Suchergebnisse - "Anglesio, Michael"

Type-Specific Cell Line Models for Type-Specific Ovarian Cancer Research von Anglesio, Michael S., Wiegand, Kimberly C., Melnyk, Nataliya, Chow, Christine, Salamanca, Clara, Prentice, Leah M., Senz, Janine, Yang, Winnie, Spillman, Monique A., Cochrane, Dawn R., Shumansky, Karey, Shah, Sohrab P., Kalloger, Steve E., Huntsman, David G.

“… OVARIAN CARCINOMAS CONSIST OF AT LEAST FIVE DISTINCT DISEASES: high-grade serous, low-grade serous, clear cell, endometrioid, and mucinous. Biomarker and …”
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Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma von Talhouk, Aline, Derocher, Heather, Schmidt, Pascal, Leung, Samuel, Milne, Katy, Gilks, C Blake, Anglesio, Michael S, Nelson, Brad H, McAlpine, Jessica N

“… Tumors with high mutation load are thought to engender stronger immune responses, which in turn promote prolonged patient survival. To investigate this, we …”
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Endometriosis-associated Ovarian Cancers von Anglesio, Michael S, Yong, Paul J

“… Endometriosis-associated cancers include clear cell and endometrioid ovarian carcinoma. A history of endometriosis has long been considered to be a risk factor …”
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Confirmation of ProMisE: A simple, genomics‐based clinical classifier for endometrial cancer von Talhouk, Aline, McConechy, Melissa K., Leung, Samuel, Yang, Winnie, Lum, Amy, Senz, Janine, Boyd, Niki, Pike, Judith, Anglesio, Michael, Kwon, Janice S., Karnezis, Anthony N., Huntsman, David G., Gilks, C. Blake, McAlpine, Jessica N.

“… BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is irreproducible and imperfectly reflects tumor biology. The authors …”
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Oncogenic mutations in histologically normal endometrium: the new normal? von Lac, Vivian, Nazeran, Tayyebeh M, Tessier‐Cloutier, Basile, Aguirre‐Hernandez, Rosalia, Albert, Arianne, Lum, Amy, Khattra, Jaswinder, Praetorius, Teresa, Mason, Madeline, Chiu, Derek, Köbel, Martin, Yong, Paul J, Gilks, Blake C, Anglesio, Michael S, Huntsman, David G

“… The advent of next generation sequencing has vastly improved the resolution of mutation detection, thereby both increasing the resolution of the analysis of …”
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Single-cell transcriptomic analysis of endometriosis von Fonseca, Marcos A. S., Haro, Marcela, Wright, Kelly N., Lin, Xianzhi, Abbasi, Forough, Sun, Jennifer, Hernandez, Lourdes, Orr, Natasha L., Hong, Jooyoon, Choi-Kuaea, Yunhee, Maluf, Horacio M., Balzer, Bonnie L., Fishburn, Aaron, Hickey, Ryan, Cass, Ilana, Goodridge, Helen S., Truong, Mireille, Wang, Yemin, Pisarska, Margareta D., Dinh, Huy Q., EL-Naggar, Amal, Huntsman, David G., Anglesio, Michael S., Goodman, Marc T., Medeiros, Fabiola, Siedhoff, Matthew, Lawrenson, Kate

“… Endometriosis is a common condition in women that causes chronic pain and infertility and is associated with an elevated risk of ovarian cancer. We profiled …”
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Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes von Wang, Yi Kan, Bashashati, Ali, Anglesio, Michael S, Cochrane, Dawn R, Grewal, Diljot S, Ha, Gavin, McPherson, Andrew, Horlings, Hugo M, Senz, Janine, Prentice, Leah M, Karnezis, Anthony N, Lai, Daniel, Aniba, Mohamed R, Zhang, Allen W, Shumansky, Karey, Siu, Celia, Wan, Adrian, McConechy, Melissa K, Li-Chang, Hector, Tone, Alicia, Provencher, Diane, de Ladurantaye, Manon, Fleury, Hubert, Okamoto, Aikou, Yanagida, Satoshi, Yanaihara, Nozomu, Saito, Misato, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Gilks, C Blake, Mes-Masson, Anne-Marie, McAlpine, Jessica N, Aparicio, Samuel, Huntsman, David G, Shah, Sohrab P

