Suchergebnisse - PHENOMENA AND PROCESSES::Genetic Phenomena::Cellular Reprogramming

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties von Panciera, Tito, Citron, Anna, Di Biagio, Daniele, Battilana, Giusy, Gandin, Alessandro, Giulitti, Stefano, Forcato, Mattia, Bicciato, Silvio, Panzetta, Valeria, Fusco, Sabato, Azzolin, Luca, Totaro, Antonio, Dei Tos, Angelo Paolo, Fassan, Matteo, Vindigni, Vincenzo, Bassetto, Franco, Rosato, Antonio, Brusatin, Giovanna, Cordenonsi, Michelangelo, Piccolo, Stefano

“… and their surrounding extracellular matrix. Microenvironments approximating the normal softness of healthy tissues, or blunting cellular mechanotransduction, prevent oncogene-mediated cell reprogramming and tumour emergence. However, RTK …”
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Methods for making induced pluripotent stem cells: reprogramming à la carte von González, Federico, Boué, Stéphanie, Belmonte, Juan Carlos Izpisúa

“… Although direct reprogramming is conceptually and technically simple, it is an extremely slow and inefficient process …”
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Genome-wide reprogramming of primary and secondary metabolism, protein synthesis, cellular growth processes, and the regulatory infrastructure of Arabidopsis in response to nitrogen von Scheible, W.R, Morcuende, R, Czechowski, T, Fritz, C, Osuna, D, Palacios-Rojas, N, Schindelasch, D, Thimm, O, Udvardi, M.K, Stitt, M

“… for >1,400 transcription factors, was performed to identify processes affected by long-term nitrogen-deprivation or short-term nitrate nutrition in Arabidopsis …”
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Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity von Abad, Maria, Hashimoto, Hisayuki, Zhou, Huanyu, Morales, Maria Gabriela, Chen, Beibei, Bassel-Duby, Rhonda, Olson, Eric N.

“… Conversion of fibroblasts into functional cardiomyocytes represents a potential means of restoring cardiac function after myocardial infarction, but so far this process remains inefficient and little …”
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The use of light for engineered control and reprogramming of cellular functions von Bacchus, William, Fussenegger, Martin

“… [Display omitted] ► Nature is equipped with solutions to use light to drive essential metabolic processes …”
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Programmable protein circuit design von Chen, Zibo, Elowitz, Michael B

“… A fundamental challenge in synthetic biology is to create molecular circuits that can program complex cellular functions …”
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Epigenetics: Linking Early Postnatal Nutrition to Obesity Programming? von Marousez, Lucie, Lesage, Jean, Eberlé, Delphine

“… ) the dynamics of epigenetic processes in key metabolic organs during the early postnatal period …”
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Robust cellular reprogramming occurs spontaneously during liver regeneration von Yanger, Kilangsungla, Zong, Yiwei, Maggs, Lara R, Shapira, Suzanne N, Maddipati, Ravi, Aiello, Nicole M, Thung, Swan N, Wells, Rebecca G, Greenbaum, Linda E, Stanger, Ben Z

“… Cellular reprogramming-the ability to interconvert distinct cell types with defined factors-is transforming the field of regenerative medicine …”
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The link between injury-induced stress and regenerative phenomena: A cellular and genetic synopsis von Erler, Piril, Monaghan, James R.

“… Injury is an inescapable phenomenon of life that affects animals at every physiological level …”
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HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance von Nagao, Ayako, Kobayashi, Minoru, Koyasu, Sho, Chow, Christalle C. T., Harada, Hiroshi

“… This metabolic phenomenon, known as aerobic glycolysis or the Warburg effect, is less efficient compared with OXPHOS, from the viewpoint of the amount of ATP produced from one molecule of glucose …”
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Dedifferentiated melanomas: Morpho-phenotypic profile, genetic reprogramming and clinical implications von Massi, Daniela, Mihic-Probst, Daniela, Schadendorf, Dirk, Dummer, Reinhard, Mandalà, Mario

“… •Dedifferentiated melanomas pose diagnostic interpretative challenges.•Dedifferentiation underlies the phenotypic and genetic plasticity of melanoma …”
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Myogenic enhancer snatching promotes adipogenic differentiation during epigenetic reprogramming mediated by lineage-specific transcription factors von Hu, Mingyang, Xu, Zhixiang, Sun, Jiahao, Li, Linmi, Liu, Pengxuan, Zhou, Honghong, Qi, Xiaolong, Ren, Weike, Liu, Yujia, Chen, Shuya, Kuang, Renzhuo, Wang, Daoyuan, Guo, Yaping, Sun, Ge, Zhao, Shuhong, Zhu, Mengjin, Li, Li, Zhao, Yunxia

“… However, the comprehensive dynamics of chromatin accessibility and interactions during this process remain largely unexplored …”
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GLIS1–3 transcription factors: critical roles in the regulation of multiple physiological processes and diseases von Jetten, Anton M.

“… They function as key regulators of embryonic development and a wide range of other physiological processes, and are implicated in a variety of pathologies. GLI-similar 1–3 (GLIS1–3 …”
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On the role of mechanics in driving mesenchymal-to-epithelial transitions von Kim, Hye Young, Jackson, Timothy R., Davidson, Lance A.

“… ) is an intrinsically mechanical process describing a multi-step progression where autonomous mesenchymal cells gradually become tightly linked, polarized epithelial cells …”
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Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans von Mouchiroud, Laurent, Molin, Laurent, Kasturi, Prasad, Triba, Mohamed N., Dumas, Marc Emmanuel, Wilson, Marieangela C., Halestrap, Andrew P., Roussel, Damien, Masse, Ingrid, Dallière, Nicolas, Ségalat, Laurent, Billaud, Marc, Solari, Florence

“… However, the metabolic and cellular processes that underly the beneficial effects of DR are poorly understood. We identified slcf …”
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Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells von Ruiz, Sergio, Lopez-Contreras, Andres J., Gabut, Mathieu, Marion, Rosa M., Gutierrez-Martinez, Paula, Bua, Sabela, Ramirez, Oscar, Olalde, Iñigo, Rodrigo-Perez, Sara, Li, Han, Marques-Bonet, Tomas, Serrano, Manuel, Blasco, Maria A., Batada, Nizar N., Fernandez-Capetillo, Oscar

“… The reasons behind the genomic instability observed in iPSC remain mostly unknown. Here we show that, similar to the phenomenon of oncogene-induced replication stress, the expression of reprogramming factors induces replication stress …”
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Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition von Silva, Jose, Barrandon, Ornella, Nichols, Jennifer, Kawaguchi, Jitsutaro, Theunissen, Thorold W, Smith, Austin

“… Induced pluripotent stem (iPS) cells are generated from somatic cells by genetic manipulation …”
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Metabolic Reprogramming at the Edge of Redox: Connections Between Metabolic Reprogramming and Cancer Redox State von Serrano, José J., Medina, Miguel Ángel

“… The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology …”
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Transdifferentiation: a cell and molecular reprogramming process von Sisakhtnezhad, Sajjad, Matin, Maryam M

“… Evidence has emerged recently indicating that differentiation is not entirely a one-way process, and that it is possible to convert one cell type to another, both in vitro and in vivo …”
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Expression pattern of Oct-4, Sox2, and c-Myc in the primary culture of human dental pulp derived cells von Liu, Lu, Wei, Xi, Ling, Junqi, Wu, Liping, Xiao, Yin

“… Recently, the transcription factors of Oct-4, Sox2, c-Myc, and Klf4 have been reported to play a regulatory role in the stem cell self-renewal process, namely cell reprogramming …”
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