Suchergebnisse - "Ashton, Thomas M"

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy von Ashton, Thomas M, McKenna, W Gillies, Kunz-Schughart, Leoni A, Higgins, Geoff S

“… Cancer cells have upregulated glycolysis compared with normal cells, which has led many to the assumption that oxidative phosphorylation (OXPHOS) is …”
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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia von Ashton, Thomas M., Fokas, Emmanouil, Kunz-Schughart, Leoni A., Folkes, Lisa K., Anbalagan, Selvakumar, Huether, Melanie, Kelly, Catherine J., Pirovano, Giacomo, Buffa, Francesca M., Hammond, Ester M., Stratford, Michael, Muschel, Ruth J., Higgins, Geoff S., McKenna, William Gillies

“… Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that …”
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Pathways for Holliday Junction Processing during Homologous Recombination in Saccharomyces cerevisiae von Ashton, Thomas M., Mankouri, Hocine W., Heidenblut, Anna, McHugh, Peter J., Hickson, Ian D.

“… Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley …”
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Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia von Kelly, Catherine J., Hussien, Kamila, Fokas, Emmanouil, Kannan, Pavitra, Shipley, Rebecca J., Ashton, Thomas M., Stratford, Michael, Pearson, Natalie, Muschel, Ruth J.

“… Inhibitors of the phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) pathway are currently in clinical trials. In addition to …”
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Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage von Mankouri, Hocine W, Ashton, Thomas M, Hickson, Ian D

“… The Sgs1-Rmi1-Top3 "dissolvasome" is required for the maintenance of genome stability and has been implicated in the processing of various types of DNA …”
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T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics von Herbert, Katharine J., Ashton, Thomas M., Prevo, Remko, Pirovano, Giacomo, Higgins, Geoff S.

“… ‘Targeted’ or ‘biological’ cancer treatments rely on differential gene expression between normal tissue and cancer, and genetic changes that render tumour …”
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TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy von Pirovano, Giacomo, Ashton, Thomas M, Herbert, Katharine J, Bryant, Richard J, Verrill, Clare L, Cerundolo, Lucia, Buffa, Francesca M, Prevo, Remko, Harrap, Iona, Ryan, Anderson J, Macaulay, Valentine, McKenna, William G, Higgins, Geoff S

“… Background: Tumour-specific radiosensitising treatments may enhance the efficacy of radiotherapy without exacerbating side effects. In this study we determined …”
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Yeast as a model system to study RecQ helicase function von Ashton, Thomas M., Hickson, Ian D.

“… Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces …”
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Yeast as a model system to study RecQ helicase function: Helicase and translocases required for the maintenance of genome stability von ASHTON, Thomas M, HICKSON, Ian D

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An analysis of the s cerevisiae rmi1 gene von Ashton, Thomas M

“… The Saccharomyces cerevisiae Rmi1 protein is a component of the highly conserved Sgs1-Top3-Rmi1 complex, which is required for the maintenance of genome …”
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