Suchergebnisse - "Beijersbergen, Roderick L."

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes von Evers, Bastiaan, Jastrzebski, Katarzyna, Heijmans, Jeroen P M, Grernrum, Wipawadee, Beijersbergen, Roderick L, Bernards, Rene

“… CRISPR knockout screens outperform shRNA and CRISPR-interference screens in a side-by-side comparison. High-throughput genetic screens have become essential …”
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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR von Prahallad, Anirudh, Sun, Chong, Huang, Sidong, Di Nicolantonio, Federica, Salazar, Ramon, Zecchin, Davide, Beijersbergen, Roderick L., Bardelli, Alberto, Bernards, René

“… Inhibition of activated BRAF has been ineffective in colon cancers with the mutation; here, this is shown to be due to the feedback activation of the epidermal …”
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Inducing and exploiting vulnerabilities for the treatment of liver cancer von Wang, Cun, Vegna, Serena, Jin, Haojie, Benedict, Bente, Lieftink, Cor, Ramirez, Christel, de Oliveira, Rodrigo Leite, Morris, Ben, Gadiot, Jules, Wang, Wei, du Chatinier, Aimée, Wang, Liqin, Gao, Dongmei, Evers, Bastiaan, Jin, Guangzhi, Xue, Zheng, Schepers, Arnout, Jochems, Fleur, Sanchez, Antonio Mulero, Mainardi, Sara, te Riele, Hein, Beijersbergen, Roderick L., Qin, Wenxin, Akkari, Leila, Bernards, René

“… Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies 1 , 2 ; broad-spectrum kinase inhibitors such as …”
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EGFR activation limits the response of liver cancer to lenvatinib von Jin, Haojie, Shi, Yaoping, Lv, Yuanyuan, Yuan, Shengxian, Ramirez, Christel F. A., Lieftink, Cor, Wang, Liqin, Wang, Siying, Wang, Cun, Dias, Matheus Henrique, Jochems, Fleur, Yang, Yuan, Bosma, Astrid, Hijmans, E. Marielle, de Groot, Marnix H. P., Vegna, Serena, Cui, Dan, Zhou, Yangyang, Ling, Jing, Wang, Hui, Guo, Yuchen, Zheng, Xingling, Isima, Nikita, Wu, Haiqiu, Sun, Chong, Beijersbergen, Roderick L., Akkari, Leila, Zhou, Weiping, Zhai, Bo, Qin, Wenxin, Bernards, René

“… Hepatocellular carcinoma (HCC)—the most common form of liver cancer—is an aggressive malignancy with few effective treatment options 1 . Lenvatinib is a …”
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MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling von Huang, Sidong, Hölzel, Michael, Knijnenburg, Theo, Schlicker, Andreas, Roepman, Paul, McDermott, Ultan, Garnett, Mathew, Grernrum, Wipawadee, Sun, Chong, Prahallad, Anirudh, Groenendijk, Floris H, Mittempergher, Lorenza, Nijkamp, Wouter, Neefjes, Jacques, Salazar, Ramon, Ten Dijke, Peter, Uramoto, Hidetaka, Tanaka, Fumihiro, Beijersbergen, Roderick L, Wessels, Lodewyk F A, Bernards, René

“… Inhibitors of the ALK and EGF receptor tyrosine kinases provoke dramatic but short-lived responses in lung cancers harboring EML4-ALK translocations or …”
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The Cancer SENESCopedia: A delineation of cancer cell senescence von Jochems, Fleur, Thijssen, Bram, De Conti, Giulia, Jansen, Robin, Pogacar, Ziva, Groot, Kelvin, Wang, Liqin, Schepers, Arnout, Wang, Cun, Jin, Haojie, Beijersbergen, Roderick L., Leite de Oliveira, Rodrigo, Wessels, Lodewyk F.A., Bernards, René

“… Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is …”
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Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance von Schep, Ruben, Brinkman, Eva K, Leemans, Christ, Vergara, Xabier, van der Weide, Robin H, Morris, Ben, van Schaik, Tom, Manzo, Stefano G, Peric-Hupkes, Daniel, van den Berg, Jeroen, Beijersbergen, Roderick L, Medema, René H, van Steensel, Bas

“… DNA double-strand break (DSB) repair is mediated by multiple pathways. It is thought that the local chromatin context affects the pathway choice, but the …”
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High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer von Wang, Liqin, Leite de Oliveira, Rodrigo, Wang, Cun, Fernandes Neto, João M., Mainardi, Sara, Evers, Bastiaan, Lieftink, Cor, Morris, Ben, Jochems, Fleur, Willemsen, Lisa, Beijersbergen, Roderick L., Bernards, René

“… Senescence is a proliferation arrest that can result from a variety of stresses. Cancer cells can also undergo senescence, but the stresses that provoke cancer …”
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Phospho-ERK is a biomarker of response to a synthetic lethal drug combination of sorafenib and MEK inhibition in liver cancer von Wang, Cun, Jin, Haojie, Gao, Dongmei, Lieftink, Cor, Evers, Bastiaan, Jin, Guangzhi, Xue, Zheng, Wang, Liqin, Beijersbergen, Roderick L., Qin, Wenxin, Bernards, René

