Suchergebnisse - "Biomedical and Life Sciences"

Knowledge-integrated research is more disruptive when supported by homogeneous funding sources: a case of US federally funded research in biomedical and life sciences von Yang, Seolmin, Kim, So Young

“… Knowledge integration is measured as the degree to which a paper combines different research subjects in three dimensions of diversity …”
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Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease von Moreno-Jiménez, Elena P, Flor-García, Miguel, Terreros-Roncal, Julia, Rábano, Alberto, Cafini, Fabio, Pallas-Bazarra, Noemí, Ávila, Jesús, Llorens-Martín, María

“… The hippocampus is one of the most affected areas in Alzheimer's disease (AD) . Moreover, this structure hosts one of the most unique phenomena of the adult …”
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A fully integrated wearable ultrasound system to monitor deep tissues in moving subjects von Lin, Muyang, Zhang, Ziyang, Gao, Xiaoxiang, Bian, Yizhou, Wu, Ray S., Park, Geonho, Lou, Zhiyuan, Zhang, Zhuorui, Xu, Xiangchen, Chen, Xiangjun, Kang, Andrea, Yang, Xinyi, Yue, Wentong, Yin, Lu, Wang, Chonghe, Qi, Baiyan, Zhou, Sai, Hu, Hongjie, Huang, Hao, Li, Mohan, Gu, Yue, Mu, Jing, Yang, Albert, Yaghi, Amer, Chen, Yimu, Lei, Yusheng, Lu, Chengchangfeng, Wang, Ruotao, Wang, Joseph, Xiang, Shu, Kistler, Erik B., Vasconcelos, Nuno, Xu, Sheng

“… On mobile subjects, the USoP can continuously monitor physiological signals, including central blood pressure, heart rate and cardiac …”
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Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects von Merico, Daniele, Antaki, Danny, Shetty, Aniket, Gujral, Madhusudan, Brandler, William M, Malhotra, Dheeraj, Alexander, Madeline, Belliveau, Richard A, Bergen, Sarah E, Bertalan, Marcelo, Bevilacqua, Elizabeth, Cantor, Rita M, Carrera, Noa, Cormican, Paul, Crespo-Facorro, Benedicto, Curtis, David, Davidson, Michael, Degenhardt, Franziska, Del Favero, Jurgen, DeLisi, Lynn E, Dudbridge, Frank, Eichhammer, Peter, Eriksson, Johan, Essioux, Laurent, Farrell, Martilias S, Freedman, Robert, Freimer, Nelson B, Georgieva, Lyudmila, Gershon, Elliot S, Giegling, Ina, Godard, Stephanie, Goldstein, Jacqueline I, Hamshere, Marian L, Hartmann, Annette M, Hofman, Andrea, Kähler, Anna K, Kalaydjieva, Luba, Kelly, Brian J, Lee, S Hong, Legge, Sophie E, Lerer, Bernard, Levy, Deborah L, Maher, Brion S, Mattingsdal, Morten, McDonald, Colm, Metspalu, Andres, Milanova, Vihra, Morris, Derek W, Murray, Robin M, Nestadt, Gerald, Nicodemus, Kristin K, Nordin, Annelie, Oh, Sang-Yun, Olsen, Line, Van Os, Jim, Pantelis, Christos, Pers, Tune H, Powell, John, Price, Alkes, Pulver, Ann E, Purcell, Shaun M, Rasmussen, Henrik B, Richards, Alexander L, Roussos, Panos, Schall, Ulrich, Schwab, Sibylle G, Smoller, Jordan W, Spencer, Chris C A, Stahl, Eli A, Stroup, T Scott, Suvisaari, Jaana, Svrakic, Dragan M, Szatkiewicz, Jin P, Veijola, Juha, Waddington, John, Webb, Bradley T, Williams, Nigel M, Williams, Stephanie, Wolen, Aaron R, Adolfsson, Rolf, Blackwood, Douglas H R, Bramon, Elvira, Buxbaum, Joseph D, Collier, David A, Daly, Mark J, Darvasi, Ariel, Domenici, Enrico, Gill, Michael, Iwata, Nakao, Jablensky, Assen V, Jönsson, Erik G, Kirov, George, Knight, Jo, Levinson, Douglas F, Ophoff, Roel A, Owen, Michael J, Rietschel, Marcella, Rujescu, Dan, O'Donovan, Michael C, Neale, Benjamin M

