Suchergebnisse - "Albiston, L."

Different cross-presentation pathways in steady-state and inflammatory dendritic cells von Segura, Elodie, Albiston, Anthony L, Wicks, Ian P, Chai, Siew Yeen, Villadangos, José A

“… Presentation of exogenous antigens on MHC class I molecules, termed cross-presentation, is essential for the induction of CD8 T-cell responses and is carried …”
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Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase von Albiston, A L, McDowall, S G, Matsacos, D, Sim, P, Clune, E, Mustafa, T, Lee, J, Mendelsohn, F A, Simpson, R J, Connolly, L M, Chai, S Y

“… Central infusion of angiotensin IV or its more stable analogues facilitates memory retention and retrieval in normal animals and reverses amnesia induced by …”
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Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase von Albiston, Anthony L, Morton, Craig J, Ng, Hooi Ling, Pham, Vi, Yeatman, Holly R, Ye, Siying, Fernando, Ruani N, De Bundel, Dimitri, Ascher, David B, Mendelsohn, Frederick A O, Parker, Michael W, Chai, Siew Yeen

“… Approximately one-quarter of people over the age of 65 are estimated to suffer some form of cognitive impairment, underscoring the need for effective …”
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Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP) von Lew, Rebecca A., Mustafa, Tomris, Ye, Siying, McDowall, Sharon G., Chai, Siew Yeen, Albiston, Anthony L.

“… Angiotensin IV (Ang IV) exerts profound effects on memory and learning, a phenomenon ascribed to its binding to a specific AT4 receptor. However the AT4 …”
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Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent von Yang, Rui, Smolders, Ilse, Vanderheyden, Patrick, Demaegdt, Heidi, Van Eeckhaut, Ann, Vauquelin, Georges, Lukaszuk, Aneta, Tourwé, Dirk, Chai, Siew Yeen, Albiston, Anthony L, Nahmias, Clara, Walther, Thomas, Dupont, Alain G

“… Recently, a new derivative of angiotensin (Ang) II, called "Ang A," has been discovered to be present in plasma of healthy humans and, in increased …”
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Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase von Albiston, Anthony L, Pham, Vi, Ye, Siying, Ng, Leelee, Lew, Rebecca A, Thompson, Philip E, Holien, Jessica K, Morton, Craig J, Parker, Michael W, Chai, Siew Yeen

“… Inhibitors of insulin-regulated aminopeptidase (IRAP) improve memory and are being developed as a novel treatment for memory loss. In this study, the binding …”
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Angiotensin IV and LVV-haemorphin 7 enhance spatial working memory in rats: Effects on hippocampal glucose levels and blood flow von De Bundel, Dimitri, Smolders, Ilse, Yang, Rui, Albiston, Anthony L., Michotte, Yvette, Chai, Siew Yeen

“… The IRAP ligands Angiotensin IV (Ang IV) and LVV-haemorphin 7 (LVV-H7) enhance performance in a range of memory paradigms in normal rats and ameliorate memory …”
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Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney von Albiston, Anthony L., Yeatman, Holly R., Pham, Vi, Fuller, Stephanie J., Diwakarla, Shanti, Fernando, Ruani N., Chai, Siew Yeen

“… The physiological importance of the insulin responsive glucose transporter GLUT4 in adipocytes and muscle in maintaining glucose homeostasis is well …”
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Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system von Fernando, Ruani N., Larm, Jari, Albiston, Anthony L., Chai, Siew Yeen

“… Central infusions of angiotensin IV enhance spatial learning, memory retention and retrieval, neurotransmitter release, and long‐term potentiation via …”
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Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice von Pham, Vi, Burns, Peta, Albiston, Anthony L., Yeatman, Holly R., Ng, Leelee, Diwakarla, Shanti, Chai, Siew Yeen

“… During human pregnancy, a circulating form of insulin-regulated aminopeptidase (IRAP EC 3.4.11.3), often termed oxytocinase or placental leucine aminopeptidase …”
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A circadian transcriptional subnetwork and EARLY FLOWERING 3 control timing of senescence and grain nutrition in bread wheat von Buckley, Christopher R., Boyte, Joshua M., Liu, Yalin, Albiston, Robert L., Hyles, Jessica, Beasley, Jesse T., Johnson, Alexander A.T., Trevaskis, Ben, Fournier‐Level, Alexandre, Haydon, Michael J.

