Výsledky vyhľadávania - "Adipocytes - drug effects"

Effects of Liraglutide on Weight Loss, Fat Distribution, and β-Cell Function in Obese Subjects With Prediabetes or Early Type 2 Diabetes Autor Santilli, Francesca, Simeone, Paola G, Guagnano, Maria T, Leo, Marika, Maccarone, Marica T, Di Castelnuovo, Augusto, Sborgia, Cristina, Bonadonna, Riccardo C, Angelucci, Ermanno, Federico, Virginia, Cianfarani, Stefano, Manzoli, Lamberto, Davì, Giovanni, Tartaro, Armando, Consoli, Agostino

“…) and visceral adipose tissue (VAT) in obese subjects with prediabetes or early type 2 diabetes…”
Zistit podrobnosti o prístupe

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease Autor Hickson, LaTonya J., Langhi Prata, Larissa G.P., Bobart, Shane A., Evans, Tamara K., Giorgadze, Nino, Hashmi, Shahrukh K., Herrmann, Sandra M., Jensen, Michael D., Jia, Qingyi, Jordan, Kyra L., Kellogg, Todd A., Khosla, Sundeep, Koerber, Daniel M., Lagnado, Anthony B., Lawson, Donna K., LeBrasseur, Nathan K., Lerman, Lilach O., McDonald, Kathleen M., McKenzie, Travis J., Passos, João F., Pignolo, Robert J., Pirtskhalava, Tamar, Saadiq, Ishran M., Schaefer, Kalli K., Textor, Stephen C., Victorelli, Stella G., Volkman, Tammie L., Xue, Ailing, Wentworth, Mark A., Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamara, Kirkland, James L.

“… In an open label Phase 1 pilot study, we administered 3 days of oral D 100 mg and Q 1000 mg to subjects with diabetic kidney disease…”
Získať plný text

Accumulation of succinate controls activation of adipose tissue thermogenesis Autor Mills, Evanna L., Pierce, Kerry A., Jedrychowski, Mark P., Garrity, Ryan, Winther, Sally, Vidoni, Sara, Yoneshiro, Takeshi, Spinelli, Jessica B., Lu, Gina Z., Kazak, Lawrence, Banks, Alexander S., Haigis, Marcia C., Kajimura, Shingo, Murphy, Michael P., Gygi, Steven P., Clish, Clary B., Chouchani, Edward T.

“…; this pathway has been subject to longstanding clinical investigation 2 – 4 . Here we apply a comparative metabolomics approach and identify an independent metabolic pathway that controls acute activation of adipose tissue thermogenesis in vivo…”
Získať plný text

Novel insights of dietary polyphenols and obesity Autor Wang, Shu, Moustaid-Moussa, Naima, Chen, Lixia, Mo, Huanbiao, Shastri, Anuradha, Su, Rui, Bapat, Priyanka, Kwun, InSook, Shen, Chwan-Li

“…The prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of…”
Získať plný text

Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation Autor Ramage, Lynne E, Akyol, Murat, Fletcher, Alison M, Forsythe, John, Nixon, Mark, Carter, Roderick N, van Beek, Edwin J R, Morton, Nicholas M, Walker, Brian R, Stimson, Roland H

“…) and energy expenditure during cold, but not warm, exposure in lean subjects. In vitro, glucocorticoids increased isoprenaline-stimulated respiration and UCP-1 in human…”
Zistit podrobnosti o prístupe

Regulation of lipolysis in small and large fat cells of the same subject Autor Laurencikiene, Jurga, Skurk, Thomas, Kulyté, Agné, Hedén, Per, Aström, Gaby, Sjölin, Eva, Rydén, Mikael, Hauner, Hans, Arner, Peter

“… Our objective was to study the role of fat cell size in the regulation of lipolysis within a subject…”
Zistit podrobnosti o prístupe

Altered Expression of miR-181a-5p and miR-23a-3p Is Associated With Obesity and TNFα-Induced Insulin Resistance Autor Lozano-Bartolomé, Javier, Llauradó, Gemma, Portero-Otin, Manel, Altuna-Coy, Antonio, Rojo-Martínez, Gemma, Vendrell, Joan, Jorba, Rosa, Rodríguez-Gallego, Esther, Chacón, Matilde R

“… (AT) expression studies and included 28 subjects with body mass index (BMI) <30 kg/m2 and 30 with BMI ≥30 kg/m2…”
Získať plný text

Omega-3 fatty acids and adipose tissue biology Autor Kuda, Ondrej, Rossmeisl, Martin, Kopecky, Jan

“…This review provides evidence for the importance of white and brown adipose tissue (i.e. WAT and BAT) function for the maintenance of healthy metabolic…”
Získať plný text

Modification in mitochondrial function is associated with the FADS1 variant and its interaction with alpha-linolenic acid-enriched diet—An exploratory study Autor Vaittinen, Maija, Ilha, Mariana, Sehgal, Ratika, Lankinen, Maria A., Ågren, Jyrki, Käkelä, Pirjo, Virtanen, Kirsi A., Laakso, Markku, Schwab, Ursula, Pihlajamäki, Jussi

“… We could demonstrate that differentiated human adipose-derived stromal cells from subjects with the TT genotype had higher mitochondrial metabolism compared with subjects with the CC genotype…”
Získať plný text

Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet Autor Perdicaro, Diahann J., Rodriguez Lanzi, Cecilia, Gambarte Tudela, Julián, Miatello, Roberto M., Oteiza, Patricia I., Vazquez Prieto, Marcela A.

