Suchergebnisse - "Atkinson, Mark A"

Type 1 diabetes von Atkinson, Mark A, Eisenbarth, George S, Michels, Aaron W

“… Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease …”
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Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome von Russell, Jordan T., Roesch, Luiz F. W., Ördberg, Malin, Ilonen, Jorma, Atkinson, Mark A., Schatz, Desmond A., Triplett, Eric W., Ludvigsson, Johnny

“… Susceptibility to many human autoimmune diseases is under strong genetic control by class II human leukocyte antigen (HLA) allele combinations. These genes …”
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Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes von Wang, Yue J, Traum, Daniel, Schug, Jonathan, Gao, Long, Liu, Chengyang, Atkinson, Mark A, Powers, Alvin C, Feldman, Michael D, Naji, Ali, Chang, Kyong-Mi, Kaestner, Klaus H

“… The interaction between the immune system and endocrine cells in the pancreas is crucial for the initiation and progression of type 1 diabetes (T1D). Imaging …”
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The streetlight effect in type 1 diabetes von Battaglia, Manuela, Atkinson, Mark A

“… In the nearly 100 years since the discovery of therapeutic insulin, significant research efforts have been directed at finding the underlying cause of type 1 …”
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A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes von Girdhar, Khyati, Huang, Qian, Chow, I-Ting, Vatanen, Tommi, Brady, Claudia, Raisingani, Amol, Autissier, Patrick, Atkinson, Mark A, Kwok, William W, Kahn, C Ronald, Altindis, Emrah

“… Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic β-cells. One of the earliest aspects of this process is the …”
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Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association von Insel, Richard A, Dunne, Jessica L, Atkinson, Mark A, Chiang, Jane L, Dabelea, Dana, Gottlieb, Peter A, Greenbaum, Carla J, Herold, Kevan C, Krischer, Jeffrey P, Lernmark, Åke, Ratner, Robert E, Rewers, Marian J, Schatz, Desmond A, Skyler, Jay S, Sosenko, Jay M, Ziegler, Anette-G

“… Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that …”
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Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes von Brown, Christopher T., Davis-Richardson, Austin G., Giongo, Adriana, Gano, Kelsey A., Crabb, David B., Mukherjee, Nabanita, Casella, George, Drew, Jennifer C., Ilonen, Jorma, Knip, Mikael, Hyöty, Heikki, Veijola, Riitta, Simell, Tuula, Simell, Olli, Neu, Josef, Wasserfall, Clive H., Schatz, Desmond, Atkinson, Mark A., Triplett, Eric W.

“… Recent studies have suggested a bacterial role in the development of autoimmune disorders including type 1 diabetes (T1D). Over 30 billion nucleotide bases of …”
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Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease von Atkinson, Mark A, von Herrath, Matthias, Powers, Alvin C, Clare-Salzler, Michael

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Large-scale electron microscopy database for human type 1 diabetes von de Boer, Pascal, Pirozzi, Nicole M., Wolters, Anouk H. G., Kuipers, Jeroen, Kusmartseva, Irina, Atkinson, Mark A., Campbell-Thompson, Martha, Giepmans, Ben N. G.

“… Autoimmune β-cell destruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear. To help address this void, we created an …”
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α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody–positive individuals von Doliba, Nicolai M., Rozo, Andrea V., Roman, Jeffrey, Qin, Wei, Traum, Daniel, Gao, Long, Liu, Jinping, Manduchi, Elisabetta, Liu, Chengyang, Golson, Maria L., Vahedi, Golnaz, Naji, Ali, Matschinsky, Franz M., Atkinson, Mark A., Powers, Alvin C., Brissova, Marcela, Kaestner, Klaus H., Stoffers, Doris A.

“… BACKGROUNDMultiple islet autoantibodies (AAbs) predict the development of type 1 diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in …”
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Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry von Wu, Minghui, Lee, Michelle Y.Y., Bahl, Varun, Traum, Daniel, Schug, Jonathan, Kusmartseva, Irina, Atkinson, Mark A., Fan, Guanjie, Kaestner, Klaus H.

