Search Results - ANATOMY::Cells::Connective Tissue Cells::Fibroblasts::Cancer-Associated Fibroblasts

HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs) by De Francesco, Ernestina Marianna, Lappano, Rosamaria, Santolla, Maria Francesca, Marsico, Stefania, Caruso, Arnaldo, Maggiolini, Marcello

“…Introduction Carcinoma-associated fibroblasts (CAFs) play a pivotal role in cancer progression by contributing to invasion, metastasis and angiogenesis…”
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Activation of cancer-associated fibroblasts is required for tumor neovascularization in a murine model of melanoma by Hutchenreuther, James, Vincent, Krista, Norley, Chris, Racanelli, Michael, Gruber, Stephen B., Johnson, Timothy M., Fullen, Douglas R., Raskin, Leon, Perbal, Bernard, Holdsworth, David W., Postovit, Lynne-Marie, Leask, Andrew

“…Metastatic melanoma is highly fatal. Within the tumor microenvironment, the role of cancer-associated fibroblasts (CAFs…”
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Activation of fibroblasts by nicotine promotes the epithelial‐mesenchymal transition and motility of breast cancer cells by Chen, Pin‐Cyuan, Lee, Wen‐Ying, Ling, Hsiang‐Hsi, Cheng, Chia‐Hsiung, Chen, Ku‐Chung, Lin, Cheng‐Wei

“… We found that nicotine induced the epithelial‐mesenchymal transition (EMT) of breast cancer cells and promoted activation of fibroblasts…”
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The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs) by Pupo, Marco, Vivacqua, Adele, Perrotta, Ida, Pisano, Assunta, Aquila, Saveria, Abonante, Sergio, Gasperi-Campani, Anna, Pezzi, Vincenzo, Maggiolini, Marcello

“… Cancer associated fibroblasts (CAFs) actively contribute to the growth and invasion of cancer cells…”
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Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway by Shan, Guang, Gu, Juan, Zhou, Daoping, Li, Lingxun, Cheng, Wei, Wang, Yueping, Tang, Tian, Wang, Xuedong

“… Cancer-associated fibroblasts (CAFs) are essential in the tumor microenvironment. We intended to study the role of CAF-derived exosomes in the context of PC and the potential regulatory mechanism associated with miR-423-5p and GREM2…”
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Stroma in normal and cancer wound healing by Huet, Eric, Jaroz, Camille, Nguyen, Hoang Quy, Belkacemi, Yazid, Taille, Alexandre, Stavrinides, Vasilis, Whitaker, Hayley

“…It is currently believed that stroma, the connective framework of biological tissues, plays a central role in normal wound healing and in cancer…”
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Research Progress of Fibroblasts in Human Diseases by Li, Xiaodong, Li, Nana, Wang, Yujie, Han, Qixiang, Sun, Boshi

“…Fibroblasts, which originate from embryonic mesenchymal cells, are the predominant cell type seen in loose connective tissue…”
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Stroma in breast development and disease by Arendt, Lisa M., Rudnick, Jenny A., Keller, Patricia J., Kuperwasser, Charlotte

“…It is increasingly apparent that normal and malignant breast tissues require complex local and systemic stromal interactions for development and progression…”
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The effect of stromal components on the modulation of the phenotype of human bronchial epithelial cells in 3D culture by Pageau, Steven C., Sazonova, Olga V., Wong, Joyce Y., Soto, Ana M., Sonnenschein, Carlos

“…) or primary human adult lung cancer-associated fibroblasts (LuCAFs), and a surface epithelium of normal human bronchial epithelial cells (HBECs…”
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Significance of Immune and Non-Immune Cell Stroma as a Microenvironment of Hepatocellular Carcinoma—From Inflammation to Hepatocellular Carcinoma Progression by Baj, Jacek, Kołodziej, Magdalena, Kobak, Joanna, Januszewski, Jacek, Syty, Kinga, Portincasa, Piero, Forma, Alicja

“… Therefore, in the following narrative review, we described the role of tumor-infiltrating neutrophils, bone-marrow-derived cells, tumor-associated mast cells, cancer-associated fibroblasts, tumor…”
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CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation by Wu, Wei, Zaal, Esther A, Berkers, Celia R, Lemeer, Simone, Heck, Albert J R

“…Fibroblast activation is associated with tumor progression and implicated in metastasis, but the initial triggering signals required to kick-start this process remain largely unknown…”
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GPER Mediates Non-Genomic Effects of Estrogen by Pupo, Marco, Maggiolini, Marcello, Musti, Anna Maria

“…) is able to mediate non-genomic action of estrogens in different cell contexts. In particular…”
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The Tumor Microenvironment in Neuroendocrine Tumors: Biology and Therapeutic Implications by Cives, Mauro, Pelle', Eleonora, Quaresmini, Davide, Rizzo, Francesca Maria, Tucci, Marco, Silvestris, Franco

“… to discover novel therapeutic targets. NET cells overexpress a plethora of proangiogenic molecules including vascular endothelial growth factor, platelet-derived growth factor, fibroblast growth factor, semaphorins, and angiopoietins…”
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PGE 2 in fibrosis and cancer: Insights into fibroblast activation by Elwakeel, Eiman, Brüne, Bernhard, Weigert, Andreas

“…Fibroblasts are the essential cellular architects of connective tissue and as such are crucial cells in contributing to organ homeostasis…”
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HIF-1[alpha]/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts by De Francesco, Ernestina Marianna, Lappano, Rosamaria, Santolla, Maria Francesca, Marsico, Stefania, Caruso, Arnaldo, Maggiolini, Marcello

“…Introduction Carcinoma-associated fibroblasts (CAFs) play a pivotal role in cancer progression by contributing to invasion, metastasis and angiogenesis…”
Get full text

Periostin and its interacting proteins in the construction of extracellular architectures by Kii, Isao, Ito, Harumi

“…Periostin is a matricellular protein that is composed of a multi-domain structure with an amino-terminal EMI domain, a tandem repeat of four FAS 1 domains, and…”
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Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer by Russo, Eleonora, Santoni, Angela, Bernardini, Giovanni

“… (cancer associated fibroblast, mesenchymal stem cell), and immune cells (tumor‐infiltrating lymphocytes or TIL, dendritic cells, eosinophils, basophils, mast cells, tumor…”
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PGE2 in fibrosis and cancer: Insights into fibroblast activation by Elwakeel, Eiman, Brüne, Bernhard, Weigert, Andreas

“…•Fibroblasts are the main cells of connective tissue and participate in wound repair upon activation…”
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A CNA-35-based high-throughput fibrosis assay reveals ORAI1 as a regulator of collagen release from pancreatic stellate cells by Schleinhege, Rieke, Neumann, Ilka, Oeckinghaus, Andrea, Schwab, Albrecht, Pethő, Zoltán

“…•Establishing a high-throughput in vitro fibrosis assay.•Orai1 is expressed in cancer-associated fibroblasts in murine pancreatic cancer…”
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The potential role of leptin in tumor invasion and metastasis by Ray, Amitabha, Cleary, Margot P.

“…: Cancer-associated fibroblasts, CTGF: Connective tissue growth factor, EGFR: Epidermal growth factor receptor, EMT: Epithelial…”
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