Výsledky vyhľadávania - "Beltman, Joost B."

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response Autor Yang, Huan, Niemeijer, Marije, van de Water, Bob, Beltman, Joost B.

“…The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors…”
Získať plný text

Quantifying the contribution of transcription factor activity, mutations and microRNAs to CD274 expression in cancer patients Autor Bruns, Imke B., Beltman, Joost B.

“…Immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) axis have been remarkably…”
Získať plný text

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age Autor Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla

“…Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce…”
Získať plný text

Model-based translation of DNA damage signaling dynamics across cell types Autor Heldring, Muriel M., Wijaya, Lukas S., Niemeijer, Marije, Yang, Huan, Lakhal, Talel, Le Dévédec, Sylvia E., van de Water, Bob, Beltman, Joost B.

“…Interindividual variability in DNA damage response (DDR) dynamics may evoke differences in susceptibility to cancer. However, pathway dynamics are often…”
Získať plný text

Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status Autor Lems, Carlijn M., Burger, Gerhard A., Beltman, Joost B.

“…Epithelial-mesenchymal transition (EMT) and immune resistance mediated by Programmed Death-Ligand 1 (PD-L1) upregulation are established drivers of tumor…”
Získať plný text

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen Autor Ariotti, Silvia, Beltman, Joost B, Chodaczek, Grzegorz, Hoekstra, Mirjam E, van Beek, Anna E, Gomez-Eerland, Raquel, Ritsma, Laila, van Rheenen, Jacco, Marée, Athanasius F M, Zal, Tomasz, de Boer, Rob J, Haanen, John B A G, Schumacher, Ton N

“…Recent work has demonstrated that following the clearance of infection a stable population of memory T cells remains present in peripheral organs and…”
Zistit podrobnosti o prístupe

Computational modelling identifies primary mediators of crosstalk between DNA damage and oxidative stress responses Autor Burgers, Elsje J., Sharma, Raju P., Eugenio, Carl Joshua S., Heldring, Muriel M., Wijaya, Lukas S., van de Water, Bob, Beltman, Joost B.

“…Cells exposed to toxicants, such as drugs, activate a wide variety of stress pathways, often simultaneously. Two important pathways that can influence cell…”
Získať plný text

Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data Autor Beck, Richard J., Bijker, Dario I., Beltman, Joost B.

“…Although quantitative insights into the killing behaviour of Cytotoxic T Lymphocytes (CTLs) are necessary for the rational design of immune-based therapies,…”
Získať plný text

Development of a Physiologically Based Pharmacokinetic Model for Nitrofurantoin in Rabbits, Rats, and Humans Autor Sharma, Raju Prasad, Burgers, Elsje J., Beltman, Joost B.

“…Nitrofurantoin (NFT) is a commonly used antibiotic for the treatment of urinary tract infections that can cause liver toxicity. Despite reports of hepatic…”
Získať plný text

Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure Autor Hiemstra, Steven, Fehling-Kaschek, Mirjam, Kuijper, Isoude A., Bischoff, Luc J. M., Wijaya, Lukas S., Rosenblatt, Marcus, Esselink, Jeroen, van Egmond, Allard, Mos, Jornt, Beltman, Joost B., Timmer, Jens, van de Water, Bob, Kaschek, Daniel

“…Cells are exposed to oxidative stress and reactive metabolites every day. The Nrf2 signaling pathway responds to oxidative stress by upregulation of…”
Získať plný text

Deciphering Epithelial–Mesenchymal Transition Regulatory Networks in Cancer through Computational Approaches Autor Burger, Gerhard A., Danen, Erik H. J., Beltman, Joost B.

