Výsledky vyhľadávania - "Bartel, Maria"

The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface Autor Bier, David, Mittal, Sumit, Bravo-Rodriguez, Kenny, Sowislok, Andrea, Guillory, Xavier, Briels, Jeroen, Heid, Christian, Bartel, Maria, Wettig, Burkhard, Brunsveld, Luc, Sanchez-Garcia, Elsa, Schrader, Thomas, Ottmann, Christian

“…Protein regions that are involved in protein-protein interactions (PPIs) very often display a high degree of intrinsic disorder, which is reduced during the…”
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Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface Autor Bier, David, Bartel, Maria, Sies, Katharina, Halbach, Sebastian, Higuchi, Yusuke, Haranosono, Yu, Brummer, Tilman, Kato, Nobuo, Ottmann, Christian

“…Small‐molecule modulation of protein–protein interactions (PPIs) is one of the most promising new areas in drug discovery. In the vast majority of cases only…”
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A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface Autor Anders, Carolin, Higuchi, Yusuke, Koschinsky, Kristin, Bartel, Maria, Schumacher, Benjamin, Thiel, Philipp, Nitta, Hajime, Preisig-Müller, Regina, Schlichthörl, Günter, Renigunta, Vijay, Ohkanda, Junko, Daut, Jürgen, Kato, Nobuo, Ottmann, Christian

“…Small-molecule stabilization of protein-protein interactions is an emerging field in chemical biology. We show how fusicoccanes, originally identified as…”
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Molecular tweezers modulate 14-3-3 protein–protein interactions Autor Bier, David, Rose, Rolf, Bravo-Rodriguez, Kenny, Bartel, Maria, Ramirez-Anguita, Juan Manuel, Dutt, Som, Wilch, Constanze, Klärner, Frank-Gerrit, Sanchez-Garcia, Elsa, Schrader, Thomas, Ottmann, Christian

“…Supramolecular chemistry has recently emerged as a promising way to modulate protein functions, but devising molecules that will interact with a protein in the…”
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Stabilizer-Guided Inhibition of Protein-Protein Interactions Autor Milroy, Lech-Gustav, Bartel, Maria, Henen, Morkos A., Leysen, Seppe, Adriaans, Joris M. C., Brunsveld, Luc, Landrieu, Isabelle, Ottmann, Christian

“…The discovery of novel protein–protein interaction (PPI) modulators represents one of the great molecular challenges of the modern era. PPIs can be modulated…”
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Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau Autor Joo, Yuyoung, Schumacher, Benjamin, Landrieu, Isabelle, Bartel, Maria, Smet-Nocca, Caroline, Jang, Ahram, Choi, Hee Soon, Jeon, Noo Li, Chang, Keun-A, Kim, Hye-Sun, Ottmann, Christian, Suh, Yoo-Hun

“…14-3-3 proteins act as adapters that exert their function by interacting with their various protein partners. 14-3-3 proteins have been implicated in a variety…”
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Multivalent Ligands with Tailor‐Made Anion Binding Motif as Stabilizers of Protein–Protein Interactions Autor Bartsch, Lina, Bartel, Maria, Gigante, Alba, Iglesias‐Fernández, Javier, Ruiz‐Blanco, Yasser B., Beuck, Christine, Briels, Jeroen, Toetsch, Niklas, Bayer, Peter, Sanchez‐Garcia, Elsa, Ottmann, Christian, Schmuck, Carsten

“…Modulation of protein–protein interactions (PPIs) is essential for understanding and tuning biologically relevant processes. Although inhibitors for PPIs are…”
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Rational Design, Binding Studies, and Crystal‐Structure Evaluation of the First Ligand Targeting the Dimerization Interface of the 14‐3‐3ζ Adapter Protein Autor Ehlers, Martin, Grad, Jean‐Noël, Mittal, Sumit, Bier, David, Mertel, Marcel, Ohl, Ludwig, Bartel, Maria, Briels, Jeroen, Heimann, Marius, Ottmann, Christian, Sanchez‐Garcia, Elsa, Hoffmann, Daniel, Schmuck, Carsten

“…14‐3‐3 Proteins play a central role in signalling pathways in cells: they interact as gatekeeper proteins with a huge number of binding partners. Their…”
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Small molecules, peptides and natural products: getting a grip on 14-3-3 protein-protein modulation Autor Bartel, Maria, Schäfer, Anja, Stevers, Loes M, Ottmann, Christian

“…One of the proteins that is found in a diverse range of eukaryotic protein-protein interactions is the adaptor protein 14-3-3. As 14-3-3 is a hub protein with…”
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States of paleostress north and south of the Periadriatic fault: Comparison of the Drau Range and the Friuli Southalpine wedge Autor Bartel, Esther Maria, Neubauer, Franz, Genser, Johann, Heberer, Bianca

“…This study focuses on the analysis of structures and kinematics of a N–S profile along the axis of maximum shortening of the European Eastern Alps. The area…”
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A low-temperature ductile shear zone: The gypsum-dominated western extension of the brittle Fella-Sava Fault, Southern Alps Autor Bartel, Esther Maria, Neubauer, Franz, Heberer, Bianca, Genser, Johann

“…Based on structural and fabric analyses at variable scales we investigate the evaporitic gypsum-dominated Comeglians-Paularo shear zone in the Southern Alps…”
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Stabilizer-Guided Inhibition of Protein-Protein Interactions Autor Milroy, Lech-Gustav, Bartel, Maria, Henen, Morkos A., Leysen, Seppe, Adriaans, Joris M. C., Brunsveld, Luc, Landrieu, Isabelle, Ottmann, Christian

“…The discovery of novel protein–protein interaction (PPI) modulators represents one of the great molecular challenges of the modern era. PPIs can be modulated…”
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Factors associated with attachment in international adoption Autor Bartel, Teresa Maria Campbell

“…As the number of adoptable infants within the U.S. has declined, many families have chosen to adopt internationally. According to the U.S. Department of State,…”
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