Výsledky vyhľadávania - "Adult"

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease Autor Moreno-Jiménez, Elena P, Flor-García, Miguel, Terreros-Roncal, Julia, Rábano, Alberto, Cafini, Fabio, Pallas-Bazarra, Noemí, Ávila, Jesús, Llorens-Martín, María

“…The hippocampus is one of the most affected areas in Alzheimer's disease (AD) . Moreover, this structure hosts one of the most unique phenomena of the adult mammalian brain, namely, the addition of new neurons throughout life…”
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Acid‐inhibitory effects of vonoprazan 20 mg compared with esomeprazole 20 mg or rabeprazole 10 mg in healthy adult male subjects ‐ a randomised open‐label cross‐over study Autor Sakurai, Y., Mori, Y., Okamoto, H., Nishimura, A., Komura, E., Araki, T., Shiramoto, M.

“…‐inhibitory effects of vonoprazan vs. two control PPIs, esomeprazole and rabeprazole, in 20 healthy Japanese adult male volunteers with CYP2C19 extensive metaboliser genotype…”
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Severe Osteoporosis in an Adult Subject with RNU4-2 Gene Mutation: Severe Osteoporosis in an Adult Subject with RNU4-2 Gene Mutation Autor Peñafiel-Sam, Joshua, Valenzuela, Irene, Peris, Pilar

“… We present an adult patient with a pathogenic variant in the RNU4-2 gene associated with the presence of severe osteoporosis…”
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Single‐subject cortical morphological brain networks across the adult lifespan Autor Ruan, Jingxuan, Wang, Ningkai, Li, Junle, Wang, Jing, Zou, Qihong, Lv, Yating, Zhang, Han, Wang, Jinhui

“… In this study, we performed a comprehensive analysis of the topological changes in single‐subject morphological brain networks across the adult lifespan…”
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Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects Autor Griffith, David C, Loutit, Jeffery S, Morgan, Elizabeth E, Durso, Stephanie, Dudley, Michael N

“…-lactams, including carbapenems. The pharmacokinetics and safety of vaborbactam were evaluated in 80 healthy adult subjects in a first-in-human randomized, placebo-controlled, double-blind, sequential single- and multiple-ascending-dose study…”
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Determinants of personal exposure to fine particulate matter (PM2.5) in adult subjects in Hong Kong Autor Chen, Xiao-Cui, Ward, Tony J., Cao, Jun-Ji, Lee, Shun-Cheng, Chow, Judith C., Lau, Gabriel N.C., Yim, Steve H.L., Ho, Kin-Fai

“…Personal monitoring for fine particulate matter (PM2.5) was conducted for adults (48 subjects, 18–63years of age…”
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Construct validity of the Post-COVID-19 Functional Status Scale in adult subjects with COVID-19 Autor Machado, Felipe V. C., Meys, Roy, Delbressine, Jeannet M., Vaes, Anouk W., Goërtz, Yvonne M. J., van Herck, Maarten, Houben-Wilke, Sarah, Boon, Gudula J. A. M., Barco, Stefano, Burtin, Chris, van ’t Hul, Alex, Posthuma, Rein, Franssen, Frits M. E., Spies, Yvonne, Vijlbrief, Herman, Pitta, Fabio, Rezek, Spencer A., Janssen, Daisy J. A., Siegerink, Bob, Klok, Frederikus A., Spruit, Martijn A.

“… We aimed to assess the construct validity of the Post-COVID-19 Functional Status (PCFS) Scale among adult subjects with confirmed and presumed COVID-19…”
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Associations of oral fluid MMP‐8 with periodontitis in Swiss adult subjects Autor Mauramo, M, Ramseier, AM, Mauramo, E, Buser, A, Tervahartiala, T, Sorsa, T, Waltimo, T

“… Subjects and Methods A total of 258 subjects (107 m, 151 f, mean age: 43.5 yr; range: 21–58 yr) acquired from the Swiss bone marrow donor registry participated in the study…”
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Reduced local segregation of single‐subject gray matter networks in adult PTSD Autor Niu, Running, Lei, Du, Chen, Fuqin, Chen, Ying, Suo, Xueling, Li, Lingjiang, Lui, Su, Huang, Xiaoqi, Sweeney, John A., Gong, Qiyong

“…To psychoradiologically investigate the topological organization of single‐subject gray matter networks in patients with PTSD. Eighty…”
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Population pharmacokinetics of cabotegravir following administration of oral tablet and long‐acting intramuscular injection in adult HIV‐1‐infected and uninfected subjects Autor Han, Kelong, Baker, Mark, Lovern, Mark, Paul, Prokash, Xiong, Yuan, Patel, Parul, Moore, Katy P., Seal, Ciara S., Cutrell, Amy G., D'Amico, Ronald D., Benn, Paul D., Landovitz, Raphael J., Marzinke, Mark A., Spreen, William R., Ford, Susan L.

