Výsledky vyhľadávania - "Abdelmohsen, Kotb"

Functional interactions among microRNAs and long noncoding RNAs Autor Yoon, Je-Hyun, Abdelmohsen, Kotb, Gorospe, Myriam

“…•LncRNA stability and function can be potently regulated by miRNAs.•LncRNAs can function as miRNA decoys, derepressing miRNA target mRNAs.•LncRNAs can compete…”
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Posttranscriptional Gene Regulation by Long Noncoding RNA Autor Yoon, Je-Hyun, Abdelmohsen, Kotb, Gorospe, Myriam

“…Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of…”
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Posttranslational control of HuR function Autor Grammatikakis, Ioannis, Abdelmohsen, Kotb, Gorospe, Myriam

“…The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts, coding and noncoding, and controls their splicing, localization, stability,…”
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RNA-binding protein nucleolin in disease Autor Abdelmohsen, Kotb, Gorospe, Myriam

“…Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane. It is involved in…”
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Transcriptome signature of cellular senescence Autor Casella, Gabriel, Munk, Rachel, Kim, Kyoung Mi, Piao, Yulan, De, Supriyo, Abdelmohsen, Kotb, Gorospe, Myriam

“…Abstract Cellular senescence, an integral component of aging and cancer, arises in response to diverse triggers, including telomere attrition, macromolecular…”
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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model Autor Zhang, Peisu, Kishimoto, Yuki, Grammatikakis, Ioannis, Gottimukkala, Kamalvishnu, Cutler, Roy G, Zhang, Shiliang, Abdelmohsen, Kotb, Bohr, Vilhelm A, Misra Sen, Jyoti, Gorospe, Myriam, Mattson, Mark P

“…Neuritic plaques, a pathological hallmark in Alzheimer's disease (AD) brains, comprise extracellular aggregates of amyloid-beta (Aβ) peptide and degenerating…”
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Posttranscriptional regulation of cancer traits by HuR Autor Abdelmohsen, Kotb, Gorospe, Myriam

“…Cancer‐related gene expression programs are strongly influenced by posttranscriptional mechanisms. The RNA‐binding protein HuR is highly abundant in many…”
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RNA in extracellular vesicles Autor Kim, Kyoung Mi, Abdelmohsen, Kotb, Mustapic, Maja, Kapogiannis, Dimitrios, Gorospe, Myriam

“…Cells release a range of membrane‐enclosed extracellular vesicles (EVs) into the environment. Among them, exosomes and microvesicles (collectively measuring…”
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The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets Autor Rossi, Martina, Abdelmohsen, Kotb

“…Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental…”
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Regulation of senescence traits by MAPKs Autor Anerillas, Carlos, Abdelmohsen, Kotb, Gorospe, Myriam

“…A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular senescence affects normal aging and age-related disease…”
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Cytoplasmic functions of long noncoding RNAs Autor Noh, Ji Heon, Kim, Kyoung Mi, McClusky, Waverly G., Abdelmohsen, Kotb, Gorospe, Myriam

“…Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found throughout the cell that lack protein‐coding function. Their functions are…”
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Noncoding RNAs in Alzheimer's disease Autor Idda, M. Laura, Munk, Rachel, Abdelmohsen, Kotb, Gorospe, Myriam

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause of dementia among the elderly worldwide. Despite intense efforts to…”
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Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 Autor Abdelmohsen, Kotb, Panda, Amaresh C., Munk, Rachel, Grammatikakis, Ioannis, Dudekula, Dawood B., De, Supriyo, Kim, Jiyoung, Noh, Ji Heon, Kim, Kyoung Mi, Martindale, Jennifer L., Gorospe, Myriam

“…HuR influences gene expression programs and hence cellular phenotypes by binding to hundreds of coding and noncoding linear RNAs. However, whether HuR binds to…”
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Noncoding RNA control of cellular senescence Autor Abdelmohsen, Kotb, Gorospe, Myriam

“…Senescent cells accumulate in normal tissues with advancing age and arise by long‐term culture of primary cells. Senescence develops following exposure to a…”
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mRNA methylation in cell senescence Autor Casella, Gabriel, Tsitsipatis, Dimitrios, Abdelmohsen, Kotb, Gorospe, Myriam

“…Cellular senescence, a developmental program central to normal aging and aging pathologies, is robustly regulated at the post‐transcriptional level. This…”
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Identification of senescent cell surface targetable protein DPP4 Autor Kim, Kyoung Mi, Noh, Ji Heon, Bodogai, Monica, Martindale, Jennifer L, Yang, Xiaoling, Indig, Fred E, Basu, Sandip K, Ohnuma, Kei, Morimoto, Chikao, Johnson, Peter F, Biragyn, Arya, Abdelmohsen, Kotb, Gorospe, Myriam

“…Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function, prompting efforts to eliminate them. Mass…”
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High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs Autor Panda, Amaresh C., De, Supriyo, Grammatikakis, Ioannis, Munk, Rachel, Yang, Xiaoling, Piao, Yulan, Dudekula, Dawood B., Abdelmohsen, Kotb, Gorospe, Myriam

“…High-throughput RNA sequencing methods coupled with specialized bioinformatic analyses have recently uncovered tens of thousands of unique circular (circ)RNAs,…”
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Emerging roles and context of circular RNAs Autor Panda, Amaresh C., Grammatikakis, Ioannis, Munk, Rachel, Gorospe, Myriam, Abdelmohsen, Kotb

“…Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have recently emerged as regulators of gene expression. They have been shown…”
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miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels Autor Abdelmohsen, Kotb, Srikantan, Subramanya, Kuwano, Yuki, Gorospe, Myriam

“…Gene expression is potently regulated through the action of RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating…”
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Identification of gingerenone A as a novel senolytic compound Autor Moaddel, Ruin, Rossi, Martina, Rodriguez, Stephanie, Munk, Rachel, Khadeer, Mohammed, Abdelmohsen, Kotb, Gorospe, Myriam, Ferrucci, Luigi

“…Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with…”
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