“… The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease …”
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Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia von Hysi, Pirro G., Choquet, Hélène, Khawaja, Anthony P., Wojciechowski, Robert, Tedja, Milly S., Yin, Jie, Simcoe, Mark J., Patasova, Karina, Mahroo, Omar A., Thai, Khanh K., Cumberland, Phillippa M., Melles, Ronald B., Verhoeven, Virginie J. M., Vitart, Veronique, Segre, Ayellet, Stone, Richard A., Wareham, Nick, Hewitt, Alex W., Mackey, David A., Klaver, Caroline C. W., MacGregor, Stuart, Khaw, Peng T., Foster, Paul J., Guggenheim, Jeremy A., Rahi, Jugnoo S., Jorgenson, Eric, Hammond, Christopher J.

“… Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the …”
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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes von Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Giese, Anne-Katrin, van der Laan, Sander W., Gretarsdottir, Solveig, Anderson, Christopher D., Almgren, Peter, Amouyel, Philippe, Bartz, Traci M., Benavente, Oscar R., Boncoraglio, Giorgio B., Butterworth, Adam S., Carrera, Caty, Chasman, Daniel I., Cotlarciuc, Ioana, Cruchaga, Carlos, de Bakker, Paul I. W., Duan, Qing, Gottesman, Rebecca F., Harris, Tamara B., Hassan, Ahamad, Havulinna, Aki S., Heckbert, Susan R., Hyacinth, Hyacinth I., Ikram, M. Arfan, Ingelsson, Erik, Jian, Xueqiu, Jukema, J. Wouter, Kanai, Masahiro, Keene, Keith L., Kissela, Brett M., Kleindorfer, Dawn O., Kooperberg, Charles, Lange, Leslie A., Langenberg, Claudia, Launer, Lenore J., Lemmens, Robin, Lewis, Cathryn M., Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K., Meschia, James F., Mitchell, Braxton D., Mosley, Thomas H., Nalls, Michael A., O’Donnell, Martin J., Pulit, Sara L., Reiner, Alexander P., Ridker, Paul M., Rothwell, Peter M., Rotter, Jerome I., Sale, Michele M., Salomaa, Veikko, Sapkota, Bishwa R., Schmidt, Reinhold, Schmidt, Carsten O., Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie L. M., Tanislav, Christian, Thijs, Vincent N. S., Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Wareham, Nicholas J., Wassertheil-Smoller, Sylvia, Wilson, James G., Pastinen, Tomi, Ruusalepp, Arno, Koplev, Simon, Björkegren, Johan L. M., Codoni, Veronica, Civelek, Mete, Christophersen, Ingrid E., Roselli, Carolina, Ellinor, Patrick T., Kato, Norihiro, van der Harst, Pim, Elliott, Paul, Takeuchi, Fumihiko, Johnson, Andrew D., Sanghera, Dharambir K., Melander, Olle, Strbian, Daniel, Fernandez-Cadenas, Israel, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Pare, Guillaume, Hopewell, Jemma C., Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B., Seshadri, Sudha, Markus, Hugh S., Debette, Stephanie, Dichgans, Martin

“… Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis …”
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A machine learning approach to radiogenomics of breast cancer: a study of 922 subjects and 529 DCE-MRI features von Saha, Ashirbani, Harowicz, Michael R, Grimm, Lars J, Kim, Connie E, Ghate, Sujata V, Walsh, Ruth, Mazurowski, Maciej A

“… Recent studies showed preliminary data on associations of MRI-based imaging phenotypes of breast tumours with breast cancer molecular, genomic, and related …”
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Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons von Schafer, Simon T, Paquola, Apua C M, Stern, Shani, Gosselin, David, Ku, Manching, Pena, Monique, Kuret, Thomas J M, Liyanage, Marvin, Mansour, Abed AlFatah, Jaeger, Baptiste N, Marchetto, Maria C, Glass, Christopher K, Mertens, Jerome, Gage, Fred H

“… To profile early neurodevelopmental alterations in ASD with macrocephaly, we monitored subject-derived induced pluripotent stem cells (iPSCs …”
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Studying and modifying brain function with non-invasive brain stimulation von Polanía, Rafael, Nitsche, Michael A, Ruff, Christian C

