Suchergebnisse - "Alleles"

HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy von Kanchan, Kanika, Grinek, Stepan, Bahnson, Henry T., Ruczinski, Ingo, Shankar, Gautam, Larson, David, Du Toit, George, Barnes, Kathleen C., Sampson, Hugh A., Suarez-Farinas, Mayte, Lack, Gideon, Nepom, Gerald T., Cerosaletti, Karen, Mathias, Rasika A.

“… We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted …”
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Identification of Subject-Specific Immunoglobulin Alleles From Expressed Repertoire Sequencing Data von Gadala-Maria, Daniel, Gidoni, Moriah, Marquez, Susanna, Vander Heiden, Jason A., Kos, Justin T., Watson, Corey T., O'Connor, Kevin C., Yaari, Gur, Kleinstein, Steven H.

“… We previously presented TIgGER, a computational method to identify subject-specific V gene genotypes, including the presence of novel V gene alleles, directly from AIRR-seq data …”
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PASTRY: achieving balanced power for detecting risk and protective minor alleles in meta-analysis of association studies with overlapping subjects von Kim, Emma E., Jang, Chloe Soohyun, Kim, Hakin, Han, Buhm

“… This can lead to unbalanced power for detecting protective minor alleles and risk minor alleles …”
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Effects of CYP2C93 and 13 alleles on the pharmacokinetics and pharmacodynamics of glipizide in healthy Korean subjects von Kim, Nam-Tae, Cho, Chang‑Keun, Kang, Pureum, Park, Hye-Jung, Lee, Yun Jeong, Bae, Jung‑Woo, Jang, Choon-Gon, Lee, Seok-Yong

“… In this study, we investigated the effects of CYP2C9*3 and *13 variant alleles on the pharmacokinetics and pharmacodynamics of glipizide …”
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HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy von Kanchan, Kanika, Grinek, Stepan, Bahnson, Henry T, Ruczinski, Ingo, Shankar, Gautam, Larson, David, Toit, George Du, Barnes, Kathleen C, Sampson, Hugh A, Suarez-Farinas, Mayte, Lack, Gideon, Nepom, Gerald T, Cerosaletti, Karen, Mathias, Rasika A

“… We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted …”
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The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum von Mahjani, Behrang, Klei, Lambertus, Mattheisen, Manuel, Halvorsen, Matthew W, Reichenberg, Abraham, Roeder, Kathryn, Pedersen, Nancy L, Boberg, Julia, de Schipper, Elles, Bulik, Cynthia M, Landén, Mikael, Fundín, Bengt, Mataix-Cols, David, Sandin, Sven, Hultman, Christina M, Crowley, James J, Buxbaum, Joseph D, Rück, Christian, Devlin, Bernie, Grice, Dorothy E

“… Obsessive-compulsive disorder (OCD) is known to be substantially heritable; however, the contribution of genetic variation across the allele frequency spectrum to this heritability remains uncertain …”
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Functional Genomics of Attention-Deficit/Hyperactivity Disorder (ADHD) Risk Alleles on Dopamine Transporter Binding in ADHD and Healthy Control Subjects von Spencer, Thomas J., Biederman, Joseph, Faraone, Stephen V., Madras, Bertha K., Bonab, Ali A., Dougherty, Darin D., Batchelder, Holly, Clarke, Allison, Fischman, Alan J.

“… ) polymorphisms of the DAT (SLC6A3) gene. Subjects consisted of 68 psychotropic (including stimulant)-naïve and smoking-naïve volunteers between 18 and 55 years of age …”
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Effect of HMGCR Variant Alleles on Low-Density Lipoprotein Cholesterol-Lowering Response to Atorvastatin in Healthy Korean Subjects von Chung, Jae Yong, Cho, Sung Kweon, Oh, Eun Sil, Lee, Dong Hwan, Lim, Lay Ahyoung, Jang, Seong Bok, Lee, Yoon Jung, Park, Kyungsoo, Park, Min Soo

