Suchergebnisse - "Becker, Winston"

Organization of the human intestine at single-cell resolution von Hickey, John W., Becker, Winston R., Nevins, Stephanie A., Horning, Aaron, Perez, Almudena Espin, Zhu, Chenchen, Zhu, Bokai, Wei, Bei, Chiu, Roxanne, Chen, Derek C., Cotter, Daniel L., Esplin, Edward D., Weimer, Annika K., Caraccio, Chiara, Venkataraaman, Vishal, Schürch, Christian M., Black, Sarah, Brbić, Maria, Cao, Kaidi, Chen, Shuxiao, Zhang, Weiruo, Monte, Emma, Zhang, Nancy R., Ma, Zongming, Leskovec, Jure, Zhang, Zhengyan, Lin, Shin, Longacre, Teri, Plevritis, Sylvia K., Lin, Yiing, Nolan, Garry P., Greenleaf, William J., Snyder, Michael

“… The intestine is a complex organ that promotes digestion, extracts nutrients, participates in immune surveillance, maintains critical symbiotic relationships …”
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High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2 von Becker, Winston R, Ober-Reynolds, Benjamin, Jouravleva, Karina, Jolly, Samson M, Zamore, Phillip D, Greenleaf, William J

“… Argonaute proteins loaded with microRNAs (miRNAs) or small interfering RNAs (siRNAs) form the RNA-induced silencing complex (RISC), which represses target RNA …”
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Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer von Becker, Winston R., Nevins, Stephanie A., Chen, Derek C., Chiu, Roxanne, Horning, Aaron M., Guha, Tuhin K., Laquindanum, Rozelle, Mills, Meredith, Chaib, Hassan, Ladabaum, Uri, Longacre, Teri, Shen, Jeanne, Esplin, Edward D., Kundaje, Anshul, Ford, James M., Curtis, Christina, Snyder, Michael P., Greenleaf, William J.

“… To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we …”
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A comprehensive thermodynamic model for RNA binding by the Saccharomyces cerevisiae Pumilio protein PUF4 von Sadée, Christoph, Hagler, Lauren D., Becker, Winston R., Jarmoskaite, Inga, Vaidyanathan, Pavanapuresan P., Denny, Sarah K., Greenleaf, William J., Herschlag, Daniel

“… Genomic methods have been valuable for identifying RNA-binding proteins (RBPs) and the genes, pathways, and processes they regulate. Nevertheless, standard …”
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A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins von Jarmoskaite, Inga, Denny, Sarah K, Vaidyanathan, Pavanapuresan P, Becker, Winston R, Andreasson, Johan O L, Layton, Curtis J, Kappel, Kalli, Shivashankar, Varun, Sreenivasan, Raashi, Das, Rhiju, Greenleaf, William J, Herschlag, Daniel

“… High-throughput methodologies have enabled routine generation of RNA target sets and sequence motifs for RNA-binding proteins (RBPs). Nevertheless, …”
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High-throughput DNA melt measurements enable improved models of DNA folding thermodynamics von Ke, Yuxi, Sharma, Eesha, Wayment-Steele, Hannah K., Becker, Winston R., Ho, Anthony, Marklund, Emil, Greenleaf, William J.

“… DNA folding thermodynamics are central to many biological processes and biotechnological applications involving base-pairing. Current methods for predicting …”
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High-throughput biochemical profiling reveals functional adaptation of a bacterial Argonaute von Ober-Reynolds, Benjamin, Becker, Winston R, Jouravleva, Karina, Jolly, Samson M, Zamore, Phillip D, Greenleaf, William J

“… Argonautes are nucleic acid-guided proteins that perform numerous cellular functions across all domains of life. Little is known about how distinct …”
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Demonstration of protein cooperativity mediated by RNA structure using the human protein PUM2 von Becker, Winston R, Jarmoskaite, Inga, Vaidyanathan, Pavanapuresan P, Greenleaf, William J, Herschlag, Daniel

