Suchergebnisse - "Antioxidants & redox signaling"

Transcriptional Regulation by Nrf2 von Tonelli, Claudia, Chio, Iok In Christine, Tuveson, David A

“… Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of …”
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The Roles of NRF2 in Modulating Cellular Iron Homeostasis von Kerins, Michael John, Ooi, Aikseng

“… Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a cofactor in enzymes for oxygen transport, oxidative phosphorylation, and …”
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Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation von Joffre, Jérémie, Hellman, Judith

“… Under homeostatic conditions, the endothelium dynamically regulates vascular barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone …”
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Metabolic Responses to Reductive Stress von Xiao, Wusheng, Loscalzo, Joseph

“… Reducing equivalents (NAD(P)H and glutathione [GSH]) are essential for maintaining cellular redox homeostasis and for modulating cellular metabolism. Reductive …”
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NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism von Xiao, Wusheng, Wang, Rui-Sheng, Handy, Diane E, Loscalzo, Joseph

“… The nicotinamide adenine dinucleotide (NAD )/reduced NAD (NADH) and NADP /reduced NADP (NADPH) redox couples are essential for maintaining cellular redox …”
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The Role of Sirtuins in Antioxidant and Redox Signaling von Singh, Chandra K, Chhabra, Gagan, Ndiaye, Mary Ann, Garcia-Peterson, Liz Mariely, Mack, Nicholas J, Ahmad, Nihal

“… Antioxidant and redox signaling (ARS) events are regulated by critical molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …”
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Regulatory Phenomena in the Glutathione Peroxidase Superfamily von Brigelius-Flohé, Regina, Flohé, Leopold

“… The selenium-containing Glutathione peroxidases (GPxs)1-4 protect against oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death …”
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GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues von Maiorino, Matilde, Conrad, Marcus, Ursini, Fulvio

“… Iron-dependent lipid peroxidation is a complex oxidative process where phospholipid hydroperoxides (PLOOH) are produced in membranes and finally transformed …”
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A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? von Cao, Xu, Ding, Lei, Xie, Zhi-Zhong, Yang, Yong, Whiteman, Matthew, Moore, Philip K, Bian, Jin-Song

“… Hydrogen sulfide (H S) has been recognized as the third gaseous transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous studies …”
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The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease von Davies, Michael J, Hawkins, Clare L

“… The release of myeloperoxidase (MPO) by activated leukocytes is critical in innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong …”
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The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus von Gerber, Philipp A, Rutter, Guy A

“… Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a disease that currently affects ∼8% of the adult population worldwide …”
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Diabetes and Kidney Disease: Role of Oxidative Stress von Jha, Jay C, Banal, Claudine, Chow, Bryna S M, Cooper, Mark E, Jandeleit-Dahm, Karin

“… Intrarenal oxidative stress plays a critical role in the initiation and progression of diabetic kidney disease (DKD). Enhanced oxidative stress results from …”
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Loop Between NLRP3 Inflammasome and Reactive Oxygen Species von Dominic, Abishai, Le, Nhat-Tu, Takahashi, Masafumi

“… Inflammasomes are cytosolic multiprotein complexes that mediate innate immune pathways. Inflammasomes activate inflammatory caspases and regulate inflammatory …”
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Oxidant Mechanisms in Renal Injury and Disease von Ratliff, Brian B, Abdulmahdi, Wasan, Pawar, Rahul, Wolin, Michael S

“… A common link between all forms of acute and chronic kidney injuries, regardless of species, is enhanced generation of reactive oxygen species (ROS) and …”
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Targeting Oxidative Stress and Inflammatory Response for Blood-Brain Barrier Protection in Intracerebral Hemorrhage von Chen, Shengpan, Li, Lingzhi, Peng, Chao, Bian, Chunjing, Ocak, Pinar Eser, Zhang, John H, Yang, Yong, Zhou, Dong, Chen, Guangzhong, Luo, Yumin

“… Blood-brain barrier (BBB) disruption is a major pathological change after intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress …”
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Reactive oxygen species in inflammation and tissue injury von Mittal, Manish, Siddiqui, Mohammad Rizwan, Tran, Khiem, Reddy, Sekhar P, Malik, Asrar B

“… Abstract Reactive oxygen species (ROS) are key signaling molecules that play an important role in the progression of inflammatory disorders. An enhanced ROS …”
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SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection von D'Onofrio, Nunzia, Servillo, Luigi, Balestrieri, Maria Luisa

“… Oxidative stress represents the common hallmark of pathological conditions associated with cardiovascular disease (CVD), including atherosclerosis, heart …”
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Clinical Relevance of Biomarkers of Oxidative Stress von Frijhoff, Jeroen, Winyard, Paul G, Zarkovic, Neven, Davies, Sean S, Stocker, Roland, Cheng, David, Knight, Annie R, Taylor, Emma Louise, Oettrich, Jeannette, Ruskovska, Tatjana, Gasparovic, Ana Cipak, Cuadrado, Antonio, Weber, Daniela, Poulsen, Henrik Enghusen, Grune, Tilman, Schmidt, Harald H H W, Ghezzi, Pietro

“… Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all …”
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Is Albumin Predictor of Mortality in COVID-19? von Violi, Francesco, Cangemi, Roberto, Romiti, Giulio Francesco, Ceccarelli, Giancarlo, Oliva, Alessandra, Alessandri, Francesco, Pirro, Matteo, Pignatelli, Pasquale, Lichtner, Miriam, Carraro, Anna, Cipollone, Francesco, D'ardes, Damiano, Pugliese, Francesco, Mastroianni, Claudio Maria

“… Coronavirus 2019 (COVID-19) is a pandemic associated with a high risk of mortality. Human serum albumin (HSA) is an acute phase reactant with antioxidant …”
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Mitochondrial Reactive Oxygen Species and Mitophagy: A Complex and Nuanced Relationship von Schofield, James H, Schafer, Zachary T

“… Mitochondria represent a major source of intracellular reactive oxygen species (ROS) generation. This is often a consequence of oxidative phosphorylation, …”
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