Suchergebnisse - "Bile Duct Neoplasms* / blood"

A Circular RNA, Cholangiocarcinoma‐Associated Circular RNA 1, Contributes to Cholangiocarcinoma Progression, Induces Angiogenesis, and Disrupts Vascular Endothelial Barriers von Xu, Yi, Leng, Kaiming, Yao, Yue, Kang, Pengcheng, Liao, Guanqun, Han, Yi, Shi, Guangjun, Ji, Daolin, Huang, Peng, Zheng, Wangyang, Li, Zhenglong, Li, Jinglin, Huang, Lining, Yu, Liang, Zhou, Yongxu, Jiang, Xingming, Wang, Hao, Li, Chunlong, Su, Zhilei, Tai, Sheng, Zhong, Xiangyu, Wang, Zhidong, Cui, Yunfu

“… Background and Aims Circular RNAs (circRNAs) and extracellular vesicles (EVs) are involved in various malignancies. We aimed to clarify the functions and …”
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Combined Vascular Resection for Locally Advanced Perihilar Cholangiocarcinoma von Mizuno, Takashi, Ebata, Tomoki, Yokoyama, Yukihiro, Igami, Tsuyoshi, Yamaguchi, Junpei, Onoe, Shunsuke, Watanabe, Nobuyuki, Kamei, Yuzuru, Nagino, Masato

“… To evaluate the efficacy and safety of combined vascular resection (VR) in advanced perihilar cholangiocarcinoma (PHC). Hepatectomy combined with portal vein …”
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YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors von Marti, Patricia, Stein, Claudia, Blumer, Tanja, Abraham, Yann, Dill, Michael T., Pikiolek, Monika, Orsini, Vanessa, Jurisic, Giorgia, Megel, Philippe, Makowska, Zuzanna, Agarinis, Claudia, Tornillo, Luigi, Bouwmeester, Tewis, Ruffner, Heinz, Bauer, Andreas, Parker, Christian N., Schmelzle, Tobias, Terracciano, Luigi M., Heim, Markus H., Tchorz, Jan S.

“… The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue development, regeneration, and tumorigenesis. However, its role in …”
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Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas von Zill, Oliver A, Greene, Claire, Sebisanovic, Dragan, Siew, Lai Mun, Leng, Jim, Vu, Mary, Hendifar, Andrew E, Wang, Zhen, Atreya, Chloe E, Kelley, Robin K, Van Loon, Katherine, Ko, Andrew H, Tempero, Margaret A, Bivona, Trever G, Munster, Pamela N, Talasaz, AmirAli, Collisson, Eric A

“… Patients with pancreatic and biliary carcinomas lack personalized treatment options, in part because biopsies are often inadequate for molecular …”
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Cytologic characteristics of circulating epithelioid cells in pancreatic disease von Rosenbaum, Matthew W., Cauley, Christy E., Kulemann, Birte, Liss, Andrew S., Castillo, Carlos Fernandez‐del, Warshaw, Andrew L., Lillemoe, Keith D., Thayer, Sarah P., Pitman, Martha B.

“… BACKGROUND Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic …”
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Genotyping of circulating tumor DNA in cholangiocarcinoma reveals diagnostic and prognostic information von Ettrich, T. J., Schwerdel, D., Dolnik, A., Beuter, F., Blätte, T. J., Schmidt, S. A., Stanescu-Siegmund, N., Steinacker, J., Marienfeld, R., Kleger, A., Bullinger, L., Seufferlein, T., Berger, A. W.

“… Diagnosis of Cholangiocarcinoma (CCA) is difficult, thus a noninvasive approach towards (i) assessing and (ii) monitoring the tumor-specific mutational profile …”
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Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma von Julich-Haertel, Henrike, Urban, Sabine K., Krawczyk, Marcin, Willms, Arnulf, Jankowski, Krzysztof, Patkowski, Waldemar, Kruk, Beata, Krasnodębski, Maciej, Ligocka, Joanna, Schwab, Robert, Richardsen, Ines, Schaaf, Sebastian, Klein, Angelina, Gehlert, Sebastian, Sänger, Hanna, Casper, Markus, Banales, Jesus M., Schuppan, Detlef, Milkiewicz, Piotr, Lammert, Frank, Krawczyk, Marek, Lukacs-Kornek, Veronika, Kornek, Miroslaw

