Suchergebnisse - "Bateman, D. Nicholas"

Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital von Antoine, Daniel J., Dear, James W., Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H., Gray, Alasdair J., Webb, David J., Moggs, Jonathan G., Bateman, D. Nicholas, Goldring, Christopher E., Park, B. Kevin

“… Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world. Early identification would …”
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Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial von Bateman, D Nicholas, Dear, James W, Thanacoody, H K Ruben, Thomas, Simon H L, Eddleston, Michael, Sandilands, Euan A, Coyle, Judy, Cooper, Jamie G, Rodriguez, Aryelly, Butcher, Isabella, Lewis, Steff C, Vliegenthart, A D Bastiaan, Veiraiah, Aravindan, Webb, David J, Gray, Alasdair

“… Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent …”
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Changing the Management of Paracetamol Poisoning von Bateman, D. Nicholas

“… The management of paracetamol poisoning was revolutionized after use of acetylcysteine in the 1970s. The protocol used, 3 weight-related infusions, requires …”
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A metabolomic analysis of thiol response for standard and modified N‐acetyl cysteine treatment regimens in patients with acetaminophen overdose von Dear, James W, Ng, Mei Li, Bateman, D. Nicholas, Leroy Sivappiragasam, Pakkiri, Choi, Hyungwon, Khoo, Benjamin Bing Jie, Ibrahim, Baharudin, Drum, Chester Lee

“… N‐acetylcysteine (NAC) is an antidote to prevent acetaminophen (paracetamol‐APAP)‐induced acute liver injury (ALI). The 3‐bag licensed 20.25 h standard …”
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Large paracetamol overdose—Higher dose acetylcysteine is required von Bateman, D. Nicholas

“… Paracetamol poisoning continues to be a worldwide problem and, despite the availability of an effective antidote, acetylcysteine (NAC), the optimal way to use …”
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Disproportionate effect on child admissions of the change in Medicines and Healthcare Products Regulatory Agency guidance for management of paracetamol poisoning: an analysis of hospital admissions for paracetamol overdose in England and Scotland von Narayan, Hafid, Thomas, Simon HL, Eddleston, Michael, Dear, James W., Sandilands, Euan, Nicholas Bateman, D.

“… Objective The aim of the present study was to assess the effects of the changes in the management of paracetamol overdose recommended by the UK Commission for …”
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Use of the online poisons information database TOXBASE and admissions rates for poisoned patients from emergency departments in England and Wales during 2008 to 2015 von Pyper, Kate, PhD, Robertson, Chris, PhD, Eddleston, Michael, ScD, Sandilands, Euan, MD, Bateman, D. Nicholas, MD

“… AbstractBackgroundThe impact of poison information services on patient care in hospital, particularly decisions on whether to admit patients after initial …”
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Exposure to liquid detergent capsules: A study undertaken by the UK National Poisons Information Service von Williams, Hayley, Bateman, D. Nicholas, Thomas, Simon HL, Thompson, John P, Scott, Robert AH, Vale, J. Allister

“… Objective. To ascertain the reported toxicity of liquid detergent capsules. Methods. Between 1 March 2008 and 30 April 2009 the UK National Poisons Information …”
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Paracetamol poisoning: beyond the nomogram von Bateman, D. Nicholas

“… Paracetamol poisoning is the commonest overdose seen in the UK. The management of patients with paracetamol poisoning has been little changed for the past 40 …”
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Histamine‐induced vasodilatation in the human forearm vasculature von Sandilands, Euan A., Crowe, Jane, Cuthbert, Hayley, Jenkins, Paul J., Johnston, Neil R., Eddleston, Michael, Bateman, D. Nicholas, Webb, David J.

“… Aim To investigate the mechanism of action of intra‐arterial histamine in the human forearm vasculature. Methods Three studies were conducted to assess changes …”
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Opioid analgesia for breastfeeding mothers von Bateman, D Nicholas, Hale, Thomas W

“… New study reports reassuring evidence on safety for infants …”
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Clinical toxicology in Edinburgh, two centuries of progress von Proudfoot, Alex T., Good, Alison M., Bateman, D. Nicholas

“… Abstract The Scottish Poisons Information Bureau was established in Edinburgh in September 1963 and shortly afterwards one of the wards of the city's Royal …”
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Acetaminophen and acetylcysteine dose and duration: Past, present and future von Rumack, Barry H, Bateman, D Nicholas

“… Abstract Acetylcysteine has been utilized successfully in the treatment of acetaminophen overdose since the 1970s. Although prospective trials as to efficacy …”
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Developing new antidotes for poisons with existing effective treatments: a case study of fomepizole in paracetamol poisoning von Dear, James W., Bateman, D. Nicholas

“… Acetylcysteine is the only effective and licensed therapy for paracetamol poisoning. However, acetylcysteine loses efficacy if treatment is delayed 8-12 hours …”
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'Ivory wave' toxicity in recreational drug users; integration of clinical and poisons information services to manage legal high poisoning von Murray, Douglas B., Potts, Stephen, Haxton, Carole, Jackson, Gillian, Sandilands, Euan A., Ramsey, John, Puchnarewicz, Malgorzata, Holt, David W., Johnston, Atholl, Nicholas Bateman, D., Dear, James W.

“… Abstract Background. Novel psychoactive substances or 'legal highs' can be defined as psychoactive substances that have been developed to avoid existing drug …”
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Toxicity of phosphate enemas - an updated review von Hamilton Smith, Rosa, Eddleston, Michael, Bateman, D. Nicholas

“… Enemas containing phosphate are widely prescribed and may cause important adverse effects. A systemic review published in 2007 reported the literature on the …”
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New Formulation of Paraquat: A Step Forward but in the Wrong Direction? von Bateman, D. Nicholas

“… There was some internal inconsistency in the approaches used to alter the formulation, in that gastric emptying was intended to be delayed by the use of an …”
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Morphine is an arteriolar vasodilator in man von Afshari, Reza, Maxwell, Simon R. J., Webb, David J., Bateman, D. Nicholas

“… WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • It has been recognized for about 10 years that morphine is a veno‐dilator in man and that this effect may be related …”
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Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use von Bateman, D Nicholas, Dear, James W

“… Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as …”
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Fifty years of paracetamol (acetaminophen) poisoning: the development of risk assessment and treatment 1973–2023 with particular focus on contributions published from Edinburgh and Denver von Bateman, D. Nicholas, Dart, Richard C., Dear, James W., Prescott, Laurie F., Rumack, Barry H.

“… Fifty years ago, basic scientific studies and the availability of assay methods made the assessment of risk in paracetamol (acetaminophen) poisoning possible …”
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