“… The investigators quantified the relationship between the genetic polymorphism of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) and the low-density …”
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Statistical Validation of Risk Alleles in Genetic Addiction Risk Severity (GARS) Test: Early Identification of Risk for Alcohol Use Disorder (AUD) in 74,566 Case–Control Subjects von Blum, Kenneth, Han, David, Gupta, Ashim, Baron, David, Braverman, Eric R., Dennen, Catherine A., Kazmi, Shan, Llanos-Gomez, Luis, Badgaiyan, Rajendra D., Elman, Igor, Thanos, Panayotis K., Downs, Bill W., Bagchi, Debasis, Gondre-Lewis, Marjorie C., Gold, Mark S., Bowirrat, Abdalla

“… Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and severe alcoholism in JAMA, there has been an explosion of genetic candidate association studies, including GWAS …”
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Molecular characterization and clinical presentation of HKαα and anti-HKαα alleles in southern Chinese subjects von Shang, X, Li, Q, Cai, R, Huang, J, Wei, X, Xu, X

“… The HKαα allele is a rearrangement occurring in the α‐globin gene cluster containing both the ‐α3.7 and ααα …”
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Identification of recurrent pathogenic alleles using exome sequencing data: Proof-of-concept study of Russian subjects von Orlov, Igor E., Laidus, Tatiana A., Tumakova, Anastasia V., Yanus, Grigoriy A., Iyevleva, Aglaya G., Sokolenko, Anna P., Bizin, Ilya V., Imyanitov, Evgeny N., Suspitsin, Evgeny N.

“… Within this proof-of-concept study we evaluated whether analysis of a small number of individual exomes is capable of identifying recurrent pathogenic alleles …”
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Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study von Hafler, David A, Compston, Alastair, Sawcer, Stephen, Lander, Eric S, Daly, Mark J, De Jager, Philip L, de Bakker, Paul I W, Gabriel, Stacey B, Mirel, Daniel B, Ivinson, Adrian J, Pericak-Vance, Margaret A, Gregory, Simon G, Rioux, John D, McCauley, Jacob L, Haines, Jonathan L, Barcellos, Lisa F, Cree, Bruce, Oksenberg, Jorge R, Hauser, Stephen L

“… : a gene in the HLA region and alleles of IL2RA and IL7RA . Both IL2RA and IL7RA have been implicated in other autoimmune diseases …”
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Molecular Identification, Subtypes Distribution, and Alleles Discrimination of Blastocystis sp., Isolated from Immunocompromised Subjects in Iran von Mohammad Rahimi, Hanieh, Karamati, Seyed Ahmad, Nemati, Sara, Mirjalali, Hamed, Zali, Mohammad Reza

“… The current study aimed to evaluate the subtype and alleles distribution of Blastocystis sp …”
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Population genetic testing and SERPINA1 sequencing identifies unidentified alpha-1 antitrypsin deficiency alleles and gene-environment interaction with hepatitis C infection von Schuler, Bryce A., Bastarache, Lisa, Wang, Janey, He, Jing, Van Driest, Sara L., Denny, Joshua C.

“… We performed a retrospective cohort study in a deidentified Electronic Health Record (EHR)-linked DNA biobank with 72,027 individuals genotyped for the M, Z, and S alleles in SERPINA1 …”
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HLA Alleles Associated With Risk of Ankylosing Spondylitis and Rheumatoid Arthritis Influence the Gut Microbiome von Asquith, Mark, Sternes, Peter R., Costello, Mary‐Ellen, Karstens, Lisa, Diamond, Sarah, Martin, Tammy M., Li, Zhixiu, Marshall, Mhairi S., Spector, Timothy D., Cao, Kim‐Anh, Rosenbaum, James T., Brown, Matthew A.

