Výsledky vyhľadávania - "Amarasinghe, Gaya K."

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway Autor Holze, Cathleen, Michaudel, Chloé, Mackowiak, Claire, Haas, Darya A., Benda, Christian, Hubel, Philipp, Pennemann, Friederike L., Schnepf, Daniel, Wettmarshausen, Jennifer, Braun, Marianne, Leung, Daisy W., Amarasinghe, Gaya K., Perocchi, Fabiana, Staeheli, Peter, Ryffel, Bernhard, Pichlmair, Andreas

“…Reactive oxygen species (ROS) are generated by virus-infected cells; however, the physiological importance of ROS generated under these conditions is unclear…”
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Itaconate confers tolerance to late NLRP3 inflammasome activation Autor Bambouskova, Monika, Potuckova, Lucie, Paulenda, Tomas, Kerndl, Martina, Mogilenko, Denis A., Lizotte, Kate, Swain, Amanda, Hayes, Sebastian, Sheldon, Ryan D., Kim, Hyeryun, Kapadnis, Unnati, Ellis, Abigail E., Isaguirre, Christine, Burdess, Samantha, Laha, Anwesha, Amarasinghe, Gaya K., Chubukov, Victor, Roddy, Thomas P., Diamond, Michael S., Jones, Russell G., Simons, Donald M., Artyomov, Maxim N.

“…Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory…”
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An intrinsically disordered peptide from Ebola virus VP35 controls viral RNA synthesis by modulating nucleoprotein-RNA interactions Autor Leung, Daisy W., Borek, Dominika M., Luthra, Priya, Binning, Jennifer M., Anantpadma, Manu, Liu, Gai, Harvey, Ian B., Su, Zhaoming, Endlich-Frazier, Ariel, Pan, Juanli, Shabman, Reed S., Chiu, Wah, Davey, Robert, Otwinowski, Zbyszek, Basler, Christopher F., Amarasinghe, Gaya K.

“…During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an RNA template-bound form and a template-free form to provide the viral…”
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Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome Autor Luthra, Priya, Ramanan, Parameshwaran, Mire, Chad E, Weisend, Carla, Tsuda, Yoshimi, Yen, Benjamin, Liu, Gai, Leung, Daisy W, Geisbert, Thomas W, Ebihara, Hideki, Amarasinghe, Gaya K, Basler, Christopher F

“…The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces type I IFN responses to control viral replication. The cellular dsRNA…”
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Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication Autor Williams, Graham D., Townsend, Dana, Wylie, Kristine M., Kim, Preston J., Amarasinghe, Gaya K., Kutluay, Sebla B., Boon, Adrianus C. M.

“…Influenza A virus nucleoprotein (NP) association with viral RNA (vRNA) is essential for packaging, but the pattern of NP binding to vRNA is unclear. Here we…”
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The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment Autor Huang, Zhou, Liu, Hejun, Nix, Jay, Xu, Rui, Knoverek, Catherine R., Bowman, Gregory R., Amarasinghe, Gaya K., Sibley, L. David

“…Signal transducer and activator of transcription (STAT) proteins communicate from cell-surface receptors to drive transcription of immune response genes. The…”
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Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1 Autor Xu, Wei, Edwards, Megan R, Borek, Dominika M, Feagins, Alicia R, Mittal, Anuradha, Alinger, Joshua B, Berry, Kayla N, Yen, Benjamin, Hamilton, Jennifer, Brett, Tom J, Pappu, Rohit V, Leung, Daisy W, Basler, Christopher F, Amarasinghe, Gaya K

“…During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-phosphorylated STAT1 (PY-STAT1), which occurs via a subset of…”
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Biochemical and HDX Mass Spectral Characterization of the SARS-CoV-2 Nsp1 Protein Autor Mishra, Nawneet, Kant, Ravi, Leung, Daisy W, Gross, Michael L, Amarasinghe, Gaya K

“…A major challenge in defining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is to better understand virally…”
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A cryptic pocket in Ebola VP35 allosterically controls RNA binding Autor Cruz, Matthew A., Frederick, Thomas E., Mallimadugula, Upasana L., Singh, Sukrit, Vithani, Neha, Zimmerman, Maxwell I., Porter, Justin R., Moeder, Katelyn E., Amarasinghe, Gaya K., Bowman, Gregory R.

