Výsledky vyhľadávania - "Badola, Sunita"

Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors Autor Tap, William D, Demetri, George, Barnette, Phillip, Desai, Jayesh, Kavan, Petr, Tozer, Richard, Benedetto, Pasquale W, Friberg, Gregory, Deng, Hongjie, McCaffery, Ian, Leitch, Ian, Badola, Sunita, Chang, Sung, Zhu, Min, Tolcher, Anthony

“…Ganitumab is a fully human monoclonal antibody against type-1 insulin-like growth factor receptor (IGF1R). An open-label phase II study was conducted to…”
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Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women Autor Paré, Guillaume, Chasman, Daniel I., Kellogg, Mark, Zee, Robert Y. L., Rifai, Nader, Badola, Sunita, Miletich, Joseph P., Ridker, Paul M.

“…While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction,…”
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The JAMM motif of human deubiquitinase Poh1 is essential for cell viability Autor Gallery, Melissa, Blank, Jonathan L, Lin, Yinghui, Gutierrez, Juan A, Pulido, Jacqueline C, Rappoli, David, Badola, Sunita, Rolfe, Mark, Macbeth, Kyle J

“…Poh1 deubiquitinase activity is required for proteolytic processing of polyubiquitinated substrates by the 26S proteasome, linking deubiquitination to complete…”
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Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank Autor Szustakowski, Joseph D., Balasubramanian, Suganthi, Kvikstad, Erika, Khalid, Shareef, Bronson, Paola G., Sasson, Ariella, Wong, Emily, Liu, Daren, Wade Davis, J., Haefliger, Carolina, Katrina Loomis, A., Mikkilineni, Rajesh, Noh, Hyun Ji, Wadhawan, Samir, Bai, Xiaodong, Hawes, Alicia, Krasheninina, Olga, Ulloa, Ricardo, Lopez, Alex E., Smith, Erin N., Waring, Jeffrey F., Whelan, Christopher D., Tsai, Ellen A., Overton, John D., Salerno, William J., Jacob, Howard, Szalma, Sandor, Runz, Heiko, Hinkle, Gregory, Nioi, Paul, Petrovski, Slavé, Miller, Melissa R., Baras, Aris, Mitnaul, Lyndon J., Reid, Jeffrey G.

“…The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private–public partnership between the UK Biobank (UKB) and eight biopharmaceutical companies that…”
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Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate Autor Parker, Alex, Izmailova, Elena S, Narang, Jigna, Badola, Sunita, Le, Tinh, Roubenoff, Ronenn, Ginsburg, Geoffrey S, Maier, Agnes, Coblyn, Jonathan S, Shadick, Nancy A, Weinblatt, Michael E

“…To evaluate peripheral blood expression of genes regulated by nuclear factor-kappaB (NF-kappaB), a key mediator of tumor necrosis factor-alpha (TNF-alpha)…”
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Randomized Phase II Study of Paclitaxel plus Alisertib versus Paclitaxel plus Placebo as Second-Line Therapy for SCLC: Primary and Correlative Biomarker Analyses Autor Owonikoko, Taofeek K, Niu, Huifeng, Nackaerts, Kristiaan, Csoszi, Tibor, Ostoros, Gyula, Mark, Zsuzsanna, Baik, Christina, Joy, Anil Abraham, Chouaid, Christos, Jaime, Jesus Corral, Kolek, Vitezslav, Majem, Margarita, Roubec, Jaromir, Santos, Edgardo S, Chiang, Anne C, Speranza, Giovanna, Belani, Chandra P, Chiappori, Alberto, Patel, Manish R, Czebe, Krisztina, Byers, Lauren, Bahamon, Brittany, Li, Cong, Sheldon-Waniga, Emily, Kong, Eric F, Williams, Miguel, Badola, Sunita, Shin, Hyunjin, Bedford, Lisa, Ecsedy, Jeffrey A, Bryant, Matthew, Jones, Sian, Simmons, John, Leonard, E Jane, Ullmann, Claudio Dansky, Spigel, David R