“… Type 2 diabetes mellitus (T2D) is a chronic age-related disorder characterized by hyperglycemia due to the failure of pancreatic beta cells to compensate for …”
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Mental state attribution and the gaze cueing effect von Cole, Geoff G., Smith, Daniel T., Atkinson, Mark A.

“… Theory of mind is said to be possessed by an individual if he or she is able to impute mental states to others. Recently, some authors have demonstrated that …”
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Toward defining the autoimmune microbiome for type 1 diabetes von Giongo, Adriana, Gano, Kelsey A, Crabb, David B, Mukherjee, Nabanita, Novelo, Luis L, Casella, George, Drew, Jennifer C, Ilonen, Jorma, Knip, Mikael, Hyöty, Heikki, Veijola, Riitta, Simell, Tuula, Simell, Olli, Neu, Josef, Wasserfall, Clive H, Schatz, Desmond, Atkinson, Mark A, Triplett, Eric W

“… Several studies have shown that gut bacteria have a role in diabetes in murine models. Specific bacteria have been correlated with the onset of diabetes in a …”
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Visual attention and action: How cueing, direct mapping, and social interactions drive orienting von Atkinson, Mark A., Simpson, Andrew A., Cole, Geoff G.

“… Despite considerable interest in both action perception and social attention over the last 2 decades, there has been surprisingly little investigation …”
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The influence of type 1 diabetes on pancreatic weight von Campbell-Thompson, Martha L., Kaddis, John S., Wasserfall, Clive, Haller, Michael J., Pugliese, Alberto, Schatz, Desmond A., Shuster, Jonathan J., Atkinson, Mark A.

“… Aims/hypothesis Previous studies of pancreases obtained at autopsy or by radiography note reduced pancreas weight (PW) and size, respectively, in type 1 …”
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Lactobacillus johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in BB-DP Rats von Valladares, Ricardo, Sankar, Dhyana, Li, Nan, Williams, Emily, Lai, Kin-Kwan, Abdelgeliel, Asmaa Sayed, Gonzalez, Claudio F., Wasserfall, Clive H., Larkin, Joseph, Schatz, Desmond, Atkinson, Mark A., Triplett, Eric W., Neu, Josef, Lorca, Graciela L.

“… The intestinal epithelium is a barrier that composes one of the most immunologically active surfaces of the body due to constant exposure to microorganisms as …”
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Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score von Onengut-Gumuscu, Suna, Chen, Wei-Min, Robertson, Catherine C, Bonnie, Jessica K, Farber, Emily, Zhu, Zhennan, Oksenberg, Jorge R, Brant, Steven R, Bridges, Jr, S Louis, Edberg, Jeffrey C, Kimberly, Robert P, Gregersen, Peter K, Rewers, Marian J, Steck, Andrea K, Black, Mary H, Dabelea, Dana, Pihoker, Catherine, Atkinson, Mark A, Wagenknecht, Lynne E, Divers, Jasmin, Bell, Ronny A, Erlich, Henry A, Concannon, Patrick, Rich, Stephen S

“… Genetic risk scores (GRS) have been developed that differentiate individuals with type 1 diabetes from those with other forms of diabetes and are starting to …”
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Central Role for Interleukin-2 in Type 1 Diabetes von Hulme, Maigan A., Wasserfall, Clive H., Atkinson, Mark A., Brusko, Todd M.

“… Type 1 diabetes presents clinically with overt hyperglycemia resulting from progressive immune-mediated destruction of pancreatic β-cells and associated …”
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Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes von Jacobsen, Laura M, Bundy, Brian N, Greco, Madison N, Schatz, Desmond A, Atkinson, Mark A, Brusko, Todd M, Mathews, Clayton E, Herold, Kevan C, Gitelman, Stephen E, Krischer, Jeffrey P, Haller, Michael J

“… Several immunotherapies have demonstrated endogenous insulin preservation in recent-onset type 1 diabetes (T1D). We considered the primary results of …”
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Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes von Putnam, Amy L., Brusko, Todd M., Lee, Michael R., Liu, Weihong, Szot, Gregory L., Ghosh, Taumoha, Atkinson, Mark A., Bluestone, Jeffrey A.

“… Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes Amy L. Putnam 1 , Todd M. Brusko 1 , Michael R. Lee 1 , Weihong Liu 1 , Gregory L …”
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