Suchergebnisse - "Alffenaar, Jan Willem"

From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics von Wicha, Sebastian G., Märtson, Anne‐Grete, Nielsen, Elisabet I., Koch, Birgit C.P., Friberg, Lena E., Alffenaar, Jan‐Willem, Minichmayr, Iris K.

“… Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have evolved as important tools to inform rational dosing of antibiotics in …”
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Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper von Abdul-Aziz, Mohd H., Alffenaar, Jan-Willem C., Bassetti, Matteo, Bracht, Hendrik, Dimopoulos, George, Marriott, Deborah, Neely, Michael N., Paiva, Jose-Artur, Pea, Federico, Sjovall, Fredrik, Timsit, Jean F., Udy, Andrew A., Wicha, Sebastian G., Zeitlinger, Markus, De Waele, Jan J., Roberts, Jason A.

“… This Position Paper aims to review and discuss the available data on therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in …”
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Bedaquiline Resistance: Its Emergence, Mechanism, and Prevention von Nguyen, Thi Van Anh, Anthony, Richard M, Bañuls, Anne-Laure, Nguyen, Thi Van Anh, Vu, Dinh Hoa, Alffenaar, Jan-Willem C

“… Bedaquiline, a new antituberculosis drug, has already been used in >50 countries. The emergence of bedaquiline resistance is alarming, as it may result in the …”
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Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Development and Validation of Dried Blood Spot-Based Methods for Therapeutic Drug Monitoring von Capiau, Sara, Veenhof, Herman, Koster, Remco A, Bergqvist, Yngve, Boettcher, Michael, Halmingh, Otto, Keevil, Brian G, Koch, Birgit C P, Linden, Rafael, Pistos, Constantinos, Stolk, Leo M, Touw, Daan J, Stove, Christophe P, Alffenaar, Jan-Willem C

“… Dried blood spot (DBS) analysis has been introduced more and more into clinical practice to facilitate Therapeutic Drug Monitoring (TDM). To assure the quality …”
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Alternative Sampling Devices to Collect Dried Blood Microsamples: State-of-the-Art von Delahaye, Lisa, Veenhof, Herman, Koch, Birgit C P, Alffenaar, Jan-Willem C, Linden, Rafael, Stove, Christophe

“… Dried blood spots (DBS) have been used in newborn screening programs for several years. More recently, there has been growing interest in using DBS as a home …”
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Consensus guidelines for optimising antifungal drug delivery and monitoring to avoid toxicity and improve outcomes in patients with haematological malignancy and haemopoietic stem cell transplant recipients, 2021 von Chau, Maggie M., Daveson, Kathryn, Alffenaar, Jan‐Willem C., Gwee, Amanda, Ho, Su Ann, Marriott, Deborah J. E., Trubiano, Jason A., Zhao, Jessie, Roberts, Jason A.

“… Antifungal agents can have complex dosing and the potential for drug interaction, both of which can lead to subtherapeutic antifungal drug concentrations and …”
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Barriers and strategies to successful tuberculosis treatment in a high-burden tuberculosis setting: a qualitative study from the patient’s perspective von Pradipta, Ivan S., Idrus, Lusiana R., Probandari, Ari, Lestari, Bony W., Diantini, Ajeng, Alffenaar, Jan-Willem C., Hak, Eelko

“… Background Previously treated tuberculosis (TB) patients are a widely reported risk factor for multidrug-resistant tuberculosis. Identifying patients’ problems …”
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Pharmacokinetic/Pharmacodynamic Background and Methods and Scientific Evidence Base for Dosing of Second-line Tuberculosis Drugs von Gumbo, Tawanda, Alffenaar, Jan-Willem C

“… A World Health Organization workshop systematically examined the evidence base for dosing second-line tuberculosis drugs, identifying knowledge gaps. To fill …”
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New Approaches and Therapeutic Options for Mycobacterium tuberculosis in a Dormant State von Caño-Muñiz, Santiago, Anthony, Richard, Niemann, Stefan, Alffenaar, Jan-Willem C

“… We are far away from the days when tuberculosis (TB) accounted for 1 in 4 deaths during the 19th century. However, complex (MTBC) strains are still the leading …”
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The association between the NAT2 genetic polymorphisms and risk of DILI during anti‐TB treatment: a systematic review and meta‐analysis von Zhang, Min, Wang, Shuqiang, Wilffert, Bob, Tong, Rongsheng, Soolingen, Dick, Hof, Susan, Alffenaar, Jan‐Willem

“… Aims The aim of this study is to evaluate the potential association between N‐acetyltransferase type 2 (NAT2) polymorphisms and drug‐induced liver injury …”
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A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings von Kandimahforoujaki, Marjan, Patanwala, Kiplin A., Alffenaar, Jan‐Willem C., Patanwala, Asad E.

“… Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying …”
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Factors influencing physicians’ antimicrobial prescribing decisions: A systematic review of qualitative studies von Reali, Savannah, Kwang, Yee Chin, Cho, Jin‐Gun, Alffenaar, Jan‐Willem, Aslani, Parisa

“… Inappropriate and overuse of antimicrobials is increasing antimicrobial resistance. Understanding physicians' antimicrobial decision‐making is essential for …”
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Comment on “Population Pharmacokinetics of Total and Unbound Isavuconazole in Critically Ill Patients: Implications for Adaptive Dosing Strategies” and “High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints” von Kong, Leping, Alffenaar, Jan-Willem C., Stocker, Sophie L.

“… Currently, there is no evidence that unbound isavuconazole concentrations are a better predictor of treatment response than total concentrations. [...]clinical …”
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Delamanid Resistance: Update and Clinical Management von Nguyen, Thi Van Anh, Anthony, Richard M, Cao, Thi Thu Huyen, Bañuls, Anne-Laure, Nguyen, Van Anh Thi, Vu, Dinh Hoa, Nguyen, Nhung Viet, Alffenaar, Jan-Willem C

“… Delamanid, a-first-in-class bicyclic nitroimidazole, was recently approved for multidrug-resistant tuberculosis treatment. Pitted against the hope for …”
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Voriconazole metabolism is influenced by severe inflammation: a prospective study von Veringa, Anette, Ter Avest, Mendy, Span, Lambert F R, van den Heuvel, Edwin R, Touw, Daan J, Zijlstra, Jan G, Kosterink, Jos G W, van der Werf, Tjip S, Alffenaar, Jan-Willem C

“… During an infection or inflammation, several drug-metabolizing enzymes in the liver are down-regulated, including cytochrome P450 iso-enzymes. Since …”
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Fast LC-MS/MS analysis of tacrolimus, sirolimus, everolimus and cyclosporin A in dried blood spots and the influence of the hematocrit and immunosuppressant concentration on recovery von Koster, Remco A., Alffenaar, Jan-Willem C., Greijdanus, Ben, Uges, Donald R.A.

“… We developed a method for the analysis of four immunosuppressants in dried blood spot (DBS) samples to facilitate therapeutic drug monitoring for transplant …”
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Saliva-based point-of-care assay to measure the concentration of pyrazinamide using a mobile UV spectrophotometer von Chen, Ricky Hao, Nguyen, Thi Anh, Kim, Hannah Yejin, Stocker, Sophie L, Alffenaar, Jan-Willem C

“… Pyrazinamide, one of the first-line antituberculosis drugs, displays variability in drug exposure that is associated with treatment response. A simple, …”
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Linezolid-based Regimens for Multidrug-resistant Tuberculosis (TB): A Systematic Review to Establish or Revise the Current Recommended Dose for TB Treatment von Bolhuis, Mathieu S, Akkerman, Onno W, Sturkenboom, Marieke G G, Ghimire, Samiksha, Srivastava, Shashikant, Gumbo, Tawanda, Alffenaar, Jan-Willem C

“… Linezolid has been successfully used for treatment of multidrug-resistant tuberculosis (MDR-TB). However, dose- and duration-related toxicity limit its use …”
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Therapeutic Drug Monitoring of Ganciclovir: Where Are We? von Märtson, Anne-Grete, Edwina, Angela E, Kim, Hannah Yejin, Knoester, Marjolein, Touw, Daan J, Sturkenboom, Marieke G G, Alffenaar, Jan-Willem C

“… Ganciclovir is the mainstay of therapy for the prophylaxis and treatment of Cytomegalovirus. However, therapy with this antiviral agent is hindered by side …”
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Tuberculosis impacts multiple aspects in quality of life in a Romanian cohort of drug‐susceptible and drug resistant patients: A patient‐reported outcome measures study von Margineanu, Ioana, Butnaru, Teodora, Lam, Marjolein, Baiceanu, Dragos, Dragomir, Raluca, Arbore, Adriana Sorete, Mahler, Beatrice, Munteanu, Ioana, Mihaltan, Florin, Akkerman, Onno, Alffenaar, Jan‐Willem, Stienstra, Ymkje

“… Background Tuberculosis (TB), and especially its drug resistant forms, is responsible for not only significant mortality, but also considerable morbidity, …”
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