Výsledky vyhledávání - "BioEssays"

Spatially Resolved Transcriptomes—Next Generation Tools for Tissue Exploration Autor Asp, Michaela, Bergenstråhle, Joseph, Lundeberg, Joakim

“…Recent advances in spatially resolved transcriptomics have greatly expanded the knowledge of complex multicellular biological systems. The field has quickly…”
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YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy Autor Thompson, Barry J.

“…The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently activated during the growth and progression of many solid tumors, including…”
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Adapting with Microbial Help: Microbiome Flexibility Facilitates Rapid Responses to Environmental Change Autor Voolstra, Christian R., Ziegler, Maren

“…Animals and plants are metaorganisms and associate with microbes that affect their physiology, stress tolerance, and fitness. Here the hypothesis that…”
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Phototoxicity in live fluorescence microscopy, and how to avoid it Autor Icha, Jaroslav, Weber, Michael, Waters, Jennifer C., Norden, Caren

“…Phototoxicity frequently occurs during live fluorescence microscopy, and its consequences are often underestimated. Damage to cellular macromolecules upon…”
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DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis Autor McKie, Shannon J., Neuman, Keir C., Maxwell, Anthony

“…DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and indispensable for cellular survival due to the numerous roles they play during DNA…”
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How reticulated are species? Autor Mallet, James, Besansky, Nora, Hahn, Matthew W

“…Many groups of closely related species have reticulate phylogenies. Recent genomic analyses are showing this in many insects and vertebrates, as well as in…”
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The gut-skin axis in health and disease: A paradigm with therapeutic implications Autor O'Neill, Catherine A., Monteleone, Giovanni, McLaughlin, John T., Paus, Ralf

“…As crucial interface organs gut and skin have much in common. Therefore it is unsurprising that several gut pathologies have skin co‐morbidities. Nevertheless,…”
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Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries Autor Oku, Masahide, Sakai, Yasuyoshi

“…Microautophagy is originally defined as lysosomal (vacuolar) membrane dynamics to directly enwrap and transport cytosolic components into the lumen of the…”
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PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery Autor Gu, Shanshan, Cui, Danrui, Chen, Xiaoyu, Xiong, Xiufang, Zhao, Yongchao

“…Proteolysis‐targeting chimeric molecules (PROTACs) represent an emerging technique that is receiving much attention for therapeutic intervention. The mechanism…”
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Is H3K4me3 instructive for transcription activation? Autor Howe, Françoise S., Fischl, Harry, Murray, Struan C., Mellor, Jane

“…Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin modification at the transcription start site of active genes in eukaryotes…”
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Coiled-coils: The long and short of it Autor Truebestein, Linda, Leonard, Thomas A.

“…Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains of some proteins are almost invariant in sequence and length,…”
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Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X) Autor Fang, Liang‐Xing, Chen, Chong, Cui, Chao‐Yue, Li, Xing‐Ping, Zhang, Yan, Liao, Xiao‐Ping, Sun, Jian, Liu, Ya‐Hong

“…Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of…”
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Are aberrant phase transitions a driver of cellular aging? Autor Alberti, Simon, Hyman, Anthony A.

“…Why do cells age? Recent advances show that the cytoplasm is organized into many membrane‐less compartments via a process known as phase separation, which…”
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The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin: SARS‐COV‐2 chimeric structure and furin cleavage site might be the result of genetic manipulation Autor Segreto, Rossana, Deigin, Yuri

“…Severe acute respiratory syndrome‐coronavirus (SARS‐CoV)‐2′s origin is still controversial. Genomic analyses show SARS‐CoV‐2 likely to be chimeric, most of its…”
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What is the total number of protein molecules per cell volume? A call to rethink some published values Autor Milo, Ron

“…Novel methods such as mass‐spectrometry enable a view of the proteomes of cells in unprecedented detail. Recently, these efforts have culminated in…”
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Ecological and Evolutionary Benefits of Temperate Phage: What Does or Doesn't Kill You Makes You Stronger Autor Harrison, Ellie, Brockhurst, Michael A.

“…Infection by a temperate phage can lead to death of the bacterial cell, but sometimes these phages integrate into the bacterial chromosome, offering the…”
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Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms Autor Alcock, Joe, Maley, Carlo C., Aktipis, C. Athena

“…Microbes in the gastrointestinal tract are under selective pressure to manipulate host eating behavior to increase their fitness, sometimes at the expense of…”
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Translational Control under Stress: Reshaping the Translatome Autor Advani, Vivek M., Ivanov, Pavel

“…Adequate reprogramming of cellular metabolism in response to stresses or suboptimal growth conditions involves a myriad of coordinated changes that serve to…”
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The Warburg effect then and now: From cancer to inflammatory diseases Autor Palsson-McDermott, Eva M., O'Neill, Luke A. J.

“…Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from…”
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Crosstalk between Cell Adhesion Complexes in Regulation of Mechanotransduction Autor Zuidema, Alba, Wang, Wei, Sonnenberg, Arnoud

“…Physical forces regulate numerous biological processes during development, physiology, and pathology. Forces between the external environment and intracellular…”
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