Výsledky vyhledávání - "Apoptosis"

Evidence for existence of an apoptosis‐inducing BH3‐only protein, sayonara, in Drosophila Autor Ikegawa, Yuko, Combet, Christophe, Groussin, Mathieu, Navratil, Vincent, Safar‐Remali, Sabrina, Shiota, Takuya, Aouacheria, Abdel, Yoo, Sa Kan

“… Since the discovery of the first BH3‐only protein Bad, BH3‐only proteins have been recognized as indispensable stress sensors that induce apoptosis. BH3…”
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Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects Autor Mejías-Peña, Yubisay, Estébanez, Brisamar, Rodriguez-Miguelez, Paula, Fernandez-Gonzalo, Rodrigo, Almar, Mar, de Paz, José A, González-Gallego, Javier, Cuevas, María J

“… inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr…”
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Neuronal cells from bipolar individuals are more susceptible to glutamate induced apoptosis than cells from non-bipolar subjects Autor Hu, Ming, Gao, Yonglin, El-Mallakh, Rif S

“…•Lithium antagonizes glutamate induced apoptosis more effectively in ONPs derived from subjects with bipolar disorder than in non-bipolar controls…”
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Pharmacokinetics, Safety, and Tolerability of Selonsertib, an Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitor, Following First-in-Human Single and Multiple Ascending Doses in Healthy Subjects Autor Nelson, Cara H., Etchevers, Kim, Yi, Saili, Breckenridge, David, Hepner, Mischa, Patel, Uptal, Ling, John, Mathias, Anita

“…Background Selonsertib is a first-in-class inhibitor of apoptosis signal-regulating kinase 1 (ASK1…”
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Dysregulated apoptosis and NFκB expression in COPD subjects Autor Brown, Vanessa, Elborn, J Stuart, Bradley, Judy, Ennis, Madeleine

“… The objectives of this study were to examine spontaneous neutrophil apoptosis in stable COPD subjects (n = 13…”
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Macrophage Migration Inhibitory Factor: A Novel Inhibitor of Apoptosis Signal-Regulating Kinase 1–p38–Xanthine Oxidoreductase–Dependent Cigarette Smoke–Induced Apoptosis Autor Fallica, Jonathan, Varela, Lidenys, Johnston, Laura, Kim, Bo, Serebreni, Leonid, Wang, Lan, Damarla, Mahendra, Kolb, Todd M., Hassoun, Paul M., Damico, Rachel

“…Cigarette smoke (CS) exposure is the leading cause of emphysema. CS mediates pathologic emphysematous remodeling of the lung via apoptosis of lung parenchymal…”
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Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1 Autor Arunachalam, Gnanapragasam, Samuel, Samson Mathews, Marei, Isra, Ding, Hong, Triggle, Chris R

“…Background and Purpose Endothelial dysfunction can be detected at an early stage in the development of diabetes‐related microvascular disease and is associated…”
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Shift in monocyte apoptosis with increasing viral load and change in apoptosis-related ISG/Bcl2 family gene expression in chronically HIV-1-infected subjects Autor Patro, Sean C, Pal, Sharmistha, Bi, Yingtao, Lynn, Kenneth, Mounzer, Karam C, Kostman, Jay R, Davuluri, Ramana V, Montaner, Luis J

“…Although monocytes and macrophages are targets of HIV-1-mediated immunopathology, the impact of high viremia on activation-induced monocyte apoptosis relative to monocyte and macrophage activation…”
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Expression of apoptosis markers in the retinas of human subjects with diabetes Autor Abu-El-Asrar, Ahmed M, Dralands, Lieve, Missotten, Luc, Al-Jadaan, Ibrahim A, Geboes, Karel

“…To investigate the expression of the apoptotic mediators in the retinas from human subjects with diabetes mellitus…”
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Neuropeptide Y directly reduced apoptosis of granulosa cells, and the expression of NPY and its receptors in PCOS subjects Autor Urata, Yoko, Salehi, Reza, Wyse, Brandon A., Jahangiri, Sahar, Librach, Clifford L., Tzeng, Chii-Ruey, Osuga, Yutaka, Tsang, Benjamin