“… In the past three decades, our understanding of brain-behavior relationships has been significantly shaped by research using non-invasive brain stimulation …”
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Therapeutically harnessing extracellular vesicles von Cheng, Lesley, Hill, Andrew F

“… The field of extracellular vesicle (EV) research has developed rapidly over the last decade from the study of fundamental biology to a subject of significant clinical relevance …”
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Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment von Watanabe, Akiko, Ishizuka, Tomoko, Yamada, Makiko, Igawa, Yoshiyuki, Shimizu, Takako, Ishizuka, Hitoshi

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Safety, pharmacodynamic, and pharmacokinetic characterization of vericiguat: results from six phase I studies in healthy subjects von Boettcher, Michael, Thomas, Dirk, Mueck, Wolfgang, Loewen, Stephanie, Arens, Erich, Yoshikawa, Kenichi, Becker, Corina

“… Methods Six phase I studies were conducted in European, Chinese, and Japanese males. Subjects received oral vericiguat as a single dose (0.5–15.0 mg solution …”
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Semantic reconstruction of continuous language from non-invasive brain recordings von Tang, Jerry, LeBel, Amanda, Jain, Shailee, Huth, Alexander G.

“… A brain–computer interface that decodes continuous language from non-invasive recordings would have many scientific and practical applications. Currently, …”
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Subject: Motivation can be suppressed, but scientific ability cannot and should not be ignored von Saki, Najmaldin, Haybar, Habib, Aghaei, Mojtaba

“… According to the faculty bestowed to researchers by God and the task assigned to them, they work to better understand and help improve the level of health, …”
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Identification of neoantigens for individualized therapeutic cancer vaccines von Lang, Franziska, Schrörs, Barbara, Löwer, Martin, Türeci, Özlem, Sahin, Ugur

“… As neoepitopes are not subject to central immune tolerance and are not expressed in healthy tissues, they are attractive targets for therapeutic cancer vaccines …”
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Immune response to COVID-19 vaccines among people living with human T-cell lymphotropic virus type 1 infection: a retrospective cohort study from Iran: Immune respone to COVID-19 vaccines in HTLV-1 subjects von Jafarzadeh Esfehani, Reza, Vahidi, Zohreh, Shariati, Mohammad, Mosavat, Arman, Shafaei, Azam, Shahi, Maryam, Rafatpanah, Houshang, Bidkhori, Hamid Reza, Boostani, Reza, Hedayati-Moghaddam, Mohammad Reza

“… ) in northeastern Iran. From December 2021 to October 2022, eighty-six HTLV-1 + subjects (50 males and 36 females; 47.7 ± 11.2 years …”
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Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects von Qian, Hong-jie, Wang, Yu, Zhang, Meng-qi, Xie, Yuan-chao, Wu, Qing-qing, Liang, Li-yu, Cao, Ye, Duan, Hua-qing, Tian, Guang-hui, Ma, Juan, Zhang, Zhuo-bing, Li, Ning, Jia, Jing-ying, Zhang, Jing, Aisa, Haji Akber, Shen, Jing-shan, Yu, Chen, Jiang, Hua-liang, Zhang, Wen-hong, Wang, Zhen, Liu, Gang-yi

“… , tolerability, and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subjects, as well as the effect …”
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Long-lasting subjective effects of LSD in normal subjects von Schmid, Yasmin, Liechti, Matthias E.

“… Rationale Lysergic acid diethylamide (LSD) and other serotonergic hallucinogens can induce profound alterations of consciousness and mystical-type experiences, …”
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Systematic underestimation of the epigenetic clock and age acceleration in older subjects von El Khoury, Louis Y., Gorrie-Stone, Tyler, Smart, Melissa, Hughes, Amanda, Bao, Yanchun, Andrayas, Alexandria, Burrage, Joe, Hannon, Eilis, Kumari, Meena, Mill, Jonathan, Schalkwyk, Leonard C.

“… Background The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has …”
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Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey von Di Renzo, Laura, Gualtieri, Paola, Pivari, Francesca, Soldati, Laura, Attinà, Alda, Cinelli, Giulia, Leggeri, Claudia, Caparello, Giovanna, Barrea, Luigi, Scerbo, Francesco, Esposito, Ernesto, De Lorenzo, Antonino

“… Background On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans …”
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