Suchergebnisse - "Anbalagan, Selvakumar"

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia von Ashton, Thomas M., Fokas, Emmanouil, Kunz-Schughart, Leoni A., Folkes, Lisa K., Anbalagan, Selvakumar, Huether, Melanie, Kelly, Catherine J., Pirovano, Giacomo, Buffa, Francesca M., Hammond, Ester M., Stratford, Michael, Muschel, Ruth J., Higgins, Geoff S., McKenna, William Gillies

“… Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that …”
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Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT von Leszczynska, Katarzyna B., Foskolou, Iosifina P., Abraham, Aswin G., Anbalagan, Selvakumar, Tellier, Céline, Haider, Syed, Span, Paul N., O’Neill, Eric E., Buffa, Francesca M., Hammond, Ester M.

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TP53 modulates radiotherapy fraction size sensitivity in normal and malignant cells von Anbalagan, Selvakumar, Ström, Cecilia, Downs, Jessica A., Jeggo, Penny A., McBay, David, Wilkins, Anna, Rothkamm, Kai, Harrington, Kevin J., Yarnold, John R., Somaiah, Navita

“… Recent clinical trials in breast and prostate cancer have established that fewer, larger daily doses (fractions) of radiotherapy are safe and effective, but …”
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Transcriptomic Profiling of the Immune Response in Orthotopic Pancreatic Tumours Exposed to Combined Boiling Histotripsy and Oncolytic Reovirus Treatment von Mouratidis, Petros, Ferreira, Ricardo C., Anbalagan, Selvakumar, Chauhan, Ritika, Rivens, Ian, ter Haar, Gail

“… Background: Boiling histotripsy (BH) uses high-amplitude, short-pulse focused ultrasound to disrupt tissue mechanically. Oncolytic virotherapy using reovirus …”
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Replication stress and chromatin context link ATM activation to a role in DNA replication von Olcina, Monica M, Foskolou, Iosifina P, Anbalagan, Selvakumar, Senra, Joana M, Pires, Isabel M, Jiang, Yanyan, Ryan, Anderson J, Hammond, Ester M

“… ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM …”
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A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells von Phadwal, Kanchan, Alegre-Abarrategui, Javier, Watson, Alexander Scarth, Pike, Luke, Anbalagan, Selvakumar, Hammond, Ester M., Wade-Martins, Richard, McMichael, Andrew, Klenerman, Paul, Simon, Anna Katharina

“… Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in …”
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Radiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity von Groselj, Blaz, Ruan, Jia-Ling, Scott, Helen, Gorrill, Jessica, Nicholson, Judith, Kelly, Jacqueline, Anbalagan, Selvakumar, Thompson, James, Stratford, Michael R L, Jevons, Sarah J, Hammond, Ester M, Scudamore, Cheryl L, Kerr, Martin, Kiltie, Anne E

“… As the population ages, more elderly patients require radiotherapy-based treatment for their pelvic malignancies, including muscle-invasive bladder cancer, as …”
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An ionising radiation-induced specific transcriptional signature of inflammation-associated genes in whole blood from radiotherapy patients: a pilot study von Cruz-Garcia, Lourdes, Badie, Christophe, Anbalagan, Selvakumar, Moquet, Jayne, Gothard, Lone, O’Brien, Grainne, Somaiah, Navita, Ainsbury, Elizabeth A.

“… Background This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to …”
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Tumour reoxygenation after intratumoural hydrogen peroxide (KORTUC) injection: a novel approach to enhance radiosensitivity von Nimalasena, Samantha, Anbalagan, Selvakumar, Box, Carol, Yu, Sheng, Boult, Jessica K. R., Bush, Nigel, Howell, Louise, Sinnett, Victoria, Murphy, William, Yarnold, John, Robinson, Simon P., Somaiah, Navita

“… Background KORTUC (0.5% hydrogen peroxide (H 2 O 2 ) in 1% sodium-hyaluronate) releases cytotoxic levels of H 2 O 2 in tissues after intratumoural injection …”
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Applicability of Scoring Calyculin A-Induced Premature Chromosome Condensation Objects for Dose Assessment Including for Radiotherapy Patients von Sun, Mingzhu, Moquet, Jayne, Lloyd, David, Barnard, Stephen, Anbalagan, Selvakumar, Steel, Harriet, Sommer, Aurore, Gothard, Lone, Somaiah, Navita, Ainsbury, Elizabeth

“… As an extension to a previous study, a linear calibration curve covering doses from 0 to 10 Gy was constructed and evaluated in the present study using …”
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Modulating Redox Biology to Improve Radiation Responses von Leung, Jacky K, Panchal, Ryan, Anbalagan, Selvakumar, Durie, Emily P, Mansfeld, Jörg, Somaiah, Navita

