Výsledky vyhledávání - Comprehensive Integration of Single-Cell Transcriptomic Data

Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification Autor Cao, Shanni, Zhao, Xue, Li, Zhuojin, Yu, Ranran, Li, Yuqi, Zhou, Xinkai, Yan, Wenhao, Chen, Dijun, He, Chao

“…) in intricate regulatory networks in a cell-type specific manner. Here we introduced a comprehensive single-cell transcriptomic atlas of Arabidopsis seedlings…”
Získat plný text

Multi-Omics Uncover Neonatal Cecal Cell Development Potentials Autor Liang Chen, Qingshi Meng, Li Shen, Yue Jiang, Cong Zhang, Shouwei Tang, Ruqing Zhong, Xiangfang Tang, Sheng Zhang, Xiaohui Feng, Yong Zhao, Hongfu Zhang

Získat plný text

Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification Autor Cao, Shanni, He, Chao, Zhao, Xue, Yu, Ranran, Li, Yuqi, Fang, Wen, Chen-Yu, Zhang, Yan, Wenhao, Chen, Dijun

“…) in intricate regulatory networks at a cell-type specific manner. Here we presented a reference single-cell transcriptomic atlas of Arabidopsis seedlings by integration…”
Získat plný text

A pillar-based microfluidic chip for T-cells and B-cells isolation and detection with machine learning algorithm Autor Bilal Turan, Taisuke Masuda, Lei Wu, Anas Mohd Noor, Koji Horio, Toshiki Saito, Yasuyuki Miyata, Fumihito Arai

Získat plný text

Comprehensive Integration of Multiple Single-Cell Transcriptomic Data Sets Defines Distinct Cell Populations and Their Phenotypic Changes in Murine Atherosclerosis Autor Sharma, Disha, Worssam, Matthew D, Pedroza, Albert J, Dalal, Alex R, Alemany, Haizea, Kim, Hyun-Jung, Kundu, Ramendra, Fischbein, Michael P, Cheng, Paul, Wirka, Robert, Quertermous, Thomas

“…The application of single-cell transcriptomic (single-cell RNA sequencing) analysis to the study of atherosclerosis has provided unique insights into the molecular and genetic mechanisms that mediate disease risk and pathophysiology…”
Zjistit podrobnosti o přístupu

A unified computational framework for single-cell data integration with optimal transport Autor Cao, Kai, Gong, Qiyu, Hong, Yiguang, Wan, Lin

“…Single-cell data integration can provide a comprehensive molecular view of cells…”
Získat plný text

Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution Autor Li, Bin, Zhang, Wen, Guo, Chuang, Xu, Hao, Li, Longfei, Fang, Minghao, Hu, Yinlei, Zhang, Xinye, Yao, Xinfeng, Tang, Meifang, Liu, Ke, Zhao, Xuetong, Lin, Jun, Cheng, Linzhao, Chen, Falai, Xue, Tian, Qu, Kun

“…-transcriptome-level data for single cells in space. Addressing this need, researchers have developed integration methods to combine spatial transcriptomic data with single-cell RNA-seq data to predict the spatial distribution of undetected transcripts…”
Získat plný text

Principled and interpretable alignability testing and integration of single-cell data Autor Ma, Rong, Sun, Eric D, Donoho, David, Zou, James

“…Single-cell data integration can provide a comprehensive molecular view of cells, and many algorithms have been developed to remove unwanted technical or biological variations and integrate…”
Zjistit podrobnosti o přístupu

Unraveling Alzheimer’s disease: insights from single-cell sequencing and spatial transcriptomic Autor He, Yibo, Lu, Wenqiang, Zhou, Xiao, Mu, Jie, Shen, Wei

“… This review highlights recent advancements in single-cell sequencing and spatial transcriptomics, which provide detailed insights into the cellular heterogeneity and neuroimmune mechanisms of AD…”
Získat plný text

Identification of immunogenic cell death signature genes in hepatocellular carcinoma: from single-cell transcriptomics to in vitro mechanistic validation and comprehensive prognostic modeling with hundreds of machine learning algorithms Autor Liu, Hongliang, Sun, Zhenni, Wang, Xi, Zhou, Bin, Cha, Lichao

“… We performed multi-omics integration of single-cell RNA sequencing data from 7 HCC samples (GSE112271, 44,461 cells…”
Získat plný text

Comprehensive Integration of Single-Cell Data Autor Stuart, Tim, Butler, Andrew, Hoffman, Paul, Hafemeister, Christoph, Papalexi, Efthymia, Mauck, 3rd, William M, Hao, Yuhan, Stoeckius, Marlon, Smibert, Peter, Satija, Rahul

“…Single-cell transcriptomics has transformed our ability to characterize cell states, but deep biological understanding requires more than a taxonomic listing of clusters…”
Zjistit podrobnosti o přístupu

