Suchergebnisse - "Barozzi, Iros"

Latent enhancers activated by stimulation in differentiated cells von Ostuni, Renato, Piccolo, Viviana, Barozzi, Iros, Polletti, Sara, Termanini, Alberto, Bonifacio, Silvia, Curina, Alessia, Prosperini, Elena, Ghisletti, Serena, Natoli, Gioacchino

“… According to current models, once the cell has reached terminal differentiation, the enhancer repertoire is completely established and maintained by …”
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Exploiting evolutionary steering to induce collateral drug sensitivity in cancer von Acar, Ahmet, Nichol, Daniel, Fernandez-Mateos, Javier, Cresswell, George D., Barozzi, Iros, Hong, Sung Pil, Trahearn, Nicholas, Spiteri, Inmaculada, Stubbs, Mark, Burke, Rosemary, Stewart, Adam, Caravagna, Giulio, Werner, Benjamin, Vlachogiannis, Georgios, Maley, Carlo C., Magnani, Luca, Valeri, Nicola, Banerji, Udai, Sottoriva, Andrea

“… Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer therapy today. However, evolving resistance to one drug may come at a …”
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Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers von Barozzi, Iros, Simonatto, Marta, Bonifacio, Silvia, Yang, Lin, Rohs, Remo, Ghisletti, Serena, Natoli, Gioacchino

“… Transcription factors (TFs) preferentially bind sites contained in regions of computationally predicted high nucleosomal occupancy, suggesting that nucleosomes …”
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A first exon termination checkpoint preferentially suppresses extragenic transcription von Austenaa, Liv M. I., Piccolo, Viviana, Russo, Marta, Prosperini, Elena, Polletti, Sara, Polizzese, Danilo, Ghisletti, Serena, Barozzi, Iros, Diaferia, Giuseppe R., Natoli, Gioacchino

“… Interactions between the splicing machinery and RNA polymerase II increase protein-coding gene transcription. Similarly, exons and splicing signals of …”
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Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages von Chen, Xuefen, Barozzi, Iros, Termanini, Alberto, Prosperini, Elena, Recchiuti, Antonio, Dalli, Jesmond, Mietton, Flore, Matteoli, Gianluca, Hiebert, Scott, Natoli, Gioacchino

“… Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the potent antiinflammatory activity of pan-HDAC inhibitors. However, the …”
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An atlas of dynamic chromatin landscapes in mouse fetal development von Gorkin, David U., Barozzi, Iros, Zhao, Yuan, Zhang, Yanxiao, Huang, Hui, Lee, Ah Young, Li, Bin, Chiou, Joshua, Wildberg, Andre, Ding, Bo, Zhang, Bo, Wang, Mengchi, Strattan, J. Seth, Davidson, Jean M., Qiu, Yunjiang, Afzal, Veena, Akiyama, Jennifer A., Plajzer-Frick, Ingrid, Novak, Catherine S., Kato, Momoe, Garvin, Tyler H., Pham, Quan T., Harrington, Anne N., Mannion, Brandon J., Lee, Elizabeth A., Fukuda-Yuzawa, Yoko, He, Yupeng, Preissl, Sebastian, Chee, Sora, Han, Jee Yun, Williams, Brian A., Trout, Diane, Amrhein, Henry, Yang, Hongbo, Cherry, J. Michael, Wang, Wei, Gaulton, Kyle, Ecker, Joseph R., Shen, Yin, Dickel, Diane E., Visel, Axel, Pennacchio, Len A., Ren, Bing

“… The Encyclopedia of DNA Elements (ENCODE) project has established a genomic resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …”
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The genomic landscapes of inflammation von Natoli, Gioacchino, Ghisletti, Serena, Barozzi, Iros

“… Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner …”
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Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy von Hong, Sung Pil, Chan, Thalia E., Lombardo, Ylenia, Corleone, Giacomo, Rotmensz, Nicole, Bravaccini, Sara, Rocca, Andrea, Pruneri, Giancarlo, McEwen, Kirsten R., Coombes, R. Charles, Barozzi, Iros, Magnani, Luca

