Výsledky vyhledávání - Genetic and Environmental Risk in AD/Defining Genetic

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing Autor Ahmad, Shahzad, Vardarajan, Badri N., Hoffmann, Per, Garnier, Jean-Guillaume, Harold, Denise, Fitzpatrick, Annette L., Valladares, Otto, Smith, Albert V., Qu, Liming, Zhao, Yi, Del Zompo, Maria, Uphill, James, Cantwell, Laura B., Fin, Bertrand, Barber, Robert C., Mayhaus, Manuel, Hartmann, Annette M., Lovestone, Simon, Garcia, Melissa E., Fairchild, Thomas J., Karamujić-Čomić, Hata, Frosch, Matthew P., Maier, Wolfgang, Li, Shuo, Huebinger, Ryan M., Kamboh, M. Ilyas, Yang, Qiong, Haapasalo, Annakaisa, Lawlor, Brian, Solfrizzi, Vincenzo, Frisardi, Vincenza, Alvarez, Ignacio, Salani, Francesca, Fievet, Nathalie, Uitterlinden, A. G. Andre, Maletta, Raffaele Giovanni, Tsuang, Debby W., Soininen, Hilkka, Avramidou, Despoina, Panza, Francesco, Passmore, Peter, Schott, Jonathan M., Powell, John F., Burns, Jeffrey M., Hardy, John, Carrasquillo, Minerva M., Crocco, Elizabeth A., Faber, Kelley M., Scherer, Martin, Ferris, Steven, Galasko, Douglas R., Geschwind, Daniel H., Honig, Lawrence S., Cushion, Thomas D., Hollingworth, Paul, Hulette, Christine M., Jessen, Frank, Lah, James J., Leverenz, James B., Morgan, Kevin, Mash, Deborah C., McCurry, Susan M., Miller, Carol A., Shaw, Christopher E., Myers, Amanda J., Paulson, Henry L., Peskind, Elaine, Cribbs, David H., Rossor, Martin, Pierce, Aimee, Potter, Huntington, Sorbi, Sandro, Reitz, Christiane, Ringman, John M., Rosen, Howard J., Mecocci, Patrizia, Slifer, Susan, Spina, Salvatore, Vinters, Harry V., Weintraub, Sandra, Welsh-Bohmer, Kathleen A., Pilotto, Alberto, Bullido, Maria J., Bennett, David, Bosco, Paola, Lleo, Alberto, Ingelsson, Martin, Fornage, Myriam, Goate, Alison M., Kehoe, Patrick G., Amin, Najaf, Launer, Lenore J., Younkin, Steven G., Dartigues, Jean-Francois, Corcoran, Chris, Schmidt, Helena, Munger, Ron, DeStefano, Anita L., Owen, Michael J., Amouyel, Phillippe

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing Autor Ahmad, Shahzad, Vardarajan, Badri N., Hoffmann, Per, Garnier, Jean-Guillaume, Harold, Denise, Fitzpatrick, Annette L., Valladares, Otto, Smith, Albert V., Qu, Liming, Zhao, Yi, Del Zompo, Maria, Uphill, James, Cantwell, Laura B., Garzia, Fabienne, Fin, Bertrand, Barber, Robert C., Mayhaus, Manuel, Hartmann, Annette M., Lovestone, Simon, Garcia, Melissa E., Fairchild, Thomas J., Karamujić-Čomić, Hata, Frosch, Matthew P., Maier, Wolfgang, Li, Shuo, Huebinger, Ryan M., Kamboh, M. Ilyas, Yang, Qiong, Haapasalo, Annakaisa, Lawlor, Brian, Solfrizzi, Vincenzo, Frisardi, Vincenza, Alvarez, Ignacio, Salani, Francesca, Fievet, Nathalie, Maletta, Raffaele Giovanni, Tsuang, Debby W., Soininen, Hilkka, Avramidou, Despoina, Panza, Francesco, Frölich, Lutz, Passmore, Peter, Schott, Jonathan M., Powell, John F., Burns, Jeffrey M., Hardy, John, Carrasquillo, Minerva M., Crocco, Elizabeth A., Faber, Kelley M., Scherer, Martin, Ferris, Steven, Galasko, Douglas R., Geschwind, Daniel H., Honig, Lawrence S., Cushion, Thomas D., Hollingworth, Paul, Hulette, Christine M., Jessen, Frank, Lah, James J., Leverenz, James B., Morgan, Kevin, Mash, Deborah C., McCurry, Susan M., Miller, Carol A., Shaw, Christopher E., Myers, Amanda J., Paulson, Henry L., Peskind, Elaine, Cribbs, David H., Rossor, Martin, Pierce, Aimee, Potter, Huntington, Sorbi, Sandro, Reitz, Christiane, Ringman, John M., Rosen, Howard J., Mecocci, Patrizia, Slifer, Susan, Spina, Salvatore, Vinters, Harry V., Weintraub, Sandra, Welsh-Bohmer, Kathleen A., Crane, Paul K., Bennett, David, Boccardi, Virginia, Lopez, Oscar L., Deloukas, Panagiotis, Cruchaga, Carlos, Berr, Claudine, Younkin, Steven G., Clarimon, Jordi, Schmidt, Reinhold, Farrer, Lindsay A., Van Broeckhoven, Christine, C. O’Donovan, Michael, Haines, Jonathan L., Gudnason, Vilmundur, Mayeux, Richard, Seshadri, Sudha, Williams, Julie

