Suchergebnisse - "Biochemical journal"

New tools for automated cryo-EM single-particle analysis in RELION-4.0 von Kimanius, Dari, Dong, Liyi, Sharov, Grigory, Nakane, Takanori, Scheres, Sjors H W

“… We describe new tools for the processing of electron cryo-microscopy (cryo-EM) images in the fourth major release of the RELION software. In particular, we …”
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Introduction to the human gut microbiota von Thursby, Elizabeth, Juge, Nathalie

“… The human gastrointestinal (GI) tract harbours a complex and dynamic population of microorganisms, the gut microbiota, which exert a marked influence on the …”
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The concept of intrinsic versus extrinsic apoptosis von Lossi, Laura

“… Regulated cell death is a vital and dynamic process in multicellular organisms that maintains tissue homeostasis and eliminates potentially dangerous cells …”
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A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications von Kell, Douglas B, Laubscher, Gert Jacobus, Pretorius, Etheresia

“… Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID' (a phenotype of COVID-19), is a relatively frequent consequence of SARS-CoV-2 …”
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New photosensitizers for photodynamic therapy von Abrahamse, Heidi, Hamblin, Michael R

“… Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since become a well-studied therapy for cancer and various non-malignant diseases …”
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The signalling role of ROS in the regulation of seed germination and dormancy von Bailly, Christophe

“… Reactive oxygen species (ROS) are versatile compounds which can have toxic or signalling effects in a wide range living organisms, including seeds. They have …”
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Molecular mechanisms of ROS production and oxidative stress in diabetes von Newsholme, Philip, Cruzat, Vinicius Fernandes, Keane, Kevin Noel, Carlessi, Rodrigo, de Bittencourt, Jr, Paulo Ivo Homem

“… Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an …”
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Structure and function of carbonic anhydrases von Supuran, Claudiu T

“… Carbonic anhydrases (CAs, EC 4.2.1.1) catalyse the interconversion between CO2 and bicarbonate as well as other hydrolytic reactions. Among the six genetic …”
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Protein oxidation and peroxidation von Davies, Michael J

“… Proteins are major targets for radicals and two-electron oxidants in biological systems due to their abundance and high rate constants for reaction. With …”
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Topoisomerases as anticancer targets von Delgado, Justine L, Hsieh, Chao-Ming, Chan, Nei-Li, Hiasa, Hiroshi

“… Many cancer type-specific anticancer agents have been developed and significant advances have been made toward precision medicine in cancer treatment. However, …”
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Interactions between plants and soil shaping the root microbiome under abiotic stress von Hartman, Kyle, Tringe, Susannah G

“… Plants growing in soil develop close associations with soil microorganisms, which inhabit the areas around, on, and inside their roots. These microbial …”
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Amino acid homeostasis and signalling in mammalian cells and organisms von Bröer, Stefan, Bröer, Angelika

“… Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss is mainly due to amino acid oxidation. Homeostasis is achieved …”
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Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics von Yang, Alexander, Mottillo, Emilio P

“… Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD) organelles by professional storage cells called adipocytes …”
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RNA-binding proteins with prion-like domains in health and disease von Harrison, Alice Ford, Shorter, James

“… Approximately 70 human RNA-binding proteins (RBPs) contain a prion-like domain (PrLD). PrLDs are low-complexity domains that possess a similar amino acid …”
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SREBP-1c and lipogenesis in the liver: an update1 von Ferré, Pascal, Phan, Franck, Foufelle, Fabienne

“… Sterol Regulatory Element Binding Protein-1c is a transcription factor that controls the synthesis of lipids from glucose in the liver, a process which is of …”
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Cancer stem cells (CSCs): metabolic strategies for their identification and eradication von De Francesco, Ernestina M, Sotgia, Federica, Lisanti, Michael P

“… Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells within different tumor types and is responsible for treatment …”
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Therapeutic targeting of non-coding RNAs in cancer von Slaby, Ondrej, Laga, Richard, Sedlacek, Ondrej

“… The majority of the human genome encodes RNAs that do not code for proteins. These non-coding RNAs (ncRNAs) affect normal expression of the genes, including …”
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Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids von Dickson, Eamonn J, Hille, Bertil

“… Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small …”
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Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding von Kalogeropulou, Alexia F, Purlyte, Elena, Tonelli, Francesca, Lange, Sven M, Wightman, Melanie, Prescott, Alan R, Padmanabhan, Shalini, Sammler, Esther, Alessi, Dario R

“… Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity …”
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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65 von Kazlauskaite, Agne, Kondapalli, Chandana, Gourlay, Robert, Campbell, David G, Ritorto, Maria Stella, Hofmann, Kay, Alessi, Dario R, Knebel, Axel, Trost, Matthias, Muqit, Miratul M K

“… We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-induced putative kinase 1) is activated by mitochondrial depolarization …”
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