“…An impaired capacity of adipose tissue expansion leads to adipocyte hypertrophy, inflammation and insulin resistance (IR) under positive energy balance. We…”
Získať plný text

Reduction in MCP-1 production in preadipocytes is mediated by PPARγ activation and JNK/SIRT1 signaling Autor Sawamoto, Atsushi, Itagaki, Ibuki, Okuyama, Satoshi, Nakajima, Mitsunari

“…Obesity-induced monocyte chemoattractant protein 1 (MCP-1) production leads to the infiltration of monocytes/macrophages into white adipose tissue (WAT), which…”
Získať plný text

MCP-1 Feedback Loop Between Adipocytes and Mesenchymal Stromal Cells Causes Fat Accumulation and Contributes to Hematopoietic Stem Cell Rarefaction in the Bone Marrow of Patients With Diabetes Autor Ferland-McCollough, David, Maselli, Davide, Spinetti, Gaia, Sambataro, Maria, Sullivan, Niall, Blom, Ashley, Madeddu, Paolo

“…) upon in vitro induction as compared with BM-MSCs from subjects without diabetes. Moreover, BM-ADs from subjects with T2D (T2D BM-ADs…”
Zistit podrobnosti o prístupe

Anti-Obesity Effects of Dietary Calcium: The Evidence and Possible Mechanisms Autor Zhang, Fenglin, Ye, Jingjing, Zhu, Xiaotong, Wang, Lina, Gao, Ping, Shu, Gang, Jiang, Qingyan, Wang, Songbo

“…Obesity is a serious health challenge worldwide and is associated with various comorbidities, including dyslipidemia, type 2 diabetes, and cardiovascular…”
Získať plný text

α‐lipoic acid reduces fatty acid esterification and lipogenesis in adipocytes from overweight/obese subjects Autor Fernández‐Galilea, Marta, Pérez‐Matute, Patricia, Prieto‐Hontoria, Pedro L., Sáinz, Neira, López‐Yoldi, Miguel, Houssier, Marianne, Martínez, J. Alfredo, Langin, Dominique, Moreno‐Aliaga, María J.

“… The aim of this study was to investigate the putative effects of α‐LA on triglyceride accumulation and lipogenesis in subcutaneous adipocytes from overweight/obese subjects and to determine the potential mechanisms involved…”
Získať plný text

Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila Autor Sousa-Nunes, Rita, Yee, Lih Ling, Gould, Alex P.

“…Nerve progenitors hungry for action The availability of nutrients prompts quiescent neural stem cells (neuroblasts) in Drosophila larvae to begin to divide. A…”
Získať plný text

Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects Autor Itoh, Michiko, Suganami, Takayoshi, Satoh, Noriko, Tanimoto-Koyama, Kanami, Yuan, Xunmei, Tanaka, Miyako, Kawano, Hiroyuki, Yano, Takashi, Aoe, Seiichiro, Takeya, Motohiro, Shimatsu, Akira, Kuzuya, Hideshi, Kamei, Yasutomi, Ogawa, Yoshihiro

“… Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects…”
Zistit podrobnosti o prístupe

Effects of glucagon‐like peptide‐1 on the differentiation and metabolism of human adipocytes Autor El Bekay, Rajaa, Coín‐Aragüez, Leticia, Fernández‐García, Diego, Oliva‐Olivera, Wilfredo, Bernal‐López, Rosa, Clemente‐Postigo, Mercedes, Delgado‐Lista, Javier, Diaz‐Ruiz, Alberto, Guzman‐Ruiz, Rocío, Vázquez‐Martínez, Rafael, Lhamyani, Said, Roca‐Rodríguez, María Mar, Veledo, Sonia Fernandez, Vendrell, Joan, Malagón, María M., Tinahones, Francisco José

“…) patients and cause weight loss in obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP…”
Získať plný text

4-hydroxynonenal causes impairment of human subcutaneous adipogenesis and induction of adipocyte insulin resistance Autor Elrayess, Mohamed A., Almuraikhy, Shamma, Kafienah, Wael, Al-Menhali, Afnan, Al-Khelaifi, Fatima, Bashah, Moataz, Zarkovic, Kamelija, Zarkovic, Neven, Waeg, Georg, Alsayrafi, Mohammed, Jaganjac, Morana

“…Increased adipose production of 4-hydroxynonenal (4-HNE), a bioreactive aldehyde, directly correlates with obesity and insulin resistance. The aim of this…”
Získať plný text

Direct effects of glucagon on glucose uptake and lipolysis in human adipocytes Autor Pereira, Maria J., Thombare, Ketan, Sarsenbayeva, Assel, Kamble, Prasad G., Almby, Kristina, Lundqvist, Martin, Eriksson, Jan W.

“… Furthermore, GCGR expression was not significantly different between subjects with T2D and matched controls, and we found no significant association with BMI…”
Získať plný text

Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro Autor D’Esposito, V., Passaretti, F., Hammarstedt, A., Liguoro, D., Terracciano, D., Molea, G., Canta, L., Miele, C., Smith, U., Beguinot, F., Formisano, P.

“…Aims/hypothesis Type 2 diabetes and obesity are associated with increased risk of site-specific cancers. We have investigated whether metabolic alterations at…”
Získať plný text