“… Posttranslational gene regulation requires a complex network of RNA-protein interactions. Cooperativity, which tunes response sensitivities, originates from …”
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Biaxial mechanical properties of swine uterosacral and cardinal ligaments von Becker, Winston R., De Vita, Raffaella

“… Mechanical alterations to pelvic floor ligaments may contribute to the development and progression of pelvic floor disorders. In this study, the first biaxial …”
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Polyclonal origins of human premalignant colorectal lesions von Van Egeren, Debra, Schenck, Ryan O., Khan, Aziz, Horning, Aaron M., Mo, Shanlan, Weiß, Clemens L., Esplin, Edward D., Becker, Winston R., Wu, Si, Hanson, Casey, Barapour, Nasim, Jiang, Lihua, Contrepois, Kévin, Lee, Hayan, Nevins, Stephanie A., Guha, Tuhin K., Zhang, Hao, He, Zhen, Ma, Zhicheng, Monte, Emma, Karathanos, Thomas V., Laquindanum, Rozelle, Mills, Meredith A., Chaib, Hassan, Chiu, Roxanne, Jian, Ruiqi, Chan, Joanne, Ellenberger, Mathew, Bahmani, Bahareh, Michael, Basil, Weimer, Annika K., Esplin, D. Glen, Lancaster, Samuel, Shen, Jeanne, Ladabaum, Uri, Longacre, Teri A., Kundaje, Anshul, Greenleaf, William J., Hu, Zheng, Ford, James M., Snyder, Michael P., Curtis, Christina

“… Cancer is generally thought to be caused by expansion of a single mutant cell . However, analyses of early colorectal cancer lesions suggest that tumors may …”
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Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement von Boyle, Evan A., Becker, Winston R., Bai, Hua B., Chen, Janice S., Doudna, Jennifer A., Greenleaf, William J.

“… A massive new resource of diverse Cas9 binding and cleavage events establishes new rules for effective CRISPR targeting. The RNA-guided nuclease Cas9 has …”
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Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis von Esplin, Edward D., Hanson, Casey, Wu, Si, Horning, Aaron M., Barapour, Nasim, Nevins, Stephanie A., Jiang, Lihua, Contrepois, Kévin, Lee, Hayan, Guha, Tuhin K., Hu, Zheng, Laquindanum, Rozelle, Mills, Meredith A., Chaib, Hassan, Chiu, Roxanne, Jian, Ruiqi, Chan, Joanne, Ellenberger, Mathew, Becker, Winston R., Bahmani, Bahareh, Khan, Aziz, Michael, Basil, Weimer, Annika K., Esplin, D. Glen, Shen, Jeanne, Lancaster, Samuel, Monte, Emma, Karathanos, Thomas V., Ladabaum, Uri, Longacre, Teri A., Kundaje, Anshul, Curtis, Christina, Greenleaf, William J., Ford, James M., Snyder, Michael P.

“… Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of premalignant polyps in affected persons and is an ideal model to study …”
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Single-cell spatial mapping reveals alteration of cell type composition and tissue microenvironment during early colorectal cancer formation von Guha, Tuhin K, Esplin, Edward D, Horning, Aaron M, Chiu, Roxanne, Paul, Kristina, Weimer, Annika K, Becker, Winston R, Rozelle Laquindanum, Mills, Meredith A, Esplin, D Glen, Shen, Jeanne, Monte, Emma, White, Shannon, Karathanos, Thomas V, Cotter, Daniel, Bi, Joanna, Ladabaum, Uri, Longacre, Teri A, Curtis, Christina, Greenleaf, William J, d, James M, Snyder, Michael P