“… [Display omitted] Large extracellular vesicles, specifically AnnexinV+ EpCAM+ CD147+ tumour-associated microparticles (taMPs), facilitate the detection of …”
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Circulating tumor DNA status and dynamics predict recurrence in patients with resected extrahepatic cholangiocarcinoma von Yoo, Changhoon, Jeong, Hyehyun, Jeong, Jae Ho, Kim, Kyu-pyo, Lee, Seonmin, Ryoo, Baek-Yeol, Hwang, Dae Wook, Lee, Jae Hoon, Moon, Deog-Bog, Kim, Ki-Hun, Lee, Sang Soo, Song, Tae Jun, Oh, Dongwook, Lee, Myung Ah, Chon, Hong Jae, Lee, Ji Sung, Laliotis, George, Rivero-Hinojosa, Samuel, Spickard, Erik, Renner, Derrick, Dutta, Punashi, Palsuledesai, Charuta C., Sharma, Shruti, Malhotra, Meenakshi, Jurdi, Adham, Liu, Minetta C.

“… Surgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an …”
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Clinical Value of Liquid Biopsy in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma During Targeted Therapy von González-Medina, Alberto, Vila-Casadesús, Maria, Gomez-Rey, Marina, Fabregat-Franco, Carles, Sierra, Alexandre, Tian, Tian V, Castet, Florian, Castillo, Gloria, Matito, Judit, Martinez, Paola, Miquel, Josep M, Nuciforo, Paolo, Pérez-López, Raquel, Macarulla, Teresa, Vivancos, Ana

“… FGFR2 fusions occur in 10% to 15% of patients with intrahepatic cholangiocarcinoma (iCCA), potentially benefiting from FGFR inhibitors (FGFRi). We aimed to …”
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A Machine-Based Approach to Preoperatively Identify Patients with the Most and Least Benefit Associated with Resection for Intrahepatic Cholangiocarcinoma: An International Multi-institutional Analysis of 1146 Patients von Tsilimigras, Diamantis I., Mehta, Rittal, Moris, Dimitrios, Sahara, Kota, Bagante, Fabio, Paredes, Anghela Z., Moro, Amika, Guglielmi, Alfredo, Aldrighetti, Luca, Weiss, Matthew, Bauer, Todd W., Alexandrescu, Sorin, Poultsides, George A., Maithel, Shishir K., Marques, Hugo P., Martel, Guillaume, Pulitano, Carlo, Shen, Feng, Soubrane, Olivier, Koerkamp, Bas Groot, Endo, Itaru, Pawlik, Timothy M.

“… Background Accurate risk stratification and patient selection is necessary to identify patients who will benefit the most from surgery or be better treated …”
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Prognostic impact of tumor microvessels in intrahepatic cholangiocarcinoma: association with tumor-infiltrating lymphocytes von Yugawa, Kyohei, Itoh, Shinji, Yoshizumi, Tomoharu, Iseda, Norifumi, Tomiyama, Takahiro, Toshima, Takeo, Harada, Noboru, Kohashi, Kenichi, Oda, Yoshinao, Mori, Masaki

“… Tumor microvessel density (MVD) is a prognostic factor for patients with intrahepatic cholangiocarcinoma (ICC). Tumor-infiltrating lymphocytes (TILs) are also …”
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Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma von Yang, Ju Dong, Campion, Michael B., Liu, Minetta C., Chaiteerakij, Roongruedee, Giama, Nasra H., Ahmed Mohammed, Hager, Zhang, Xiaodan, Hu, Chunling, Campion, Victoria L., Jen, Jin, Venkatesh, Sudhakar K., Halling, Kevin C., Kipp, Benjamin R., Roberts, Lewis R.