“…Epithelial-mesenchymal transition (EMT), the process by which epithelial cells can convert into motile mesenchymal cells, plays an important role in…”
Získať plný text

A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure Autor Bischoff, Luc J. M., Kuijper, Isoude A., Schimming, Johannes P., Wolters, Liesanne, Braak, Bas ter, Langenberg, Jan P., Noort, Daan, Beltman, Joost B., van de Water, Bob

“…Oxidative stress leads to the activation of the Nuclear factor-erythroid-2-related factor 2 (Nrf2) pathway. While most studies have focused on the activation…”
Získať plný text

Dynamic Modeling of Mitochondrial Membrane Potential Upon Exposure to Mitochondrial Inhibitors Autor Yang, Huan, van der Stel, Wanda, Lee, Randy, Bauch, Caroline, Bevan, Sam, Walker, Paul, van de Water, Bob, Danen, Erik H. J., Beltman, Joost B.

“…Mitochondria are the main bioenergetic organelles of cells. Exposure to chemicals targeting mitochondria therefore generally results in the development of…”
Získať plný text

Heritable tumor cell division rate heterogeneity induces clonal dominance Autor Palm, Margriet M., Elemans, Marjet, Beltman, Joost B.

“…Tumors consist of a hierarchical population of cells that differ in their phenotype and genotype. This hierarchical organization of cells means that a few…”
Získať plný text

A general functional response of cytotoxic T lymphocyte-mediated killing of target cells Autor Gadhamsetty, Saikrishna, Marée, Athanasius F M, Beltman, Joost B, de Boer, Rob J

“…Cytotoxic T lymphocytes (CTLs) kill virus-infected cells and tumor cells, and play a critical role in immune protection. Our knowledge of how the CTL killing…”
Zistit podrobnosti o prístupe

Random Migration and Signal Integration Promote Rapid and Robust T Cell Recruitment Autor Textor, Johannes, Henrickson, Sarah E., Mandl, Judith N., von Andrian, Ulrich H., Westermann, Jürgen, de Boer, Rob J., Beltman, Joost B.

“…To fight infections, rare T cells must quickly home to appropriate lymph nodes (LNs), and reliably localize the antigen (Ag) within them. The first challenge…”
Získať plný text

Mathematical modeling identifies LAG3 and HAVCR2 as biomarkers of T cell exhaustion in melanoma Autor Beck, Richard J., Sloot, Sander, Matsushita, Hirokazu, Kakimi, Kazuhiro, Beltman, Joost B.

“…Cytotoxic T lymphocytes (CTLs) control tumors via lysis of antigen-presenting targets or through secretion of cytokines such as interferon-γ (IFNG), which…”
Získať plný text

Bidirectional crosstalk between epithelial–mesenchymal plasticity and IFN γ -induced PD-L1 expression promotes tumour progression Autor Burger, Gerhard A., Nesenberend, Daphne N., Lems, Carlijn M., Hille, Sander C., Beltman, Joost B.

“…Epithelial–mesenchymal transition (EMT) and immunoevasion through upregulation of programmed death-ligand 1 (PD-L1) are important drivers of cancer…”
Získať plný text

TIL therapy broadens the tumor-reactive CD8+ T cell compartment in melanoma patients Autor Kvistborg, Pia, Shu, Chengyi Jenny, Heemskerk, Bianca, Fankhauser, Manuel, Thrue, Charlotte Albæk, Toebes, Mireille, van Rooij, Nienke, Linnemann, Carsten, van Buuren, Marit M., Urbanus, Jos H.M., Beltman, Joost B., thor Straten, Per, Li, Yong F., Robbins, Paul F., Besser, Michal J., Schachter, Jacob, Kenter, Gemma G., Dudley, Mark E., Rosenberg, Steven A., Haanen, John B.A.G., Hadrup, Sine Reker, Schumacher, Ton N.M.

“…There is strong evidence that both adoptive T cell transfer and T cell checkpoint blockade can lead to regression of human melanoma. However, little data are…”
Získať plný text

Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling Autor Kuijper, Isoude A., Yang, Huan, Van De Water, Bob, Beltman, Joost B.

“…Introduction: Drug-induced liver injury (DILI) is a significant threat to human health and a major problem in drug development. It is hard to predict due to…”
Získať plný text