“… Resistant tumours are thought to arise from the action of Darwinian selection on genetically heterogenous cancer cell populations. However, simple clonal …”
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The co-evolution of the genome and epigenome in colorectal cancer von Heide, Timon, Househam, Jacob, Cresswell, George D., Spiteri, Inmaculada, Lynn, Claire, Mossner, Maximilian, Kimberley, Chris, Fernandez-Mateos, Javier, Chen, Bingjie, Zapata, Luis, James, Chela, Barozzi, Iros, Chkhaidze, Ketevan, Nichol, Daniel, Gunasri, Vinaya, Berner, Alison, Schmidt, Melissa, Lakatos, Eszter, Baker, Ann-Marie, Costa, Helena, Mitchinson, Miriam, Piazza, Rocco, Jansen, Marnix, Caravagna, Giulio, Ramazzotti, Daniele, Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Graham, Trevor A., Sottoriva, Andrea

“… Colorectal malignancies are a leading cause of cancer-related death 1 and have undergone extensive genomic study 2 , 3 . However, DNA mutations alone do not …”
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A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers von De Santa, Francesca, Barozzi, Iros, Mietton, Flore, Ghisletti, Serena, Polletti, Sara, Tusi, Betsabeh Khoramian, Muller, Heiko, Ragoussis, Jiannis, Wei, Chia-Lin, Natoli, Gioacchino

“… Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long …”
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Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation von Cuartero, Sergi, Weiss, Felix D., Dharmalingam, Gopuraja, Guo, Ya, Ing-Simmons, Elizabeth, Masella, Silvia, Robles-Rebollo, Irene, Xiao, Xiaolin, Wang, Yi-Fang, Barozzi, Iros, Djeghloul, Dounia, Amano, Mariane T., Niskanen, Henri, Petretto, Enrico, Dowell, Robin D., Tachibana, Kikuë, Kaikkonen, Minna U., Nasmyth, Kim A., Lenhard, Boris, Natoli, Gioacchino, Fisher, Amanda G., Merkenschlager, Matthias

“… Cohesin is important for 3D genome organization. Nevertheless, even the complete removal of cohesin has surprisingly little impact on steady-state gene …”
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Progressive Loss of Function in a Limb Enhancer during Snake Evolution von Kvon, Evgeny Z, Kamneva, Olga K, Melo, Uirá S, Barozzi, Iros, Osterwalder, Marco, Mannion, Brandon J, Tissières, Virginie, Pickle, Catherine S, Plajzer-Frick, Ingrid, Lee, Elizabeth A, Kato, Momoe, Garvin, Tyler H, Akiyama, Jennifer A, Afzal, Veena, Lopez-Rios, Javier, Rubin, Edward M, Dickel, Diane E, Pennacchio, Len A, Visel, Axel

“… The evolution of body shape is thought to be tightly coupled to changes in regulatory sequences, but specific molecular events associated with major …”
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Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions von Bhatt, Dev M, Pandya-Jones, Amy, Tong, Ann-Jay, Barozzi, Iros, Lissner, Michelle M, Natoli, Gioacchino, Black, Douglas L, Smale, Stephen T

“… Macrophages respond to inflammatory stimuli by modulating the expression of hundreds of genes in a defined temporal cascade, with diverse transcriptional and …”
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A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages von Mancino, Alessandra, Termanini, Alberto, Barozzi, Iros, Ghisletti, Serena, Ostuni, Renato, Prosperini, Elena, Ozato, Keiko, Natoli, Gioacchino