“… Summary Circadian clocks control daily and seasonal timing of physiology and development. Because of their influence on photoperiodic flowering, variants in …”
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Structure-activity study of LVV-hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase von Lee, Joohyung, Mustafa, Tomris, McDowall, Sharon G, Mendelsohn, Frederick A O, Brennan, Michelle, Lew, Rebecca A, Albiston, Anthony L, Chai, Siew Yeen

“… The decapeptide LVV-hemorphin-7 binds with high affinity to the angiotensin IV (Ang IV) receptor (AT(4) receptor), eliciting a number of physiological effects, …”
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Cannula implantation into the lateral ventricle does not adversely affect recognition or spatial working memory von Seyer, Benjamin, Pham, Vi, Albiston, Anthony L., Chai, Siew Yeen

“… •Previous work suggests cranial cannulation can impair memory.•Here we demonstrate that cannulation into the ventricle does not impair recognition or spatial …”
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Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse von Burns, Peta, Bowditch, Joshua, McFadyen, James, Loiacono, Richard, Albiston, Anthony L., Pham, Vi, Chai, Siew Yeen

“… •Male, not female, insulin-regulated aminopeptidase (IRAP) knockout mice showed greater interaction with a stranger mouse compared to wildtype.•A decrease in …”
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AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement von Albiston, Anthony L, Mustafa, Tomris, McDowall, Sharon G, Mendelsohn, Frederick A.O, Lee, Joohyung, Chai, Siew Yeen

“… Although angiotensin IV (Ang IV) was thought initially to be an inactive product of Ang II degradation, it was subsequently shown that the hexapeptide markedly …”
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Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats von Albiston, Anthony L, Cacador, Mauricio, Sinnayah, Puspha, Burns, Peta, Chai, Siew Yeen

“… Insulin-regulated aminopeptidase (IRAP) co-localizes with the glucose transporter 4 (GLUT4) in GLUT4 storage vesicles (GSV) in insulin-responsive cells. In …”
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The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus - potential role in modulation of glucose uptake in neurones? von Fernando, Ruani N., Albiston, Anthony L., Chai, Siew Y.

“… It is proposed that insulin‐regulated aminopeptidase (IRAP) is the site of action of two peptides, angiotensin IV and LVV‐hemorphin 7, which have facilitatory …”
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Synthesis, Structure-Activity Relationships and Brain Uptake of a Novel Series of Benzopyran Inhibitors of Insulin-Regulated Aminopeptidase von Mountford, Simon J., Albiston, Anthony L., Charman, William N., Ng, Leelee, Holien, Jessica K., Parker, Michael W., Nicolazzo, Joseph A., Thompson, Philip E., Chai, Siew Yeen

“… Peptide inhibitors of insulin-regulated aminopeptidase (IRAP) enhance fear avoidance and spatial memory and accelerate spatial learning in a number of memory …”
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Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory von Yeatman, Holly R., Albiston, Anthony L., Burns, Peta, Chai, Siew Yeen

“… Central infusion of Insulin-Regulated Aminopeptidase (IRAP) inhibitors improves memory in both normal rodents and in models of memory deficit. However, in …”
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Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigms von Albiston, Anthony L, Pederson, Eric S, Burns, Peta, Purcell, Brett, Wright, John W, Harding, Joseph W, Mendelsohn, Frederick A, Weisinger, Richard S, Chai, Siew Yeen

“… Central administration of angiotensin IV (Ang IV) analogues attenuates scopolamine-induced amnesia. Ang IV mediates its effects by binding to a high affinity, …”
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