Suchergebnisse - "Addya, Sankar"

CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion von Jiao, Xuanmao, Velasco-Velázquez, Marco A, Wang, Min, Li, Zhiping, Rui, Hallgeir, Peck, Amy R, Korkola, James E, Chen, Xuelian, Xu, Shaohua, DuHadaway, James B, Guerrero-Rodriguez, Sandra, Addya, Sankar, Sicoli, Daniela, Mu, Zhaomei, Zhang, Gang, Stucky, Andres, Zhang, Xi, Cristofanilli, Massimo, Fatatis, Alessandro, Gray, Joe W, Zhong, Jiang F, Prendergast, George C, Pestell, Richard G

“… The functional significance of the chemokine receptor CCR5 in human breast cancer epithelial cells is poorly understood. Here, we report that CCR5 expression …”
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RB Loss Promotes Prostate Cancer Metastasis von Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, Haber, Alex, Ertel, Adam, Bhardwaj, Anshul, Addya, Sankar, Williams, Noelle, Ciment, Stephen J, Cotzia, Paolo, Dean, Jeffry L, Snook, Adam, McNair, Chris, Price, Matt, Hernandez, James R, Zhao, Shuang G, Birbe, Ruth, McCarthy, James B, Turley, Eva A, Pienta, Kenneth J, Feng, Felix Y, Dicker, Adam P, Knudsen, Karen E, Den, Robert B

“… RB loss occurs commonly in neoplasia but its contributions to advanced cancer have not been assessed directly. Here we show that RB loss in multiple murine …”
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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma von Pavlides, Stephanos, Whitaker-Menezes, Diana, Castello-Cros, Remedios, Flomenberg, Neal, Witkiewicz, Agnieszka K., Frank, Philippe G., Casimiro, Mathew C., Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Pestell, Richard G., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

“… Here, we propose a new model for understanding the Warburg effect in tumor metabolism.  Our hypothesis is that epithelial cancer cells induce the Warburg …”
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HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk von Shukla, Sanket Kumar, Liu, Weijing, Sikder, Kunal, Addya, Sankar, Sarkar, Amrita, Wei, Yidong, Rafiq, Khadija

“… Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk …”
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Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genes von Abignano, Giuseppina, Hermes, Heidi, Piera-Velazquez, Sonsoles, Addya, Sankar, Del Galdo, Francesco, Jimenez, Sergio A.

“… Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc …”
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Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer von Thangavel, Chellappagounder, Boopathi, Ettickan, Liu, Yi, McNair, Christopher, Haber, Alex, Perepelyuk, Maryna, Bhardwaj, Anshul, Addya, Sankar, Ertel, Adam, Shoyele, Sunday, Birbe, Ruth, Salvino, Joseph M, Dicker, Adam P, Knudsen, Karen E, Den, Robert B

“… The retinoblastoma tumor suppressor (RB), a key regulator of cell-cycle progression and proliferation, is functionally suppressed in up to 50% of non-small …”
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Integrative genomics and pathway analysis identified prevalent FA-BRCA pathway alterations in arsenic-associated urinary bladder carcinoma: Chronic arsenic accumulation in cancer tissues hampers the FA-BRCA pathway von Basu, Mukta, Ghosh, Sabnam, Roychowdhury, Anirban, Samadder, Sudip, Das, Pijush, Addya, Sankar, Roy, Anup, Pal, Dilip Kumar, Roychoudhury, Susanta, Ghosh, Amlan, Panda, Chinmay Kumar

“… Arsenic in drinking water is one of the major etiological factors in urinary bladder carcinoma (BlCa). Here, high-resolution CGH-SNP microarray analysis in …”
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Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": A transcriptional informatics analysis with validation von Pavlides, Stephanos, Tsirigos, Aristotelis, Vera, Iset, Flomenberg, Neal, Frank, Philippe G., Casimiro, Mathew C., Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Pestell, Richard G., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

“… Cav-1 (-/-) deficient stromal cells are a new genetic model for myofibroblasts and cancer-associated fibroblasts. Using an unbiased informatics analysis of the …”
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DNA methylation patterns in umbilical cord blood from infants of methadone maintained opioid dependent mothers von Adegboyega, Oluwatobi, Gayen nee’ Betal, Suhita, Urday, Pedro, Huang, Rachel, Bodycot, Katherine, Al-Kouatly, Huda B., Solarin, Kolawole, Chan, Joanna S. Y., Addya, Sankar, Boelig, Rupsa C., Aghai, Zubair H.

