Search Results - "Amino acid sequence"

Nucleoporins' exclusive amino acid sequence features regulate their transient interaction with and selectivity of cargo complexes in the nuclear pore by Peyro, Mohaddeseh, Dickson, Andrew M, Mofrad, Mohammad R K

“…Nucleocytoplasmic traffic of nucleic acids and proteins across the nuclear envelop via the nuclear pore complexes (NPCs) is vital for eukaryotic cells. NPCs…”
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H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer by Yeh, Yi-Chun, Kuo, Hsin-Yu, Chang, Wei-Lun, Yang, Hsiao-Bai, Lu, Cheng-Chan, Cheng, Hsiu-Chi, Wu, Ming-Shiang, Sheu, Bor-Shyang

“…Background H. pylori CagL-Y58/E59 increase gastric cancer risk by stronger binding with integrin to faciliate type IV secretory system (T4SS). H. pylori can…”
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A novel monoclonal antibody generated by immunization with granular tau oligomers binds to tau aggregates at 423-430 amino acid sequence by Soeda, Yoshiyuki, Hayashi, Emi, Nakatani, Naoko, Ishigaki, Shinsuke, Takaichi, Yuta, Tachibana, Taro, Riku, Yuichi, Chambers, James K., Koike, Riki, Mohammad, Moniruzzaman, Takashima, Akihiko

“…Prior to the formation of amyloid fibrils, the pathological hallmark in tau-related neurodegenerative disease, tau monomers aggregate into a diverse range of…”
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Modification of amino-acid sequence of cosmetic peptide Eyeseryl enhances the affinity towards copper(II) ion by Wyrzykowski, Dariusz, Kloska, Anna, Zdrowowicz, Magdalena, Wieczorek, Robert, Makowska, Joanna

“…Results of a study on the interactions between Cu2+ ions and two tetrapeptides: a) Ac -βAHSH-OH, having cosmetic potential which is used in a preparation…”
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Navigating the amino acid sequence space between functional proteins using a deep learning framework by Bitard-Feildel, Tristan

“…Shedding light on the relationships between protein sequences and functions is a challenging task with many implications in protein evolution, diseases…”
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Autoantibody against the amino acid sequence 661–680 in apo B-100 is associated with decreased carotid stenosis and cardiovascular events by Fredrikson, Gunilla Nordin, Schiopu, Alexandru, Berglund, Göran, Alm, Ragnar, Shah, Prediman K., Nilsson, Jan

“…Immunization with malondialdehyde (MDA)-modified peptides corresponding to the amino acid sequence between 661 and 680 in apo B-100 (p45…”
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Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry by Sancho Solis, Raquel, Ge, Ying, Walker, Jeffery W

“… Two of the three subunits, cTnI and cTnT, are subject to post-translational modifications such as proteolysis and phosphorylation, but linking modification patterns to function remains a major challenge…”
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Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis by Nakatsuji, Teruaki, Chen, Tiffany H, Narala, Saisindhu, Chun, Kimberly A, Two, Aimee M, Yun, Tong, Shafiq, Faiza, Kotol, Paul F, Bouslimani, Amina, Melnik, Alexey V, Latif, Haythem, Kim, Ji-Nu, Lockhart, Alexandre, Artis, Keli, David, Gloria, Taylor, Patricia, Streib, Joanne, Dorrestein, Pieter C, Grier, Alex, Gill, Steven R, Zengler, Karsten, Hata, Tissa R, Leung, Donald Y M, Gallo, Richard L

“…) collected from the skin of healthy and AD subjects. CoNS strains with antimicrobial activity were common on the normal population but rare on AD subjects…”
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Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine-elicited human sera by Muik, Alexander, Wallisch, Ann-Kathrin, Sänger, Bianca, Swanson, Kena A, Mühl, Julia, Chen, Wei, Cai, Hui, Maurus, Daniel, Sarkar, Ritu, Türeci, Özlem, Dormitzer, Philip R, Şahin, Uğur

“…Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage called B.1.1.7 (variant of concern: VOC 202012/01), which is reported to…”
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Cutaneous amyloidoses: A minimum common denominator in their amino acid sequence by Guarneri, Fabrizio, Cannavò, Serafinella Patrizia, Benvenga, Salvatore

“…”). Once segments containing the motif were found, these were subject to multiple alignment to detect similarities and dissimilarities…”
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Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes by McGinty, John W, Chow, I-Ting, Greenbaum, Carla, Odegard, Jared, Kwok, William W, James, Eddie A

“… Our objective was to identify posttranslationally modified GAD65 peptides, which are recognized by subjects with type 1 diabetes, and to assess their disease relevance…”
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The pyruvate dehydrogenase complexes: structure-based function and regulation by Patel, Mulchand S, Nemeria, Natalia S, Furey, William, Jordan, Frank