“… Redox biology plays an important role in cancer progression and therapy resistance. Tumor cells maintain elevated levels of reactive oxygen species to support …”
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Intratumoral Hydrogen Peroxide With Radiation Therapy in Locally Advanced Breast Cancer: Results From a Phase 1 Clinical Trial von Nimalasena, Samantha, Gothard, Lone, Anbalagan, Selvakumar, Allen, Steven, Sinnett, Victoria, Mohammed, Kabir, Kothari, Gargi, Musallam, Annette, Lucy, Claire, Yu, Sheng, Nayamundanda, Gift, Kirby, Anna, Ross, Gill, Sawyer, Elinor, Castell, Fiona, Cleator, Susan, Locke, Imogen, Tait, Diana, Westbury, Charlotte, Wolstenholme, Virginia, Box, Carol, Robinson, Simon P, Yarnold, John, Somaiah, Navita

“… Hydrogen peroxide (H O ) plays a vital role in normal cellular processes but at supraphysiological concentrations causes oxidative stress and cytotoxicity, a …”
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Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT von Leszczynska, Katarzyna B, Foskolou, Iosifina P, Abraham, Aswin G, Anbalagan, Selvakumar, Tellier, Céline, Haider, Syed, Span, Paul N, O'Neill, Eric E, Buffa, Francesca M, Hammond, Ester M

“… Restoration of hypoxia-induced apoptosis in tumors harboring p53 mutations has been proposed as a potential therapeutic strategy; however, the transcriptional …”
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Longitudinal Assessment of Tumor-Infiltrating Lymphocytes in Primary Breast Cancer Following Neoadjuvant Radiation Therapy von Yoneyama, Miki, Zormpas-Petridis, Konstantinos, Robinson, Ruth, Sobhani, Faranak, Provenzano, Elena, Steel, Harriet, Lightowlers, Sara, Towns, Catherine, Castillo, Simon P, Anbalagan, Selvakumar, Lund, Tom, Wennerberg, Erik, Melcher, Alan, Coles, Charlotte E, Roxanis, Ioannis, Yuan, Yinyin, Somaiah, Navita

“… Tumor-infiltrating lymphocytes (TILs) have prognostic significance in several cancers, including breast cancer. Despite interest in combining radiation therapy …”
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1013: Imaging and transcriptomic biomarkers of breast tumour response to radiotherapy in the KORTUC trial von Durie, Emily, Morris, Megan, Anbalagan, Selvakumar, Chauhan, Ritika, Price, Daniel, Roxanis, Ioannis, Tunariu, Nina, Sinnett, Victoria, Salehi-Bird, Seema, Healy, Nuala, Seth, Archana, Allen, Steven, Gothard, Lone, Hughes, Justine, Harrington, Kevin, Ladame, Sylvain, Mansfeld, Joerg, Tang, Meng-Xing, Blackledge, Matthew, Somaiah, Navita

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Randomised single centre double-blind placebo controlled phase II trial of Tocovid SupraBio in combination with pentoxifylline in patients suffering long-term gastrointestinal adverse effects of radiotherapy for pelvic cancer: The PPALM study von Andreyev, H. Jervoise N., Matthews, Jennifer, Adams, Carolyn, Gothard, Lone, Lucy, Claire, Tovey, Holly, Boyle, Sue, Anbalagan, Selvakumar, Musallam, Annette, Yarnold, John, Abraham, David, Bliss, Judith, Abdi, Bahja Ahmed, Taylor, Alexandra, Hauer-Jensen, Martin

“… •First human trial of gamma-tocotrienol with pentoxifylline assessing its potential to reduce radiotherapy-induced gastrointestinal damage .•Change in …”
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Longitudinal assessment of tumor-infiltrating lymphocytes in primary breast cancer following neoadjuvant radiotherapy von Yoneyama, Miki, Zormpas-Petridis, Konstantinos, Robinson, Ruth, Sobhani, Faranak, Provenzano, Elena, Steel, Harriet, Lightowlers, Sara, Towns, Catherine, Castillo, Simon P, Anbalagan, Selvakumar, Lund, Tom, Wennerberg, Erik, Melcher, Alan, Coles, Charlotte E, Roxanis, Ioannis, Yuan, Yinyin, Somaiah, Navita

“… Tumor-infiltrating lymphocytes (TILs) have prognostic significance in several cancers, including breast. Despite interest in combining radiotherapy with …”
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In Vitro Radiosensitization of Esophageal Cancer Cells with the Aminopeptidase Inhibitor CHR-2797 von Anbalagan, Selvakumar, Biasoli, Deborah, Leszczynska, Katarzyna B., Mukherjee, Somnath, Hammond, Ester M.

“… With the increased incidence of esophageal cancer, chemoradiotherapy continues to play an important role in the management of this disease. Developing potent …”
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Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1 von Leszczynska, Katarzyna B., Göttgens, Eva-Leonne, Biasoli, Deborah, Olcina, Monica M., Ient, Jonathan, Anbalagan, Selvakumar, Bernhardt, Stephan, Giaccia, Amato J., Hammond, Ester M.

“… Hypoxia-induced replication stress is one of the most physiologically relevant signals known to activate ATM in tumors. Recently, the ATM interactor (ATMIN) …”
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Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy von Anbalagan, Selvakumar, Pires, Isabel M., Blick, Christopher, Hill, Mark A., Ferguson, David J.P., Chan, Denise A., Hammond, Ester M.

“… For patients diagnosed with advanced renal cell carcinoma (RCC), there are few therapeutic options. Radiation therapy is predominantly used to treat metastasis …”
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