“…We assessed the Aurora A kinase inhibitor, alisertib, plus paclitaxel (henceforth referred to as alisertib/paclitaxel) as second-line treatment for SCLC. In…”
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New loci associated with kidney function and chronic kidney disease Autor Böger, Carsten A, Fuchsberger, Christian, Olden, Matthias, Glazer, Nicole L, Parsa, Afshin, Gao, Xiaoyi, Yang, Qiong, O'Connell, Jeffrey R, Li, Man, Tanaka, Toshiko, Isaacs, Aaron, Ketkar, Shamika, Dehghan, Abbas, Teumer, Alexander, Paré, Guillaume, Atkinson, Elizabeth J, Zeller, Tanja, Lohman, Kurt, Cornelis, Marilyn C, Probst-Hensch, Nicole M, Kronenberg, Florian, Tönjes, Anke, Hayward, Caroline, Aspelund, Thor, Eiriksdottir, Gudny, Rampersaud, Evadnie, Mitchell, Braxton D, Singleton, Andrew, Giallauria, Francesco, Metter, Jeffrey, de Boer, Ian H, Haritunians, Talin, Lumley, Thomas, Siscovick, David, Zillikens, M Carola, Oostra, Ben A, Feitosa, Mary, Province, Michael, de Andrade, Mariza, Turner, Stephen T, Schillert, Arne, Ziegler, Andreas, Schnabel, Renate B, Wilde, Sandra, Munzel, Thomas F, Leak, Tennille S, Klopp, Norman, Meisinger, Christa, Wichmann, H-Erich, Koenig, Wolfgang, Zgaga, Lina, Zemunik, Tatijana, Kolcic, Ivana, Hu, Frank B, Igl, Wilmar, Zaboli, Ghazal, Campbell, Harry, Ellinghaus, David, Aulchenko, Yurii S, Felix, Janine F, Rivadeneira, Fernando, Hofman, Albert, Imboden, Medea, Nitsch, Dorothea, Brandstätter, Anita, Stumvoll, Michael, Campbell, Susan, Endlich, Karlhans, Völzke, Henry, Nauck, Matthias, Völker, Uwe, Polasek, Ozren, Vitart, Veronique, Badola, Sunita, Parker, Alexander N, Ridker, Paul M, Blankenberg, Stefan, Liu, Yongmei, Curhan, Gary C, Franke, Andre, Paulweber, Bernhard, Prokopenko, Inga, Wang, Wei, Gudnason, Vilmundur, Shuldiner, Alan R, Coresh, Josef, Schmidt, Reinhold, Ferrucci, Luigi, Shlipak, Michael G, van Duijn, Cornelia M, Borecki, Ingrid, Gyllensten, Ulf, Wilson, James F, Witteman, Jacqueline C, Pramstaller, Peter P, Rettig, Rainer, Hastie, Nick, Kao, W H, Heid, Iris M, Fox, Caroline S

“…Caroline Fox and colleagues report results of a large genome-wide association meta-analysis and replication study for indices of renal function. Their work…”
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Putative predictive biomarkers of survival in patients with metastatic pancreatic adenocarcinoma treated with gemcitabine and ganitumab, an IGF1R inhibitor Autor McCaffery, Ian, Tudor, Yanyan, Deng, Hongjie, Tang, Rui, Suzuki, Samuel, Badola, Sunita, Kindler, Hedy L, Fuchs, Charles S, Loh, Elwyn, Patterson, Scott D, Chen, Li, Gansert, Jennifer L

“…This planned exploratory analysis assessed the predictive nature of baseline circulating factors of the insulin-like growth factor (IGF) axis on the treatment…”
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CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes Autor Soler, Dulce, Chapman, Tobias R, Poisson, Louis R, Wang, Lin, Cote-Sierra, Javier, Ryan, Mark, McDonald, Alice, Badola, Sunita, Fedyk, Eric, Coyle, Anthony J, Hodge, Martin R, Kolbeck, Roland

“…CD4+ Th2 cells are important regulators of allergic inflammation. CCR8 is thought to play a role in Th2-mediated responses, however, expression of CCR8 in…”
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Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein Autor Ligthart, Symen, de Vries, Paul S., Uitterlinden, André G., Hofman, Albert, Franco, Oscar H., Chasman, Daniel I., Dehghan, Abbas

“…Pleiotropic genetic variants have independent effects on different phenotypes. C-reactive protein (CRP) is associated with several cardiometabolic phenotypes…”
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c‐MYC expression and maturity phenotypes are associated with outcome benefit from addition of ixazomib to lenalidomide‐dexamethasone in myeloma Autor Di Bacco, Alessandra, Bahlis, Nizar J., Munshi, Nikhil C., Avet‐Loiseau, Hervé, Masszi, Tamás, Viterbo, Luísa, Pour, Ludek, Ganly, Peter, Cavo, Michele, Langer, Christian, Kumar, Shaji K., Rajkumar, S. Vincent, Keats, Jonathan J., Berg, Deborah, Lin, Jianchang, Li, Bin, Badola, Sunita, Shen, Lei, Zhang, Jacob, Esseltine, Dixie‐Lee, Luptakova, Katarina, Velde, Helgi, Richardson, Paul G., Moreau, Philippe