“… Circulating tumor cells (CTCs) in blood are associated with poor survival of patients with breast, prostate, or colon cancer. We hypothesized that CTCs are …”
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Initial outcomes of a single-institution hepatic artery infusion pump program for colorectal liver metastases and intrahepatic cholangiocarcinoma: Safety, feasibility, and circulating tumor DNA tracking von Ocuin, Lee M., Stitzel, Henry, Chung, Michelle, Tirumani, Sree Harsha, Elshami, Mohamedraed, Tomaro, Maria, Miller-Ocuin, Jennifer L., Deitz, David W., Steinhagen, Emily, Charles, Ronald, Costedio, Meagan, Liu, Michael, Lumish, Melissa, Selfridge, J. Eva

“… Hepatic artery infusion with floxuridine is a treatment option for patients with colorectal liver metastases or intrahepatic cholangiocarcinoma. Outcomes from …”
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Prognostic significance of the cachexia index for patients with perihilar cholangiocarcinoma von Sakashita, Katsuya, Otsuka, Shimpei, Ashida, Ryo, Ohgi, Katsuhisa, Kato, Yoshiyasu, Dei, Hideyuki, Notsu, Akifumi, Uesaka, Katsuhiko, Sugiura, Teiichi

“… The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear. We retrospectively evaluated 236 …”
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Silencing of LAMC2 Reverses Epithelial-Mesenchymal Transition and Inhibits Angiogenesis in Cholangiocarcinoma via Inactivation of the Epidermal Growth Factor Receptor Signaling Pathway von Pei, Yao-Fei, Liu, Jie, Cheng, Jian, Wu, Wei-Ding, Liu, Xi-Qiang

“… Cholangiocarcinoma (CCA) is a malignant cancer that is associated with high mortality rates. The relationship between laminin γ 2 chain gene (LAMC2) and …”
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A New Clinically Based Staging System for Perihilar Cholangiocarcinoma von Chaiteerakij, Roongruedee, Harmsen, William S, Marrero, Carlos Romero, Aboelsoud, Mohammed M., Ndzengue, Albert, Kaiya, Joseph, Therneau, Terry M, Sanchez, William, Gores, Gregory J, Roberts, Lewis R

“… Current staging systems for perihilar cholangiocarcinoma (pCCA) are inadequate, as they are based on surgical pathology and therefore not relevant to …”
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Prognostic Impact of Albumin Bilirubin Score In Patients Undergoing Surgery for Perihilar Cholangiocarcinoma von Miki, Atsushi, Sakuma, Yasunaru, Teratani, Takumi, Sasanuma, Hideki, Nishimura, Wataru, Yamaguchi, Hironori

“… The Albumin-Bilirubin (ALBI) score was initially developed to estimate prognosis in patients with hepatocellular carcinoma. Recently, its prognostic relevance …”
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Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma von Borger, Darrell R, Goyal, Lipika, Yau, Thomas, Poon, Ronnie T, Ancukiewicz, Marek, Deshpande, Vikram, Christiani, David C, Liebman, Hannah M, Yang, Hua, Kim, Hyeryun, Yen, Katharine, Faris, Jason E, Iafrate, A John, Kwak, Eunice L, Clark, Jeffrey W, Allen, Jill N, Blaszkowsky, Lawrence S, Murphy, Janet E, Saha, Supriya K, Hong, Theodore S, Wo, Jennifer Y, Ferrone, Cristina R, Tanabe, Kenneth K, Bardeesy, Nabeel, Straley, Kimberly S, Agresta, Sam, Schenkein, David P, Ellisen, Leif W, Ryan, David P, Zhu, Andrew X

“… Mutations in the IDH1 and IDH2 (IDH1/2) genes occur in approximately 20% of intrahepatic cholangiocarcinoma and lead to accumulation of 2-hydroxyglutarate …”
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HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium von Xu, Yun-Fei, Liu, Zeng-Li, Pan, Chang, Yang, Xiao-Qing, Ning, Shang-Lei, Liu, Hong-Da, Guo, Sen, Yu, Jin-Ming, Zhang, Zong-Li

“… Perihilar cholangiocarcinoma (PHCCA) is the most common type of cholangiocarcinoma with low resection rate and high morbidity. The study of PHCCA biomarkers …”
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Soluble programmed death-ligand 1 (sPDL1) and neutrophil-to-lymphocyte ratio (NLR) predicts survival in advanced biliary tract cancer patients treated with palliative chemotherapy von Ha, Hyerim, Nam, Ah-Rong, Bang, Ju-Hee, Park, Ji-Eun, Kim, Tae-Yong, Lee, Kyung-Hun, Han, Sae-Won, Im, Seock-Ah, Kim, Tae-You, Bang, Yung-Jue, Oh, Do-Youn

“… Programmed death-ligand 1 (PD-L1) expression in tumor tissue is under investigation as a candidate biomarker in immuno-oncology dug development. The soluble …”
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