Výsledky vyhledávání - "82/80"

Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease Autor Ait-Aissa, Karima, Blaszak, Scott C., Beutner, Gisela, Tsaih, Shirng-Wern, Morgan, Garrett, Santos, Janine H., Flister, Michael J., Joyce, David L., Camara, Amadou K. S., Gutterman, David D., Donato, Anthony J., Porter, George A., Beyer, Andreas M.

“…Coronary artery disease (CAD) is a leading cause of death worldwide and frequently associated with mitochondrial dysfunction. Detailed understanding of…”
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The proteomic profile of whole and glandular saliva in healthy pain-free subjects Autor Jasim, Hajer, Olausson, Patrik, Hedenberg-Magnusson, Britt, Ernberg, Malin, Ghafouri, Bijar

“…Determination of the variability in the salivary proteome is a prerequisite for the development of saliva as a diagnostic and prognostic tool in particular…”
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The Bor1 elevator transport cycle is subject to autoinhibition and activation Autor Jiang, Yan, Jiang, Jiansen

“…Boron, essential for plant growth, necessitates precise regulation due to its potential toxicity. This regulation is achieved by borate transporters (BORs),…”
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A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis Autor Zhang, Mingming, Zhou, Lixing, Xu, Yuejie, Yang, Min, Xu, Yilai, Komaniecki, Garrison Paul, Kosciuk, Tatsiana, Chen, Xiao, Lu, Xuan, Zou, Xiaoping, Linder, Maurine E., Lin, Hening

“… Here we report that the key T helper 17 (T H 17) cell differentiation stimulator, STAT3 3 , 4 , is subject to reversible S-palmitoylation on cysteine 108…”
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Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients Autor Zhao, Liuyang, Zhang, Xiang, Zhou, Yunfei, Fu, Kaili, Lau, Harry Cheuk-Hay, Chun, Tommy Wai-Yiu, Cheung, Alvin Ho-Kwan, Coker, Olabisi Oluwabukola, Wei, Hong, Wu, William Ka-Kei, Wong, Sunny Hei, Sung, Joseph Jao-Yiu, To, Ka Fai, Yu, Jun

“… We investigated the role and clinical significance of P. micra in colorectal tumorigenesis. The abundance of P. micra was examined in 309 fecal samples and 165 colon biopsy tissues of CRC patients and healthy subjects…”
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Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma Autor Wilson, Wyndham H, Young, Ryan M, Schmitz, Roland, Yang, Yandan, Pittaluga, Stefania, Wright, George, Lih, Chih-Jian, Williams, P Mickey, Shaffer, Arthur L, Gerecitano, John, de Vos, Sven, Goy, Andre, Kenkre, Vaishalee P, Barr, Paul M, Blum, Kristie A, Shustov, Andrei, Advani, Ranjana, Fowler, Nathan H, Vose, Julie M, Elstrom, Rebecca L, Habermann, Thomas M, Barrientos, Jacqueline C, McGreivy, Jesse, Fardis, Maria, Chang, Betty Y, Clow, Fong, Munneke, Brian, Moussa, Davina, Beaupre, Darrin M, Staudt, Louis M

“… In a phase 1/2 clinical trial that involved 80 subjects with relapsed or refractory DLBCL, ibrutinib produced complete or partial responses in 37% (14/38…”
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Strigolactone perception and deactivation by a hydrolase receptor DWARF14 Autor Seto, Yoshiya, Yasui, Rei, Kameoka, Hiromu, Tamiru, Muluneh, Cao, Mengmeng, Terauchi, Ryohei, Sakurada, Akane, Hirano, Rena, Kisugi, Takaya, Hanada, Atsushi, Umehara, Mikihisa, Seo, Eunjoo, Akiyama, Kohki, Burke, Jason, Takeda-Kamiya, Noriko, Li, Weiqiang, Hirano, Yoshinori, Hakoshima, Toshio, Mashiguchi, Kiyoshi, Noel, Joseph P., Kyozuka, Junko, Yamaguchi, Shinjiro

“…The perception mechanism for the strigolactone (SL) class of plant hormones has been a subject of debate because their receptor, DWARF14 (D14), is an α/β…”
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Structural insights into the lipid and ligand regulation of serotonin receptors Autor Xu, Peiyu, Huang, Sijie, Zhang, Huibing, Mao, Chunyou, Zhou, X. Edward, Cheng, Xi, Simon, Icaro A., Shen, Dan-Dan, Yen, Hsin-Yung, Robinson, Carol V., Harpsøe, Kasper, Svensson, Bo, Guo, Jia, Jiang, Hualiang, Gloriam, David E., Melcher, Karsten, Jiang, Yi, Zhang, Yan, Xu, H. Eric

“… . 5-HT receptors have high levels of basal activity and are subject to regulation by lipids, but the structural basis for the lipid regulation and basal activation of these receptors and the pan…”
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Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice Autor Andres-Hernando, Ana, Li, Nanxing, Cicerchi, Christina, Inaba, Shinichiro, Chen, Wei, Roncal-Jimenez, Carlos, Le, Myphuong T., Wempe, Michael F., Milagres, Tamara, Ishimoto, Takuji, Fini, Mehdi, Nakagawa, Takahiko, Johnson, Richard J., Lanaspa, Miguel A.

