Suchergebnisse - "Basler, Christopher"

Propagation, Inactivation, and Safety Testing of SARS-CoV-2 von Jureka, Alexander, Silvas, Jesus, Basler, Christopher

“… In late 2019, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, the capital of the Chinese province Hubei …”
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Molecular pathogenesis of viral hemorrhagic fever von Basler, Christopher F.

“… The clinical syndrome referred to as viral hemorrhagic fever (VHF) can be caused by several different families of RNA viruses, including select members of the …”
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Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus von Messaoudi, Ilhem, Amarasinghe, Gaya K., Basler, Christopher F.

“… Key Points The 2014–2015 Ebola virus outbreak in West Africa is the largest filovirus outbreak to date. Filovirus infections in humans are acquired by direct …”
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Innate immune evasion by filoviruses von Basler, Christopher F.

“… Ebola viruses and Marburg viruses, members of the filovirus family, cause severe hemorrhagic fever. The ability of these viruses to potently counteract host …”
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An intrinsically disordered peptide from Ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions von Leung, Daisy W., Borek, Dominika M., Luthra, Priya, Binning, Jennifer M., Anantpadma, Manu, Liu, Gai, Harvey, Ian B., Su, Zhaoming, Endlich-Frazier, Ariel, Pan, Juanli, Shabman, Reed S., Chiu, Wah, Davey, Robert, Otwinowski, Zbyszek, Basler, Christopher F., Amarasinghe, Gaya K.

“… During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an RNA template-bound form and a template-free form to provide the viral …”
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Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication von Williams, Caroline G., Jureka, Alexander S., Silvas, Jesus A., Nicolini, Anthony M., Chvatal, Stacie A., Carlson-Stevermer, Jared, Oki, Jennifer, Holden, Kevin, Basler, Christopher F.

“… Coronaviruses rely on host membranes for entry, establishment of replication centers, and egress. Compounds targeting cellular membrane biology and lipid …”
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Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome von Luthra, Priya, Ramanan, Parameshwaran, Mire, Chad E, Weisend, Carla, Tsuda, Yoshimi, Yen, Benjamin, Liu, Gai, Leung, Daisy W, Geisbert, Thomas W, Ebihara, Hideki, Amarasinghe, Gaya K, Basler, Christopher F

“… The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces type I IFN responses to control viral replication. The cellular dsRNA …”
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Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1 von Xu, Wei, Edwards, Megan R, Borek, Dominika M, Feagins, Alicia R, Mittal, Anuradha, Alinger, Joshua B, Berry, Kayla N, Yen, Benjamin, Hamilton, Jennifer, Brett, Tom J, Pappu, Rohit V, Leung, Daisy W, Basler, Christopher F, Amarasinghe, Gaya K

“… During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-phosphorylated STAT1 (PY-STAT1), which occurs via a subset of …”
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Molecular pathogenesis of viral hemorrhagic fever von Basler, Christopher F.

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ICTV Virus Taxonomy Profile: Filoviridae von Kuhn, Jens H, Amarasinghe, Gaya K, Basler, Christopher F, Bavari, Sina, Bukreyev, Alexander, Chandran, Kartik, Crozier, Ian, Dolnik, Olga, Dye, John M, Formenty, Pierre B H, Griffiths, Anthony, Hewson, Roger, Kobinger, Gary P, Leroy, Eric M, Mühlberger, Elke, Netesov Нетёсов Сергей Викторович, Sergey V, Palacios, Gustavo, Pályi, Bernadett, Pawęska, Janusz T, Smither, Sophie J, Takada 高田礼人, Ayato, Towner, Jonathan S, Wahl, Victoria, Ictv Report Consortium

“… Members of the family Filoviridae produce variously shaped, often filamentous, enveloped virions containing linear non-segmented, negative-sense RNA genomes of …”
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Immunological features underlying viral hemorrhagic fevers von Messaoudi, Ilhem, Basler, Christopher F

