita L., Farrer, Lindsay, Goate, Alison, Mayeux, Richard, Pericak‐Vance, Margaret, Schellenberg, Gerard, Seshadri, Sudha, Wijsman, Ellen, Haines, Jonathan L., Blue, Elizabeth E.

“… Introduction Genes implicated by genome‐wide association studies and family‐based studies of Alzheimer's disease (AD) are largely discordant. We hypothesized …”
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Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium von Olden, Matthias, Teumer, Alexander, Bochud, Murielle, Pattaro, Cristian, Köttgen, Anna, Turner, Stephen T, Rettig, Rainer, Chen, Ming-Huei, Dehghan, Abbas, Bastardot, Francois, Schmidt, Reinhold, Vollenweider, Peter, Schunkert, Heribert, Reilly, Muredach P, Fornage, Myriam, Launer, Lenore J, Verwoert, Germaine C, Mitchell, Gary F, Bis, Joshua C, O'Donnell, Christopher J, Cheng, Ching-Yu, Sim, Xueling, Siscovick, David S, Coresh, Josef, Kao, W H Linda, Fox, Caroline S, O'Seaghdha, Conall M

“… Chronic kidney disease is associated with cardiovascular disease. We tested for evidence of a shared genetic basis to these traits. We conducted 2 targeted …”
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Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium von Wolters, Frank J, Chibnik, Lori B, Waziry, Reem, Anderson, Roy, Berr, Claudine, Beiser, Alexa, Bis, Joshua C, Blacker, Deborah, Bos, Daniel, Brayne, Carol, Dartigues, Jean-François, Darweesh, Sirwan K L, Davis-Plourde, Kendra L, de Wolf, Frank, Debette, Stephanie, Dufouil, Carole, Fornage, Myriam, Goudsmit, Jaap, Grasset, Leslie, Gudnason, Vilmundur, Hadjichrysanthou, Christoforos, Helmer, Catherine, Ikram, M Arfan, Ikram, M Kamran, Joas, Erik, Kern, Silke, Kuller, Lewis H, Launer, Lenore, Lopez, Oscar L, Matthews, Fiona E, McRae-McKee, Kevin, Meirelles, Osorio, Mosley, Jr, Thomas H, Pase, Matthew P, Psaty, Bruce M, Satizabal, Claudia L, Seshadri, Sudha, Skoog, Ingmar, Stephan, Blossom C M, Wetterberg, Hanna, Wong, Mei Mei, Zettergren, Anna, Hofman, Albert

“… To determine changes in the incidence of dementia between 1988 and 2015. This analysis was performed in aggregated data from individuals >65 years of age in 7 …”
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Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study von Lin, Honghuang, Sinner, Moritz F, Brody, Jennifer A, Arking, Dan E, Lunetta, Kathryn L, Rienstra, Michiel, Lubitz, Steven A, Magnani, Jared W, Sotoodehnia, Nona, McKnight, Barbara, McManus, David D, Boerwinkle, Eric, Psaty, Bruce M, Rotter, Jerome I, Bis, Joshua C, Gibbs, Richard A, Muzny, Donna, Kovar, Christie L, Morrison, Alanna C, Gupta, Mayetri, Folsom, Aaron R, Kääb, Stefan, Heckbert, Susan R, Alonso, Alvaro, Ellinor, Patrick T, Benjamin, Emelia J

“… Genome-wide association studies (GWAS) have identified common genetic variants that predispose to atrial fibrillation (AF). It is unclear whether rare and …”
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Associations of NINJ2 Sequence Variants with Incident Ischemic Stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) Consortium von Bis, Joshua C., DeStefano, Anita, Liu, Xiaoming, Brody, Jennifer A., Choi, Seung Hoan, Verhaaren, Benjamin F. J., Debette, Stéphanie, Ikram, M. Arfan, Shahar, Eyal, Butler, Kenneth R., Gottesman, Rebecca F., Muzny, Donna, Kovar, Christie L., Psaty, Bruce M., Hofman, Albert, Lumley, Thomas, Gupta, Mayetri, Wolf, Philip A., van Duijn, Cornelia, Gibbs, Richard A., Mosley, Thomas H., Longstreth, W. T., Boerwinkle, Eric, Seshadri, Sudha, Fornage, Myriam

“… Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study …”
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