Suchergebnisse - "Abell, Nathan"

Multiple causal variants underlie genetic associations in humans von Abell, Nathan S, DeGorter, Marianne K, Gloudemans, Michael J, Greenwald, Emily, Smith, Kevin S, He, Zihuai, Montgomery, Stephen B

“… Associations between genetic variation and traits are often in noncoding regions with strong linkage disequilibrium (LD), where a single causal variant is …”
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Toward optimizing diversifying base editors for high-throughput mutational scanning studies von Schwartz, Carley I, Abell, Nathan S, Li, Amy, Aradhana, Tycko, Josh, Truong, Alisa, Montgomery, Stephen B, Hess, Gaelen T

“… Abstract Base editors, including diversifying base editors that create C>N mutations, are potent tools for systematically installing point mutations in …”
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Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine von McFadden, Michael J., McIntyre, Alexa B.R., Mourelatos, Haralambos, Abell, Nathan S., Gokhale, Nandan S., Ipas, Hélène, Xhemalçe, Blerta, Mason, Christopher E., Horner, Stacy M.

“… Type I interferons (IFNs) induce hundreds of IFN-stimulated genes (ISGs) in response to viral infection. Induction of these ISGs must be regulated for an …”
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Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx von Gay, Nicole R., Gloudemans, Michael, Antonio, Margaret L., Abell, Nathan S., Balliu, Brunilda, Park, YoSon, Martin, Alicia R., Musharoff, Shaila, Rao, Abhiram S., Aguet, François, Barbeira, Alvaro N., Bonazzola, Rodrigo, Hormozdiari, Farhad, Ardlie, Kristin G., Brown, Christopher D., Im, Hae Kyung, Lappalainen, Tuuli, Wen, Xiaoquan, Montgomery, Stephen B.

“… Background Population structure among study subjects may confound genetic association studies, and lack of proper correction can lead to spurious findings. The …”
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Click Quantitative Mass Spectrometry Identifies PIWIL3 as a Mechanistic Target of RNA Interference Activator Enoxacin in Cancer Cells von Abell, Nathan S, Mercado, Marvin, Cañeque, Tatiana, Rodriguez, Raphaël, Xhemalce, Blerta

“… Enoxacin is a small molecule that stimulates RNA interference (RNAi) and acts as a growth inhibitor selectively in cancer but not in untransformed cells. Here, …”
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BCDIN3D RNA methyltransferase stimulates Aldolase C expression and glycolysis through let-7 microRNA in breast cancer cells von Reinsborough, Calder W., Ipas, Hélène, Abell, Nathan S., Gouws, Ellen B., Williams, J. Paige, Mercado, Marvin, Van Den Berg, Carla, Xhemalçe, Blerta

“… Type II diabetes (T2D) and specific cancers share many risk factors, however, the molecular mechanisms underlying these connections are often not …”
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MiR-191 Regulates Primary Human Fibroblast Proliferation and Directly Targets Multiple Oncogenes von Polioudakis, Damon, Abell, Nathan S., Iyer, Vishwanath R.

“… miRNAs play a central role in numerous pathologies including multiple cancer types. miR-191 has predominantly been studied as an oncogene, but the role of …”
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Evaluating the Genomic Parameters Governing rAAV-Mediated Homologous Recombination von Spector, Laura P, Tiffany, Matthew, Ferraro, Nicole M, Abell, Nathan S, Montgomery, Stephen B, Kay, Mark A

“… Recombinant adeno-associated virus (rAAV) vectors have the unique ability to promote targeted integration of transgenes via homologous recombination at …”
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Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases von Guo, Margaret G., Reynolds, David L., Ang, Cheen E., Liu, Yingfei, Zhao, Yang, Donohue, Laura K. H., Siprashvili, Zurab, Yang, Xue, Yoo, Yongjin, Mondal, Smarajit, Hong, Audrey, Kain, Jessica, Meservey, Lindsey, Fabo, Tania, Elfaki, Ibtihal, Kellman, Laura N., Abell, Nathan S., Pershad, Yash, Bayat, Vafa, Etminani, Payam, Holodniy, Mark, Geschwind, Daniel H., Montgomery, Stephen B., Duncan, Laramie E., Urban, Alexander E., Altman, Russ B., Wernig, Marius, Khavari, Paul A.

“… Noncoding variants of presumed regulatory function contribute to the heritability of neuropsychiatric disease. A total of 2,221 noncoding variants connected to …”
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Genetic regulation of gene expression and splicing during a 10-year period of human aging von Balliu, Brunilda, Durrant, Matthew, Goede, Olivia de, Abell, Nathan, Li, Xin, Liu, Boxiang, Gloudemans, Michael J., Cook, Naomi L., Smith, Kevin S., Knowles, David A., Pala, Mauro, Cucca, Francesco, Schlessinger, David, Jaiswal, Siddhartha, Sabatti, Chiara, Lind, Lars, Ingelsson, Erik, Montgomery, Stephen B.

