Suchergebnisse - "Basisty, Nathan"

A proteomic atlas of senescence-associated secretomes for aging biomarker development von Basisty, Nathan, Kale, Abhijit, Jeon, Ok Hee, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Holtz, Anja, Shah, Samah, Sharma, Vagisha, Ferrucci, Luigi, Campisi, Judith, Schilling, Birgit

“… The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, …”
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Connecting aging biology and inflammation in the omics era von Walker, Keenan A., Basisty, Nathan, Wilson, David M., Ferrucci, Luigi

“… Aging is characterized by the accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood and solid tissues, …”
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Plasma senescence associated secretory proteins: A new link to mild cognitive impairment von Banarjee, Reema, Basisty, Nathan

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Short-term senolytic treatment: a paradigm to promote fracture repair during aging von Beerman, Isabel, Basisty, Nathan, de Cabo, Rafael

“… Increased age is blamed for a wide range of bone physiological changes, and although the underlying mechanisms affecting the decreased capacity for fracture …”
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Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions von Christensen, David G., Xie, Xueshu, Basisty, Nathan, Byrnes, James, McSweeney, Sean, Schilling, Birgit, Wolfe, Alan J.

“… Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity to an existing proteome. The large number of known PTMs highlights …”
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Plasma proteomic biomarker signature of age predicts health and life span von Tanaka, Toshiko, Basisty, Nathan, Fantoni, Giovanna, Candia, Julián, Moore, Ann Z, Biancotto, Angelique, Schilling, Birgit, Bandinelli, Stefania, Ferrucci, Luigi

“… Older age is a strong shared risk factor for many chronic diseases, and there is increasing interest in identifying aging biomarkers. Here, a proteomic …”
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Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice von Chiao, Ying Ann, Zhang, Huiliang, Sweetwyne, Mariya, Whitson, Jeremy, Ting, Ying Sonia, Basisty, Nathan, Pino, Lindsay K, Quarles, Ellen, Nguyen, Ngoc-Han, Campbell, Matthew D, Zhang, Tong, Gaffrey, Matthew J, Merrihew, Gennifer, Wang, Lu, Yue, Yongping, Duan, Dongsheng, Granzier, Henk L, Szeto, Hazel H, Qian, Wei-Jun, Marcinek, David, MacCoss, Michael J, Rabinovitch, Peter

“… Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial …”
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Quantification and Identification of Post-Translational Modifications Using Modern Proteomics Approaches von Holtz, Anja, Basisty, Nathan, Schilling, Birgit

“… Post-translational modifications (PTMs) occur dynamically, allowing cells to quickly respond to changes in the environment. Lysine residues can be targeted by …”
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Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI von Chiba, Takuto, Peasley, Kevin D, Cargill, Kasey R, Maringer, Katherine V, Bharathi, Sivakama S, Mukherjee, Elina, Zhang, Yuxun, Holtz, Anja, Basisty, Nathan, Yagobian, Shiva D, Schilling, Birgit, Goetzman, Eric S, Sims-Lucas, Sunder

“… The primary site of damage during AKI, proximal tubular epithelial cells, are highly metabolically active, relying on fatty acids to meet their energy demands …”
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Altered proteome turnover and remodeling by short‐term caloric restriction or rapamycin rejuvenate the aging heart von Dai, Dao‐Fu, Karunadharma, Pabalu P., Chiao, Ying A., Basisty, Nathan, Crispin, David, Hsieh, Edward J., Chen, Tony, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S.

“… Summary Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and …”
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Editorial: Molecular crosstalk between endocrine factors, paracrine signals, and the immune system during aging von Sellegounder, Durai, Ferrucci, Luigi, Anbazhagan, Rajakumar, Basisty, Nathan

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Cellular Models of Aging and Senescence von Kim, Byunggik, Lee, Dong I., Basisty, Nathan, Dai, Dao-Fu

“… Aging, a state of progressive decline in physiological function, is an important risk factor for chronic diseases, ranging from cancer and musculoskeletal …”
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Comprehensive proteomic quantification of bladder stone progression in a cystinuric mouse model using data-independent acquisitions von Rose, Jacob, Basisty, Nathan, Zee, Tiffany, Wehrfritz, Cameron, Bose, Neelanjan, Desprez, Pierre-Yves, Kapahi, Pankaj, Stoller, Marshall, Schilling, Birgit

“… Cystinuria is one of various disorders that cause biomineralization in the urinary system, including bladder stone formation in humans. It is most prevalent in …”
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Simultaneous Quantification of the Acetylome and Succinylome by ‘One‐Pot’ Affinity Enrichment von Basisty, Nathan, Meyer, Jesse G, Wei, Lei, Gibson, Bradford W, Schilling, Birgit

“… Protein posttranslational modifications (PTMs) are of increasing interest in biomedical research, yet studies rarely examine more than one PTM. One barrier to …”
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Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts von Chiao, Ying Ann, Kolwicz, Stephen C, Basisty, Nathan, Gagnidze, Arni, Zhang, Julia, Gu, Haiwei, Djukovic, Danijel, Beyer, Richard P, Raftery, Daniel, MacCoss, Michael, Tian, Rong, Rabinovitch, Peter S

“… Rapamycin, an inhibitor of mTOR signaling, has been shown to reverse diastolic dysfunction in old mice in 10 weeks, highlighting its therapeutic potential for …”
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Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose von Meyer, Jesse G., Softic, Samir, Basisty, Nathan, Rardin, Matthew J., Verdin, Eric, Gibson, Bradford W., Ilkayeva, Olga, Newgard, Christopher B., Kahn, C. Ronald, Schilling, Birgit

“… Dietary macronutrient composition alters metabolism through several mechanisms, including post-translational modification (PTM) of proteins. To connect diet …”
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Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptides von Dai, Dao-Fu, Hsieh, Edward J, Chen, Tony, Menendez, Lorena G, Basisty, Nathan B, Tsai, Lauren, Beyer, Richard P, Crispin, David A, Shulman, Nicholas J, Szeto, Hazel H, Tian, Rong, MacCoss, Michael J, Rabinovitch, Peter S

“… We investigated the protective effects of mitochondrial-targeted antioxidant and protective peptides, Szeto-Schiller (SS) 31 and SS20, on cardiac function, …”
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Age modifies respiratory complex I and protein homeostasis in a muscle type‐specific manner von Kruse, Shane E., Karunadharma, Pabalu P., Basisty, Nathan, Johnson, Richard, Beyer, Richard P., MacCoss, Michael J., Rabinovitch, Peter S., Marcinek, David J.

“… Summary Changes in mitochondrial function with age vary between different muscle types, and mechanisms underlying this variation remain poorly defined. We …”
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Composition and Acidification of the Culture Medium Influences Chronological Aging Similarly in Vineyard and Laboratory Yeast von Murakami, Christopher J., Wall, Valerie, Basisty, Nathan, Kaeberlein, Matt

“… Chronological aging has been studied extensively in laboratory yeast by culturing cells into stationary phase in synthetic complete medium with 2% glucose as …”
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Editorial: Multi-omics studies on aging and age-related diseases von Wang, He-Ping, Basisty, Nathan, Qu, Jia-Hua, Wang, Xiaoman

“… Through LASSO regression method and Cox regression analysis, three genes GPC3, GPX3 and PRICKLE1 were identified as prognostic risk signatures for overall …”
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