“…Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics…”
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Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing Autor Brian W. Kunkle, Aura Frizatti, Nandini Badarinarayan, Kara L. Hamilton-Nelson, Robert Olaso, Taniesha Morgan, Shahzad Ahmad, Jacques Epelbaum, Denise Harold, Marie-Laure Moutet, Maria Del Zompo, Nick C. Fox, Joseph T. Hughes, Hieab H. Adams, David Wallon, Laura B. Cantwell, Fabienne Garzia, Edith Hofer, Will S. Bush, Charles C. White, Manuel Mayhaus, Alessio Squassina, Melissa E. Garcia, Rachelle S. Doody, Matthew P. Frosch, Amit Kawalia, Shuo Li, Lena Kilander, Isabel Hernández, Qiong Yang, Letizia Concari, C. Dirk Keene, Iwona Kloszewska, Anne Maria Koivisto, Annakaisa Haapasalo, Michael Gill, Thomas J. Montine, Fernando Rivadeneira, Antonio Ciaramella, Eric M. Reiman, Joan S. Reisch, Chiara Cupidi, A. G. Andre Uitterlinden, Raffaele Giovanni Maletta, Itziar de Rojas, Mary Sano, Olymbia Gkatzima, Inés Quintela, Bradley F. Boeve, Michelle K. Lupton, Michelangelo Mancuso, Ubaldo Bonuccelli, Jose Bras, Mariet Allen, Elizabeth A. Crocco, Charles DeCarli, Malcolm Dick, Li Ma, Ranjan Duara, Tatiana M. Foroud, Daniel H. Geschwind, Lindy E. Harrell, Matthew J. Huentelman, Lee-Way Jin, Joel H. Kramer, Kristelle Brown, Nigel M. Hooper, Hendrik van den Bussche, Bruce L. Miller, Amanda J. Myers, David H. Cribbs, Martin Rossor, Natalie S. Ryan, Wayne W. Poon, Eleonora Sacchinelli, Paola Bossù, Donald Warden, Erik D. Roberson, Ekaterina Rogaeva, Roger N. Rosenberg, Patrizia Mecocci, Pau Pastor, Julie A. Schneider, John Q. Trojanowski, Vivianna M. Van Deerlin, Randall L. Woltjer, Chang-En Yu, Alberto Pilotto, Oliver Peters, David Bennett, Alison M. Goate, Nilifur Ertekin-Taner, Claudine Berr, Chris Corcoran, Helena Schmidt, Christine Van Broeckhoven, Bruce M. Psaty, Alfredo Ramirez, Julie Williams, Phillippe Amouyel

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Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology Autor Kumar, Prateek, Goettemoeller, Annie M., Espinosa-Garcia, Claudia, Tobin, Brendan R., Tfaily, Ali, Nelson, Ruth S., Natu, Aditya, Dammer, Eric B., Santiago, Juliet V., Malepati, Sneha, Cheng, Lihong, Xiao, Hailian, Duong, Duc D., Seyfried, Nicholas T., Wood, Levi B., Rowan, Matthew J. M., Rangaraju, Srikant

“…Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD…”
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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease Autor Rathore, Nisha, Ramani, Sree Ranjani, Pantua, Homer, Payandeh, Jian, Bhangale, Tushar, Wuster, Arthur, Kapoor, Manav, Sun, Yonglian, Kapadia, Sharookh B., Gonzalez, Lino, Zarrin, Ali A., Goate, Alison, Hansen, David V., Behrens, Timothy W., Graham, Robert R.

“… We show here that a common missense variant (G78R, rs1859788) of PILRA is the likely causal allele for the confirmed Alzheimer's disease risk locus at 7q21 (rs1476679…”
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