“… •Several families of RNA viruses cause viral hemorrhagic fever in humans.•Viral hemorrhagic fever (VHF) is characterized by fever, vascular leak and …”
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Inclusion bodies are a site of ebolavirus replication von Hoenen, Thomas, Shabman, Reed S, Groseth, Allison, Herwig, Astrid, Weber, Michaela, Schudt, Gordian, Dolnik, Olga, Basler, Christopher F, Becker, Stephan, Feldmann, Heinz

“… Inclusion bodies are a characteristic feature of ebolavirus infections in cells. They contain large numbers of preformed nucleocapsids, but their biological …”
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Marburg and Ebola Virus mRNA 3' Untranslated Regions Contain Negative Regulators of Translation That Are Modulated by ADAR1 Editing von Khadka, Sudip, Williams, Caroline G, Sweeney-Gibbons, Joyce, Basler, Christopher F

“… The filovirus family includes deadly pathogens such as Ebola virus (EBOV) and Marburg virus (MARV). A substantial portion of filovirus genomes encode 5' and 3' …”
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The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response von Bharaj, Preeti, Wang, Yao E., Dawes, Brian E., Yun, Tatyana E., Park, Arnold, Yen, Benjamin, Basler, Christopher F., Freiberg, Alexander N., Lee, Benhur, Rajsbaum, Ricardo

“… For efficient replication, viruses have developed mechanisms to evade innate immune responses, including the antiviral type-I interferon (IFN-I) system. Nipah …”
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Pulsed Broad-Spectrum UV Light Effectively Inactivates SARS-CoV-2 on Multiple Surfaces and N95 Material von Jureka, Alexander S., Williams, Caroline G., Basler, Christopher F.

“… The ongoing SARS-CoV-2 pandemic has resulted in an increased need for technologies capable of efficiently disinfecting public spaces as well as personal …”
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Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines von Manicassamy, Balaji, Medina, Rafael A., Hai, Rong, Tsibane, Tshidi, Stertz, Silke, Nistal-Villán, Estanislao, Palese, Peter, Basler, Christopher F., García-Sastre, Adolfo

“… The recent 2009 pandemic H1N1 virus infection in humans has resulted in nearly 5,000 deaths worldwide. Early epidemiological findings indicated a low level of …”
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Taxonomy of the order Mononegavirales: update 2019 von Amarasinghe, Gaya K., Ayllón, María A., Bào, Yīmíng, Basler, Christopher F., Bavari, Sina, Blasdell, Kim R., Briese, Thomas, Brown, Paul A., Bukreyev, Alexander, Balkema-Buschmann, Anne, Buchholz, Ursula J., Chabi-Jesus, Camila, Chandran, Kartik, Chiapponi, Chiara, Crozier, Ian, de Swart, Rik L., Dietzgen, Ralf G., Dolnik, Olga, Drexler, Jan F., Dürrwald, Ralf, Dundon, William G., Duprex, W. Paul, Dye, John M., Easton, Andrew J., Fooks, Anthony R., Formenty, Pierre B. H., Fouchier, Ron A. M., Freitas-Astúa, Juliana, Griffiths, Anthony, Hewson, Roger, Horie, Masayuki, Hyndman, Timothy H., Jiāng, Dàohóng, Kitajima, Elliott W., Kobinger, Gary P., Kondō, Hideki, Kurath, Gael, Kuzmin, Ivan V., Lamb, Robert A., Lavazza, Antonio, Lee, Benhur, Lelli, Davide, Leroy, Eric M., Lǐ, Jiànróng, Maes, Piet, Marzano, Shin-Yi L., Moreno, Ana, Mühlberger, Elke, Netesov, Sergey V., Nowotny, Norbert, Nylund, Are, Økland, Arnfinn L., Palacios, Gustavo, Pályi, Bernadett, Pawęska, Janusz T., Payne, Susan L., Prosperi, Alice, Ramos-González, Pedro Luis, Rima, Bertus K., Rota, Paul, Rubbenstroth, Dennis, Shī, Mǎng, Simmonds, Peter, Smither, Sophie J., Sozzi, Enrica, Spann, Kirsten, Stenglein, Mark D., Stone, David M., Takada, Ayato, Tesh, Robert B., Tomonaga, Keizō, Tordo, Noël, Towner, Jonathan S., van den Hoogen, Bernadette, Vasilakis, Nikos, Wahl, Victoria, Walker, Peter J., Wang, Lin-Fa, Whitfield, Anna E., Williams, John V., Zerbini, F. Murilo, Zhāng, Tāo, Zhang, Yong-Zhen, Kuhn, Jens H.