“… The human PDC is subject to inactivation at E1 by serine phosphorylation by four kinases, an inactivation reversed by the action of two phosphatases…”
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Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy by Lim, Jae Seok, Kim, Woo-il, Kang, Hoon-Chul, Kim, Se Hoon, Park, Ah Hyung, Park, Eun Kyung, Cho, Young-Wook, Kim, Sangwoo, Kim, Ho Min, Kim, Jeong A, Kim, Junho, Rhee, Hwanseok, Kang, Seok-Gu, Kim, Heung Dong, Kim, Daesoo, Kim, Dong-Seok, Lee, Jeong Ho

“…×) validated by site-specific amplicon sequencing (100–347,499×) in paired brain-blood DNA from four subjects with FCDII and uncovered a de novo brain somatic mutation, mechanistic target of rapamycin ( MTOR) c.7280T>C (p.Leu2427Pro) in two subjects…”
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Characterization, evolution, and expression analysis of TLR7 gene subfamily members in Mastacembelus armatus (Synbranchiformes: Mastacembelidae) by Han, Chong, Li, Qiang, Liu, Jinmei, Hao, Zhiqiang, Huang, Jianrong, Zhang, Yong

“… (MaTLR7, MaTLR8 and MaTLR9). The amino acid sequence identities of MaTLR7 and MaTLR8 with Monopterus albus TLR7 were 87.2% and 76.5…”
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease by Badarinarayan, Nandini, Bis, Joshua C, Heilmann-Heimbach, Stefanie, Sleegers, Kristel, Vronskaya, Maria, White, Charles C, Hamilton-Nelson, Kara L, Choi, Seung-Hoan, Forstner, Andreas J, Bacq, Delphine, Brody, Jennifer A, Wolters, Frank J, Fornage, Myriam, Majounie, Elisa, Wallon, David, Lupton, Michelle K, Jian, Xueqiu, Mukherjee, Shubhabrata, Solfrizzi, Vincenzo, Allen, Mariet, Cupples, L Adrienne, Giegling, Ina, Giedraitis, Vilmantas, Wang, Xue, Mecocci, Patrizia, Eiriksdottir, Gudny, Chen, Yuning, Frosch, Matthew P, Huebinger, Ryan M, Morris, John, Sotolongo-Grau, Oscar, Katz, Mindy J, Braddel, Amy, Chapman, Jade, Hill, Matt, Vellas, Bruno, Soininen, Hilkka, Hughes, Joseph T, Mayhaus, Manuel, Maletta, Raffaele Giovanni, Carrell, David, Pilotto, Alberto, Fox, Nick C, Arnold, Steven E, Becker, James T, Burke, James R, Carlsson, Cynthia M, Clark, David G, Cribbs, David H, Duara, Ranjan, Evans, Denis A, Fallon, Kenneth B, Farlow, Martin R, Foroud, Tatiana M, Galasko, Douglas R, Jin, Lee-Way, Lah, James J, Levey, Allan I, Lieberman, Andrew P, McKee, Ann C, Morris, John C, Paulson, Henry L, Peskind, Elaine, Quinn, Joseph F, Raskind, Murray, Spina, Salvatore, Swerdlow, Russell H, Van Eldik, Linda J, Vinters, Harry V, Vonsattel, Jean Paul, De Deyn, Peter P, Concari, Letizia, Brice, Alexis, Dubois, Bruno, Tschanz, JoAnn, Fitzpatrick, Annette L, Kukull, Walter A, Bullido, María J, Coto, Eliecer, Reiman, Eric M, Gallo, Maura, Scarpini, Elio, Tsuang, Debby W, Bonuccelli, Ubaldo, Rubinsztein, David C, Bras, Jose, Guerreiro, Rita, Lovestone, Simon, Owen, Michael J, Cruchaga, Carlos, Powell, John, De Jager, Philip L, Rujescu, Dan, Ortega-Cubero, Sara, Ikram, M Arfan, Mayeux, Richard, Deleuze, Jean-François, Amin, Najaf, Amouyel, Philippe, van Duijn, Cornelia M

“… We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control study of 85,133 subjects…”
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Tau Kinetics in Neurons and the Human Central Nervous System by Sato, Chihiro, Barthélemy, Nicolas R, Mawuenyega, Kwasi G, Patterson, Bruce W, Gordon, Brian A, Jockel-Balsarotti, Jennifer, Sullivan, Melissa, Crisp, Matthew J, Kasten, Tom, Kirmess, Kristopher M, Kanaan, Nicholas M, Yarasheski, Kevin E, Baker-Nigh, Alaina, Benzinger, Tammie L S, Miller, Timothy M, Karch, Celeste M, Bateman, Randall J

