Výsledky vyhledávání - "Bäckström, Torbjörn"

Positive GABAA receptor modulating steroids and their antagonists: Implications for clinical treatments Autor Bäckström, Torbjörn, Das, Roshni, Bixo, Marie

“…GABA is the main inhibitory neurotransmitter in the brain and GABAergic transmission has been shown to be of importance for regulation of mood, memory and food…”
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Neurosteroids and premenstrual dysphoric disorder Autor Bixo, Marie, Stiernman, Louise, Bäckström, Torbjörn

“…Premenstrual dysphoric disorder (PMDD) is common, with at least 3% of the female population affected by one or more of the typical mood symptoms of depression,…”
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The GABA system, a new target for medications against cognitive impairment—Associated with neuroactive steroids Autor Bäckström, Torbjörn, Turkmen, Sahruh, Das, Roshni, Doverskog, Magnus, Blackburn, Thomas P.

“…The prevalence of cognitive dysfunction, dementia, and neurodegenerative disorders such as Alzheimer's disease (AD) is increasing in parallel with an aging…”
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Brain Metabolism of Allopregnanolone and Isoallopregnanolone in Male Rat Brain Autor Öfverman, Charlotte, Hill, Martin, Johansson, Maja, Bäckström, Torbjörn

“…Allopregnanolone (allo) and isoallopregnanolone (isoallo) are neuroactive steroid epimers that differ in hydroxyl orientation at carbon three. Allo is a potent…”
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Allopregnanolone and its antagonist modulate neuroinflammation and neurological impairment Autor Bäckström, Torbjörn, Doverskog, Magnus, Blackburn, Thomas P., Scharschmidt, Bruce F., Felipo, Vicente

“…Neuroinflammation accompanies several brain disorders, either as a secondary consequence or as a primary cause and may contribute importantly to disease…”
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Identifying Risk Factors for PTSD in Women Seeking Medical Help after Rape Autor Moller, AT, Backstrom, T, Sondergaard, HP, Helstrom, L

“…Rape has been found to be the trauma most commonly associated with Posttraumatic Stress Disorder (PTSD) among women. It is therefore important to be able to…”
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Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls—a pilot study Autor Timby, Erika, Bäckström, Torbjörn, Nyberg, Sigrid, Stenlund, Hans, Wihlbäck, Anna-Carin N., Bixo, Marie

“…Rationale In premenstrual dysphoric disorder (PMDD), a condition that afflicts 3–8 % of women in fertile ages, the cyclic recurrence of debilitating mood…”
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Women with polycystic ovary syndrome have elevated serum concentrations of and altered GABAA receptor sensitivity to allopregnanolone Autor Hedström, Helena, Bäckström, Torbjörn, Bixo, Marie, Nyberg, Sigrid, Wang, Mingde, Gideonsson, Ida, Turkmen, Sahruh

“…Summary Objective Several studies have reported that γ‐aminobutyric acid (GABA) ergic circuits are involved in the pathophysiology of polycystic ovary syndrome…”
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Influence of endometrial nerve fibers and hormones on pain in women with endometriosis Autor Sommar, Anton, Bahat, Pinar Yalcin, Özaydin, Ipek Yildiz, Bixo, Marie, Bäckström, Torbjörn, Oral, Engin, Turkmen, Sahruh

“…•Women with endometriosis had a higher density of PGP9.5-positive nerve fibers in the endometrium compared to healthy controls.•Higher nerve fiber density was…”
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Roux-en-Y Gastric Bypass Surgery in Patients with Polycystic Ovary Syndrome and Metabolic Syndrome Autor Turkmen, Sahruh, Ahangari, Alebtekin, Bäckstrom, Torbjörn

“…Background We aimed to evaluate the impact of Roux-en-Y gastric bypass (RYGB) surgery on metabolic syndrome-related variables in obese women with polycystic…”
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ISPMD consensus on the management of premenstrual disorders Autor Nevatte, Tracy, O’Brien, Patrick Michael Shaughn, Bäckström, Torbjorn, Brown, Candace, Dennerstein, Lorraine, Endicott, Jean, Epperson, C. Neill, Eriksson, Elias, Freeman, Ellen W., Halbreich, Uriel, Ismail, Khalid, Panay, Nicholas, Pearlstein, Teri, Rapkin, Andrea, Reid, Robert, Rubinow, David, Schmidt, Peter, Steiner, Meir, Studd, John, Sundström-Poromaa, Inger, Yonkers, Kimberly