Quantitative analysis of high‐throughput biological data Autor Juan, Hsueh‐Fen, Huang, Hsuan‐Cheng

“… We first review the quantitative analysis of not only bulk but also single‐cell transcriptomics data, as well as proteomics data…”
Získat plný text

Identification of genomic enhancers through spatial integration of single‐cell transcriptomics and epigenomics Autor Bravo González‐Blas, Carmen, Quan, Xiao‐Jiang, Duran‐Romaña, Ramon, Taskiran, Ibrahim Ihsan, Koldere, Duygu, Davie, Kristofer, Christiaens, Valerie, Makhzami, Samira, Hulselmans, Gert, de Waegeneer, Maxime, Mauduit, David, Poovathingal, Suresh, Aibar, Sara, Aerts, Stein

“…Single‐cell technologies allow measuring chromatin accessibility and gene expression in each cell, but jointly utilizing both layers to map bona fide gene regulatory networks and enhancers remains challenging…”
Získat plný text

Geometric Sketching Compactly Summarizes the Single-Cell Transcriptomic Landscape Autor Hie, Brian, Cho, Hyunghoon, DeMeo, Benjamin, Bryson, Bryan, Berger, Bonnie

“… Here, we describe how to enhance and accelerate single-cell data analysis by summarizing the transcriptomic heterogeneity within a dataset using a small subset of cells, which we refer to as a geometric sketch…”
Zjistit podrobnosti o přístupu

Panpipes: a pipeline for multiomic single-cell and spatial transcriptomic data analysis Autor Curion, Fabiola, Rich-Griffin, Charlotte, Agarwal, Devika, Ouologuem, Sarah, Rue-Albrecht, Kevin, May, Lilly, Garcia, Giulia E. L., Heumos, Lukas, Thomas, Tom, Lason, Wojciech, Sims, David, Theis, Fabian J., Dendrou, Calliope A.

“…Single-cell multiomic analysis of the epigenome, transcriptome, and proteome allows for comprehensive characterization of the molecular circuitry that underpins cell identity and state…”
Získat plný text

Resolving single-cell gene expression by pseudo-temporal integration of transcriptomic and proteomic datasets Autor Barry, Craig P, Talbo, Gert H, Beauglehole, Aiden, Ovchinnikov, Dmitry, Munro, Trent, Mahler, Stephen, Baker, Kym, Nielsen, Lars K, Mercer, Tim R, Marcellin, Esteban

“… We collected longitudinal single-cell samples following hypoxia. By leveraging key markers, we constructed pseudo-temporal trajectories for each data type, revealing transcriptional and translational responses to hypoxia…”
Získat plný text

Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics Autor Chen, Tao, Xu, Yiliang, Xu, Xiaocui, Wang, Jianzhang, Qiu, Zhiruo, Yu, Yayuan, Jiang, Xiaohong, Shao, Wanqi, Bai, Dandan, Wang, Mingzhu, Mei, Shuyan, Cheng, Tao, Wu, Li, Gao, Shaorong, Che, Xuan

“… Using single-cell RNA sequencing and spatial profiling, we mapped transcriptional alterations across eutopic endometrium, lesions, and EMJ…”
Získat plný text

Single-cell transcriptomics: a new frontier in plant biotechnology research Autor Singh, Shilpy, Praveen, Afsana, Dudha, Namrata, Sharma, Varun Kumar, Bhadrecha, Pooja

“… We present a comprehensive overview of the latest advancements in single-cell transcriptomics, emphasizing their application in elucidating complex cellular processes and developmental pathways in plants…”
Získat plný text

Integration of Pan-Cancer Single-Cell and Spatial Transcriptomics Reveals Stromal Cell Features and Therapeutic Targets in Tumor Microenvironment Autor Du, Yanhua, Shi, Jintong, Wang, Jiaxin, Xun, Zhenzhen, Yu, Zhuo, Sun, Hongxiang, Bao, Rujuan, Zheng, Junke, Li, Zhigang, Ye, Youqiong

“… cells. Here, we performed a pan-cancer analysis of 214,972 nonimmune stromal cells using single-cell RNA sequencing from 258 patients across 16 cancer types and analyzed spatial transcriptomics from 16…”
Zjistit podrobnosti o přístupu

Large-Scale Integration of Single-Cell RNA-Seq Data Reveals Astrocyte Diversity and Transcriptomic Modules across Six Central Nervous System Disorders Autor Qian, Zhenwei, Qin, Jinglin, Lai, Yiwen, Zhang, Chen, Zhang, Xiannian

“… Here, we demonstrate how large-scale integration of multi-omics data, including single-cell and spatial transcriptomic and proteomic data, overcomes these limitations…”
Získat plný text