Search Results - "Altmeyer, Matthias"

Phase Separation: Linking Cellular Compartmentalization to Disease by Aguzzi, Adriano, Altmeyer, Matthias

“…Eukaryotic cells are complex structures capable of coordinating numerous biochemical reactions in space and time. Key to such coordination is the subdivision…”
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The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency by Gatti, Marco, Imhof, Ralph, Huang, Qingyao, Baudis, Michael, Altmeyer, Matthias

“…PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether specific vulnerabilities to PARPi exist beyond BRCA mutations and related…”
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Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance by Michelena, Jone, Lezaja, Aleksandra, Teloni, Federico, Schmid, Thomas, Imhof, Ralph, Altmeyer, Matthias

“…Exploiting the full potential of anti-cancer drugs necessitates a detailed understanding of their cytotoxic effects. While standard omics approaches are…”
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Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose) by Altmeyer, Matthias, Neelsen, Kai J., Teloni, Federico, Pozdnyakova, Irina, Pellegrino, Stefania, Grøfte, Merete, Rask, Maj-Britt Druedahl, Streicher, Werner, Jungmichel, Stephanie, Nielsen, Michael Lund, Lukas, Jiri

“…Intrinsically disordered proteins can phase separate from the soluble intracellular space, and tend to aggregate under pathological conditions. The…”
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Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin by Pellegrino, Stefania, Michelena, Jone, Teloni, Federico, Imhof, Ralph, Altmeyer, Matthias

“…The bivalent histone modification reader 53BP1 accumulates around DNA double-strand breaks (DSBs), where it dictates repair pathway choice decisions by…”
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RPA shields inherited DNA lesions for post-mitotic DNA synthesis by Lezaja, Aleksandra, Panagopoulos, Andreas, Wen, Yanlin, Carvalho, Edison, Imhof, Ralph, Altmeyer, Matthias

“…The paradigm that checkpoints halt cell cycle progression for genome repair has been challenged by the recent discovery of heritable DNA lesions escaping…”
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Sequential role of RAD51 paralog complexes in replication fork remodeling and restart by Berti, Matteo, Teloni, Federico, Mijic, Sofija, Ursich, Sebastian, Fuchs, Jevgenij, Palumbieri, Maria Dilia, Krietsch, Jana, Schmid, Jonas A., Garcin, Edwige B., Gon, Stéphanie, Modesti, Mauro, Altmeyer, Matthias, Lopes, Massimo

“…Homologous recombination (HR) factors were recently implicated in DNA replication fork remodeling and protection. While maintaining genome stability,…”
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ATR prohibits replication catastrophe by preventing global exhaustion of RPA by Toledo, Luis Ignacio, Altmeyer, Matthias, Rask, Maj-Britt, Lukas, Claudia, Larsen, Dorthe Helena, Povlsen, Lou Klitgaard, Bekker-Jensen, Simon, Mailand, Niels, Bartek, Jiri, Lukas, Jiri

“…ATR, activated by replication stress, protects replication forks locally and suppresses origin firing globally. Here, we show that these functions of ATR are…”
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Activation of homologous recombination in G1 preserves centromeric integrity by Yilmaz, Duygu, Furst, Audrey, Meaburn, Karen, Lezaja, Aleksandra, Wen, Yanlin, Altmeyer, Matthias, Reina-San-Martin, Bernardo, Soutoglou, Evi

“…Centromeric integrity is key for proper chromosome segregation during cell division 1 . Centromeres have unique chromatin features that are essential for…”
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Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses by Jungmichel, Stephanie, Rosenthal, Florian, Altmeyer, Matthias, Lukas, Jiri, Hottiger, Michael O, Nielsen, Michael L

“…Poly(ADP-ribos)ylation (PARylation) is a reversible posttranslational modification found in higher eukaryotes. However, little is known about PARylation…”
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A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis by Duda, Heike, Arter, Meret, Gloggnitzer, Jiradet, Teloni, Federico, Wild, Philipp, Blanco, Miguel G, Altmeyer, Matthias, Matos, Joao