“…Protein-protein and protein-nucleic acid interactions are often considered difficult drug targets because the surfaces involved lack obvious druggable pockets…”
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Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination Autor Tomaszewski, Kelly L., Blanchard, Meagan, Olaniyi, Reuben, Brenton, Hannah R., Hayes, Samantha, Fatma, Farheen, Amarasinghe, Gaya K., Cho, Byoung-Kyu, Goo, Young Ah, DeDent, Andrea C., Fritz, Stephanie A., Wardenburg, Juliane Bubeck

“…Staphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S. aureus…”
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Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site Autor van Vliet, Vera J. E., Huynh, Nhan, Palà, Judith, Patel, Ankoor, Singer, Alex, Slater, Cole, Chung, Jacky, van Huizen, Mariska, Teyra, Joan, Miersch, Shane, Luu, Gia-Khanh, Ye, Wei, Sharma, Nitin, Ganaie, Safder S., Russell, Raquel, Chen, Chao, Maynard, Mindy, Amarasinghe, Gaya K., Mark, Brian L., Kikkert, Marjolein, Sidhu, Sachdev S.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has made it clear that combating coronavirus outbreaks benefits from a combination of…”
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Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25 Autor Kalita, Parismita, Khatavkar, Oam, Uwase, Grace, Korshunova, Yulia, Hu, Yuying, Wagner, Nicole D., Xu, Jian, Pan, Jiehong, Nix, Jay C., Gross, Michael L., Brody, Steven L., Borek, Dominika, Amarasinghe, Gaya K., Payton, Jacqueline E., Leung, Daisy W.

“…The Mediator complex facilitates interactions between transcription factors and RNA polymerase II, a process that is required for host gene transcription,…”
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Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis Autor Xu, Wei, Luthra, Priya, Wu, Chao, Batra, Jyoti, Leung, Daisy W., Basler, Christopher F., Amarasinghe, Gaya K.

“…Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays…”
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The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway Autor Edwards, Megan R., Johnson, Britney, Mire, Chad E., Xu, Wei, Shabman, Reed S., Speller, Lauren N., Leung, Daisy W., Geisbert, Thomas W., Amarasinghe, Gaya K., Basler, Christopher F.

“…Kelch-like ECH-associated protein 1 (Keap1) is a ubiquitin E3 ligase specificity factor that targets transcription factor nuclear factor (erythroid-derived…”
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SARS-CoV-2 antibody responses in children exhibit higher FcR engagement and avidity than in adults Autor Cohen, Carolyn A., Grzelak, Ludivine, Chiu, Susan S., Hui, David SC, Kwan, Mike YW, Tsang, Owen TY, Chan, Wai Hung, Yau, Yat Sun, Lee, Kelly WK, Mori, Masashi, Amarasinghe, Gaya K., Cheng, Samuel MS, Poon, Leo LM, Peiris, Malik, Valkenburg, Sophie A.

“…As intrinsic differences in humoral immune response to SARS-CoV-2 between children and adults remain unclear, we improved characterisation by defining the…”
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Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies Autor Boggs, Kerri Beth, Edmonds, Kearstin, Cifuentes-Munoz, Nicolas, El Najjar, Farah, Ossandón, Conny, Roe, McKenna, Wu, Chao, Moncman, Carole L., Creamer, Trevor P., Amarasinghe, Gaya K., Leung, Daisy W., Dutch, Rebecca Ellis

“…Human metapneumovirus (HMPV) is a leading cause of respiratory disease among children, immunocompromised individuals, and the elderly. Currently, no vaccines…”
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Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly Autor Su, Zhaoming, Wu, Chao, Shi, Liuqing, Luthra, Priya, Pintilie, Grigore D, Johnson, Britney, Porter, Justin R, Ge, Peng, Chen, Muyuan, Liu, Gai, Frederick, Thomas E, Binning, Jennifer M, Bowman, Gregory R, Zhou, Z Hong, Basler, Christopher F, Gross, Michael L, Leung, Daisy W, Chiu, Wah, Amarasinghe, Gaya K

“…Ebola virus nucleoprotein (eNP) assembles into higher-ordered structures that form the viral nucleocapsid (NC) and serve as the scaffold for viral RNA…”
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Structural basis for Marburg virus VP35-mediated immune evasion mechanisms Autor Ramanan, Parameshwaran, Edwards, Megan R, Shabman, Reed S, Leung, Daisy W, Endlich-Frazier, Ariel C, Borek, Dominika M, Otwinowski, Zbyszek, Liu, Gai, Huh, Juyoung, Basler, Christopher F, Amarasinghe, Gaya K

“…Filoviruses, marburgvirus (MARV) and ebolavirus (EBOV), are causative agents of highly lethal hemorrhagic fever in humans. MARV and EBOV share a common genome…”
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The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target Autor Wang, Wenjie, Shin, Woo-Jin, Zhang, Bojie, Choi, Younho, Yoo, Ji-Seung, Zimmerman, Maxwell I., Frederick, Thomas E., Bowman, Gregory R., Gross, Michael L., Leung, Daisy W., Jung, Jae U., Amarasinghe, Gaya K.

“…Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–30% case mortality rates and is related to the Heartland virus (HRTV)…”
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Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription Autor Ivanov, Andrey, Ramanathan, Palaniappan, Parry, Christian, Ilinykh, Philipp A., Lin, Xionghao, Petukhov, Michael, Obukhov, Yuri, Ammosova, Tatiana, Amarasinghe, Gaya K., Bukreyev, Alexander, Nekhai, Sergei

“…Ebola virus (EBOV) causes severe human disease with a high case fatality rate. The balance of evidence implies that the virus circulates in bats. The molecular…”
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