Výsledky vyhľadávania - "Antineoplastic Agents - pharmacology"

Immune checkpoint blockade: a common denominator approach to cancer therapy Autor Topalian, Suzanne L, Drake, Charles G, Pardoll, Drew M

“…, is currently the subject of intense study…”
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Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update Autor Roskoski, Robert

“… currently the subject of many drug discovery programs in the pharmaceutical industry. The US FDA approved four small molecule protein kinase antagonists in 2019…”
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Ferrocifen type anti cancer drugs Autor Jaouen, Gérard, Vessières, Anne, Top, Siden

“…Despite current developments in therapeutics focusing on biotechnologically-oriented species, the unflagging utility of small molecules or peptides in medicine…”
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Understanding and targeting resistance mechanisms in NSCLC Autor Rotow, Julia, Bivona, Trever G.

“…Key Points The spectrum of known and putative oncogenic drivers with companion targeted therapies continues to increase. As broader mutational testing becomes…”
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The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations Autor Ru, Yuanbin, Kechris, Katerina J., Tabakoff, Boris, Hoffman, Paula, Radcliffe, Richard A., Bowler, Russell, Mahaffey, Spencer, Rossi, Simona, Calin, George A., Bemis, Lynne, Theodorescu, Dan

“…microRNAs (miRNAs) regulate expression by promoting degradation or repressing translation of target transcripts. miRNA target sites have been catalogued in…”
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Sono‐Controllable and ROS‐Sensitive CRISPR‐Cas9 Genome Editing for Augmented/Synergistic Ultrasound Tumor Nanotherapy Autor Pu, Yinying, Yin, Haohao, Dong, Caihong, Xiang, Huijing, Wu, Wencheng, Zhou, Bangguo, Du, Dou, Chen, Yu, Xu, Huixiong

“…The potential of the cluster regularly interspaced short palindromic repeat (CRISPR)‐associated protein 9 (Cas9)‐based therapeutic genome editing is severely…”
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Recent developments of C-4 substituted coumarin derivatives as anticancer agents Autor Dandriyal, Jyoti, Singla, Ramit, Kumar, Manvendra, Jaitak, Vikas

“… Coumarin scaffold became an attractive subject due to their broad spectrum of pharmacological activities…”
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Immunogenic cell stress and death in the treatment of cancer Autor Pan, Hui, Liu, Peng, Zhao, Liwei, Pan, Yuhong, Mao, Misha, Kroemer, Guido, Kepp, Oliver

“… The exploration of ICD for cancer treatment has been subject to extensive research. However, functional heterogeneity among ICD activating therapies in many cases requires specific co-medications to achieve full-blown efficacy…”
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Targeting Regulated Cell Death with Pharmacological Small Molecules: An Update on Autophagy-Dependent Cell Death, Ferroptosis, and Necroptosis in Cancer Autor Wu, Junhao, Ye, Jing, Xie, Qiang, Liu, Bo, Liu, Ming

“…Regulated cell death is a widely attractive subject among the topics of cancer therapy and has gained some advances for discovery of targeted anticancer drugs…”
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Overcoming trastuzumab resistance in HER2‐positive breast cancer using combination therapy Autor Derakhshani, Afshin, Rezaei, Zohreh, Safarpour, Hossein, Sabri, Morteza, Mir, Atefeh, Sanati, Mohammad Amin, Vahidian, Fatemeh, Gholamiyan Moghadam, Ali, Aghadoukht, Ali, Hajiasgharzadeh, Khalil, Baradaran, Behzad

“…Human epidermal growth factor receptor 2 (HER2)‐positive breast cancer (BC) comprises around 20–30% of all BC subtypes and is correlated with poor prognosis…”
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Chitosan: A compound for drug delivery system in gastric cancer-a review Autor Shafabakhsh, Rana, Yousefi, Bahman, Asemi, Zatollah, Nikfar, Banafsheh, Mansournia, Mohammad Ali, Hallajzadeh, Jamal

“…•Gastric cancer is the fourth most common and the second main cause of cancer death.•Local recurrence, hematogenous metastasis and drug resistance remains yet…”
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Targeting cancer stem cells by curcumin and clinical applications Autor Li, Yanyan, Zhang, Tao

“…Curcumin is a well-known dietary polyphenol derived from the rhizomes of turmeric, an Indian spice. The anticancer effect of curcumin has been demonstrated in…”
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Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update Autor Mao, Qingcheng, Unadkat, Jashvant D.

“…The human breast cancer resistance protein (BCRP, gene symbol ABCG2 ) is an ATP-binding cassette (ABC) efflux transporter. It was so named because it was…”
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MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1 Autor Li, Hui, Li, Chia-Wei, Li, Xiaoqiang, Ding, Qingqing, Guo, Lei, Liu, Shuang, Liu, Chunxiao, Lai, Chien-Chen, Hsu, Jung-Mao, Dong, Qiongzhu, Xia, Weiya, Hsu, Jennifer L, Yamaguchi, Hirohito, Du, Yi, Lai, Yun-Ju, Sun, Xian, Koller, Paul B, Ye, Qinghai, Hung, Mien-Chie

“…Inhibitors of MET have not produced satisfactory outcomes in trials of patients with liver cancer. We investigated the mechanisms of liver tumor resistance to…”
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Role of ion channels in gastrointestinal cancer Autor Anderson, Kyle J, Cormier, Robert T, Scott, Patricia M

“…In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell. The functions of ion…”
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Smart hydrogel: A new platform for cancer therapy Autor Guo, Li, Fu, Ziming, Li, Haoran, Wei, Ruibo, Guo, Jing, Wang, Haiwang, Qi, Jian

“…Cancer is a significant contributor to mortality worldwide, posing a significant threat to human life and health. The unique bioactivity, ability to precisely…”
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Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy Autor Motyka, Sara, Jafernik, Karolina, Ekiert, Halina, Sharifi-Rad, Javad, Calina, Daniela, Al-Omari, Basem, Szopa, Agnieszka, Cho, William C.

“…The use of plant secondary metabolites has gained considerable attention among clinicians in the prevention and treatment of cancer. A secondary metabolite…”
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Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity Autor Atkins, Charity, Liu, Qi, Minthorn, Elisabeth, Zhang, Shu-Yun, Figueroa, David J, Moss, Katherine, Stanley, Thomas B, Sanders, Brent, Goetz, Aaron, Gaul, Nathan, Choudhry, Anthony E, Alsaid, Hasan, Jucker, Beat M, Axten, Jeffrey M, Kumar, Rakesh

“…The unfolded protein response (UPR) is a signal transduction pathway that coordinates cellular adaptation to microenvironmental stresses that include hypoxia,…”
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Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients: A systematic review and meta-analysis Autor Nishijima, Tomohiro F., Muss, Hyman B., Shachar, Shlomit S., Moschos, Stergios J.

“… Little is known whether an age-related decline in immune function negatively influences antitumor response and in so doing diminishes the efficacy of ICIs in elderly subjects…”
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Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis Autor Llabani, Evijola, Hicklin, Robert W., Lee, Hyang Yeon, Motika, Stephen E., Crawford, Lisa A., Weerapana, Eranthie, Hergenrother, Paul J.

“… Herein, we subject the diterpene natural product pleuromutilin to reaction sequences focused on creating ring system diversity in few synthetic steps…”
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