“… In February 2019, following the annual taxon ratification vote, the order Mononegavirales was amended by the addition of four new subfamilies and 12 new genera …”
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Marburg virus VP40 antagonizes interferon signaling in a species-specific manner von Valmas, Charalampos, Basler, Christopher F

“… Marburgviruses are zoonotic pathogens that cause lethal hemorrhagic fever in humans and nonhuman primates. However, they do not cause lethal disease in …”
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Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus von Kash, John C, Tumpey, Terrence M, Proll, Sean C, Carter, Victoria, Perwitasari, Olivia, Thomas, Matthew J, Basler, Christopher F, Palese, Peter, Taubenberger, Jeffery K, García-Sastre, Adolfo, Swayne, David E, Katze, Michael G

“… The influenza pandemic of 1918-19 was responsible for about 50 million deaths worldwide1. Modern histopathological analysis of autopsy samples from human …”
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2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales von Kuhn, Jens H., Alioto, Daniela, Amarasinghe, Gaya K., Anthony, Simon J., Avšič-Županc, Tatjana, Ayllón, María A., Balkema-Buschmann, Anne, Ballinger, Matthew J., Basler, Christopher, Bavari, Sina, Beer, Martin, Bente, Dennis A., Blair, Carol, Blasdell, Kim R., Breyta, Rachel, Brown, Paul A., Bukreyev, Alexander, Burt, Felicity, Calisher, Charles H., Cao, Mengji, Charrel, Rémi N., Chen, Biao, Chiumenti, Michela, Clegg, J. Christopher S., Crozier, Ian, da Graça, John V., Dal Bó, Elena, de la Torre, Juan Carlos, de Swart, Rik L., Di Serio, Francesco, Dolja, Valerian V., Dundon, William G., Dye, John M., Easton, Andrew J., Fouchier, Ron A. M., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, Garrison, Aura R., Hammond, John, Hassan, Mohamed, Hepojoki, Jussi, Hepojoki, Satu, Hetzel, Udo, Hewson, Roger, Horie, Masayuki, Hughes, Holly R., Hyndman, Timothy H., Jiāng, Dàohóng, Jonson, Gilda B., Karadağ, Serpil, Klempa, Boris, Klingström, Jonas, Kobinger, Gary, Krupovic, Mart, Lamb, Robert A., Lambert, Amy J., Lemos, Elba R. S., Leroy, Eric M., Liú, Yàn, Martin, Robert R., Marzano, Shin-Yi L., McCauley, John W., Minafra, Angelantonio, Mühlbach, Hans-Peter, Naidu, Rayapati, Neumann, Gabriele, Økland, Arnfinn L., Palacios, Gustavo, Pawęska, Janusz T., Payne, Susan, Pérez, Daniel R., Radoshitzky, Sheli R., Rahman, Aziz-ul, Reyes, Carina A., Robles Luna, Gabriel, Rubbenstroth, Dennis, Runstadler, Jonathan A., Ruzek, Daniel, Salát, Jiří, Salvato, Maria S., Shabbir, Muhammad Z., Shirako, Yukio, Smura, Teemu, Stenglein, Mark D., Straková, Petra, Takada, Ayato, Tesh, Robert B., Thornburg, Natalie J., Tomonaga, Keizō, Towner, Jonathan S., Tzanetakis, Ioannis, Varsani, Arvind, Vasilakis, Nikos, Wang, Jianwei, Wang, Xifeng, Wèi, Tàiyún, Wolf, Yuri I., Yang, Xin, Yutin, Natalya

“… In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota …”
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