“… Background Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects …”
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ChemRAP uncovers specific mRNA translation regulation via RNA 5′ phospho-methylation von Ipas, Hélène, Gouws, Ellen B, Abell, Nathan S, Chiou, Po-Chin, Devanathan, Sravan K, Hervé, Solène, Lee, Sidae, Mercado, Marvin, Reinsborough, Calder, Halabelian, Levon, Arrowsmith, Cheryl H, Xhemalçe, Blerta

“… 5′-end modifications play key roles in determining RNA fates. Phospho-methylation is a noncanonical cap occurring on either 5′-PPP or 5′-P ends. We used …”
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BCDIN3D regulates tRNAHis 3’ fragment processing von Reinsborough, Calder W., Ipas, Hélène, Abell, Nathan S., Nottingham, Ryan M., Yao, Jun, Devanathan, Sravan K., Shelton, Samantha B., Lambowitz, Alan M., Xhemalçe, Blerta

“… 5' ends are important for determining the fate of RNA molecules. BCDIN3D is an RNA phospho-methyltransferase that methylates the 5' monophosphate of specific …”
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miR-503 represses human cell proliferation and directly targets the oncogene DDHD2 by non-canonical target pairing von Polioudakis, Damon, Abell, Nathan S, Iyer, Vishwanath R

“… Background The pathways regulating the transition of mammalian cells from quiescence to proliferation are mediated by multiple miRNAs. Despite significant …”
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Functional analysis of cancer-associated germline risk variants von Kellman, Laura N, Neela, Poornima H, Srinivasan, Suhas, Siprashvili, Zurab, Shanderson, Ronald L, Hong, Audrey W, Rao, Deepti, Porter, Douglas F, Reynolds, David L, Meyers, Robin M, Guo, Margaret G, Yang, Xue, Zhao, Yang, Wozniak, Glenn G, Donohue, Laura K H, Shenoy, Rajani, Ko, Lisa A, Nguyen, Duy T, Mondal, Smarajit, Garcia, Omar S, Elcavage, Lara E, Elfaki, Ibtihal, Abell, Nathan S, Tao, Shiying, Lopez, Christopher M, Montgomery, Stephen B, Khavari, Paul A

“… Single-nucleotide variants (SNVs) in regulatory DNA are linked to inherited cancer risk. Massively parallel reporter assays of 4,041 SNVs linked to 13 …”
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High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery von Howard, Conor J, Abell, Nathan S, Osuna, Beatriz A, Jones, Eric M, Chan, Leon Y, Chan, Henry, Artis, Dean R, Asfaha, Jonathan B, Bloom, Joshua S, Cooper, Aaron R, Liao, Andrew, Mahdavi, Eden, Mohammed, Nabil, Su, Alan L, Uribe, Giselle A, Kosuri, Sriram, Dickel, Diane E, Lubock, Nathan B

“… Deep Mutational Scanning (DMS) is an emerging method to systematically test the functional consequences of thousands of sequence changes to a protein target in …”
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Crosstalk between the RNA Methylation and Histone-Binding Activities of MePCE Regulates P-TEFb Activation on Chromatin von Shelton, Samantha B., Shah, Nakul M., Abell, Nathan S., Devanathan, Sravan K., Mercado, Marvin, Xhemalçe, Blerta

“… RNAP II switching from the paused to the productive transcription elongation state is a pivotal regulatory step that requires specific phosphorylations …”
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NAT10 and N4-acetylcytidine restrain R-loop levels and related inflammatory responses von Debnath, Turja K, Abell, Nathan S, Li, Yi-Ru, Devanathan, Sravan K, Navedo, Enrique, Xhemalçe, Blerta

“… N4-acetylcytidine (ac4C) is deposited on diverse RNAs by N-acetyltransferase 10 (NAT10), a protein with high biological relevance for aging and cancer. We …”
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NAT10 and N 4 -acetylcytidine restrain R-loop levels and related inflammatory responses von Debnath, Turja K., Abell, Nathan S., Li, Yi-Ru, Devanathan, Sravan K., Navedo, Enrique, Xhemalçe, Blerta

“… N 4 -acetylcytidine (ac 4 C) is deposited on diverse RNAs by N -acetyltransferase 10 (NAT10), a protein with high biological relevance for aging and cancer. We …”
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A Myc–microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes von Polioudakis, Damon, Bhinge, Akshay A., Killion, Patrick J., Lee, Bum-Kyu, Abell, Nathan S., Iyer, Vishwanath R.

“… The transition of mammalian cells from quiescence to proliferation is accompanied by the differential expression of several microRNAs (miRNAs) and …”
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Small RNA Sequencing in Cells and Exosomes Identifies eQTLs and 14q32 as a Region of Active Export von Tsang, Emily K, Abell, Nathan S, Li, Xin, Anaya, Vanessa, Karczewski, Konrad J, Knowles, David A, Sierra, Raymond G, Smith, Kevin S, Montgomery, Stephen B

“… Abstract Exosomes are small extracellular vesicles that carry heterogeneous cargo, including RNA, between cells. Increasing evidence suggests that exosomes are …”
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