Suchergebnisse - "Beld, Joris"

The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life von Beld, Joris, Sonnenschein, Eva C, Vickery, Christopher R, Noel, Joseph P, Burkart, Michael D

“… Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not …”
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Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering von Beld, Joris, Lee, D John, Burkart, Michael D

“… Fatty acids are primary metabolites synthesized by complex, elegant, and essential biosynthetic machinery. Fatty acid synthases resemble an iterative assembly …”
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An Amoebal Grazer of Cyanobacteria Requires Cobalamin Produced by Heterotrophic Bacteria von Ma, Amy T, Beld, Joris, Brahamsha, Bianca

“… Amoebae are unicellular eukaryotes that consume microbial prey through phagocytosis, playing a role in shaping microbial food webs. Many amoebal species can be …”
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Visualizing the Chain-Flipping Mechanism in Fatty-Acid Biosynthesis von Beld, Joris, Cang, Hu, Burkart, Michael D.

“… The acyl carrier protein (ACP) from fatty acid synthases sequesters elongating products within its hydrophobic core, but this dynamic mechanism remains poorly …”
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Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection von Lucarelli, Ronald, Gorrochotegui-Escalante, Norma, Taddeo, Jessica, Buttaro, Bettina, Beld, Joris, Tam, Vincent

“… Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are …”
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Molecular basis for interactions between an acyl carrier protein and a ketosynthase von Milligan, Jacob C., Lee, D. John, Jackson, David R., Schaub, Andrew J., Beld, Joris, Barajas, Jesus F., Hale, Joseph J., Luo, Ray, Burkart, Michael D., Tsai, Shiou-Chuan

“… Fatty acid synthases are dynamic ensembles of enzymes that can biosynthesize long hydrocarbon chains efficiently. Here we visualize the interaction between the …”
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Manipulating Fatty Acid Biosynthesis in Microalgae for Biofuel through Protein-Protein Interactions von Blatti, Jillian L., Beld, Joris, Behnke, Craig A., Mendez, Michael, Mayfield, Stephen P., Burkart, Michael D.

“… Microalgae are a promising feedstock for renewable fuels, and algal metabolic engineering can lead to crop improvement, thus accelerating the development of …”
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Production and analysis of a mammalian septin hetero‐octamer complex von DeRose, Barry T., Kelley, Robert S., Ravi, Roshni, Kokona, Bashkim, Beld, Joris, Spiliotis, Elias T., Padrick, Shae B.

“… The septins are filament‐forming proteins found in diverse eukaryotes from fungi to vertebrates, with roles in cytokinesis, shaping of membranes and modifying …”
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PPARα exacerbates Salmonella Typhimurium infection by modulating the immunometabolism and macrophage polarization von Taddeo, Jessica R., Wilson, Naomi, Kowal, Anita, Beld, Joris, Klein-Szanto, Andres, Tükel, Çagla, Tam, Vincent C.

“…  Salmonella enterica serovar Typhimurium (STm) is a causative pathogen for robust inflammatory gastrointestinal disease and can lead to systemic infection …”
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A broad inhibitor of acyl-acyl carrier protein synthetases von Todorinova, Magdalena, Beld, Joris, Jaremko, Kara L.

“… The acyl-acyl carrier protein synthetase enzyme enables some bacteria to scavenge free fatty acids from the environment for direct use in lipids. This fatty …”
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Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells von Esquea, Emily M., Ciraku, Lorela, Young, Riley G., Merzy, Jessica, Talarico, Alexandra N., Ahmed, Nusaiba N., Karuppiah, Mangalam, Ramesh, Anna, Chatoff, Adam, Crispim, Claudia V., Rashad, Adel A., Cocklin, Simon, Snyder, Nathaniel W., Beld, Joris, Simone, Nicole L., Reginato, Mauricio J., Dick, Alexej

“… Breast cancer brain metastasis (BCBM) typically results in an end-stage diagnosis and is hindered by a lack of brain-penetrant drugs. Tumors in the brain rely …”
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Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold von Coquière, David, Bos, Jeffrey, Beld, Joris, Roelfes, Gerard

“… Site creation: Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the …”
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Dissecting modular synthases through inhibition: A complementary chemical and genetic approach von Vickery, Christopher R., McCulloch, Ian P., Sonnenschein, Eva C., Beld, Joris, Noel, Joseph P., Burkart, Michael D.

“… [Display omitted] Modular synthases, such as fatty acid, polyketide, and non-ribosomal peptide synthases (NRPSs), are sophisticated machineries essential in …”
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Diazirine Photoprobes for the Identification of Vancomycin-Binding Proteins von Rotsides, Photis, Lee, Paula J., Webber, Nakoa, Grasty, Kimberly C., Beld, Joris, Loll, Patrick J.

“… Vancomycin’s interactions with cellular targets drive its antimicrobial activity and also trigger expression of resistance against the antibiotic. Interaction …”
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Rapid and Quantitative Cyclization of Multiple Peptide Loops onto Synthetic Scaffolds for Structural Mimicry of Protein Surfaces von Timmerman, Peter, Beld, Joris, Puijk, Wouter C, Meloen, Rob H

“… No need for side‐chain protection in the cyclization reaction of cysteine‐containing linear peptides onto bromomethylated aromatic scaffolds (see scheme). The …”
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Music exposure enhances resistance to Salmonella infection by promoting healthy gut microbiota von Zhu, Clara Y., Byun, Hyuntae, Do, Elyza A., Zhang, Yue, Tanchoco, Ethan, Beld, Joris, Hsiao, Ansel, Zhu, Jun

“… Music therapy is increasingly recognized as a low-cost approach to improving health, but how it works remains unclear. Our study demonstrates that music can …”
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Catalysis of oxidative protein folding by small-molecule diselenides von Beld, Joris, Woycechowsky, Kenneth J, Hilvert, Donald

“… The production of recombinant, disulfide-containing proteins often requires oxidative folding in vitro. Here, we show that diselenides, such as …”
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Trapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction von Tallorin, Lorillee, Finzel, Kara, Nguyen, Quynh G., Beld, Joris, La Clair, James J., Burkart, Michael D.

“… An ideal target for metabolic engineering, fatty acid biosynthesis remains poorly understood on a molecular level. These carrier protein-dependent pathways …”
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Expression of Heterologous OsDHAR Gene Improves Glutathione (GSH)-Dependent Antioxidant System and Maintenance of Cellular Redox Status in Synechococcus elongatus PCC 7942 von Kim, Young-Saeng, Park, Seong-Im, Kim, Jin-Ju, Boyd, Joseph S., Beld, Joris, Taton, Arnaud, Lee, Kyoung-In, Kim, Il-Sup, Golden, James W., Yoon, Ho-Sung

“… An excess of reactive oxygen species (ROS) can cause severe oxidative damage to cellular components in photosynthetic cells. Antioxidant systems, such as the …”
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Selenoglutathione-Mediated Rescue of Kinetically Trapped Intermediates in Oxidative Protein Folding von Metanis, Norman, Foletti, Carlotta, Beld , Joris, Hilvert, Donald

“… Selenoglutathione has been shown to have considerable potential as a catalyst of oxidative protein folding. Here we examine how this reagent modulates the …”
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