“…We developed stable isotope labeling and mass spectrometry approaches to measure the kinetics of multiple isoforms and fragments of tau in the human central…”
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Enzymatic properties, crystallization, and deduced amino acid sequence of an alkaline endoglucanase from Bacillus circulans by Hakamada, Yoshihiro, Endo, Keiji, Takizawa, Shuichi, Kobayashi, Tohru, Shirai, Tsuyoshi, Yamane, Takashi, Ito, Susumu

“…A high-isoelectric-point (p I), alkaline endo-1,4-β-glucanase (Egl-257) of Bacillus circulans KSM-N257 was purified to homogeneity and crystallized. The…”
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Synaptic, transcriptional and chromatin genes disrupted in autism by De Rubeis, Silvia, He, Xin, Goldberg, Arthur P., Poultney, Christopher S., Samocha, Kaitlin, Ercument Cicek, A., Kou, Yan, Liu, Li, Fromer, Menachem, Walker, Susan, Singh, Tarjinder, Klei, Lambertus, Kosmicki, Jack, Fu, Shih-Chen, Aleksic, Branko, Biscaldi, Monica, Bolton, Patrick F., Brownfeld, Jessica M., Cai, Jinlu, Campbell, Nicholas G., Carracedo, Angel, Chahrour, Maria H., Chiocchetti, Andreas G., Coon, Hilary, Crawford, Emily L., Crooks, Lucy, Curran, Sarah R., Dawson, Geraldine, Duketis, Eftichia, Fernandez, Bridget A., Gallagher, Louise, Geller, Evan, Guter, Stephen J., Sean Hill, R., Ionita-Laza, Iuliana, Jimenez Gonzalez, Patricia, Kilpinen, Helena, Klauck, Sabine M., Kolevzon, Alexander, Lee, Irene, Lei, Jing, Lehtimäki, Terho, Lin, Chiao-Feng, Ma’ayan, Avi, Marshall, Christian R., McInnes, Alison L., Neale, Benjamin, Owen, Michael J., Ozaki, Norio, Parellada, Mara, Parr, Jeremy R., Purcell, Shaun, Puura, Kaija, Rajagopalan, Deepthi, Rehnström, Karola, Reichenberg, Abraham, Sabo, Aniko, Sachse, Michael, Sanders, Stephan J., Schafer, Chad, Schulte-Rüther, Martin, Skuse, David, Stevens, Christine, Szatmari, Peter, Tammimies, Kristiina, Valladares, Otto, Voran, Annette, Wang, Li-San, Weiss, Lauren A., Jeremy Willsey, A., Yu, Timothy W., Yuen, Ryan K. C., Cook, Edwin H., Freitag, Christine M., Gill, Michael, Hultman, Christina M., Lehner, Thomas, Palotie, Aarno, Schellenberg, Gerard D., Sklar, Pamela, State, Matthew W., Sutcliffe, James S., Walsh, Christopher A., Scherer, Stephen W., Zwick, Michael E., Barrett, Jeffrey C., Cutler, David J., Roeder, Kathryn, Devlin, Bernie, Daly, Mark J., Buxbaum, Joseph D.

“…% of autistic subjects. Many of the genes implicated encode proteins for synaptic formation, transcriptional regulation and chromatin-remodelling pathways…”
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SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways by Park, Jeongsoon, Chen, Yue, Tishkoff, Daniel X, Peng, Chao, Tan, Minjia, Dai, Lunzhai, Xie, Zhongyu, Zhang, Yi, Zwaans, Bernadette M M, Skinner, Mary E, Lombard, David B, Zhao, Yingming

“… The spectrum of protein substrates subject to these modifications is unknown. We report systematic profiling of the mammalian succinylome, identifying 2,565 succinylation sites on 779 proteins…”
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Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses by Joyce, M Gordon, Wheatley, Adam K, Thomas, Paul V, Chuang, Gwo-Yu, Soto, Cinque, Bailer, Robert T, Druz, Aliaksandr, Georgiev, Ivelin S, Gillespie, Rebecca A, Kanekiyo, Masaru, Kong, Wing-Pui, Leung, Kwanyee, Narpala, Sandeep N, Prabhakaran, Madhu S, Yang, Eun Sung, Zhang, Baoshan, Zhang, Yi, Asokan, Mangaiarkarasi, Boyington, Jeffrey C, Bylund, Tatsiana, Darko, Sam, Lees, Christopher R, Ransier, Amy, Shen, Chen-Hsiang, Wang, Lingshu, Whittle, James R, Wu, Xueling, Yassine, Hadi M, Santos, Celia, Matsuoka, Yumiko, Tsybovsky, Yaroslav, Baxa, Ulrich, Mullikin, James C, Subbarao, Kanta, Douek, Daniel C, Graham, Barney S, Koup, Richard A, Ledgerwood, Julie E, Roederer, Mario, Shapiro, Lawrence, Kwong, Peter D, Mascola, John R, McDermott, Adrian B

“… Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable…”
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