Výsledky vyhledávání - "692/4028/67/589/466"
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Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer
ISSN: 2041-1723, 2041-1723Vydáno: London Nature Publishing Group UK 29.11.2016Vydáno v Nature communications (29.11.2016)“…Molecularly targeted therapies for advanced prostate cancer include castration modalities that suppress ligand-dependent transcriptional activity of the…”
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Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects
ISSN: 2041-1723, 2041-1723Vydáno: London Nature Publishing Group UK 23.08.2023Vydáno v Nature communications (23.08.2023)“…), which has a critical role in PrCa. Taking advantage of large Japanese samples ever, a multi-ancestry meta-analysis comprising more than 300,000 subjects in total identifies 9 unreported loci including ZFHX3 , a tumor suppressor gene…”
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Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations
ISSN: 1759-4812, 1759-4820, 1759-4820Vydáno: England Nature Publishing Group 01.04.2023Vydáno v Nature reviews. Urology (01.04.2023)“…; however, optimal screening protocols for individuals with these mutations have been a subject of debate…”
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A QSP model of prostate cancer immunotherapy to identify effective combination therapies
ISSN: 2045-2322, 2045-2322Vydáno: London Nature Publishing Group UK 03.06.2020Vydáno v Scientific reports (03.06.2020)“…Immunotherapy, by enhancing the endogenous anti-tumor immune responses, is showing promising results for the treatment of numerous cancers refractory to…”
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Thiol Groups as a Biomarker for the Diagnosis and Prognosis of Prostate Cancer
ISSN: 2045-2322, 2045-2322Vydáno: London Nature Publishing Group UK 04.06.2020Vydáno v Scientific reports (04.06.2020)“… This case-control study recruited 204 subjects, 73 patients with PCa, 67 patients with benign prostate hyperplasia (BPH…”
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Intraprostatic locations of tumor foci of higher grade missed by diagnostic prostate biopsy among potential candidates for active surveillance
ISSN: 2045-2322, 2045-2322Vydáno: London Nature Publishing Group UK 09.11.2016Vydáno v Scientific reports (09.11.2016)“… Among 444 subjects, patients with upgrading showed relatively higher prevalence of index tumor foci in anterior prostate than those without upgrading, though not reaching statistical significance (p = 0.252…”
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Computational imaging reveals shape differences between normal and malignant prostates on MRI
ISSN: 2045-2322, 2045-2322Vydáno: London Nature Publishing Group UK 01.02.2017Vydáno v Scientific reports (01.02.2017)“… (Bx+) subjects from three institutions (Gleason scores: 6–9, Stage: T1–T3). The negative group (PCa…”
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