“… [Display omitted] •ERK2 inhibition was identified as an enhancer of the response to sorafenib in HCC.•Selumetinib increases the response of sorafenib in HCC …”
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Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3 von Sun, Chong, Hobor, Sebastijan, Bertotti, Andrea, Zecchin, Davide, Huang, Sidong, Galimi, Francesco, Cottino, Francesca, Prahallad, Anirudh, Grernrum, Wipawadee, Tzani, Anna, Schlicker, Andreas, Wessels, Lodewyk F.A., Smit, Egbert F., Thunnissen, Erik, Halonen, Pasi, Lieftink, Cor, Beijersbergen, Roderick L., Di Nicolantonio, Federica, Bardelli, Alberto, Trusolino, Livio, Bernards, Rene

“… There are no effective therapies for the ~30% of human malignancies with mutant RAS oncogenes. Using a kinome-centered synthetic lethality screen, we find that …”
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PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs von Prahallad, Anirudh, Heynen, Guus J.J.E., Germano, Giovanni, Willems, Stefan M., Evers, Bastiaan, Vecchione, Loredana, Gambino, Valentina, Lieftink, Cor, Beijersbergen, Roderick L., Di Nicolantonio, Federica, Bardelli, Alberto, Bernards, Rene

“… Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors, but BRAF mutant colon cancers are intrinsically resistant to these drugs because …”
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Chromatin context-dependent effects of epigenetic drugs on CRISPR-Cas9 editing von Schep, Ruben, Trauernicht, Max, Vergara, Xabier, Friskes, Anoek, Morris, Ben, Gregoricchio, Sebastian, Manzo, Stefano G, Zwart, Wilbert, Beijersbergen, Roderick L, Medema, René H, van Steensel, Bas

“… The efficiency and outcome of CRISPR/Cas9 editing depends on the chromatin state at the cut site. It has been shown that changing the chromatin state can …”
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ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors von Berns, Katrien, Caumanns, Joseph J., Hijmans, E. Marielle, Gennissen, Annemiek M. C., Severson, Tesa M., Evers, Bastiaan, Wisman, G. Bea A., Jan Meersma, Gert, Lieftink, Cor, Beijersbergen, Roderick L., Itamochi, Hiroaki, van der Zee, Ate G. J., de Jong, Steven, Bernards, René

“… Current treatment for advanced stage ovarian clear cell cancer is severely hampered by a lack of effective systemic therapy options, leading to a poor outlook …”
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ADARp150 counteracts whole genome duplication von van Gemert, Frank, Drakaki, Alexandra, Lozano, Isabel Morales, de Groot, Daniël, Uiterkamp, Maud Schoot, Proost, Natalie, Lieftink, Cor, van de Ven, Marieke, Beijersbergen, Roderick L, Jacobs, Heinz, te Riele, Hein

“… Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA …”
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Widespread chromatin context-dependencies of DNA double-strand break repair proteins von Vergara, Xabier, Manjón, Anna G., de Haas, Marcel, Morris, Ben, Schep, Ruben, Leemans, Christ, Friskes, Anoek, Beijersbergen, Roderick L., Sanders, Mathijs A., Medema, René H., van Steensel, Bas

“… DNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ). The …”
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Statistical methods for analysis of high-throughput RNA interference screens von Birmingham, Amanda, Selfors, Laura M, Forster, Thorsten, Wrobel, David, Kennedy, Caleb J, Shanks, Emma, Santoyo-Lopez, Javier, Dunican, Dara J, Long, Aideen, Kelleher, Dermot, Smith, Queta, Beijersbergen, Roderick L, Ghazal, Peter, Shamu, Caroline E

“… RNA interference (RNAi) has become a powerful technique for reverse genetics and drug discovery, and in both of these areas large-scale high-throughput RNAi …”
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Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related ( ATR ) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer von Combès, Eve, Andrade, Augusto F, Tosi, Diego, Michaud, Henri-Alexandre, Coquel, Flavie, Garambois, Veronique, Desigaud, Delphine, Jarlier, Marta, Coquelle, Arnaud, Pasero, Philippe, Bonnefoy, Nathalie, Moreaux, Jerome, Martineau, Pierre, Del Rio, Maguy, Beijersbergen, Roderick L, Vezzio-Vie, Nadia, Gongora, Celine

“… Although many patients with colorectal cancer initially respond to the chemotherapeutic agent oxaliplatin, acquired resistance to this treatment remains a …”
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A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma von Wang, Liqin, Šuštić, Tonći, Leite de Oliveira, Rodrigo, Lieftink, Cor, Halonen, Pasi, van de Ven, Marieke, Beijersbergen, Roderick L., van den Heuvel, Michel M., Bernards, René, van der Heijden, Michiel S.

“… Activating mutations and translocations of the FGFR3 gene are commonly seen in urothelial cell carcinoma (UCC) of the bladder and urinary tract. Several …”
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A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing von Vizoso, Miguel, E. J. Pritchard, Colin, Bombardelli, Lorenzo, van den Broek, Bram, Krimpenfort, Paul, Beijersbergen, Roderick L., Jalink, Kees, van Rheenen, Jacco

“… The experimental need to engineer the genome both in time and space, has led to the development of several photoactivatable Cre recombinase systems. However, …”
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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer von Berns, Katrien, Horlings, Hugo M, Hennessy, Bryan T, Madiredjo, Mandy, Hijmans, E Marielle, Beelen, Karin, Linn, Sabine C, Gonzalez-Angulo, Ana Maria, Stemke-Hale, Katherine, Hauptmann, Michael, Beijersbergen, Roderick L, Mills, Gordon B, van de Vijver, Marc J, Bernards, René

“… A large-scale RNA interference screen to discover genes involved in trastuzumab resistance in breast cancer identified only PTEN as a modulator of drug …”
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