“… Methadone maintenance treatment for opioid dependent mothers is standard of care. Infants of methadone maintained opioid dependent (MMOD) mothers have better …”
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CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines von Sicoli, Daniela, Jiao, Xuanmao, Ju, Xiaoming, Velasco-Velazquez, Marco, Ertel, Adam, Addya, Sankar, Li, Zhiping, Andò, Sebastiano, Fatatis, Alessandro, Paudyal, Bishnuhari, Cristofanilli, Massimo, Thakur, Mathew L, Lisanti, Michael P, Pestell, Richard G

“… Src family kinases (SFK) integrate signal transduction for multiple receptors, regulating cellular proliferation, invasion, and metastasis in human cancer …”
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Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph + Acute Lymphoblastic Leukemia von De Dominici, Marco, Porazzi, Patrizia, Soliera, Angela Rachele, Mariani, Samanta A, Addya, Sankar, Fortina, Paolo, Peterson, Luke F, Spinelli, Orietta, Rambaldi, Alessandro, Martinelli, Giovanni, Ferrari, Anna, Iacobucci, Ilaria, Calabretta, Bruno

“… Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph ALL) is currently treated with BCR-ABL1 tyrosine kinase inhibitors (TKI) in combination with …”
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Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation von Wu, Kongming, Chen, Ke, Wang, Chenguang, Jiao, Xuanmao, Wang, Liping, Zhou, Jie, Wang, Jing, Li, Zhiping, Addya, Sankar, Sorensen, Poul H, Lisanti, Michael P, Quong, Andrew, Ertel, Adam, Pestell, Richard G

“… The epithelial-mesenchymal transition (EMT) enhances cellular invasiveness and confers tumor cells with cancer stem cell-like characteristics, through …”
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ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice von Casimiro, Mathew C., Crosariol, Marco, Loro, Emanuele, Ertel, Adam, Yu, Zuoren, Dampier, William, Saria, Elizabeth A., Papanikolaou, Alex, Stanek, Timothy J., Li, Zhiping, Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Tozeren, Aydin, Knudsen, Erik S., Arnold, Andrew, Pestell, Richard G.

“… Chromosomal instability (CIN) in tumors is characterized by chromosomal abnormalities and an altered gene expression signature; however, the mechanism of CIN …”
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Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-Coronaviruses von Sengupta, Sourodip, Bhattacharyya, Debina, Kasle, Grishma, Karmakar, Souvik, Sahu, Omkar, Ganguly, Anirban, Addya, Sankar, Das Sarma, Jayasri

“… The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced COVID-19 has emerged as a defining global health crisis in current times. Data from …”
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HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms von Jain, Aditi, McCoy, Matthew, Coats, Carolyn, Brown, Samantha Z., Addya, Sankar, Pelz, Carl, Sears, Rosalie C., Yeo, Charles J., Brody, Jonathan R.

“… Human Antigen R (HuR/ELAVL1) is known to regulate stability of mRNAs involved in pancreatic ductal adenocarcinoma (PDAC) cell survival. Although several HuR …”
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Inflammatory breast cancer (IBC): clues for targeted therapies von Fernandez, Sandra V., Robertson, Fredika M., Pei, Jianming, Aburto-Chumpitaz, Lucy, Mu, Zhaomei, Chu, Khoi, Alpaugh, R. K., Huang, Yong, Cao, Yu, Ye, Zaiming, Cai, Kathy Q., Boley, Kimberly M., Klein-Szanto, Andres J., Devarajan, Karthik, Addya, Sankar, Cristofanilli, Massimo

“… Inflammatory breast cancer (IBC) is the most aggressive type of advanced breast cancer characterized by rapid proliferation, early metastatic development and …”
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Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo von Gu, Lei, Vogiatzi, Paraskevi, Puhr, Martin, Dagvadorj, Ayush, Lutz, Jacqueline, Ryder, Amy, Addya, Sankar, Fortina, Paolo, Cooper, Carlton, Leiby, Benjamin, Dasgupta, Abhijit, Hyslop, Terry, Bubendorf, Lukas, Alanen, Kalle, Mirtti, Tuomas, Nevalainen, Marja T

“… There are no effective therapies for disseminated prostate cancer. Constitutive activation of Stat5 in prostate cancer is associated with cancer lesions of …”
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Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates von Gayen nee’ Betal, Suhita, Murthy, Swati, Favara, Michael, Fong, Gina, Chan, Joanna S. Y., Addya, Sankar, Shaffer, Thomas H., Greenspan, Jay, Bhandari, Vineet, Rahman, Irfan, Aghai, Zubair H.

“… Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased …”
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Cell Cycle- and Cancer-Associated Gene Networks Activated by Dsg2: Evidence of Cystatin A Deregulation and a Potential Role in Cell-Cell Adhesion von Gupta, Abhilasha, Nitoiu, Daniela, Brennan-Crispi, Donna, Addya, Sankar, Riobo, Natalia A., Kelsell, David P., Mahoney, Mỹ G.

“… Cell-cell adhesion is paramount in providing and maintaining multicellular structure and signal transmission between cells. In the skin, disruption to …”
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Dachshund binds p53 to block the growth of lung adenocarcinoma cells von Chen, Ke, Wu, Kongming, Cai, Shaoxin, Zhang, Wei, Zhou, Jie, Wang, Jing, Ertel, Adam, Li, Zhiping, Rui, Hallgeir, Quong, Andrew, Lisanti, Michael P, Tozeren, Aydin, Tanes, Ceylan, Addya, Sankar, Gormley, Michael, Wang, Chenguang, McMahon, Steven B, Pestell, Richard G

“… Hyperactive EGF receptor (EGFR) and mutant p53 are common genetic abnormalities driving the progression of non-small cell lung cancer (NSCLC), the leading …”
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