“… The transcription factor (TF) interferon regulatory factor 8 (IRF8) controls both developmental and inflammatory stimulus-inducible genes in macrophages, but …”
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Supervised enhancer prediction with epigenetic pattern recognition and targeted validation von Sethi, Anurag, Gu, Mengting, Gumusgoz, Emrah, Chan, Landon, Yan, Koon-Kiu, Rozowsky, Joel, Barozzi, Iros, Afzal, Veena, Akiyama, Jennifer A., Plajzer-Frick, Ingrid, Yan, Chengfei, Novak, Catherine S., Kato, Momoe, Garvin, Tyler H., Pham, Quan, Harrington, Anne, Mannion, Brandon J., Lee, Elizabeth A., Fukuda-Yuzawa, Yoko, Visel, Axel, Dickel, Diane E., Yip, Kevin Y., Sutton, Richard, Pennacchio, Len A., Gerstein, Mark

“… Enhancers are important non-coding elements, but they have traditionally been hard to characterize experimentally. The development of massively parallel assays …”
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Ultraconserved Enhancers Are Required for Normal Development von Dickel, Diane E, Ypsilanti, Athena R, Pla, Ramón, Zhu, Yiwen, Barozzi, Iros, Mannion, Brandon J, Khin, Yupar S, Fukuda-Yuzawa, Yoko, Plajzer-Frick, Ingrid, Pickle, Catherine S, Lee, Elizabeth A, Harrington, Anne N, Pham, Quan T, Garvin, Tyler H, Kato, Momoe, Osterwalder, Marco, Akiyama, Jennifer A, Afzal, Veena, Rubenstein, John L R, Pennacchio, Len A, Visel, Axel

“… Non-coding "ultraconserved" regions containing hundreds of consecutive bases of perfect sequence conservation across mammalian genomes can function as …”
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Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells von Vella, Pietro, Barozzi, Iros, Cuomo, Alessandro, Bonaldi, Tiziana, Pasini, Diego

“… The Yin Yang 1 (YY1) transcription factor is a master regulator of development, essential for early embryogenesis and adult tissues formation. YY1 is the …”
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Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages von Ghisletti, Serena, Barozzi, Iros, Mietton, Flore, Polletti, Sara, De Santa, Francesca, Venturini, Elisa, Gregory, Lorna, Lonie, Lorne, Chew, Adeline, Wei, Chia-Lin, Ragoussis, Jiannis, Natoli, Gioacchino

“… Enhancers determine tissue-specific gene expression programs. Enhancers are marked by high histone H3 lysine 4 mono-methylation (H3K4me1) and by the …”
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High-resolution label-free 3D mapping of extracellular pH of single living cells von Zhang, Yanjun, Takahashi, Yasufumi, Hong, Sung Pil, Liu, Fengjie, Bednarska, Joanna, Goff, Philip S., Novak, Pavel, Shevchuk, Andrew, Gopal, Sahana, Barozzi, Iros, Magnani, Luca, Sakai, Hideki, Suguru, Yoshimoto, Fujii, Takuto, Erofeev, Alexander, Gorelkin, Peter, Majouga, Alexander, Weiss, Dominik J., Edwards, Christopher, Ivanov, Aleksandar P., Klenerman, David, Sviderskaya, Elena V., Edel, Joshua B., Korchev, Yuri

“… Dynamic mapping of extracellular pH (pHe) at the single-cell level is critical for understanding the role of H + in cellular and subcellular processes, with …”
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Long non-coding RNA TINCR suppresses metastatic melanoma dissemination by preventing ATF4 translation von Melixetian, Marine, Bossi, Daniela, Mihailovich, Marija, Punzi, Simona, Barozzi, Iros, Marocchi, Federica, Cuomo, Alessandro, Bonaldi, Tiziana, Testa, Giuseppe, Marine, Jean-Christophe, Leucci, Eleonora, Minucci, Saverio, Pelicci, Pier Giuseppe, Lanfrancone, Luisa

“… Transition from proliferative-to-invasive phenotypes promotes metastasis and therapy resistance in melanoma. Reversion of the invasive phenotype, however, is …”
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