Výsledky vyhľadávania - "Beltman, Joost"

Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy Autor Swart, Maarten, Verbrugge, Inge, Beltman, Joost B.

“…In healthy individuals, immune-checkpoint molecules prevent autoimmune responses and limit immune cell-mediated tissue damage. Tumors frequently exploit these…”
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Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity Autor Cazaux, Marine, Grandjean, Capucine L, Lemaître, Fabrice, Garcia, Zacarias, Beck, Richard J, Milo, Idan, Postat, Jérémy, Beltman, Joost B, Cheadle, Eleanor J, Bousso, Philippe

“…CAR T cells represent a potentially curative strategy for B cell malignancies. However, the outcome and dynamics of CAR T cell interactions in distinct…”
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A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool Autor Kok, Lianne, Dijkgraaf, Feline E, Urbanus, Jos, Bresser, Kaspar, Vredevoogd, David W, Cardoso, Rebeca F, Perié, Leïla, Beltman, Joost B, Schumacher, Ton N

“…An increasing body of evidence emphasizes the role of tissue-resident memory T cells (TRM) in the defense against recurring pathogens and malignant neoplasms…”
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age Autor Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla

“…Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce…”
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ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response Autor Yang, Huan, Niemeijer, Marije, van de Water, Bob, Beltman, Joost B.

“…The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors…”
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Quantifying the contribution of transcription factor activity, mutations and microRNAs to CD274 expression in cancer patients Autor Bruns, Imke B., Beltman, Joost B.

“…Immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) axis have been remarkably…”
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Model-based translation of DNA damage signaling dynamics across cell types Autor Heldring, Muriel M., Wijaya, Lukas S., Niemeijer, Marije, Yang, Huan, Lakhal, Talel, Le Dévédec, Sylvia E., van de Water, Bob, Beltman, Joost B.

“…Interindividual variability in DNA damage response (DDR) dynamics may evoke differences in susceptibility to cancer. However, pathway dynamics are often…”
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Computational modelling identifies primary mediators of crosstalk between DNA damage and oxidative stress responses Autor Burgers, Elsje J., Sharma, Raju P., Eugenio, Carl Joshua S., Heldring, Muriel M., Wijaya, Lukas S., van de Water, Bob, Beltman, Joost B.

“…Cells exposed to toxicants, such as drugs, activate a wide variety of stress pathways, often simultaneously. Two important pathways that can influence cell…”
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Contact-Dependent Killing by Cytotoxic T Lymphocytes Is Insufficient for EL4 Tumor Regression In Vivo Autor Beck, Richard J, Slagter, Maarten, Beltman, Joost B

“…Immunotherapies are an emerging strategy for treatment of solid tumors. Improved understanding of the mechanisms employed by cytotoxic T lymphocytes (CTL) to…”
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Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data Autor Beck, Richard J., Bijker, Dario I., Beltman, Joost B.

“…Although quantitative insights into the killing behaviour of Cytotoxic T Lymphocytes (CTLs) are necessary for the rational design of immune-based therapies,…”
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Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics Autor Zenke, Simon, Palm, Margriet M, Braun, Julia, Gavrilov, Alina, Meiser, Philippa, Böttcher, Jan P, Beyersdorf, Niklas, Ehl, Stephan, Gerard, Audrey, Lämmermann, Tim, Schumacher, Ton N, Beltman, Joost B, Rohr, Jan C

“…T cell responses upon infection display a remarkably reproducible pattern of expansion, contraction, and memory formation. If the robustness of this pattern…”
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Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status Autor Lems, Carlijn M., Burger, Gerhard A., Beltman, Joost B.

“…Epithelial-mesenchymal transition (EMT) and immune resistance mediated by Programmed Death-Ligand 1 (PD-L1) upregulation are established drivers of tumor…”
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Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling Autor Sharma, Raju Prasad, Loonstra-Wolters, Liesanne, ter Braak, Bas, Niemeijer, Marije, White, Andrew, van de Water, Bob, Middleton, Alistair M., Beltman, Joost B.

“…Nuclear factor erythroid 2-related factor 2 (NRF2) plays a vital role in the regulation of various antioxidant response element (ARE) genes, which control…”
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Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen Autor Ariotti, Silvia, Beltman, Joost B, Chodaczek, Grzegorz, Hoekstra, Mirjam E, van Beek, Anna E, Gomez-Eerland, Raquel, Ritsma, Laila, van Rheenen, Jacco, Marée, Athanasius F M, Zal, Tomasz, de Boer, Rob J, Haanen, John B A G, Schumacher, Ton N

“…Recent work has demonstrated that following the clearance of infection a stable population of memory T cells remains present in peripheral organs and…”
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Tissue patrol by resident memory CD8+ T cells in human skin Autor Dijkgraaf, Feline E., Matos, Tiago R., Hoogenboezem, Mark, Toebes, Mireille, Vredevoogd, David W., Mertz, Marjolijn, van den Broek, Bram, Song, Ji-Ying, Teunissen, Marcel B. M., Luiten, Rosalie M., Beltman, Joost B., Schumacher, Ton N.

“…Emerging data show that tissue-resident memory T (T RM ) cells play an important protective role at murine and human barrier sites. T RM cells in the epidermis…”
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Heritable tumor cell division rate heterogeneity induces clonal dominance Autor Palm, Margriet M., Elemans, Marjet, Beltman, Joost B.

“…Tumors consist of a hierarchical population of cells that differ in their phenotype and genotype. This hierarchical organization of cells means that a few…”
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Heterogeneous differentiation patterns of individual CD8+ T cells Autor Gerlach, Carmen, Rohr, Jan C, Perié, Leïla, van Rooij, Nienke, van Heijst, Jeroen W J, Velds, Arno, Urbanus, Jos, Naik, Shalin H, Jacobs, Heinz, Beltman, Joost B, de Boer, Rob J, Schumacher, Ton N M

“…Upon infection, antigen-specific CD8(+) T lymphocyte responses display a highly reproducible pattern of expansion and contraction that is thought to reflect a…”
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Toward Assay-Aware Bioactivity Model(er)s: Getting a Grip on Biological Context Autor Schoenmaker, Linde, Sastrokarijo, Enzo G, Heitman, Laura H, Beltman, Joost B, Jespers, Willem, van Westen, Gerard J P

“…Protein-ligand interaction prediction with proteochemometric (PCM) models can provide valuable insights during early drug discovery and chemical safety…”
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Mathematical modelling reveals compound-specific stress pathway activity Autor Burgers, Elsje J., Danilyuk, Tamara Y., Sharma, Raju P., Renner, Nadine, Verlohner, Andreas, Rocker, Nicole, Ternes, Philipp, Wijaya, Lukas S., Leist, Marcel, Bouwman, Peter, Zickgraf, Franziska M., Schildknecht, Stefan, van de Water, Bob, Beltman, Joost B.

“…Drug-induced liver injury (DILI) is a major problem for the drug development industry. It has been suggested that activation of stress pathways within cells is…”
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Development of a Physiologically Based Pharmacokinetic Model for Nitrofurantoin in Rabbits, Rats, and Humans Autor Sharma, Raju Prasad, Burgers, Elsje J., Beltman, Joost B.

“…Nitrofurantoin (NFT) is a commonly used antibiotic for the treatment of urinary tract infections that can cause liver toxicity. Despite reports of hepatic…”
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