“… Objective HLA alleles affect susceptibility to more than 100 diseases, but the mechanisms that account for these genotype …”
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Discovering lethal alleles across the turkey genome using a transmission ratio distortion approach von Abdalla, E. A., Id‐Lahoucine, S., Cánovas, A., Casellas, J., Schenkel, F. S., Wood, B. J., Baes, C. F.

“… In contrast, the allelic model uncovered 12 haplotype alleles with the allelic …”
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LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry von Katsumata, Yuriko, Fardo, David W, Shade, Lincoln M P, Nelson, Peter T

“… The allele frequencies of the LATE-associated alleles were significantly different between persons of primarily African (versus European) ancestry …”
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Polymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects von Assone, Tatiane, Malta, Fernanda M., Bakkour, Sonia, Montalvo, Leilani, Paiva, Arthur M., Smid, Jerusa, de Oliveira, Augusto César Penalva, de Toledo Gonçalves, Fernanda, do Carmo Luiz, Olinda, Fonseca, Luiz Augusto M., Norris, Philip J., Casseb, Jorge

“… 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases “Emilio Ribas” (IIER …”
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Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB115 alleles von Saper, Vivian E, Ombrello, Michael J, Tremoulet, Adriana H, Montero-Martin, Gonzalo, Prahalad, Sampath, Canna, Scott, Shimizu, Chisato, Deutsch, Gail, Tan, Serena Y, Remmers, Elaine F, Monos, Dimitri, Hahn, Timothy, Phadke, Omkar K, Cassidy, Elaine, Ferguson, Ian, Mallajosyula, Vamsee, Xu, Jianpeng, Rosa Duque, Jaime S, Chua, Gilbert T, Ghosh, Debopam, Szymanski, Ann Marie, Rubin, Danielle, Burns, Jane C, Tian, Lu, Fernandez-Vina, Marcelo A, Mellins, Elizabeth D, Hollenbach, Jill A, Aziz, Rabheh Abdul, Berard, Roberta, Bingham, Catherine A, Bonaparth, Alexis D, Casey, Alicia, Collins, Kathleen P, Cidon, Michal, Goodman, Steven I, Grom, Alexei A, Hazen, Melissa, Hoftman, Alice, Ibarra, Maria, Jerath, Rita, Kingsbury, Daniel J, Klein-Gitelman, Marisa S, Lai, Khanh, Lapidus, Sivia, Mendoza-Londono, Roberto, Onel, Karen, Perez, Maria, Radhakrishna, Suhas M, Reinhardt, Adam, Riskalla, Mona, Roth, Johannes, Rosenwasser, Natalie, Saad, Nadine, Schulert, Grant S, Shenoi, Susan, Smith, Judith A, Soep, Jennifer, Stingl, Cory, Stoll, Matthew L, Tesher, Melissa, Whitehead, Benjamin, Zemel, Lawrence, Anton, Jordi, Bohnsack, John F, Cobb, Joanna, Demirkaya, Erkan, Foell, Dirk, Gattorno, Marco, Grom, Alexei, Hilario, Maria Odete, Ilowite, Norman T, Haas, Johannes-Peter, Hinks, Anne, Kastner, Daniel L, Langfeld, Carl D, Martini, Alberto, Mellins, Elizabeth D, Minden, Kirsten, Oliveira, Sheila, Ombrello, Michael J, Özen, Seza, Prahalad, Sampath, Rosen-Wolff, Angela, Rosenberg, Alan, Russo, Ricardo, Signa, Sara, Tachmazidou, Ioanna, Tenbrock, Klaus, Thompson, Susan, Thomson, Wendy, Wedderburn, Lucy R, Woo, Patricia, Yeung, Rae S M, Zeft, Andrew S, Len, Claudio

“… ) alleles for association to inhibitor-related DHR, including in a small Kawasaki disease (KD …”
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Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals von Ozarda, Yesim, Sucu, Derya Kaynak, Hizli, Banu, Aslan, Diler

“… In homozygote subjects for MTHFR 677C‐>T serum folate concentration was lower and serum tHcy concentration was higher than those in …”
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