Suchergebnisse - "Biochemical Society transactions"

Omega-3 fatty acids and inflammatory processes: from molecules to man von Calder, Philip C

“… Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical …”
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MSC exosome works through a protein-based mechanism of action von Toh, Wei Seong, Lai, Ruenn Chai, Zhang, Bin, Lim, Sai Kiang

“… Mesenchymal stem cell (MSC) exosome specifically defines the 50-200 nm vesicles that are secreted into the extracellular space when multivesicular bodies in …”
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Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways von Wardyn, Joanna D, Ponsford, Amy H, Sanderson, Christopher M

“… In most tissues, cells are exposed to frequent changes in levels of oxidative stress and inflammation. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and …”
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ERK1/2 in immune signalling von Lucas, Richard M, Luo, Lin, Stow, Jennifer L

“… Extracellular signal-related kinases 1 and 2 (ERK1/2) are the final components of the mitogen-activated protein kinase (MAPK) phosphorylation cascade, an …”
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Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis von Erdogan, Begum, Webb, Donna J

“… Cancer-associated fibroblasts (CAFs) are major components of the surrounding stroma of carcinomas that emerge in the tumor microenvironment as a result of …”
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Insulin signalling and GLUT4 trafficking in insulin resistance von van Gerwen, Julian, Shun-Shion, Amber S, Fazakerley, Daniel J

“… Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining whole-body glucose homeostasis. Insulin promotes glucose uptake into …”
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Carcinogens and DNA damage von Barnes, Jessica L, Zubair, Maria, John, Kaarthik, Poirier, Miriam C, Martin, Francis L

“… Humans are variously and continuously exposed to a wide range of different DNA-damaging agents, some of which are classed as carcinogens. DNA damage can arise …”
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The Warburg effect: 80 years on von Potter, Michelle, Newport, Emma, Morten, Karl J

“… Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells' energy generation is different from that of normal cells. They …”
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The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease von Babu, M Madan

“… In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a protein is determined by its amino acid sequence. This work laid …”
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LRRK2 links genetic and sporadic Parkinson's disease von Kluss, Jillian H, Mamais, Adamantios, Cookson, Mark R

“… The past two decades in research has revealed the importance of leucine-rich repeat kinase 2 (LRRK2) in both monogenic and sporadic forms of Parkinson's …”
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Structure determination of GPCRs: cryo-EM compared with X-ray crystallography von García-Nafría, Javier, Tate, Christopher G

“… G protein-coupled receptors (GPCRs) are the largest single family of cell surface receptors encoded by the human genome and they play pivotal roles in …”
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Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically? von Macdonald, Ruby, Barnes, Katy, Hastings, Christopher, Mortiboys, Heather

“… Mitochondrial abnormalities have been identified as a central mechanism in multiple neurodegenerative diseases and, therefore, the mitochondria have been …”
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Structure and function of the cytochrome P450 peroxygenase enzymes von Munro, Andrew W, McLean, Kirsty J, Grant, Job L, Makris, Thomas M

“… The cytochromes P450 (P450s or CYPs) constitute a large heme enzyme superfamily, members of which catalyze the oxidative transformation of a wide range of …”
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Mucins: the frontline defence of the lung von Ridley, Caroline, Thornton, David J

“… Mucus plays a vital role in protecting the lungs from environmental factors, but conversely, in muco-obstructive airway disease, mucus becomes pathologic. In …”
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Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis von Lev, Sima

“… Targeting of estrogen receptor is commonly used as a first-line treatment for hormone-positive breast cancer patients, and is considered as a keystone of …”
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Endothelial response to glucose: dysfunction, metabolism, and transport von Clyne, Alisa Morss

“… The endothelial cell response to glucose plays an important role in both health and disease. Endothelial glucose-induced dysfunction was first studied in …”
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Bacteria autoaggregation: how and why bacteria stick together von Nwoko, El-Shama Q A, Okeke, Iruka N

“… Autoaggregation, adherence between identical bacterial cells, is important for colonization, kin and kind recognition, and survival of bacteria. It is directly …”
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Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase von Hiu, Jia Jin, Yap, Michelle Khai Khun

“… The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes found in the venoms from most snake species. These enzymes have been …”
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Molecular mechanisms involved in plant photoprotection von Pinnola, Alberta, Bassi, Roberto

“… Photosynthesis uses sunlight to convert water and carbon dioxide into biomass and oxygen. When in excess, light can be dangerous for the photosynthetic …”
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Vitamin C and immune cell function in inflammation and cancer von Ang, Abel, Pullar, Juliet M, Currie, Margaret J, Vissers, Margreet C M

“… Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many aspects of the immune response. Intracellular levels generally …”
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