“…Objectives In the TOURMALINE‐MM1 phase 3 trial in relapsed/refractory multiple myeloma, ixazomib‐lenalidomide‐dexamethasone (IRd) showed different magnitudes…”
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Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women: e1000118 Autor Paré, Guillaume, Chasman, Daniel I, Kellogg, Mark, Zee, Robert YL, Rifai, Nader, Badola, Sunita, Miletich, Joseph P, Ridker, Paul M

“…While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction,…”
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Correlation of serpin–protease expression by comparative analysis of real-time PCR profiling data Autor Badola, Sunita, Spurling, Heidi, Robison, Keith, Fedyk, Eric R., Silverman, Gary A., Strayle, Jochen, Kapeller, Rosana, Tsu, Christopher A.

“…Imbalanced protease activity has long been recognized in the progression of disease states such as cancer and inflammation. Serpins, the largest family of…”
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Multiple New Loci Associated with Kidney Function and Chronic Kidney Disease: The CKDGen consortium Autor Köttgen, Anna, Pattaro, Cristian, Böger, Carsten A., Fuchsberger, Christian, Olden, Matthias, Glazer, Nicole L., Parsa, Afshin, Gao, Xiaoyi, Yang, Qiong, Smith, Albert V., O’Connell, Jeffrey R., Li, Man, Schmidt, Helena, Tanaka, Toshiko, Isaacs, Aaron, Ketkar, Shamika, Hwang, Shih-Jen, Johnson, Andrew D., Dehghan, Abbas, Teumer, Alexander, Paré, Guillaume, Atkinson, Elizabeth J., Zeller, Tanja, Lohman, Kurt, Cornelis, Marilyn C., Probst-Hensch, Nicole M., Kronenberg, Florian, Tönjes, Anke, Hayward, Caroline, Aspelund, Thor, Eiriksdottir, Gudny, Launer, Lenore, Harris, Tamara B., Rapmersaud, Evadnie, Mitchell, Braxton D., Boerwinkle, Eric, Struchalin, Maksim, Cavalieri, Margherita, Singleton, Andrew, Giallauria, Francesco, Metter, Jeffery, de Boer, Ian, Haritunians, Talin, Lumley, Thomas, Siscovick, David, Psaty, Bruce M., Zillikens, M. Carola, Oostra, Ben A., Feitosa, Mary, Province, Michael, Levy, Daniel, de Andrade, Mariza, Turner, Stephen T., Schillert, Arne, Ziegler, Andreas, Wild, Philipp S., Schnabel, Renate B., Wilde, Sandra, Muenzel, Thomas F., Leak, Tennille S, Illig, Thomas, Klopp, Norman, Meisinger, Christa, Wichmann, H.-Erich, Koenig, Wolfgang, Zgaga, Lina, Zemunik, Tatijana, Kolcic, Ivana, Minelli, Cosetta, Hu, Frank B., Johansson, Åsa, Igl, Wilmar, Zaboli, Ghazal, Wild, Sarah H, Wright, Alan F, Campbell, Harry, Ellinghaus, David, Schreiber, Stefan, Aulchenko, Yurii S, Rivadeneira, Fernando, Uitterlinden, Andre G, Hofman, Albert, Imboden, Medea, Nitsch, Dorothea, Brandstätter, Anita, Kollerits, Barbara, Kedenko, Lyudmyla, Mägi, Reedik, Stumvoll, Michael, Kovacs, Peter, Boban, Mladen, Campbell, Susan, Endlich, Karlhans, Völzke, Henry, Kroemer, Heyo K., Nauck, Matthias, Völker, Uwe, Polasek, Ozren, Vitart, Veronique, Badola, Sunita

“…Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen…”
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CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3 super(+) Regulatory and Th2 Effector Lymphocytes Autor Soler, Dulce, Chapman, Tobias R, Poisson, Louis R, Wang, Lin, Cote-Sierra, Javier, Ryan, Mark, McDonald, Alice, Badola, Sunita, Fedyk, Eric, Coyle, Anthony J, Hodge, Martin R, Kolbeck, Roland

“…CD4 super(+) Th2 cells are important regulators of allergic inflammation. CCR8 is thought to play a role in Th2-mediated responses, however, expression of CCR8…”
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