“… Sohrab Shah, David Huntsman and colleagues report the genomic analysis of 133 ovarian cancers spanning different subtypes. They identify seven subgroups using …”
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Clear cell carcinoma of the ovary: A report from the first Ovarian Clear Cell Symposium, June 24th, 2010 von Anglesio, Michael S., Carey, Mark S., Köbel, Martin, MacKay, Helen, Huntsman, David G.

“… Recent literature has highlighted histological types of ovarian carcinoma as distinct diseases, each with unique clinical and molecular features. Historically, …”
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Cell State of Origin Impacts Development of Distinct Endometriosis-Related Ovarian Carcinoma Histotypes von Beddows, Ian, Fan, Huihui, Heinze, Karolin, Johnson, Benjamin K, Leonova, Anna, Senz, Janine, Djirackor, Svetlana, Cho, Kathleen R, Pearce, Celeste Leigh, Huntsman, David G, Anglesio, Michael S, Shen, Hui

“… Clear cell ovarian carcinoma (CCOC) and endometrioid ovarian carcinoma (ENOC) are ovarian carcinoma histotypes, which are both thought to arise from ectopic …”
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Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality von Anglesio, Michael S, Wang, Yi Kan, Maassen, Madlen, Horlings, Hugo M, Bashashati, Ali, Senz, Janine, Mackenzie, Robertson, Grewal, Diljot S, Li-Chang, Hector, Karnezis, Anthony N, Sheffield, Brandon S, McConechy, Melissa K, Kommoss, Friedrich, Taran, Florin A, Staebler, Annette, Shah, Sohrab P, Wallwiener, Diethelm, Brucker, Sara, Gilks, C Blake, Kommoss, Stefan, Huntsman, David G

“… Many women with ovarian endometrioid carcinoma present with concurrent endometrial carcinoma. Organ-confined and low-grade synchronous endometrial and ovarian …”
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Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma von DeVorkin, Lindsay, Hattersley, Matthew, Kim, Paul, Ries, Jenna, Spowart, Jaeline, Anglesio, Michael S, Levi, Samuel M, Huntsman, David G, Amaravadi, Ravi K, Winkler, Jeffrey D, Tinker, Anna V, Lum, Julian J

“… Clear cell ovarian carcinoma (CCOC) is an aggressive form of epithelial ovarian cancer that exhibits low response rates to systemic therapy and poor patient …”
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Somatic Genomic Events in Endometriosis: Review of the Literature and Approach to Phenotyping von Yong, Paul J., Talhouk, Aline, Anglesio, Michael S.

“… In this review, we provide a survey and appraisal of research into somatic genomic events in endometriosis. Methodologies have evolved from conventional …”
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Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes von Bolton, Kelly L, Chen, Denise, Corona de la Fuente, Rosario, Fu, Zhuxuan, Murali, Rajmohan, Köbel, Martin, Tazi, Yanis, Cunningham, Julie M, Chan, Irenaeus C C, Wiley, Brian J, Moukarzel, Lea A, Winham, Stacey J, Armasu, Sebastian M, Lester, Jenny, Elishaev, Esther, Laslavic, Angela, Kennedy, Catherine J, Piskorz, Anna, Sekowska, Magdalena, Brand, Alison H, Chiew, Yoke-Eng, Pharoah, Paul, Elias, Kevin M, Drapkin, Ronny, Churchman, Michael, Gourley, Charlie, DeFazio, Anna, Karlan, Beth, Brenton, James D, Weigelt, Britta, Anglesio, Michael S, Huntsman, David, Gayther, Simon, Konner, Jason, Modugno, Francesmary, Lawrenson, Kate, Goode, Ellen L, Papaemmanuil, Elli