“…; NPY function in apoptosis and proliferation of granulosa cells (GCs) is follicular-stage dependent…”
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Leber's hereditary optic neuropathy (LHON)-associated ND5 12338T > C mutation altered the assembly and function of complex I, apoptosis and mitophagy Autor Zhang, Juanjuan, Ji, Yanchun, Lu, Yuanyuan, Fu, Runing, Xu, Man, Liu, Xiaoling, Guan, Min-Xin

“…>C mutation and a control subject belonging to the same mtDNA haplogroup, we demonstrated that the m.12338T…”
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Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy Autor Liang, Min, Ji, Yanchun, Zhang, Liyao, Wang, Xuan, Hu, Cuifang, Zhang, Juanjuan, Zhu, Yiwei, Mo, Jun Q, Guan, Min-Xin

“…Leber's hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mitochondrial DNA (mtDNA) mutations. LHON-linked ND6 14484T > C…”
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Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects Autor Sheikh, A.M., Li, X., Wen, G., Tauqeer, Z., Brown, W.T., Malik, M.

“… It plays an important role in regulation of cellular apoptosis and has been shown to mediate apoptosis induced by cytokines tumor necrosis factor (TNF)-α and interferon (IFN)-γ…”
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Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration Autor Ou, Xuancheng, Ying, Jinwei, Bai, Xuedong, Wang, Chaofeng, Ruan, Dike

“…) and chemokine receptor 2 (CCR2) inhibitors. Indices related to NPMSC growth, proliferation, differentiation and apoptosis were measured…”
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Evaluation of Soluble Tumor Necrosis Factor-Like Weak Inducer of Apoptosis, Omentin, and Tumor Necrosis Factor-α in Subjects with Periodontitis and Type 2 Diabetes Mellitus Autor Ramasundaram, Vinu, Ponnaiyan, Deepa, Anitha, C M, Prakash, P S G, Victor, D J, Singh, Akanksha

“…), involving inflammatory markers such as soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK…”
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The gene BRAF is underexpressed in bipolar subject olfactory neuroepithelial progenitor cells undergoing apoptosis Autor Schroeder, Emily, Gao, Yonglin, Lei, Zhenmin, Roisen, Fred, El-Mallakh, Rif S.

“… The documentation of brain tissue loss implicates apoptosis as the likely underlying degenerative process, but direct experimental demonstration is lacking…”
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Vitamin E succinate mediated apoptosis by juxtaposing endoplasmic reticulum and mitochondria Autor Ray, Manobendro Nath, Kiyofuji, Michiko, Ozono, Mizune, Kogure, Kentaro

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EGCG’s anticancer potential unveiled: triggering apoptosis in lung cancer cell lines through in vitro investigation Autor Khair, Al Moutassem Billah, Maniangat Luke, Alexander, Patnaik, Rajashree, Testarelli, Luca

“…) signaling pathway, which in turn causes apoptosis in H1299 lung cancer cells. In this experiment, multiple dosages of EGCG were applied to five H1299 cells and five A549 cell lines for a duration of 72 h…”
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Metformin Induces Apoptosis through AMPK-Dependent Inhibition of UPR Signaling in ALL Lymphoblasts Autor Leclerc, Gilles M., Leclerc, Guy J., Kuznetsov, Jeffim N., DeSalvo, Joanna, Barredo, Julio C.

“… (ALL) or those who relapse remains poor. We investigated the mechanism of cell death induced by metformin in Bp- and T-ALL cell models and primary cells, and show that metformin effectively induces apoptosis in ALL cells…”
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Omega-3 DHA- and EPA–dopamine conjugates induce PPARγ-dependent breast cancer cell death through autophagy and apoptosis Autor Rovito, Daniela, Giordano, Cinzia, Plastina, Pierluigi, Barone, Ines, De Amicis, Francesca, Mauro, Loredana, Rizza, Pietro, Lanzino, Marilena, Catalano, Stefania, Bonofiglio, Daniela, Andò, Sebastiano

“…The omega-3 docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) may form conjugates with amines that have potential health benefits against common…”
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