“…The second consensus meeting of the International Society for Premenstrual Disorders (ISPMD) took place in London during March 2011. The primary goal was to…”
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Chemokines and Their Association With Symptom Severity in Women With Endometriosis Autor Sommar, Anton, Bahat, Pinar Yalcin, Özaydin, Ipek Yildiz, Güler, Eray Metin, Bixo, Marie, Bäckström, Torbjörn, Oral, Engin, Turkmen, Sahruh

“…ABSTRACT Problem Various chemokines have been linked to endometriosis. Notably, chemokines such as CCL2, CXCL8, and CXCL1 have also been shown to promote…”
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A randomized, double-blind study on efficacy and safety of sepranolone in premenstrual dysphoric disorder Autor Bäckström, Torbjörn, Ekberg, Karin, Hirschberg, Angelica Lindén, Bixo, Marie, Epperson, C. Neill, Briggs, Paula, Panay, Nick, O’Brien, Shaughn

“…Women with premenstrual dysphoric disorder (PMDD) experience mood symptoms related to the increase in progesterone and the neuroactive steroid…”
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Altered GABAA receptor function in women with endometriosis: a possible pain‐related mechanism Autor Sandström, Anton, Bixo, Marie, Bäckström, Torbjörn, Möller, Anna, Turkmen, Sahruh

“…Introduction The mechanism underlying endometriosis‐related pain remains poorly understood. Previous studies have indicated that γ‐aminobutyric acid (GABA)…”
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Low Serum Allopregnanolone Is Associated with Symptoms of Depression in Late Pregnancy Autor Hellgren, Charlotte, Åkerud, Helena, Skalkidou, Alkistis, Bäckström, Torbjörn, Sundström-Poromaa, Inger

“…Background: Allopregnanolone (3α-hydroxy-5α-pregnan-20-one) is a neurosteroid which has an inhibitory function through interaction with the GABA A receptor…”
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GABAA Receptor-Modulating Steroids in Relation to Women’s Behavioral Health Autor Bäckström, Torbjörn, Bixo, Marie, Strömberg, Jessica

“…In certain women, increased negative mood relates to the progesterone metabolite, allopregnanolone (allo), during the luteal phase of ovulatory menstrual…”
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The effect of premenstrual symptoms on activities of daily life Autor Dennerstein, Lorraine, Lehert, Philippe, Bäckström, Torbjörn Carl, Heinemann, Klaas

“…To assess impact of premenstrual symptoms on activities of women's daily lives (ADL). Cross-sectional population-based survey. Market research company. A total…”
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Medroxyprogesterone acetate positively modulates specific GABAA-receptor subtypes - affecting memory and cognition Autor Das, Roshni, Ragagnin, Gianna, Sjöstedt, Jessica, Johansson, Maja, Haage, David, Druzin, Michael, Johansson, Staffan, Bäckström, Torbjörn

“…Medroxyprogesterone acetate (MPA) is a progestin widely used in humans as hormone replacement therapy and at other indications. Many progestin metabolites, as…”
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Isoallopregnanolone reduces tic‐like behaviours in the D1CT‐7 mouse model of Tourette syndrome Autor Cadeddu, Roberto, Bäckström, Torbjörn, Floris, Gabriele, Nordkild, Peter, Segerdahl, Märta, Bortolato, Marco

“…Tourette syndrome (TS) is a neuropsychiatric disorder characterised by multiple, persistent tics. These semi‐voluntary motor and phonic manifestations are…”
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GABAA receptor modulating steroid antagonists (GAMSA) are functional in vivo Autor Johansson, Maja, Strömberg, Jessica, Ragagnin, Gianna, Doverskog, Magnus, Bäckström, Torbjörn

“…[Display omitted] •The neurosteroid allopregnanolone positively modulates the GABA-A receptor.•Allopregnanolone induces cognitive deficits and…”
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