“…Acute kidney injury is associated with high mortality, especially in intensive care unit patients. The polyol pathway is a metabolic route able to convert…”
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Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology Autor Simon, Matthew J., Wang, Marie X., Murchison, Charles F., Roese, Natalie E., Boespflug, Erin L., Woltjer, Randall L., Iliff, Jeffrey J.

“…). Impairment of glymphatic function in the aging rodent brain is associated with reduced perivascular AQP4 localization, and in human subjects, reduced perivascular AQP4 localization is associated…”
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Serum high-sensitivity C-reactive protein as a biomarker in patients with metabolic syndrome: evidence-based study with 7284 subjects Autor Mirhafez, S R, Ebrahimi, M, Saberi Karimian, M, Avan, A, Tayefi, M, Heidari-Bakavoli, A, Parizadeh, M R, Moohebati, M, Azarpazhooh, M R, Esmaily, H, Nematy, M, Safarian, M, Ferns, G A, Ghayour-Mobarhan, M

“… Here we explored the value of CRP as a biomarker in 7284 subjects and also investigated which features of MetS have the greatest association with the hs-CRP level. Subjects/Methods…”
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Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice Autor Jendryka, Martin, Palchaudhuri, Monika, Ursu, Daniel, van der Veen, Bastiaan, Liss, Birgit, Kätzel, Dennis, Nissen, Wiebke, Pekcec, Anton

“…Muscarinic Designer Receptors Exclusively Activated by Designer Drugs (DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation in…”
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Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy Autor Belaidi, Abdel Ali, Masaldan, Shashank, Southon, Adam, Kalinowski, Pawel, Acevedo, Karla, Appukuttan, Ambili T., Portbury, Stuart, Lei, Peng, Agarwal, Puja, Leurgans, Sue E., Schneider, Julie, Conrad, Marcus, Bush, Ashley I., Ayton, Scott

“…Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of…”
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Accumulation of succinate controls activation of adipose tissue thermogenesis Autor Mills, Evanna L., Pierce, Kerry A., Jedrychowski, Mark P., Garrity, Ryan, Winther, Sally, Vidoni, Sara, Yoneshiro, Takeshi, Spinelli, Jessica B., Lu, Gina Z., Kazak, Lawrence, Banks, Alexander S., Haigis, Marcia C., Kajimura, Shingo, Murphy, Michael P., Gygi, Steven P., Clish, Clary B., Chouchani, Edward T.

“…; this pathway has been subject to longstanding clinical investigation 2 – 4 . Here we apply a comparative metabolomics approach and identify an independent metabolic pathway that controls acute activation of adipose tissue thermogenesis in vivo…”
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Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects Autor Sapunar, Jorge, Fonseca, Luis, Molina, Víctor, Ortiz, Eugenia, Barra, Maria Ines, Reimer, Camila, Charles, Maria, Schneider, Constance, Ortiz, Manuel, Brito, Roberto, Manríquez, Víctor, Pavez, Monica, Cerda, Alvaro

“… Clinical and anthropometric data were obtained and blood samples were drawn from 99 lean (BMI: 18.5-24.9 kg/m ) and 151 obese (BMI > 30 kg/m ) subjects…”
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Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus Autor Hanssen, Mark J W, Hoeks, Joris, Brans, Boudewijn, van der Lans, Anouk A J J, Schaart, Gert, van den Driessche, José J, Jörgensen, Johanna A, Boekschoten, Mark V, Hesselink, Matthijs K C, Havekes, Bas, Kersten, Sander, Mottaghy, Felix M, van Marken Lichtenbelt, Wouter D, Schrauwen, Patrick

“…% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK…”
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Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects Autor Scott, Madeline R, Meador-Woodruff, James H

“… (chymotrypsin-, trypsin-, and caspase-like) in the superior temporal gyrus (STG) of 25 SZ and 25 comparison subjects using flourogenic…”
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Amyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer’s disease Autor Chen, Si-Han, Tian, Ding-Yuan, Shen, Ying-Ying, Cheng, Yuan, Fan, Dong-Yu, Sun, Hao-Lun, He, Chen-Yang, Sun, Pu-Yang, Bu, Xian-Le, Zeng, Fan, Liu, Juan, Deng, Juan, Xu, Zhi-Qiang, Chen, Yang, Wang, Yan-Jiang

“…–89 years, 24 AD patients, 25 age- and sex-matched cognitively normal (CN) subjects, 15 Parkinson’s disease patients (PD…”
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Inflammatory signaling in human tuberculosis granulomas is spatially organized Autor Marakalala, Mohlopheni J, Raju, Ravikiran M, Sharma, Kirti, Zhang, Yanjia J, Eugenin, Eliseo A, Prideaux, Brendan, Daudelin, Isaac B, Chen, Pei-Yu, Booty, Matthew G, Kim, Jin Hee, Eum, Seok Yong, Via, Laura E, Behar, Samuel M, Barry, Clifton E, Mann, Matthias, Dartois, Véronique, Rubin, Eric J

“… To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects with tuberculosis in an unbiased manner…”
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Potential depression and antidepressant-response biomarkers in human lymphoblast cell lines from treatment-responsive and treatment-resistant subjects: roles of SSRIs and omega-3 polyunsaturated fatty acids Autor Chukaew, Phatcharee, Leow, Alex, Saengsawang, Witchuda, Rasenick, Mark M

“… This study made use of banked human lymphoblast cell lines (LCLs) from normal and depressed subjects…”
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