“…While DNA replication and mitosis occur in a sequential manner, precisely how cells maintain their temporal separation and order remains elusive. Here, we…”
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CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks by Rother, Magdalena B., Pellegrino, Stefania, Smith, Rebecca, Gatti, Marco, Meisenberg, Cornelia, Wiegant, Wouter W., Luijsterburg, Martijn S., Imhof, Ralph, Downs, Jessica A., Vertegaal, Alfred C. O., Huet, Sébastien, Altmeyer, Matthias, van Attikum, Haico

“…Chromatin structure is dynamically reorganized at multiple levels in response to DNA double-strand breaks (DSBs). Yet, how the different steps of chromatin…”
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A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells by Ahuja, Akshay K., Jodkowska, Karolina, Teloni, Federico, Bizard, Anna H., Zellweger, Ralph, Herrador, Raquel, Ortega, Sagrario, Hickson, Ian D., Altmeyer, Matthias, Mendez, Juan, Lopes, Massimo

“…Embryonic stem cells (ESCs) represent a transient biological state, where pluripotency is coupled with fast proliferation. ESCs display a constitutively active…”
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Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding by Asher, Gad, Reinke, Hans, Altmeyer, Matthias, Gutierrez-Arcelus, Maria, Hottiger, Michael O, Schibler, Ueli

“…Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are readily entrained by feeding-fasting cycles. However, the molecular…”
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Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling by Galarreta, Antonio, Pasti, Virginia, Vornberger, Julia, Imhof, Ralph, Oppikofer, Mariano, Altmeyer, Matthias

“…Tumor suppressor p53 has inherent propensities to self-associate, which can lead to oncogenic p53 aggregation. The genome caretaker 53BP1 interacts with p53,…”
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TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes by Gudjonsson, Thorkell, Altmeyer, Matthias, Savic, Velibor, Toledo, Luis, Dinant, Christoffel, Grøfte, Merete, Bartkova, Jirina, Poulsen, Maria, Oka, Yasuyoshi, Bekker-Jensen, Simon, Mailand, Niels, Neumann, Beate, Heriche, Jean-Karim, Shearer, Robert, Saunders, Darren, Bartek, Jiri, Lukas, Jiri, Lukas, Claudia

“…Histone ubiquitylation is a prominent response to DNA double-strand breaks (DSBs), but how these modifications are confined to DNA lesions is not understood…”
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Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites by Altmeyer, Matthias, Messner, Simon, Hassa, Paul O, Fey, Monika, Hottiger, Michael O

“…Poly(ADP-ribose) polymerase 1 (PARP1) synthesizes poly(ADP-ribose) (PAR) using nicotinamide adenine dinucleotide (NAD) as a substrate. Despite intensive…”
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Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells by Groelly, Florian J, Dagg, Rebecca A, Petropoulos, Michalis, Rossetti, Giacomo G, Prasad, Birbal, Panagopoulos, Andreas, Paulsen, Teressa, Karamichali, Angeliki, Jones, Samuel E, Ochs, Fena, Dionellis, Vasilis S, Puig Lombardi, Emilia, Miossec, Matthieu J, Lockstone, Helen, Legube, Gaëlle, Blackford, Andrew N, Altmeyer, Matthias, Halazonetis, Thanos D, Tarsounas, Madalena

“…Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis…”
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Addicted to PAR?: A closer look at PARP inhibitor sensitivity by Altmeyer, Matthias

“…Comment on: Oplustilova L, et al. Cell Cycle 2012; 11:3837-50…”
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Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress by Pellegrino, Stefania, Altmeyer, Matthias

“…Cells employ a complex network of molecular pathways to cope with endogenous and exogenous genotoxic stress. This multilayered response ensures that genomic…”
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