“… To identify molecular subclasses of clear cell ovarian carcinoma (CCOC) and assess their impact on clinical presentation and outcomes. We profiled 421 primary …”
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Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers von Helland, Åslaug, Anglesio, Michael S., George, Joshy, Cowin, Prue A., Johnstone, Cameron N., House, Colin M., Sheppard, Karen E., Etemadmoghadam, Dariush, Melnyk, Nataliya, Rustgi, Anil K., Phillips, Wayne A., Johnsen, Hilde, Holm, Ruth, Kristensen, Gunnar B., Birrer, Michael J., Pearson, Richard B., Børresen-Dale, Anne-Lise, Huntsman, David G., deFazio, Anna, Creighton, Chad J., Smyth, Gordon K., Bowtell, David D. L.

“… Molecular subtypes of serous ovarian cancer have been recently described. Using data from independent datasets including over 900 primary tumour samples, we …”
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Molecular analysis suggests oligoclonality and metastasis of endometriosis lesions across anatomically defined subtypes von Praetorius, Teresa H, Leonova, Anna, Lac, Vivian, Senz, Janine, Tessier-Cloutier, Basile, Nazeran, Tayyebeh M, Köbel, Martin, Grube, Marcel, Kraemer, Bernhard, Yong, Paul J, Kommoss, Stefan, Anglesio, Michael S

“… To investigate the heterogeneity of somatic cancer-driver mutations within patients and across endometriosis types. A single-center cohort, retrospective …”
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HACE1 is a potential tumor suppressor in osteosarcoma von El-Naggar, Amal M, Clarkson, Paul W., Negri, Gian Luca, Turgu, Busra, Zhang, Fan, Anglesio, Michael S., Sorensen, Poul H.

“… Osteosarcoma is a malignant bone sarcoma characterized by extensive genomic disruption and a propensity for metastatic spread. Osteoid production suggests a …”
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Molecular Classification of Epithelial Ovarian Cancer Based on Methylation Profiling: Evidence for Survival Heterogeneity von Bodelon, Clara, Killian, J Keith, Sampson, Joshua N, Anderson, William F, Matsuno, Rayna, Brinton, Louise A, Lissowska, Jolanta, Anglesio, Michael S, Bowtell, David D L, Doherty, Jennifer A, Ramus, Susan J, Talhouk, Aline, Sherman, Mark E, Wentzensen, Nicolas

“… Ovarian cancer is a heterogeneous disease that can be divided into multiple subtypes with variable etiology, pathogenesis, and prognosis. We analyzed DNA …”
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Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms von Mackenzie, Robertson, Kommoss, Stefan, Winterhoff, Boris J., Kipp, Benjamin R., Garcia, Joaquin J., Voss, Jesse, Halling, Kevin, Karnezis, Anthony, Senz, Janine, Yang, Winnie, Prigge, Elena-Sophie, Reuschenbach, Miriam, Doeberitz, Magnus Von Knebel, Gilks, Blake C., Huntsman, David G., Bakkum-Gamez, Jamie, McAlpine, Jessica N., Anglesio, Michael S.

“… Background Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major …”
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Pathogenesis of bowel endometriosis von Yong, Paul J., Bedaiwy, Mohamed A., Alotaibi, Fahad, Anglesio, Michael S.

“… The pathogenesis of bowel endometriosis is multifactorial. There is a predilection for disease of the rectum/sigmoid colon because refluxed endometrium is more …”
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Cellular origins of mucinous ovarian carcinoma von Meagher, Nicola S, Köbel, Martin, Karnezis, Anthony N, Talhouk, Aline, Anglesio, Michael S, Berchuck, Andrew, Gayther, Simon A, Pharoah, Paul PD, Webb, Penelope M, Ramus, Susan J, Gorringe, Kylie L

“… Mucinous ovarian carcinoma (MOC) is a rare histotype of epithelial ovarian cancer. Its origins are obscure: while many mucinous tumours in the ovary are …”
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