“… 926 plasma concentrations from 1647 adult HIV‐1‐infected (72%) and uninfected (28%) subjects in 16 studies at seven dose levels (oral 10‐60 mg, long‐acting [LA…”
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Magnetic Resonance Spectroscopy of 2‐Hydroxyglutarate and Glycine in Adult Subjects With Brainstem Gliomas Autor Tiwari, Vivek, Ganji, Sandeep K., An, Zhongxu, Pinho, Marco C., Davis, Larry T., McKnight, Colin D., Berry, Julia D., Mobley, Bret C., Luo, Leo Y., Mohler, Alexander C., Merrell, Ryan T., Kelly, Patrick D., Thompson, Reid C., Mickey, Bruce E., Malloy, Craig R., Gore, John C., Patel, Toral R., Maher, Elizabeth A., Choi, Changho

“… significance of glycine MRS in brainstem tumors in vivo. Twenty adult patients with radiographically identified presumed brainstem gliomas were prospectively enrolled in the study…”
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Safety, Pharmacokinetics, and Mosquito‐Lethal Effects of Ivermectin in Combination With Dihydroartemisinin‐Piperaquine and Primaquine in Healthy Adult Thai Subjects Autor Kobylinski, Kevin C., Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Pantuwatana, Kanchana, Phasomkusolsil, Siriporn, Davidson, Silas A., Winterberg, Markus, Hoglund, Richard M., Mukaka, Mavuto, Pluijm, Rob W., Dondorp, Arjen, Day, Nicholas P.J., White, Nicholas J., Tarning, Joel

“…‐lethal effect across all subjects. Exposure to piperaquine was also increased when coadministered with ivermectin, but electrocardiograph QT…”
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Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases Autor Tadolini, Marina, Codecasa, Luigi Ruffo, García-García, José-María, Blanc, François-Xavier, Borisov, Sergey, Alffenaar, Jan-Willem, Andréjak, Claire, Bachez, Pierre, Bart, Pierre-Alexandre, Belilovski, Evgeny, Cardoso-Landivar, José, Centis, Rosella, D'Ambrosio, Lia, Luiza De Souza-Galvão, María-, Dominguez-Castellano, Angel, Dourmane, Samir, Fréchet Jachym, Mathilde, Froissart, Antoine, Giacomet, Vania, Goletti, Delia, Grard, Soazic, Gualano, Gina, Izadifar, Armine, Le Du, Damien, Marín Royo, Margarita, Mazza-Stalder, Jesica, Motta, Ilaria, Ong, Catherine Wei Min, Palmieri, Fabrizio, Rivière, Frédéric, Rodrigo, Teresa, Silva, Denise Rossato, Sánchez-Montalvá, Adrián, Saporiti, Matteo, Scarpellini, Paolo, Schlemmer, Frédéric, Spanevello, Antonio, Sumarokova, Elena, Tabernero, Eva, Tambyah, Paul Anantharajah, Tiberi, Simon, Torre, Alessandro, Visca, Dina, Zabaleta Murguiondo, Miguel, Sotgiu, Giovanni, Migliori, Giovanni Battista

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Bronchopulmonary disposition of IV cefepime/taniborbactam (2–0.5 g) administered over 2 h in healthy adult subjects Autor Asempa, Tomefa E, Kuti, Joseph L, Nascimento, Jeffrey C, Pope, Samuel J, Salerno, Edward L, Troy, Patrick J, Nicolau, David P

“… Objectives To assess the safety profile and pulmonary disposition of 2–0.5 g cefepime/taniborbactam administered as a 2 h IV infusion every 8 h following three doses in healthy adult subjects…”
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Intrapulmonary pharmacokinetics of cefiderocol, a novel siderophore cephalosporin, in healthy adult subjects Autor Katsube, Takayuki, Saisho, Yutaka, Shimada, Jingoro, Furuie, Hidetoshi

“…) in healthy adult males. Materials and methods Each subject underwent one bronchoscopy with bronchoalveolar lavage (BAL…”
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Dietary Patterns and Metabolic Syndrome in Adult Subjects: A Systematic Review and Meta-Analysis Autor Fabiani, Roberto, Naldini, Giulia, Chiavarini, Manuela

“… A literature search on PubMed, Web of Science, and Scopus databases, up to March 2019, was conducted to identify all eligible case-control, prospective, or cross-sectional studies involving adult subjects of both sexes…”
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Efficacy of high-dissolution turmeric-sesame formulation for pain relief in adult subjects with acute musculoskeletal pain compared to acetaminophen: A randomized controlled study Autor Rudrappa, Girish H., Chakravarthi, Pruthvi T., Benny, Irin Rosanna

“… musculoskeletal pain as quickly as acetaminophen. In this randomized active controlled open label study, 88 healthy subjects with acute musculoskeletal pain were randomized to receive treatment capsule (Rhuleave-K; 1,000 mg/d) or 1,000…”
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Suicide risk among adult subjects hospitalized in an acute psychiatric ward: 6-year retrospective investigation Autor Di Lorenzo, Rosaria, Scala, Carmela, Reami, Matteo, Rovesti, Sergio, Ferri, Paola

“… The objective of this study was to evaluate the characteristics of subjects admitted to a SPDC over a 6-year period for SR represented…”
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Parameters for Simulation of Adult Subjects During Mechanical Ventilation Autor Arnal, Jean-Michel, Garnero, Aude, Saoli, Mathieu, Chatburn, Robert L

“… This study collected data in passively-ventilated adult human subjects and summarized the results as a set of parameters that can be used for simulation studies of intubated, passive, adult subjects…”
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Pharmacokinetics, Safety, and Tolerability of Tezepelumab (AMG 157) in Healthy and Atopic Dermatitis Adult Subjects Autor Parnes, Jane R., Sullivan, John T., Chen, Li, Dias, Clapton

“…‐ascending doses in two randomized, double‐blind, placebo‐controlled phase I studies. Healthy and atopic dermatitis subjects were enrolled in the single…”
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