“… Colorectal cancer (CRC) is the third leading cause of cancer mortality in the United States. Familial adenomatous polyposis (FAP) is a hereditary syndrome that …”
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Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19 von Wilk, Aaron J, Lee, Madeline J, Wei, Bei, Parks, Benjamin, Pi, Ruoxi, Martínez-Colón, Giovanny J, Ranganath, Thanmayi, Zhao, Nancy Q, Taylor, Shalina, Becker, Winston, Jimenez-Morales, David, Blomkalns, Andra L, O'Hara, Ruth, Ashley, Euan A, Nadeau, Kari C, Yang, Samuel, Holmes, Susan, Rabinovitch, Marlene, Rogers, Angela J, Greenleaf, William J, Blish, Catherine A

“… Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by …”
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Dissecting Gene Regulation at the RNA and Chromatin Levels von Becker, Winston

“… Development, homeostasis, and healthy aging depend on precise regulation of gene expression programs. As a result, a central challenge in biology is to …”
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Single-cell analyses reveal a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer von Becker, Winston R, Nevins, Stephanie A, Chen, Derek C, Chiu, Roxanne, Horning, Aaron, Rozelle Laquindanum, Mills, Meredith, Chaib, Hassan, Ladabaum, Uri, Longacre, Teri, Shen, Jeanne, Esplin, Edward D, Kundaje, Anshul, d, James M, Curtis, Christina, Snyder, Michael P, Greenleaf, William J

“… To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we …”
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High Resolution Single Cell Maps Reveals Distinct Cell Organization and Function Across Different Regions of the Human Intestine von Hickey, John W, Becker, Winston R, Nevins, Stephanie A, Horning, Aaron M, Almudena Espin Perez, Chiu, Roxanne, Chen, Derek C, Cotter, Daniel, Esplin, Edward D, Weimer, Annika, Caraccio, Chiara, Venkataraaman, Vishal, Schurch, Christian M, Black, Sarah, Brbic, Maria, Cao, Kaidi, Leskovec, Jure, Zhang, Zhengyan, Lin, Shin, Longacre, Teri, Plevitis, Sylvia K, Lin, Yiing, Nolan, Garry P, Greenleaf, William, Snyder, Michael P

“… The colon is a complex organ that promotes digestion, extracts nutrients, participates in immune surveillance, maintains critical symbiotic relationships with …”
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Quantitative high-throughput tests of ubiquitous RNA secondary structure prediction algorithms via RNA/protein binding von Becker, Winston R, Jarmoskaite, Inga, Kappel, Kalli, Vaidyanathan, Pavanapuresan P, Denny, Sarah K, Das, Rhiju, Greenleaf, William J, Herschlag, Daniel

“… Nearest-neighbor (NN) rules provide a simple and powerful quantitative framework for RNA structure prediction that is strongly supported for canonical …”
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A quantitative and predictive model for RNA binding by human Pumilio proteins von Jarmoskaite, Inga, Denny, Sarah K, Vaidyanathan, Pavanapuresan P, Becker, Winston R, Johan Ol Andreasson, Layton, Curtis J, Kappel, Kalli, Shivashankar, Varun, Sreenivasan, Raashi, Das, Rhiju, Greenleaf, William J, Herschlag, Daniel

“… High-throughput methodologies have enabled routine generation of RNA target sets and sequence motifs for RNA-binding proteins (RBPs). Nevertheless, …”
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Single-cell spatial mapping reveals alteration of tissue microenvironment during early colorectal cancer von Guha, Tuhin K, Esplin, Edward D, Horning, Aaron M, Chiu, Roxanne, Paul, Kristina, Weimer, Annika K, Becker, Winston R, Laquindanum, Rozelle, Mills, Meredith A, Esplin, D Glen, Shen, Jeanne, Monte, Emma, White, Shannon, Karathanos, Thomas V, Cotter, Daniel, Bi, Joanna, Ladabaum, Uri, Longacre, Teri A, Curtis, Christina, Ford, James M, Greenleaf, William J, Snyder, Michael P

“… Familial adenomatous polyposis (FAP) is a rare, hereditary syndrome that raises the risk of developing colorectal cancer (CRC). This disease model is well …”
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